{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:08:28Z","timestamp":1785362908079,"version":"3.55.0"},"reference-count":16,"publisher":"Akademiai Kiado Zrt.","issue":"11","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,3,13]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic> Az \u00fajsz\u00fcl\u00f6ttkori szepszis ritka, de magas\n                    mortalit\u00e1ssal j\u00e1r\u00f3 \u00e1llapot. Az Eg\u00e9szs\u00e9g\u00fcgyi Szakmai Koll\u00e9gium Neonatol\u00f3giai\n                    Tagozata 2017-ben bevezette a korai szepszisr\u0151l sz\u00f3l\u00f3 \u00e1ll\u00e1sfoglal\u00e1st,\n                    meghat\u00e1rozva a kezel\u00e9s indik\u00e1ci\u00f3j\u00e1t a t\u00falzott m\u00e9rt\u00e9k\u0171 antibiotikumad\u00e1s\n                    elker\u00fcl\u00e9se c\u00e9lj\u00e1b\u00f3l. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> Retrospekt\u00edv anal\u00edzissel\n                    vizsg\u00e1ltuk az \u00e1ll\u00e1sfoglal\u00e1s el\u0151tti \u00e9s ut\u00e1ni id\u0151szak antibiotikumhaszn\u00e1lat\u00e1t\n                    klinik\u00e1nk beteganyag\u00e1n. <jats:italic>M\u00f3dszer:<\/jats:italic> Az int\u00e9zm\u00e9ny\u00fcnkben 2014. 01.\n                    01. \u00e9s 2018. 12. 31. k\u00f6z\u00f6tt sz\u00fcletett, a 34. gestati\u00f3s hetet bet\u00f6lt\u00f6tt\n                    \u00fajsz\u00fcl\u00f6ttek adatait vizsg\u00e1ltuk a k\u00f6vetkez\u0151 kimenetelekre koncentr\u00e1lva:\n                    szepszisre utal\u00f3 klinikai t\u00fcnetek jelenl\u00e9te, az antibiotikummal kezelt\n                    \u00fajsz\u00fcl\u00f6ttek sz\u00e1ma, koraiszepszis-incidencia, mortalit\u00e1s. A statisztikai anal\u00edzis\n                    az RStudio programmal t\u00f6rt\u00e9nt (szignifikancia: p&lt;0,05).\n                        <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A vizsg\u00e1lt 5 \u00e9vben \u00f6sszesen 12\u00a0347 \u00fajsz\u00fcl\u00f6tt\n                    j\u00f6tt a vil\u00e1gra, k\u00f6z\u00fcl\u00fck antibiotikumot kapott 1502 (12,16%); \u00e9vekre lebontva:\n                    2014-ben 517 (21,10%), 2015-ben 401 (16,63%), 2016-ban 459 (17,96%), 2017-ben 61\n                    (2,39%), 2018-ban 64 (2,69%). Az antibiotikumter\u00e1pi\u00e1ban r\u00e9szes\u00fcltek (n = 1502)\n                    k\u00f6z\u00fcl 239 (15,91%) \u00fajsz\u00fcl\u00f6ttnek volt fert\u0151z\u00e9sre utal\u00f3 t\u00fcnete. A klinikai\n                    t\u00fcneteket mutat\u00f3 \u00fajsz\u00fcl\u00f6ttek sz\u00e1ma nem n\u00f6vekedett szignifik\u00e1nsan (p = 0,285);\n                    2014-ben 52 (2,12%), 2015-ben 42 (1,74%), 2016-ban 42 (1,64%), 2017-ben 46\n                    (1,80%), 2018-ban 57 (2,40%). Hemokult\u00fara-pozit\u00edv szepszis \u00f6sszesen: 4;\n                    koraiszepszis-incidencia: 0,324\/1000. Szepszishez k\u00f6thet\u0151 hal\u00e1leset nem volt.\n                        <jats:italic>Megbesz\u00e9l\u00e9s:<\/jats:italic> A protokollv\u00e1lt\u00e1st megel\u0151z\u0151en az \u00fajsz\u00fcl\u00f6ttek\n                    csup\u00e1n rizik\u00f3faktorok alapj\u00e1n is r\u00e9szes\u00fcltek antibiotikumter\u00e1pi\u00e1ban, 2017 \u00f3ta\n                    azonban els\u0151sorban a fert\u0151z\u00e9s klinikai t\u00fcneteit mutat\u00f3 \u00fajsz\u00fcl\u00f6tteket kezelj\u00fck,\n                    ami az antibiotikumhaszn\u00e1lat szignifik\u00e1ns cs\u00f6kken\u00e9s\u00e9hez vezetett. A kor\u00e1bbi,\n                    rizik\u00f3faktorok alapj\u00e1n adott antibiotikumter\u00e1pia megsz\u00fcntet\u00e9s\u00e9t k\u00f6vet\u0151en nem\n                    emelkedett a t\u00fcnetet mutat\u00f3 szeptikus \u00fajsz\u00fcl\u00f6ttek sz\u00e1ma, sem a korai szepszis\n                    okozta mortalit\u00e1s. <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> A 34. gestati\u00f3s hetet\n                    bet\u00f6lt\u00f6tt \u00fajsz\u00fcl\u00f6ttekn\u00e9l a korai szepszis gyan\u00faja miatti antibiotikumhaszn\u00e1lat\n                    biztons\u00e1ggal cs\u00f6kkenthet\u0151 volt, ezzel megel\u0151zve a felesleges antibiotikumkezel\u00e9s\n                    r\u00f6vid \u00e9s hossz\u00fa t\u00e1v\u00fa mell\u00e9khat\u00e1sait. Orv Hetil. 2022; 163(11): 431\u2013437.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold>\n                    <jats:italic>Introduction:<\/jats:italic> Early-onset neonatal sepsis is a rare, but\n                    life-threatening condition. In 2017, the Hungarian Neonatal Society issued a\n                    national guideline to rationalize the use of antibiotic use in neonatal sepsis.\n                        <jats:italic>Objective:<\/jats:italic> To retrospectively determine the frequency of\n                    prescribed antibiotics before and after the introduction of national guidance.\n                        <jats:italic>Method:<\/jats:italic> Data of neonates (&gt;34. gestational weeks)\n                    delivered in our hospital between 1st January 2014 and 31st December 2018 were\n                    analysed with focusing on signs of sepsis, number of neonates treated with\n                    antibiotics, incidence of early-onset neonatal sepsis, sepsis-related mortality.\n                    Statistical analysis was performed with RStudio software (significance:\n                    p&lt;0.05). <jats:italic>Results:<\/jats:italic> During the analysed time period, 12 347\n                    neonates were born, 1502 (12.16%) neonates were given antibiotics, showing a\n                    significant decrease after 2017: 517 (21.10%) in 2014, 401 (16.63%) in 2015, 459\n                    (17.96%) in 2016, 61 (2.39%) in 2017, 64 (2.69%) in 2018, respectively. Out of\n                    the group of neonates treated with antibiotics (n = 1502), only 239 (15.91%)\n                    neonates showed the clinical signs of sepsis. No significant change was observed\n                    in the number of symptomatic newborns during the study period: 52 (2.12%) in\n                    2014, 42 (1.74%) in 2015, 42 (1.64%) in 2016, 46 (1.80%) in 2017, 57 (2.40%) in\n                    2018, p = 0.285. Blood culture confirmed neonatal sepsis was observed in 4\n                    babies, incidence of early-onset neonatal sepsis was 0.324\/1000, sepsis-related\n                    mortality was zero. <jats:italic>Discussion:<\/jats:italic> Before the introduction of the\n                    national guideline, most of the neonates were prescribed antibiotics based on\n                    risk factors. Since 2017, antibiotics have been mainly preserved for newborns\n                    with clinical signs of sepsis. Despite cessation of antiobiotic treatment\n                    indicated by risk factors, the number of symptomatic babies and sepsis-related\n                    mortality have not increased. <jats:italic>Conclusion:<\/jats:italic> The use of\n                    antibiotics for neonates &gt;34th gestational week can be safely reduced,\n                    entailing a decrease in short- and long-term complications of early antibiotic\n                    use. Orv Hetil. 2022; 163(11): 431\u2013437.<\/jats:p>","DOI":"10.1556\/650.2022.32401","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T09:50:55Z","timestamp":1668765055000},"page":"431-437","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":4,"title":["Antibiotikumhaszn\u00e1lat korai szepszis gyan\u00faja eset\u00e9n \u00fajsz\u00fcl\u00f6ttkorban"],"prefix":"10.1556","volume":"163","author":[{"given":"Judit","family":"Mari","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekklinika Szeged, Temesv\u00e1ri k\u00f6r\u00fat 35\u201337., 6726 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9ka","family":"Kajlik","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gajda","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekklinika Szeged, Temesv\u00e1ri k\u00f6r\u00fat 35\u201337., 6726 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Kiss","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekklinika Szeged, Temesv\u00e1ri k\u00f6r\u00fat 35\u201337., 6726 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zita","family":"Gyurkovits","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Szeged Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"1 Fleischmann-Struzek","year":"2018","unstructured":"1 Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, et al. 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