{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T11:12:19Z","timestamp":1698750739316},"reference-count":16,"publisher":"Akademiai Kiado Zrt.","issue":"38","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,9,19]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> A nekrotiz\u00e1l\u00f3 sarcoid granulomatosis a granulomatosus\n                    pulmonalis angitisek k\u00f6z\u00e9 tartoz\u00f3, ritka k\u00f3rk\u00e9p. Egyesek a sarcoidosis\n                    vari\u00e1ns\u00e1nak, m\u00e1sok primer pulmonalis vasculitisnek tartj\u00e1k. A k\u00f3rk\u00e9p klinikai \u00e9s\n                    patol\u00f3giai jellegzetess\u00e9geit k\u00e9t eset bemutat\u00e1s\u00e1val ismertetj\u00fck. A 20 \u00e9ves\n                    n\u0151beteg s\u00fcrg\u0151ss\u00e9ggel ker\u00fclt pulmonol\u00f3giai oszt\u00e1lyra sz\u00e1raz k\u00f6h\u00f6g\u00e9s, jobb oldali,\n                    m\u00e9ly bel\u00e9gz\u00e9ssel \u00f6sszef\u00fcgg\u0151 mellkasi f\u00e1jdalom \u00e9s l\u00e1z miatt, a 63 \u00e9ves f\u00e9rfi\n                    beteget pedig pneumoni\u00e1t k\u00f6vet\u0151 kontroll-mellkasr\u00f6ntgenfelv\u00e9telen l\u00e1tott\n                    elv\u00e1ltoz\u00e1s kivizsg\u00e1l\u00e1sa sor\u00e1n \u00e9szlelt\u00e9k. Az autoimmun panel vizsg\u00e1lata, a\n                    mikrobiol\u00f3giai tesztek mindk\u00e9t betegn\u00e9l negat\u00edvnak bizonyultak, a l\u00e9gz\u00e9sfunkci\u00f3s\n                    vizsg\u00e1lat \u00e9s a bronchoszk\u00f3pos vizsg\u00e1lat nem tal\u00e1lt elt\u00e9r\u00e9st. A\n                    mellkas-CT-felv\u00e9telen l\u00e1gyr\u00e9sz-denzit\u00e1s\u00fa nodulusok l\u00e1tszottak egyoldali\n                    dominanci\u00e1val, a folyamatot nem k\u00eds\u00e9rte a hilusi nyirokcsom\u00f3k szimmetrikus\n                    megnagyobbod\u00e1sa. A nodulusok sz\u00f6vettani vizsg\u00e1lata v\u00e1lt indokoltt\u00e1, melyet\n                    videoassziszt\u00e1lt torakoszk\u00f3pos t\u00fcd\u0151reszekci\u00f3s mintav\u00e9tellel biztos\u00edtottak.\n                    Mikroszk\u00f3posan a t\u00fcd\u0151parenchym\u00e1ban g\u00f3cos nekr\u00f3zisokat, a k\u00f6rnyezet\u00fckben el nem\n                    sajtosod\u00f3 epitheloid sejtes granulomatosus g\u00f3cokat, az \u00e1tfut\u00f3 art\u00e9ri\u00e1kban pedig\n                    granulomatosus arteritist l\u00e1ttak; a klinikai adatok figyelembev\u00e9tel\u00e9vel a t\u00fcd\u0151\n                    nekrotiz\u00e1l\u00f3 sarcoid granulomatosisa diagn\u00f3zis\u00e1t \u00e1ll\u00edtott\u00e1k fel. A t\u00fcd\u0151betegs\u00e9g\n                    mindk\u00e9t betegn\u00e9l egy \u00e9v alatt spont\u00e1n regredi\u00e1lt. Az irodalom adatait \u00e9s az\n                    eseteket \u00f6sszegezve, a t\u00fcd\u0151 nekrotiz\u00e1l\u00f3 sarcoid granulomatosis\u00e1ban\n                    mikrobiol\u00f3giai vizsg\u00e1latokkal nem igazolhat\u00f3 t\u00fcd\u0151fert\u0151z\u00e9s, \u00e9s az immunol\u00f3giai\n                    kivizsg\u00e1l\u00e1s sem t\u00e1r fel sziszt\u00e9m\u00e1s autoimmun betegs\u00e9get; a diagn\u00f3zis a klinikai\n                    k\u00e9p \u00e9s a k\u00e9palkot\u00f3 vizsg\u00e1latok alapj\u00e1n indik\u00e1lt sz\u00f6vettani vizsg\u00e1lattal\n                    \u00e1ll\u00edthat\u00f3 fel. A betegs\u00e9g szteroidkezel\u00e9sre j\u00f3l reag\u00e1l, de el\u0151fordul spont\u00e1n\n                    regresszi\u00f3 is, az ut\u00f3bbira l\u00e1ttunk p\u00e9ld\u00e1t. B\u00e1r az entit\u00e1s \u00e1tmenetet k\u00e9pez a\n                    nekrotiz\u00e1l\u00f3 vasculitisek \u00e9s a sarcoidosis k\u00f6z\u00f6tt, egyre t\u00f6bb \u00e9rv sz\u00f3l amellett,\n                    hogy a sarcoidosis spektrum\u00e1ba tartozik. Orv Hetil. 2021; 162(38):\n                    1541\u20131547.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> Necrotizing sarcoid granulomatosis is a rare entity\n                    currently classified as a subtype of granulomatous pulmonary angiitis. It is\n                    considered to be either a variant of sarcoidosis or a primary pulmonary\n                    angiitis. Two cases are demonstrated to present its clinical and pathological\n                    features. A 20-year-old female patient was admitted to the department of\n                    pulmonology with dry cough, right-sided chest pain during hyperventilation and\n                    fever. A 63-year-old male patient was observed with a right-sided lesion on\n                    chest X-ray after pneumonia. In both cases, autoimmune panel examination,\n                    microbiology tests, spirometry function test and bronchoscopy were unremarkable.\n                    Chest CT scans have revealed nodules with soft-tissue density without bilateral\n                    hilar lymphadenopathy. In order to clarify the diagnosis, video-assisted\n                    thoracoscopic resection (biopsy) was performed. Microscopically, parenchymal\n                    focal necrosis with adjacent to non-caseating granulomas and granulomatous\n                    angiitis were detected. In both cases, spontaneous remission occurred within a\n                    year. Histological examination \u2013 integrated with clinical data and radiological\n                    tests\u2019 results \u2013 is the gold standard form of evaluation to confirm necrotizing\n                    sarcoid granulomatosis; furthermore, exclusion of pneumonia and autoimmune\n                    diseases are also required. The disease responds well to corticosteroids;\n                    moreover, spontaneous remission is often reported, as it happened in both cases.\n                    Necrotizing sarcoid granulomatosis is a transition between necrotizing\n                    vasculitides and sarcoidosis; although more and more evidence appears supporting\n                    the fact that necrotizing sarcoid granulomatosis may belong to the spectrum of\n                    sarcoidosis. Orv Hetil. 2021; 162(38): 1541\u20131547.<\/jats:p>","DOI":"10.1556\/650.2021.32236","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:09:26Z","timestamp":1633914566000},"page":"1541-1547","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["A t\u00fcd\u0151 nekrotiz\u00e1l\u00f3 sarcoid granulomatosisa"],"prefix":"10.1556","volume":"162","author":[{"given":"No\u00e9mi","family":"Zombori-T\u00f3th","sequence":"first","affiliation":[{"name":"1 Csongr\u00e1d-Csan\u00e1d Megyei Mellkasi Betegs\u00e9gek Szakk\u00f3rh\u00e1za, Deszk"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Ugocsai","sequence":"additional","affiliation":[{"name":"1 Csongr\u00e1d-Csan\u00e1d Megyei Mellkasi Betegs\u00e9gek Szakk\u00f3rh\u00e1za, Deszk"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1rp\u00e1d","family":"Vincze","sequence":"additional","affiliation":[{"name":"2 B\u00e9k\u00e9s Megyei K\u00f6zponti K\u00f3rh\u00e1z, Gyula"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Fur\u00e1k","sequence":"additional","affiliation":[{"name":"3 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Seb\u00e9szeti Klinika, Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Tiszlavicz","sequence":"additional","affiliation":[{"name":"4 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai Int\u00e9zet, Szeged, \u00c1llom\u00e1s u. 2., 6701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Iv\u00e1nyi","sequence":"additional","affiliation":[{"name":"4 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai Int\u00e9zet, Szeged, \u00c1llom\u00e1s u. 2., 6701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Zombori","sequence":"additional","affiliation":[{"name":"4 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai Int\u00e9zet, Szeged, \u00c1llom\u00e1s u. 2., 6701"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","unstructured":"1 Liebow AA. 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