{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T11:15:10Z","timestamp":1698491710428},"reference-count":48,"publisher":"Akademiai Kiado Zrt.","issue":"50","license":[{"start":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T00:00:00Z","timestamp":1639267200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,12,12]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic> A Dengue-, Zika- \u00e9s Chikungunya-v\u00edrus-fert\u0151z\u00e9sek a\n                    tr\u00f3pusokr\u00f3l import\u00e1lt leggyakoribb arbov\u00edrusfert\u0151z\u00e9sek. F\u00f6ldrajzi elterjed\u00e9s\u00fck\n                    \u00e1tfed\u0151, k\u00f6z\u00f6s vektoraik \u00e9s hasonl\u00f3 t\u00fcneteik miatt szerol\u00f3giai \u00e9s molekul\u00e1ris\n                    m\u00f3dszerek egy\u00fcttes alkalmaz\u00e1s\u00e1n alapul\u00f3 mikrobiol\u00f3giai vizsg\u00e1latokkal\n                    k\u00fcl\u00f6n\u00edthet\u0151k el megb\u00edzhat\u00f3an. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> Munk\u00e1nk c\u00e9lja a 2016\n                    \u00e9s 2020 k\u00f6z\u00f6tt end\u00e9mi\u00e1s ter\u00fcleten j\u00e1rt, t\u00fcnetes \u00e9s t\u00fcnetmentes utaz\u00f3k vizsg\u00e1lata\n                    volt, minden esetben mindh\u00e1rom v\u00edrusfert\u0151z\u00e9s ir\u00e1ny\u00e1ban. A diagnosztikus tesztek\n                    sor\u00e1n az alvad\u00e1sg\u00e1tolt teljes v\u00e9r \u00e9s vizelet bevon\u00e1s\u00e1val vizsg\u00e1ltuk a v\u00edrus-RNS\n                    kimutathat\u00f3s\u00e1g\u00e1nak es\u00e9ly\u00e9t a k\u00fcl\u00f6nb\u00f6z\u0151 mintat\u00edpusokb\u00f3l.\n                        <jats:italic>M\u00f3dszer:<\/jats:italic> Sav\u00f3p\u00e1rmint\u00e1k szerol\u00f3giai anal\u00edzise sor\u00e1n a\n                    Dengue-, Zika- \u00e9s Chikungunya-v\u00edrus-specifikus ellenanyagv\u00e1lasz alakul\u00e1s\u00e1t\n                    vizsg\u00e1ltuk ELISA-m\u00f3dszerrel. Reakt\u00edv eredm\u00e9nyek eset\u00e9ben a szerol\u00f3giai\n                    keresztreakci\u00f3k kiz\u00e1r\u00e1s\u00e1ra immunfluoreszcens \u00e9s ELISA-technik\u00e1n alapul\u00f3 tov\u00e1bbi\n                    vizsg\u00e1latokat v\u00e9gezt\u00fcnk a hazai \u00e9s az utaz\u00e1s sor\u00e1n \u00e9rintett ter\u00fcleteken\n                    el\u0151fordul\u00f3 flavi- \u00e9s alphavirusok ir\u00e1ny\u00e1ban. V\u00e9rsav\u00f3-, alvad\u00e1sg\u00e1tolt teljes v\u00e9r\n                    \u00e9s vizeletmint\u00e1kb\u00f3l reverztranszkripci\u00f3t k\u00f6vet\u0151 val\u00f3s idej\u0171\n                    polimer\u00e1z-l\u00e1ncreakci\u00f3val v\u00edrus-RNS-kimutat\u00e1st v\u00e9gezt\u00fcnk.\n                        <jats:italic>Eredm\u00e9nyek:<\/jats:italic> Az 1037 vizsg\u00e1lt utaz\u00f3 k\u00f6z\u00fcl 133 esetben\n                    kaptunk reakt\u00edv szerol\u00f3giai \u00e9s\/vagy molekul\u00e1ris eredm\u00e9nyt. Az alvad\u00e1sg\u00e1tolt\n                    teljes v\u00e9r mint\u00e1b\u00f3l siker\u00fclt a legnagyobb ar\u00e1nyban v\u00edrusnukleinsavat kimutatni\n                    mind a Dengue- \u00e9s Zika-, mind a Chikungunya-v\u00edrus eset\u00e9ben.\n                        <jats:italic>Megbesz\u00e9l\u00e9s:<\/jats:italic> End\u00e9mi\u00e1s ter\u00fcletr\u0151l hazat\u00e9rt utaz\u00f3k\n                    vizsg\u00e1lat\u00e1t a t\u00fcnetek hasonl\u00f3s\u00e1ga miatt mindh\u00e1rom v\u00edrusfert\u0151z\u00e9s ir\u00e1ny\u00e1ban\n                    egy\u00fcttesen indokolt elv\u00e9gezni. A flavi- \u00e9s alphavirusokra jellemz\u0151 nagyfok\u00fa\n                    szerol\u00f3giai keresztreaktivit\u00e1s miatt a nukleinsav-kimutat\u00e1s jav\u00edthatja a\n                    mikrobiol\u00f3giai diagnosztika pontoss\u00e1g\u00e1t. <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> A h\u00e1rom\n                    v\u00edrus mikrobiol\u00f3giai diagnosztik\u00e1j\u00e1t seg\u00edti a korai mintav\u00e9tel \u00e9s a molekul\u00e1ris\n                    vizsg\u00e1latok kiterjeszt\u00e9se tov\u00e1bbi mintat\u00edpusokra: alvad\u00e1sg\u00e1tolt teljes v\u00e9r \u00e9s\n                    vizelet. A behurcolt v\u00edrusfert\u0151z\u00e9sek azonos\u00edt\u00e1sa fokozott jelent\u0151s\u00e9g\u0171, mert az\n                    Eur\u00f3p\u00e1ban is jelen l\u00e9v\u0151 vektorsz\u00fanyogfajok felvetik az autochton \u00e1tvitel\n                    lehet\u0151s\u00e9g\u00e9t. Orv Hetil. 2021; 162(50): 2000\u20132009.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold>\n                    <jats:italic>Introduction:<\/jats:italic> Dengue-, Zika- and Chikungunya infections are\n                    among the most frequently imported tropical arbovirus infections. Due to their\n                    shared endemic regions, vectors and similar clinical symptoms, differential\n                    diagnosis is based on serological and molecular analysis.\n                        <jats:italic>Objective:<\/jats:italic> The aim of our study was to identify the\n                    imported arbovirus infections of travellers between 2016 and 2020. Furthermore,\n                    to improve the diagnostic sensitivity, anticoagulated whole blood and urine\n                    samples were involved in molecular diagnosis. <jats:italic>Method:<\/jats:italic>\n                    Virus-specific antibody kinetics was tested in paired sera of patients by ELISA\n                    method. In case of reactive results, further serological analysis was performed\n                    using immunofluorescence assays and\/or ELISA tests to exclude serological\n                    cross-reactions caused by other members of the flavi- and alphaviruses.\n                    Detection of viral RNA was attempted from serum, anticoagulated whole blood and\n                    urine specimens using reverse transcription and real-time polymerase chain\n                    reaction. <jats:italic>Results:<\/jats:italic> Out of the tested 1037 travellers, reactive\n                    serological and\/or molecular results were obtained in 133 cases. Anticoagulated\n                    whole blood proved to be the most suitable specimen for viral RNA detection of\n                    the three viruses. <jats:italic>Discussion:<\/jats:italic> Parallel testing of Dengue-,\n                    Zika- and Chikungunya infections is recommended, as symptom-based differential\n                    diagnosis is challenging. Due to the characteristic serological cross-reactivity\n                    of flavi- and alphaviruses, microbiological diagnosis relies on both serological\n                    and molecular tests. <jats:italic>Conclusion:<\/jats:italic> Involving anticoagulated whole\n                    blood and urine samples into molecular analysis and early sample collection\n                    improve the sensitivity of microbiological diagnostics. Identification of\n                    imported tropical arbovirus infections is of high importance as the presence of\n                    vector mosquitos in Europe raises the possibility of autochthon transmission.\n                    Orv Hetil. 2021; 162(50): 2000\u20132009.<\/jats:p>","DOI":"10.1556\/650.2021.32247","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T13:25:11Z","timestamp":1639401911000},"page":"2000-2009","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Magyarorsz\u00e1gra behurcolt tr\u00f3pusi arbov\u00edrusfert\u0151z\u00e9sek 2016 \u00e9s 2020 k\u00f6z\u00f6tt"],"prefix":"10.1556","volume":"162","author":[{"given":"Orsolya","family":"Nagy","sequence":"first","affiliation":[{"name":"Nemzeti N\u00e9peg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Virol\u00f3giai Laborat\u00f3riumi Oszt\u00e1ly Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 2\u20136., 1097"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Orvosi Mikrobiol\u00f3giai Int\u00e9zet Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Nagy","sequence":"additional","affiliation":[{"name":"Nemzeti N\u00e9peg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Virol\u00f3giai Laborat\u00f3riumi Oszt\u00e1ly Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 2\u20136., 1097"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szilvia","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Infektol\u00f3giai Oszt\u00e1ly Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Koroknai","sequence":"additional","affiliation":[{"name":"Nemzeti N\u00e9peg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Virol\u00f3giai Laborat\u00f3riumi Oszt\u00e1ly Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 2\u20136., 1097"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ria","family":"Tak\u00e1cs","sequence":"additional","affiliation":[{"name":"Nemzeti N\u00e9peg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Virol\u00f3giai Laborat\u00f3riumi Oszt\u00e1ly Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 2\u20136., 1097"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Orvosi Mikrobiol\u00f3giai Int\u00e9zet Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.antiviral.2009.10.008","article-title":"Present and future arboviral threats","volume":"85","author":"Weaver SC","year":"2010","unstructured":"1 Weaver SC, Reisen WK. 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