{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:06:18Z","timestamp":1785366378113,"version":"3.55.0"},"reference-count":20,"publisher":"Akademiai Kiado Zrt.","issue":"16","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,4,18]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> \u00dajabb megfigyel\u00e9sek szerint a SARS-CoV-2-fert\u0151z\u00e9st\n                    k\u00f6vet\u0151en gyermekekben a paediatric inflammatory multisystem syndrome (PIMS)\n                    elnevez\u00e9s\u0171, sokk\u00e1llapottal sz\u00f6v\u0151d\u00f6tt Kawasaki-megbeteged\u00e9shez hasonl\u00edt\u00f3,\n                    t\u00f6bbszervi el\u00e9gtelens\u00e9gnek megfelel\u0151 t\u00fcnetegy\u00fcttes alakulhat ki. A gyermekek\n                    t\u00f6bbs\u00e9g\u00e9ben ilyenkor a direkt v\u00edruskimutat\u00e1s m\u00e1r sikertelen, azonban a\n                    SARS-CoV-2 ellen k\u00e9pz\u0151d\u00f6tt antitest igazolhatja a diagn\u00f3zist. Dolgozatunk c\u00e9lja\n                    az egyik els\u0151 hazai eset ismertet\u00e9se. Egy 15 \u00e9ves fi\u00fa ker\u00fclt gyermek intenz\u00edv\n                    oszt\u00e1lyos felv\u00e9telre t\u00f6bb napon \u00e1t \u00e9szlelt magas l\u00e1z, keszty\u0171-, zokniszer\u0171\n                    exanthema, conjunctivitis, t\u00f6bbszervi el\u00e9gtelens\u00e9g, szeptikus sokk t\u00fcneteivel,\n                    akut gyullad\u00e1sra utal\u00f3 laborat\u00f3riumi elt\u00e9r\u00e9sekkel \u00e9s diff\u00faz hasi panaszokkal.\n                    Felv\u00e9tel\u00e9t megel\u0151z\u0151en n\u00e9h\u00e1ny h\u00e9ttel SARS-CoV-2-fert\u0151z\u00e9sen esett \u00e1t. Felv\u00e9telekor\n                    a direkt v\u00edruskimutat\u00e1s sikertelen volt, \u00e1m a SARS-CoV-2 elleni antitest\n                    vizsg\u00e1lata pozit\u00edv lett. Komplex intenz\u00edv ter\u00e1pia mellett \u00e1llapota\n                    stabiliz\u00e1l\u00f3dott. Az irodalmi aj\u00e1nl\u00e1soknak megfelel\u0151en immunglobulin-,\n                    acetilszalicilsav- \u00e9s szteroidkezel\u00e9sben r\u00e9szes\u00edtett\u00fck, melynek hat\u00e1s\u00e1ra\n                    \u00e1llapota maradv\u00e1nyt\u00fcnetek n\u00e9lk\u00fcl rendez\u0151d\u00f6tt. A n\u00f6vekv\u0151 esetsz\u00e1m\u00fa gyermekkori\n                    SARS-CoV-2-fert\u0151z\u00e9s mellett egyre gyakrabban v\u00e1rhat\u00f3 a SARS-CoV-2-fert\u0151z\u00e9st\n                    k\u00f6vet\u0151, a Kawasaki-betegs\u00e9g t\u00fcneteire eml\u00e9keztet\u0151 PIMS kialakul\u00e1sa. Gyermekekben\n                    s\u00falyos szeptikus \u00e1llapot \u00e9s t\u00f6bbszervi el\u00e9gtelens\u00e9g eset\u00e9n gondolni kell a PIMS\n                    lehet\u0151s\u00e9g\u00e9re, mely esetenk\u00e9nt intenz\u00edv oszt\u00e1lyos ell\u00e1t\u00e1st \u00e9s c\u00e9lzott ter\u00e1pi\u00e1t\n                    ig\u00e9nyel. Legjobb tudom\u00e1sunk szerint a le\u00edr\u00e1sra ker\u00fclt beteg a Magyarorsz\u00e1gon\n                    diagnosztiz\u00e1lt egyik legkor\u00e1bbi eset. Orv Hetil. 2021; 162(16): 602\u2013607.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> Recently following SARS-CoV-2 infection, a new, multisystem\n                    disease (paediatric inflammatory multisystem syndrome, PIMS) with fever was\n                    recognized in children with shock and multiorgan failure. On of the first\n                    Hungarian cases will be described. A 15-year-old boy was admitted to the\n                    Paediatric Intensive Care Unit with persistent high fever, diffuse abdominal\n                    pain, septic shock, multiple organ failure, gloves- and socks-shaped cutan\n                    exanthema, conjunctivitis and laboratory signs of inflammation. Some weeks\n                    preceding his admission, symptoms of mild SARS-CoV-2 infection were revealed. At\n                    admission, the SARS-CoV-2 PCR and antigen tests were negative, however, the\n                    presence of IgG antibody was shown. Following complex supportive intensive care\n                    along with internationally recommended immunoglobulin, aspirin and steroid\n                    treatment, the patient was completely cured without any sequalae. In children\n                    after SARS-CoV-2 infection, PIMS could occur mimicking Kawasaki syndrome. At\n                    this time, in children virus PCR or antigen tests are usually negative already,\n                    but the presence of SARS-CoV-2 antibody could prove the preceding disease. Due\n                    to the increasing number of SARS-CoV-2 infections, the occurrence of\n                    post-SARS-CoV-2 PIMS in childhood is expected to increase. For paediatric\n                    patients, in case of severe septic state and multiple organ failure, PIMS should\n                    be also considered, which may require intensive care and targeted therapy. As\n                    far as we know, the described case is one of the earliest cases of PIMS in\n                    Hungary. Orv Hetil. 2021; 162(16): 602\u2013607.<\/jats:p>","DOI":"10.1556\/650.2021.32129","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T13:22:49Z","timestamp":1626268969000},"page":"602-607","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":2,"title":["SARS-CoV-2-fert\u0151z\u00e9shez t\u00e1rsul\u00f3 t\u00f6bbszervi megbeteged\u00e9s 15 \u00e9ves fi\u00faban"],"prefix":"10.1556","volume":"162","author":[{"given":"Cec\u00edlia","family":"Ormay","sequence":"first","affiliation":[{"name":"1 Velkey L\u00e1szl\u00f3 Gyermekeg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Borsod-Aba\u00faj-Zempl\u00e9n Megyei K\u00f6zponti K\u00f3rh\u00e1z \u00e9s Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, Miskolc, Szentp\u00e9teri kapu 72\u201376., 3525"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u00e1ta","family":"Onoz\u00f3","sequence":"additional","affiliation":[{"name":"1 Velkey L\u00e1szl\u00f3 Gyermekeg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Borsod-Aba\u00faj-Zempl\u00e9n Megyei K\u00f6zponti K\u00f3rh\u00e1z \u00e9s Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, Miskolc, Szentp\u00e9teri kapu 72\u201376., 3525"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9ka","family":"Fitala","sequence":"additional","affiliation":[{"name":"1 Velkey L\u00e1szl\u00f3 Gyermekeg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Borsod-Aba\u00faj-Zempl\u00e9n Megyei K\u00f6zponti K\u00f3rh\u00e1z \u00e9s Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, Miskolc, Szentp\u00e9teri kapu 72\u201376., 3525"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1roly","family":"Hal\u00e1sz","sequence":"additional","affiliation":[{"name":"1 Velkey L\u00e1szl\u00f3 Gyermekeg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Borsod-Aba\u00faj-Zempl\u00e9n Megyei K\u00f6zponti K\u00f3rh\u00e1z \u00e9s Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, Miskolc, Szentp\u00e9teri kapu 72\u201376., 3525"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzs\u00e9bet","family":"Szakos","sequence":"additional","affiliation":[{"name":"1 Velkey L\u00e1szl\u00f3 Gyermekeg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Borsod-Aba\u00faj-Zempl\u00e9n Megyei K\u00f6zponti K\u00f3rh\u00e1z \u00e9s Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, Miskolc, Szentp\u00e9teri kapu 72\u201376., 3525"},{"name":"2 Miskolci Egyetem, Eg\u00e9szs\u00e9g\u00fcgyi Kar, Miskolc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoletta","family":"Kosztopulosz","sequence":"additional","affiliation":[{"name":"1 Velkey L\u00e1szl\u00f3 Gyermekeg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Borsod-Aba\u00faj-Zempl\u00e9n Megyei K\u00f6zponti K\u00f3rh\u00e1z \u00e9s Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, Miskolc, Szentp\u00e9teri kapu 72\u201376., 3525"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Hauser","sequence":"additional","affiliation":[{"name":"1 Velkey L\u00e1szl\u00f3 Gyermekeg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Borsod-Aba\u00faj-Zempl\u00e9n Megyei K\u00f6zponti K\u00f3rh\u00e1z \u00e9s Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, Miskolc, Szentp\u00e9teri kapu 72\u201376., 3525"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1 World Health Organization. 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[Diagnosztikus l\u00e9p\u00e9sek \u00e9s a betegs\u00e9g progn\u00f3zis\u00e1nak becsl\u00e9se COVID-19-fert\u0151z\u00f6tt betegeken.] Orv Hetil. 2020; 161: 667-671. [Hungarian]","DOI":"10.1556\/650.2020.31815"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4 Berh\u00e9s M, F\u00e1bi\u00e1n \u00c1, L\u00e1szl\u00f3 I, et al. Organ replacement therapy and life-supporting treatment modalities in critically ill COVID-19 patients. [Emelt szint\u0171 szervt\u00e1mogat\u00f3 \u00e9s \u00e9letfenntart\u00f3 kezel\u00e9sek kritikus \u00e1llapot\u00fa COVID-19-fert\u0151z\u00f6tt betegeken.] Orv Hetil. 2020; 161: 704-709. [Hungarian]","DOI":"10.1556\/650.2020.31813"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5 V\u00e1radi A, Ferenci T, Falus A, et al. The coronavirus-induced COVID-19 pandemic. Previous experiences and scientific evidences at the end of March, 2020. [A koronav\u00edrus okozta COVID-19-pand\u00e9mia. Kor\u00e1bbi tapasztalatok \u00e9s tudom\u00e1nyos evidenci\u00e1k 2020. m\u00e1rcius v\u00e9g\u00e9n.] Orv Hetil. 2020; 161: 644-651. [Hungarian]","DOI":"10.1556\/650.2020.31830"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6 Carlotti APCP, Carvalho WB, Johnston C, et al. COVID-19 diagnostic and management protocol for pediatric patients. Clinics (Sao Paulo) 2020; 75: e1894.","DOI":"10.6061\/clinics\/2020\/e1894"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7 Harwood R, Allin B, Jones CE, et al. A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. Lancet Child Adolesc Health 2021; 5: 133-141. [Erratum: Lancet Child Adolesc Health 2021; 5: e5.]","DOI":"10.1016\/S2352-4642(20)30304-7"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1001\/jama.2020.10369","article-title":"Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2","volume":"324","author":"8 Whittaker","year":"2020","unstructured":"8 Whittaker E, Bamford A, Kenny J, et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA 2020; 324: 259-269.","journal-title":"JAMA"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0140-6736(20)31094-1","article-title":"Hyperinflammatory shock in children during COVID-19 pandemic","volume":"395","author":"9 Riphagen","year":"2020","unstructured":"9 Riphagen S, Gomez X, Gonzales-Martinez C, et al. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020; 395: 1607-1608.","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10 Grimaud M, Starck J, Levy M, et al. Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. Ann. Intensive Care 2020; 10: 69.","DOI":"10.1186\/s13613-020-00690-8"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","article-title":"An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study","volume":"395","author":"11 Verdoni","year":"2020","unstructured":"11 Verdoni L, Mazza A, Gervasoni A, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet 2020; 395: 1771-1778.","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(20)31129-6","article-title":"Kawasaki-like disease: emerging complication during the COVID-19 pandemic","volume":"395","author":"Viner RM","year":"2020","unstructured":"12 Viner RM, Whittaker E. Kawasaki-like disease: emerging complication during the COVID-19 pandemic. Lancet 2020; 395: 1741-1743.","journal-title":"Lancet"},{"key":"ref12","unstructured":"13 Swann OV, Holden KA, Turtle L, et al. Clinical characteristics of children and young people admitted to hospital with COVID-19 in the United Kingdom: prospective multicentre observational cohort study. BMJ 2020; 370: m3249."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14 Toubiana J, Poirault C, Corsia A, et al. Kawasaki-like multisystem inflammatory syndrome in children during the COVID-19 pandemic in Paris, France: prospective observational study. BMJ 2020; 369: m2094.","DOI":"10.1136\/bmj.m2094"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1001\/jamapediatrics.2020.1467","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review","volume":"174","author":"15 Castagnoli","year":"2020","unstructured":"15 Castagnoli R, Votto M, Licari A, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review. JAMA Pediatr. 2020; 174: 882-889.","journal-title":"JAMA Pediatr"},{"key":"ref15","unstructured":"16 European Centre for Disease Prevention and Control. Paediatric inflammatory multisystem syndrome and SARS-CoV-2 infection in children - 15 May 2020. ECDC, Stockholm, 2020."},{"key":"ref16","unstructured":"17 World Health Organization. Multisystem inflammatory syndrome in children and adolescents with COVID-19. WHO Ref. No: WHO\/2019nCoV\/Sci_Brief\/Multisystem_Syndrome_Children\/2020.1."},{"key":"ref17","unstructured":"18 US Centers for Disease Control and Prevention. Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19). CDC, Atlanta, GA (CDCHAN-00432) May 14, 2020. Available from: https:\/\/emergency.cdc.gov\/han\/2020\/han00432.asp."},{"key":"ref18","unstructured":"19 Tulassay T, T\u00f3th-Heyn P. Systemic vasculites. In: Ol\u00e1h \u00c9. (ed.) Handbook of pediatrics. [Sziszt\u00e9m\u00e1s vasculitisek. In: Ol\u00e1h \u00c9. (szerk.) Gyermekgy\u00f3gy\u00e1szati k\u00e9zik\u00f6nyv]. Medicina K\u00f6nyvkiad\u00f3, Budapest, 2009; pp. 1495-1505. [Hungarian]"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3389\/fped.2020.00574","article-title":"Pediatric inflammatory multisystem syndrome temporally related with SARS-CoV-2: immunological similarities with acute rheumatic fever and toxic shock syndrome","volume":"8","author":"20 Buonsenso","year":"2020","unstructured":"20 Buonsenso D, Riitano F, Valentini P. Pediatric inflammatory multisystem syndrome temporally related with SARS-CoV-2: immunological similarities with acute rheumatic fever and toxic shock syndrome. 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