{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:14:52Z","timestamp":1785208492219,"version":"3.55.0"},"reference-count":18,"publisher":"Akademiai Kiado Zrt.","issue":"10","license":[{"start":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T00:00:00Z","timestamp":1646524800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,3,6]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> A gyermekkorban kialakul\u00f3 Cushing-szindr\u00f3ma ritka\n                    betegs\u00e9g, a leggyakrabban exog\u00e9n szteroidad\u00e1s k\u00f6vetkezm\u00e9nyek\u00e9nt jelentkezik. A\n                    daganatos betegs\u00e9gek k\u00f6z\u00fcl a hypophysis kortikotropint szekret\u00e1l\u00f3 adenom\u00e1ja,\n                    illetve a mell\u00e9kvesek\u00e9reg-tumorok okoznak a leggyakrabban Cushing-szindr\u00f3m\u00e1t.\n                    Jelen tanulm\u00e1nyunkban egy Cushing-szindr\u00f3m\u00e1val diagnosztiz\u00e1lt fi\u00fa eset\u00e9t\n                    mutatjuk be. Az endokrinol\u00f3giai kivizsg\u00e1l\u00e1s adrenokortikotropin\n                    (ACTH)-independens hypercortisolismust t\u00e1masztott al\u00e1. A hasi MRI-felv\u00e9telen egy\n                    \u00e9les hat\u00e1rral rendelkez\u0151, 3,5 cm nagys\u00e1g\u00fa terime \u00e1br\u00e1zol\u00f3dott a jobb\n                    mell\u00e9kvese-r\u00e9gi\u00f3ban. A tumort parci\u00e1lis mell\u00e9kvese-elt\u00e1vol\u00edt\u00e1s sor\u00e1n\n                    t\u00e1vol\u00edtott\u00e1k el. A sz\u00f6vettani elemz\u00e9s mell\u00e9kvesek\u00e9reg-adenom\u00e1t igazolt. A\n                    gyermek klinikailag \u00e9s labor\u00e9rt\u00e9kei alapj\u00e1n gy\u00f3gyultnak tekinthet\u0151. A\n                    Cushing-szindr\u00f3m\u00e1val kezelt betegek hossz\u00fa t\u00e1v\u00fa nyomon k\u00f6vet\u00e9se sz\u00fcks\u00e9ges,\n                    melynek sor\u00e1n sz\u00fcks\u00e9g szerint biztos\u00edtani kell a gl\u00fckokortikoidok \u00e9s az egy\u00e9b\n                    szteroidhormonok megfelel\u0151 p\u00f3tl\u00e1s\u00e1t, a kialakult sz\u00f6v\u0151dm\u00e9nyek kezel\u00e9s\u00e9t, \u00e9s\n                    adott esetben id\u0151ben fel kell ismerni a Cushing-szindr\u00f3ma k\u00e9s\u0151i relapsus\u00e1t is.\n                    Orv Hetil. 2022; 163(10): 407\u2013412.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> Cushing\u2019s syndrome (CS) in children is a rare disease, most\n                    frequently caused by either an adrenal tumor or a corticotropin-secreting\n                    pituitary adenoma. Its early detection and effective treatment are highly\n                    important to avoid the short- and long-term consequences of hypercortisolism. We\n                    report a case of a child with Cushing\u2019s syndrome resulting from an\n                    adrenocortical adenoma. Endocrinological data revealed adrenocorticotropin\n                    (ACTH) independent hypercortisolism. MRI scan of the adrenal glands showed a\n                    single, well-encapsulated tumor on the right adrenal gland with a diameter of\n                    3.5 cm. Adrenal gland sparing surgery was performed with total excision of the\n                    tumor. The histological analysis confirmed the diagnosis of adrenal adenoma. The\n                    child was cured clinically and biochemically. The long-term follow-up of\n                    patients treated for Cushing\u2019s syndrome should include the adequate replacement\n                    of glucocorticoids and other steroid hormones, treatment of osteoporosis and\n                    other pathologic effects of hypercortisolism and long-term screening for the\n                    relapse of Cushing\u2019s syndrome. Orv Hetil. 2022; 163(10): 407\u2013412.<\/jats:p>","DOI":"10.1556\/650.2022.32358","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T09:12:19Z","timestamp":1668762739000},"page":"407-412","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":2,"title":["Cushing-szindr\u00f3m\u00e1t okoz\u00f3 gyermekkori mell\u00e9kvesek\u00e9reg-adenoma"],"prefix":"10.1556","volume":"163","author":[{"given":"Bence","family":"Bukovszky","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, II. Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, T\u0171zolt\u00f3 u. 7\u20139., 1094 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"G\u00e1cs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, II. Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, T\u0171zolt\u00f3 u. 7\u20139., 1094 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Jen\u0151v\u00e1ri","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, II. Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, T\u0171zolt\u00f3 u. 7\u20139., 1094 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9lia","family":"Somogyi","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, II. Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, T\u0171zolt\u00f3 u. 7\u20139., 1094 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Micsik","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Patol\u00f3giai \u00e9s K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, II. Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, T\u0171zolt\u00f3 u. 7\u20139., 1094 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Sallai","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, II. 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