{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T11:12:18Z","timestamp":1698750738010},"reference-count":38,"publisher":"Akademiai Kiado Zrt.","issue":"38","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,9,19]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold>\n                    <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> A monoklon\u00e1lis gammopathia szem\u00e9szeti jeleinek \u00e9s\n                    sz\u00f6v\u0151dm\u00e9nyeinek vizsg\u00e1lata. <jats:italic>Betegek \u00e9s m\u00f3dszerek:<\/jats:italic> K\u00e9t nagy\n                    budapesti hematol\u00f3giai ell\u00e1t\u00f3hely 1999 \u00e9s 2020 k\u00f6z\u00f6tt diagnosztiz\u00e1lt \u00e9s\/vagy\n                    kezelt, monoklon\u00e1lis gammopathi\u00e1t mutat\u00f3 betegeit vizsg\u00e1ltuk (42 beteg 84 szeme,\n                    42,86% f\u00e9rfi; \u00e1tlag\u00e9letkor 63,83 \u00b1 10,76 \u00e9v). A hematol\u00f3giai diagn\u00f3zis 3 esetben\n                    bizonytalan jelent\u0151s\u00e9g\u0171 monoklon\u00e1lis gammopathia, 34 esetben myeloma multiplex,\n                    3 esetben par\u00e1zsl\u00f3 myeloma, 1-1 esetben Waldenstr\u00f6m-macroglobulinaemia \u00e9s\n                    amyloidosis voltak. Kontrollcsoportk\u00e9nt v\u00e9letlenszer\u0171en kiv\u00e1lasztott, hasonl\u00f3\n                    korcsoport\u00fa, hematol\u00f3giai betegs\u00e9g n\u00e9lk\u00fcli egy\u00e9neket vizsg\u00e1ltunk (43 beteg 86\n                    szeme, 32,56% f\u00e9rfi; \u00e1tlag\u00e9letkor 62,44 \u00b1 11,89 \u00e9v). A szem\u00e9szeti vizsg\u00e1lat\n                    el\u0151tt minden szem\u00e9ly kit\u00f6lt\u00f6tte a Szemfelsz\u00edni Betegs\u00e9g Index (OSDI-) k\u00e9rd\u0151\u00edvet.\n                    A szem\u00e9szeti vizsg\u00e1lat sor\u00e1n a l\u00e1t\u00f3\u00e9less\u00e9g vizsg\u00e1lata mellett pupillat\u00e1g\u00edt\u00e1st\n                    k\u00f6vet\u0151en r\u00e9sl\u00e1mp\u00e1s vizsg\u00e1latot v\u00e9gezt\u00fcnk. <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    Monoklon\u00e1lis gammopathi\u00e1ban az OSDI-\u00e9rt\u00e9k szignifik\u00e1nsan magasabb volt, mint a\n                    kontrollokban (p = 0,002). Gammopathi\u00e1ban 3 beteg 5 szem\u00e9n\u00e9l (5,95%) tal\u00e1ltunk\n                    potenci\u00e1lis szaruh\u00e1rtya-immunglobulinlerak\u00f3d\u00e1st. Gammopathi\u00e1ban\n                    sz\u00e1razszem-betegs\u00e9g 66,67%-ban, sz\u00fcrke h\u00e1lyog 55,95%-ban,\n                    Meibom-mirigy-diszfunkci\u00f3 20,24%-ban, h\u00e1ts\u00f3 k\u00e9rgi sz\u00fcrke h\u00e1lyog 19,05%-ban,\n                    egy\u00e9b szaruh\u00e1rtyahegek \u00e9s -hom\u00e1lyok 17,86%-ban, kr\u00f3nikus szemh\u00e9jgyullad\u00e1s\n                    14,29%-ban, szem\u00e9szeti elt\u00e9r\u00e9s hi\u00e1nya 11,90%-ban, macula- \u00e9s\/vagy retinadrusen\n                    9,52%-ban, szaruh\u00e1rtya-immunglobulinlerak\u00f3d\u00e1s 5,95%-ban, epiretinalis membr\u00e1n\n                    5,95%-ban, kor\u00e1bbi sz\u00fcrkeh\u00e1lyog-m\u0171t\u00e9t 5,95%-ban, glaucoma 4,76%-ban,\n                    Fuchs-dystrophia 2,38%-ban, perif\u00e9ri\u00e1s retinadegener\u00e1ci\u00f3 2,38%-ban, chorioidea\n                    naevus 2,38%-ban, diabeteses retinopathia 1,19%-ban, arteria centralis retinae\n                    elz\u00e1r\u00f3d\u00e1s 1,19%-ban, vena centralis retinae \u00e1gelz\u00e1r\u00f3d\u00e1s 1,19%-ban, amblyopia\n                    1,19%-ban volt kimutathat\u00f3. A sz\u00e1razszem-betegs\u00e9g (p = 0,002), a h\u00e1ts\u00f3 k\u00e9rgi\n                    sz\u00fcrke h\u00e1lyog (p = 0,001), a sz\u00fcrke h\u00e1lyog (p&lt;0,00001) \u00e9s az egy\u00e9b\n                    szaruh\u00e1rtyahegek \u00e9s -hom\u00e1lyok (p = 0,01) szignifik\u00e1nsan magasabb ar\u00e1nyban\n                    fordultak el\u0151 a monoklon\u00e1lis gammopathi\u00e1t mutat\u00f3 betegekben, mint a\n                    kontrollokban. <jats:italic>K\u00f6vetkeztet\u00e9s :<\/jats:italic> Monoklon\u00e1lis gammopathi\u00e1ban a\n                    sz\u00e1razszem-betegs\u00e9g \u00e9s a sz\u00fcrke h\u00e1lyog a leggyakoribb szem\u00e9szeti elt\u00e9r\u00e9s. A\n                    monoklon\u00e1lis gammopathia potenci\u00e1lis szem\u00e9szeti jelei \u00e9s sz\u00f6v\u0151dm\u00e9nyei miatt\n                    javasoljuk a betegek \u00e9venk\u00e9nti szem\u00e9szeti ellen\u0151rz\u00e9s\u00e9t, \u00e9letmin\u0151s\u00e9g\u00fck jav\u00edt\u00e1sa\n                    \u00e9rdek\u00e9ben. Orv Hetil. 2021; 162(38): 1533\u20131540.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold>\n                    <jats:italic>Objective:<\/jats:italic> To examine ocular signs and ocular comorbidities in\n                    monoclonal gammopathy. <jats:italic>Patients and methods:<\/jats:italic> We analyzed\n                    patients from two large referral hematology centers in Budapest, who were\n                    diagnosed and\/or treated with monoclonal gammopathy between 1997 and 2020 (84\n                    eyes of 42 patients, 42.86% male, mean age 63.83 \u00b1 10.76 years). Before the\n                    ophthalmic examination, the subjects filled in the Ocular Surface Disease Index\n                    (OSDI) questionnaire. Ophthalmic examination included visual acuity test and\n                    slit-lamp examination following dilation of the pupil. <jats:italic>Results:<\/jats:italic>\n                    OSDI scores were significantly higher in subjects with monoclonal gammopathy\n                    than in controls (p = 0.002). Among gammopathy subjects, we observed potential\n                    corneal immunoglobulin deposition in 5 eyes of 3 patients (5.95%). In gammopathy\n                    subjects, there was dry eye disease (66.67%), cataract (55.95%), Meibomian gland\n                    dysfunction (20.24%), posterior cortical cataract (19.05%), corneal scars and\n                    degenerations (17.86%), chronic blepharitis (14.29%), absence of ocular\n                    complaint (11.90%), macular or retinal drusen (9.52%), corneal immunoglobulin\n                    deposition (5.95%), epiretinal membrane (5.95%), previous cataract surgery\n                    (5.95%), glaucoma (4.76%), Fuchs dystrophy (2.38%), peripheral retinal\n                    degeneration (2.38%), chorioideal naevus (2.38%), diabetic retinopathy (1.19%),\n                    central retinal artery occlusion (1.19%), central retinal vein branch occlusion\n                    (1.19%) and amblyopia (1.19%). The proportion of dry eye disease (p = 0.002),\n                    posterior cortical cataract (p = 0.001), cataract (p&lt;0.00001), and corneal\n                    scars and degenerations (p = 0.01) were significantly higher in gammopathy\n                    subjects than in controls. <jats:italic>Conclusion:<\/jats:italic> Dry eye disease and\n                    cataracts are the most common ocular comorbidities in patients with monoclonal\n                    gammopathy. Therefore, due to the potential ocular signs and comorbidities of\n                    monoclonal gammopathy, we suggest a regular, yearly ophthalmic checkup of these\n                    patients to improve their quality of life. Orv Hetil. 2021; 162(38):\n                    1533\u20131540.<\/jats:p>","DOI":"10.1556\/650.2021.32228","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:09:26Z","timestamp":1633914566000},"page":"1533-1540","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["A monoklon\u00e1lis gammopathia szem\u00e9szeti jelei \u00e9s sz\u00f6v\u0151dm\u00e9nyei."],"prefix":"10.1556","volume":"162","author":[{"given":"Kitti","family":"Korm\u00e1nyos","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika, Budapest, M\u00e1ria u. 39., 1085"},{"name":"2 Magyar Honv\u00e9ds\u00e9g Eg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Szem\u00e9szeti Oszt\u00e1ly, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaudia","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika, Budapest, M\u00e1ria u. 39., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsolya","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"3 Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Szem\u00e9szeti Oszt\u00e1ly, Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika, Budapest, M\u00e1ria u. 39., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor L\u00e1szl\u00f3","family":"S\u00e1ndor","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika, Budapest, M\u00e1ria u. 39., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Csorba","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika, Budapest, M\u00e1ria u. 39., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cec\u00edlia N\u00f3ra","family":"Czak\u00f3","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika, Budapest, M\u00e1ria u. 39., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Langenbucher","sequence":"additional","affiliation":[{"name":"4 Experimental Ophthalmology, Saarland University, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n Zsolt","family":"Nagy","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika, Budapest, M\u00e1ria u. 39., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergely","family":"Varga","sequence":"additional","affiliation":[{"name":"5 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, III. Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3giai Klinika, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Gopcsa","sequence":"additional","affiliation":[{"name":"6 D\u00e9l-pesti Centrum K\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Hematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Mikala","sequence":"additional","affiliation":[{"name":"6 D\u00e9l-pesti Centrum K\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Hematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Szentm\u00e1ry","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika, Budapest, M\u00e1ria u. 39., 1085"},{"name":"7 Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1046\/j.1365-2141.2003.04355.x","article-title":"Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group","volume":"121","author":"International Myeloma Working Group","year":"2003","unstructured":"1 International Myeloma Working Group, Kyle RA, Child A, Anderson K, et al. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 2003; 121: 749-757.","journal-title":"Br J Haematol"},{"key":"ref1","unstructured":"2 Nagy Z. Multiple myeloma and other plasma cell dyscrasias. 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