{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T11:14:36Z","timestamp":1698491676737},"reference-count":16,"publisher":"Akademiai Kiado Zrt.","issue":"48","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,11,28]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic> Az 1-es t\u00edpus\u00fa diabetes mellitus \u00e9s a coeliakia\n                    gyakori t\u00e1rsul\u00e1sa j\u00f3l ismert. N\u00e9h\u00e1ny tanulm\u00e1ny besz\u00e1mol \u00e1tmeneti\n                    antitranszglutamin\u00e1z-emelked\u00e9sr\u0151l 1-es t\u00edpus\u00fa diabeteses betegekben, akikn\u00e9l az\n                    emelkedett antitestszint glut\u00e9nmentes di\u00e9ta bevezet\u00e9se n\u00e9lk\u00fcl normaliz\u00e1l\u00f3dik.\n                        <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> Kutat\u00e1sunk sor\u00e1n az \u00e1tmeneti\n                    antitranszglutamin\u00e1z-emelked\u00e9s gyakoris\u00e1g\u00e1nak meghat\u00e1roz\u00e1s\u00e1t t\u0171zt\u00fck ki c\u00e9lul.\n                    Tov\u00e1bbi c\u00e9lunk volt a coeliakia gyakoris\u00e1g\u00e1nak meg\u00e1llap\u00edt\u00e1sa 1-es t\u00edpus\u00fa\n                    diabetesszel gondozott betegeink k\u00f6z\u00f6tt. <jats:italic>M\u00f3dszer:<\/jats:italic> A Semmelweis\n                    Egyetem I. Gyermekgy\u00f3gy\u00e1szati Klinik\u00e1j\u00e1n 1-es t\u00edpus\u00fa diabetesszel gondozott\n                    betegeket vontuk be vizsg\u00e1latunkba (238 l\u00e1ny, 265 fi\u00fa, medi\u00e1n [IR] \u00e9letkor az\n                    1-es t\u00edpus\u00fa diabetes diagn\u00f3zisakor: 7,83 [4,67\u201311] \u00e9v). Vizsg\u00e1ltuk a jelens\u00e9g\n                    id\u0151beli megjelen\u00e9s\u00e9t, az emelked\u00e9s m\u00e9rt\u00e9k\u00e9t, gyakoris\u00e1g\u00e1t \u00e9s az antitest\n                    t\u00edpus\u00e1t. Le\u00edr\u00f3 statisztikai m\u00f3dszereket \u00e9s khi-n\u00e9gyzet-pr\u00f3b\u00e1t alkalmaztunk.\n                        <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A vizsg\u00e1lt popul\u00e1ci\u00f3ban a coeliakia gyakoris\u00e1ga\n                    12,52%. \u00c1tmeneti antitranszglutamin\u00e1ztiter-emelked\u00e9st 48 gyermekn\u00e9l (10,9%)\n                    \u00e9szlelt\u00fcnk. \u00d6sszesen 71-szer m\u00e9rt\u00fcnk \u00e1tmeneti antitranszglutamin\u00e1z-emelked\u00e9st. A\n                    gyermekek k\u00f6z\u00fcl 34 esetben (70,83%) egyszer fordult el\u0151 emelked\u00e9st mutat\u00f3\n                    antitest, a t\u00f6bbi betegn\u00e9l 2\u20138 alkalommal. Gyakrabban tapasztaltunk izol\u00e1lt\n                    IgA-t\u00edpus\u00fa emelked\u00e9st, mint izol\u00e1lt IgG-t\u00edpus\u00fat (54 <jats:italic>vs.<\/jats:italic> 5).\n                        <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> Az \u00e1tmeneti antitranszglutamin\u00e1z-emelked\u00e9s\n                    gyakoris\u00e1ga magas, \u00f6sszevethet\u0151 a val\u00f3di coeliaki\u00e1s csoporttal. Kutat\u00e1sunk\n                    al\u00e1t\u00e1masztja a nemzetk\u00f6zi aj\u00e1nl\u00e1st, miszerint m\u00e9rs\u00e9kelt m\u00e9rt\u00e9k\u0171\n                    antitranszglutamin\u00e1z-emelked\u00e9s eset\u00e9n, t\u00fcnetmentes 1-es t\u00edpus\u00fa diabetesszel\n                    gondozott betegben a glut\u00e9nfogyaszt\u00e1s folytat\u00e1sa \u00e9s az antitestszintek gyakori\n                    kontrollja javasolt. Orv Hetil. 2021; 162(48): 1924\u20131930.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold>\n                    <jats:italic>Introduction:<\/jats:italic> The frequent association of type 1 diabetes\n                    mellitus with coeliac disease is well known. Development of transitional\n                    elevation of anti-tissue transglutaminase antibodies in the diagnosis of type 1\n                    diabetes is reported in some studies. In these cases, the anti-tissue\n                    transglutaminase antibodies returned to normal without gluten-free diet.\n                        <jats:italic>Objective:<\/jats:italic> Our aim was to assess the frequency of\n                    transitional elevation of anti-tissue transglutaminase in our type 1 diabetes\n                    patients. We aimed to investigate the prevalence of coeliac disease in patients\n                    with type 1 diabetes. <jats:italic>Method:<\/jats:italic> Patients with type 1 diabetes at\n                    the Ist Department of Paediatrics, Semmelweis University, were enrolled in the\n                    study (238 girls, 265 boys; the median age at the time of type 1 diabetes\n                    diagnosis was 7.83 [4.67\u201311] years). Descriptive statistical analysis was done\n                    and the time of appearance, extent, frequency and type of elevated anti-tissue\n                    transglutaminase antibodies were examined. <jats:italic>Results:<\/jats:italic> The\n                    proportion of children with diagnosed coeliac disease was 12.52%. We detected\n                    transitional anti-tissue transglutaminase elevation in 48 cases (10.9%).\n                    Temporarily elevated antibody levels were measured 71 times. In 34 children\n                    (70.83%), the temporary elevation occured once, while in the others, antibody\n                    levels became positive 2\u20138 times. The elevation of the IgA antibody was more\n                    frequent than the elevation of the IgG antibody (54 <jats:italic>vs.<\/jats:italic> 5).\n                        <jats:italic>Conclusion:<\/jats:italic> The frequency of temporary elevated anti-tissue\n                    transglutaminase levels is considered high. Our study confirms the\n                    recommendation that in the case of moderate anti-tissue transglutaminase levels\n                    with lack of clinical symptoms, control antibody measurement is necessary with\n                    ongoing gluten consumption. Orv Hetil. 2021; 162(48): 1924\u20131930.<\/jats:p>","DOI":"10.1556\/650.2021.32287","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T13:24:50Z","timestamp":1639401890000},"page":"1924-1930","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["A sz\u00f6veti antitranszglutamin\u00e1z \u00e1tmeneti emelked\u00e9se coeliaki\u00e1val nem t\u00e1rsult I-es t\u00edpus\u00fa cukorbeteg gyermekekben"],"prefix":"10.1556","volume":"162","author":[{"given":"Eszter","family":"Muzslay","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Gyermekgy\u00f3gy\u00e1szati Klinika, Budapest, B\u00f3kay J. u. 53.,1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"H\u00e1mory","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivien","family":"Herczeg","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Gyermekgy\u00f3gy\u00e1szati Klinika, Budapest, B\u00f3kay J. u. 53.,1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"T\u00f3th-Heyn","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Gyermekgy\u00f3gy\u00e1szati Klinika, Budapest, B\u00f3kay J. u. 53.,1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"K\u00f6rner","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Gyermekgy\u00f3gy\u00e1szati Klinika, Budapest, B\u00f3kay J. u. 53.,1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Mad\u00e1csy","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Gyermekgy\u00f3gy\u00e1szati Klinika, Budapest, B\u00f3kay J. u. 53.,1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Luczay","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Gyermekgy\u00f3gy\u00e1szati Klinika, Budapest, B\u00f3kay J. u. 53.,1083"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1 Mayer-Davis EJ, Kahkoska AR, Jefferies C, et al. ISPAD Clinical Practice Consensus Guidelines 2018: definition, epidemiology, and classification of diabetes in children and adolescents. Pediatr Diabetes 2018; 19(Suppl 27): 7-19.","DOI":"10.1111\/pedi.12773"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2 Mahmud FH, Elbarbary NS, Fr\u00f6hlich-Reiterer E, et al. ISPAD Clinical Practice Consensus Guidelines 2018: other complications and associated conditions in children and adolescents with type 1 diabetes. Pediatr Diabetes 2018; 19(Suppl 27): 275-286.","DOI":"10.1111\/pedi.12740"},{"key":"ref2","unstructured":"3 K\u00f6rner A. Other diseases associated with childhood and adolescent diabetes. In: Barkai L, Mad\u00e1csy L. (eds.) 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