{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:21:36Z","timestamp":1791588096868,"version":"4.3.4"},"reference-count":38,"publisher":"Akademiai Kiado Zrt.","issue":"20","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["Orv Hetil."],"published-print":{"date-parts":[[2021,5,16]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic> A citol\u00f3giai alap\u00fa m\u00e9hnyakr\u00e1ksz\u0171r\u00e9s \u00e1tmeneti\n                    kateg\u00f3ri\u00e1inak optim\u00e1lis menedzsel\u00e9se a hum\u00e1n papillomav\u00edrus (HPV) sz\u0171r\u00e9se \u00e9s\n                    tipiz\u00e1l\u00e1sa ellen\u00e9re jelenleg is kih\u00edv\u00e1s. Vizsg\u00e1latunk c\u00e9lja a modern\n                    cervixspektroszk\u00f3pi\u00e1nak (multimod\u00e1lis hiperspektroszk\u00f3pia \u2013 MHS), egy azonnali\n                    eredm\u00e9nyt ny\u00fajt\u00f3, digit\u00e1lis technol\u00f3gi\u00e1ra \u00e9p\u00fcl\u0151 m\u00f3dszernek a vizsg\u00e1lata volt a\n                    citol\u00f3giai alap\u00fa m\u00e9hnyaksz\u0171r\u00e9s tal\u00e1lati biztons\u00e1g\u00e1nak jav\u00edt\u00e1s\u00e1ra.\n                        <jats:italic>Betegek \u00e9s m\u00f3dszer:<\/jats:italic> Vizsg\u00e1latainkat 208, 18 \u00e9s 75 \u00e9v\n                    k\u00f6z\u00f6tti n\u0151beteg bevon\u00e1s\u00e1val v\u00e9gezt\u00fck, akikn\u00e9l m\u00e1r indik\u00e1l\u00e1sra ker\u00fclt valamely, a\n                    m\u00e9hnyakon v\u00e9gzend\u0151 m\u0171t\u00e9t, citol\u00f3giai eredm\u00e9ny\u00fck rendelkez\u00e9sre \u00e1llt (a\n                    HPV-tesztet, amennyiben nem t\u00f6rt\u00e9nt meg, elv\u00e9gezt\u00fck), valamint valamennyi\n                    betegn\u00e9l elv\u00e9gezt\u00fck a m\u0171t\u00e9t el\u0151tt az MHS-vizsg\u00e1latot. A sz\u00f6vettani mintav\u00e9tel\n                    166 betegn\u00e9l t\u00f6rt\u00e9nt meg. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A citol\u00f3giai vizsg\u00e1latot\n                    (az \u00f6sszes betegre tekintve) magas \u00e1lpozit\u00edv ar\u00e1ny jellemezte (69,28%), amely\n                    megfigyel\u00e9sek mindenk\u00e9ppen utalnak az \u00fajabb komponens alkalmaz\u00e1s\u00e1nak ig\u00e9ny\u00e9re a\n                    tri\u00e1zsban. Az \u00f6sszes citol\u00f3giai kateg\u00f3ri\u00e1ra n\u00e9zve az MHS-eredm\u00e9nyek k\u00f6z\u00fcl\n                    kiemelend\u0151 az \u00e1lnegat\u00edv leletek rendk\u00edv\u00fcl alacsony ar\u00e1nya (3\/166 = 1,8%), mely a\n                    HPV-teszt eset\u00e9n enn\u00e9l magasabb volt (11\/165 = 6,66%). A spektroszk\u00f3pi\u00e1s\n                    vizsg\u00e1lat \u00e1lpozit\u00edv ar\u00e1nya ugyanakkor kedvez\u0151tlenebbnek bizonyult (91\/166 =\n                    54,81%) a HPV-vizsg\u00e1lat \u00e1lpozit\u00edv ar\u00e1ny\u00e1n\u00e1l (40\/165 = 24,24%). Az at\u00edpusos\n                    laph\u00e1msejt (ASC-US\/ASC-H) citol\u00f3giai kateg\u00f3ria eset\u00e9n a spektroszk\u00f3pia \u00e1lnegat\u00edv\n                    eredm\u00e9nyeinek ar\u00e1nya (3\/126 = 2,38%) szint\u00e9n kedvez\u0151bb volt, mint a\n                    HPV-vizsg\u00e1lat\u00e9 (9\/126 = 7,14%). A cervicalis intraepithelialis neoplasia-2 vagy\n                    s\u00falyosabb fokozat\u00fa h\u00e1melv\u00e1ltoz\u00e1sok azonos\u00edt\u00e1s\u00e1ban a spektroszk\u00f3pia\n                    szenzitivit\u00e1sa 94% (95% CI = 0,84\u20130,99), specificit\u00e1sa 22% (95% CI = 0,15\u20130,31),\n                    negat\u00edv predikt\u00edv \u00e9rt\u00e9ke 90% (95% CI = 0,73\u20130,98), pozit\u00edv predikt\u00edv \u00e9rt\u00e9ke 34%\n                    (95% CI = 0,26\u20130,43) volt (p = 0,00130). <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> Az MHS\n                    fejlett innovat\u00edv technol\u00f3gi\u00e1n alapul\u00f3, azonnali eredm\u00e9nyt ad\u00f3 vizsg\u00e1l\u00f3elj\u00e1r\u00e1s,\n                    amely kiemelked\u0151en alacsony \u00e1lnegat\u00edv eredm\u00e9nye miatt nagy seg\u00edts\u00e9get ny\u00fajt a\n                    citol\u00f3giai elt\u00e9r\u00e9ssel rendelkez\u0151 betegek tov\u00e1bbi vizsg\u00e1lat\u00e1ban. Orv Hetil. 2021;\n                    162(20): 790\u2013799.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold>\n                    <jats:italic>Introduction:<\/jats:italic> Despite the use of human papillomavirus (HPV)\n                    testing, the management of the transitional categories of cytology-based\n                    screening still remains a challenge. The modern multimodal hyperspectroscopy\n                    (MHS) of the cervix is a novel digital technology based on artificial\n                    intelligence, providing an instant result in the assessment of cytology-based\n                    screening abnormalities. <jats:italic>Patients and methods:<\/jats:italic> 208 women (age\n                    18\u201375) were enrolled. The patients already had cytology results and an operation\n                    on the cervix indicated at the time of inclusion. HPV and the hyperspectroscopy\n                    examination was performed pre-operatively. The pre-indicated operation was\n                    performed on 166 patients. <jats:italic>Results:<\/jats:italic> Cytology-based screening\n                    alone (in the category of all patients) resulted in a high false-positive rate\n                    (69.28%). In this category, the MHS had an outstanding false-negative rate\n                    (3\/166 = 1.80%) compared to the HPV (11\/165 = 6.66%). The false-positive rate of\n                    the spectroscopy examination (91\/166 = 54.81%) was higher than that of the HPV\n                    testing (40\/165 = 24.24%). In the atypical squamous cell (ASC-US\/ASC-H)\n                    category, the false-negative rate of the spectroscopy (3\/126 = 2.38%) was also\n                    lower than that of the HPV test (9\/126 = 7.14%). In the detection of high-grade\n                    abnormalities (cervical intraepithelial neoplasia 2 and worse), the spectroscopy\n                    had a 94% sensitivity (95% CI = 0.84\u20130.99), with a 22% specificity (95% CI =\n                    0.15\u20130.31), an 90% negative predictive value (95% CI = 0.73\u20130.98), and a 34%\n                    positive predictive value (95% CI = 0.26\u20130.43) (p = 0.00130).\n                        <jats:italic>Conclusion:<\/jats:italic> In the case of cytological abnormality, the MHS\n                    provides an immediate result based on advanced digital technology, and because\n                    of its outstanding false negative rate it is a great aid and should be\n                    considered in the triage of such patients. Orv Hetil. 2021; 162(20):\n                    790\u2013799.<\/jats:p>","DOI":"10.1556\/650.2021.32096","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T10:05:26Z","timestamp":1630404326000},"page":"790-799","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":2,"title":["Multimod\u00e1lis hiperspektroszk\u00f3pia \u2013 el\u0151rel\u00e9p\u00e9s a digit\u00e1lis technol\u00f3gia fel\u00e9 a m\u00e9hnyaksz\u0171r\u00e9sben"],"prefix":"10.1556","volume":"162","author":[{"given":"Zo\u00e1rd Tibor","family":"Krasznai","sequence":"first","affiliation":[{"name":"1 Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet, Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsa","family":"Bagoly","sequence":"additional","affiliation":[{"name":"2 Debreceni Egyetem, Laborat\u00f3riumi Medicina Int\u00e9zet, Klinikai Laborat\u00f3riumi Kutat\u00f3 Tansz\u00e9k, Debrecen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Nagy","sequence":"additional","affiliation":[{"name":"3 D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Farkas","sequence":"additional","affiliation":[{"name":"1 Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet, Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3bert","family":"P\u00f3ka","sequence":"additional","affiliation":[{"name":"1 Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet, Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"1 Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet, Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Lamp\u00e9","sequence":"additional","affiliation":[{"name":"1 Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet, Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Hern\u00e1di","sequence":"additional","affiliation":[{"name":"1 Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet, Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1 Bray F, Ferlay J, Soerjomataram I, et al. 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