{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T11:14:36Z","timestamp":1698491676886},"reference-count":37,"publisher":"Akademiai Kiado Zrt.","issue":"45","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,11,7]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic> A k\u00f3rboncol\u00e1s hozz\u00e1j\u00e1rul a s\u00falyos akut l\u00e9gz\u0151szervi\n                    szindr\u00f3m\u00e1t okoz\u00f3 koronav\u00edrus-2 (SARS-CoV-2-) fert\u0151z\u00e9s klinikopatol\u00f3giai\n                    vonatkoz\u00e1sainak megismer\u00e9s\u00e9hez. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> A\n                    SARS-CoV-2-fert\u0151z\u00f6ttek boncol\u00e1sa sor\u00e1n gy\u0171jt\u00f6tt tapasztalatok bemutat\u00e1sa.\n                        <jats:italic>M\u00f3dszer:<\/jats:italic> Egym\u00e1st k\u00f6vet\u0151en boncolt, v\u00e9d\u0151olt\u00e1sban nem\n                    r\u00e9szes\u00fclt, SARS-CoV-2-fert\u0151z\u00f6tt elhunytak klinikai adatait, makro- \u00e9s\n                    mikroszk\u00f3pos \u00e9szleleteit \u00f6sszegezt\u00fck; a t\u00fcd\u0151kimetsz\u00e9seket\n                    SARS-CoV-2-nukleokapszid-immunfest\u00e9ssel vizsg\u00e1ltuk. <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    A boncol\u00e1st a hal\u00e1lok meg\u00e1llap\u00edt\u00e1s\u00e1ra (n = 14), tumorgyan\u00fa (n = 9), illetve\n                    t\u00f6rv\u00e9nyi k\u00f6telezetts\u00e9g (n = 3) miatt v\u00e9gezt\u00fck. A fert\u0151z\u00e9st a klinikai \u00e9szlel\u00e9s\n                    vagy a boncol\u00e1s sor\u00e1n (n = 4) v\u00e9gzett SARS-CoV-2-nukleinsav-teszt igazolta. A\n                    t\u00fcnetes betegs\u00e9g \u00e1tlagos hossza 12,9 nap volt. 21 betegn\u00e9l (medi\u00e1n \u00e9letkor 69\n                    \u00e9v; 18 f\u00e9rfi) \u00e1llt fenn COVID\u201319-pneumonia, mely 16 esetben \u00f6nmag\u00e1ban, 4 esetben\n                    bakteri\u00e1lis pneumoni\u00e1val vagy \u00e1lh\u00e1rty\u00e1s colitisszel sz\u00f6v\u0151dve okozott hal\u00e1lt; 1\n                    antikoagul\u00e1lt pneumoni\u00e1s beteg heveny retroperitonealis v\u00e9rz\u00e9sben halt meg. 3\n                    betegn\u00e9l a hal\u00e1lt disszemin\u00e1l\u00f3dott malignus tumor, 1 betegn\u00e9l\n                    coronariathrombosis, 1 ment\u00e1lisan retard\u00e1lt betegn\u00e9l pedig pulmonalis emboli\u00e1s\n                    sz\u00f6v\u0151dm\u00e9ny okozta. A COVID\u201319-pneumoni\u00e1s t\u00fcd\u0151k nehezek, t\u00f6m\u00f6ttek \u00e9s v\u00f6r\u00f6sen\n                    foltozottak voltak. Sz\u00f6vettanilag a betegs\u00e9g id\u0151tartam\u00e1t\u00f3l f\u00fcgg\u0151en diff\u00faz\n                    alveolaris k\u00e1rosod\u00e1s korai exsudativ vagy k\u00e9s\u0151bbi proliferativ f\u00e1zisa l\u00e1tszott\n                    at\u00edpusos pneumocyt\u00e1kkal; gyakori volt a microthrombosis (n = 7), a\n                    macrothrombosis (n = 5), illetve a pulmonalis embolia (n = 4). A\n                    SARS-CoV-2-immunfest\u00e9s pozit\u00edvnak bizonyult az esetek 38,5%-\u00e1ban, domin\u00e1l\u00f3an az\n                    exsudativ f\u00e1zisban. Minden elhunyt t\u00e1rsbetegs\u00e9g(ek)ben szenvedett, \u00edgy\n                    magasv\u00e9rnyom\u00e1s-betegs\u00e9gben (n = 17), \u00e9relmeszesed\u00e9sben (n = 14), 2-es t\u00edpus\u00fa\n                    diabetesben (n = 8), rosszindulat\u00fa daganatban (n = 6), kr\u00f3nikus obstrukt\u00edv\n                    t\u00fcd\u0151betegs\u00e9gben (n = 4), elh\u00edz\u00e1sban (n = 3), vesetranszplant\u00e1ci\u00f3 ut\u00e1ni\n                    immunszuppresszi\u00f3ban (n = 3). <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> Az irodalmi\n                    adatokkal \u00f6sszhangban, hal\u00e1los COVID\u201319-pneumonia t\u00falnyom\u00f3an id\u0151s,\n                    t\u00e1rsbetegs\u00e9g(ek)t\u0151l s\u00fajtott f\u00e9rfiakban alakult ki. A boncol\u00e1si gyakorlatban a\n                    SARS-CoV-2-nukleokapszid-immunfest\u00e9st\u0151l a diff\u00faz alveolaris k\u00e1rosod\u00e1s korai\n                    f\u00e1zis\u00e1ban v\u00e1rhat\u00f3 pozitivit\u00e1s. Orv Hetil. 2021; 162(45): 1791\u20131802.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold>\n                    <jats:italic>Introduction:<\/jats:italic> Autopsy is an important tool for the evaluation\n                    of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection.\n                        <jats:italic>Objectice:<\/jats:italic> The aim of this study was to present our\n                    experience with autopsies of patients diagnosed with SARS-CoV-2 infection.\n                        <jats:italic>Method:<\/jats:italic> Clinical data, macroscopic and microscopic findings\n                    of consecutive postmortems of non-vaccinated SARS-CoV-2 patients are summarized.\n                    Lung samples were evaluated with SARS-CoV-2 nucleocapsid immunohistochemistry.\n                        <jats:italic>Results:<\/jats:italic> Autopsies were performed to determine the cause of\n                    death (n = 14), suspected tumours (n = 9) or due to legal obligation (n = 3).\n                    SARS-CoV-2 infection was verified by ante mortem (n = 22) and post mortem (n =\n                    4) polymerase chain reaction. The mean duration of symptomatic disease was 12.9\n                    days. Of 21 patients with COVID-19 pneumonia, 16 died of respiratory failure, 4\n                    had additional bacterial pneumonia or <jats:italic>Clostridioides difficile<\/jats:italic>\n                    infection, and 1 developed hemorrhagic complication (n = 1). Other causes of\n                    death included disseminated malignancies (n = 3), coronary thrombosis (n = 1)\n                    and pulmonary embolism (n = 1). The affected lungs were heavy and had patchy red\n                    appearance. Exudative or proliferative phases of diffuse alveolar damage (DAD)\n                    were detected with atypical pneumocytes. Microthrombosis (n = 7),\n                    macrothrombosis (n = 5) and pulmonary embolism (n = 4) were frequent. The\n                    SARS-CoV-2 immunohistochemical reaction was positive in 38.5% of cases. All\n                    patients had co-morbidities, namely, hypertension (n = 17), atherosclerosis (n =\n                    14), diabetes (n = 8), malignancies (n = 6), chronic obstructive pulmonary\n                    diseases (n = 4), obesity (n = 3) and immunosuppression after kidney\n                    transplantation (n = 3). <jats:italic>Conclusion:<\/jats:italic> Fatal COVID-19 pneumonia\n                    occurred mostly in elderly males with co-morbidities. In the autopsy practice,\n                    the SARS-CoV-2 nucleocapsid immunohistochemical reaction may confirm the\n                    infectious etiology in the early phase of DAD. Orv Hetil. 2021; 162(45):\n                    1791\u20131802.<\/jats:p>","DOI":"10.1556\/650.2021.32387","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T13:24:28Z","timestamp":1639401868000},"page":"1791-1802","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["\u201eDum spiro spero\u201d: a SARS-CoV-2-fert\u0151z\u00e9s klinikopatol\u00f3gi\u00e1ja 26 eset kapcs\u00e1n"],"prefix":"10.1556","volume":"162","author":[{"given":"Tam\u00e1s","family":"Zombori","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai Int\u00e9zet, Szeged, \u00c1llom\u00e1s u. 1., 6725"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"Kuthi","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 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