{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:26:32Z","timestamp":1761719192721},"reference-count":52,"publisher":"Akademiai Kiado Zrt.","issue":"5","license":[{"start":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:00:00Z","timestamp":1643500800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,1,30]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> A kr\u00f3nikus mucocutan candidiasis genetikailag\n                    heterog\u00e9n betegs\u00e9gcsoport, amelyre a b\u0151r, a k\u00f6rm\u00f6k \u00e9s a ny\u00e1lkah\u00e1rty\u00e1k\n                        <jats:italic>Candida<\/jats:italic> okozta tart\u00f3s vagy visszat\u00e9r\u0151, nem invaz\u00edv\n                    fert\u0151z\u00e9se jellemz\u0151. A <jats:italic>Candida<\/jats:italic>-fert\u0151z\u00e9sek ir\u00e1nti fokozott\n                    fog\u00e9konys\u00e1g oka a Th17-sejtes immunit\u00e1s defektusa, amelynek h\u00e1tter\u00e9ben k\u00fcl\u00f6nb\u00f6z\u0151\n                    g\u00e9nek mut\u00e1ci\u00f3ja \u00e1llhat. A betegs\u00e9g izol\u00e1lt form\u00e1j\u00e1ban, amelyet m\u00e1s n\u00e9ven\n                    kr\u00f3nikus mucocutan candidiasis betegs\u00e9gnek is nevez\u00fcnk, a mucocutan candidiasis\n                    a betegs\u00e9g egyetlen vagy els\u0151dleges t\u00fcnete. Ezzel szemben a betegs\u00e9g \u00fan.\n                    szindr\u00f3m\u00e1s form\u00e1ira a nem invaz\u00edv <jats:italic>Candida<\/jats:italic>-fert\u0151z\u00e9sek mellett\n                    autoimmun betegs\u00e9g t\u00e1rsul\u00e1sa is jellemz\u0151, amely a leggyakrabban az endokrin\n                    rendszert \u00e9rinti. A diagn\u00f3zis meger\u0151s\u00edt\u00e9s\u00e9ben fontos a genetikai vizsg\u00e1lat,\n                    amely az \u00e9rintett csal\u00e1dokban lehet\u0151s\u00e9get teremt praenatalis genetikai\n                    vizsg\u00e1latok v\u00e9gz\u00e9s\u00e9re is. A szerz\u0151k bemutatj\u00e1k a kr\u00f3nikus mucocutan candidiasis\n                    f\u0151bb t\u00edpusait, klinikum\u00e1t, \u00e9s elemzik a diagnosztikus, illetve ter\u00e1pi\u00e1s\n                    lehet\u0151s\u00e9geket. A szerz\u0151k \u00f6sszefoglalj\u00e1k tov\u00e1bb\u00e1 a betegs\u00e9g molekul\u00e1ris genetikai\n                    h\u00e1tter\u00e9t \u00e9s a patomechanizmus jelenleg ismert folyamatait. Orv Hetil. 2022;\n                    163(5): 171\u2013180.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> Chronic mucocutaneous candidiasis is a genetically\n                    heterogeneous group of disorders, which are characterised by chronic or\n                    recurrent non-invasive skin, nail and mucous membrane infections caused by\n                        <jats:italic>Candida<\/jats:italic>. The increased susceptibility to\n                        <jats:italic>Candida<\/jats:italic> infections is due to a Th17-cell mediated immune\n                    defect with different gene mutations in the background. The isolated form of the\n                    disorder, referred to as chronic mucocutaneous candidiasis, presents primarily\n                    or only with mucocutaneous candidiasis. In contrast, the syndromic form of the\n                    disorder is characterised, besides the non-invasive <jats:italic>Candida<\/jats:italic>\n                    infections, by autoimmune disorders, which most commonly affect the endocrine\n                    system. Genetic tests are important in confirming the diagnosis, which in\n                    affected families would provide the opportunity for prenatal genetic testing.\n                    The authors present the main types of chronic mucocutaneous candidiasis,\n                    exploring the clinical aspects, diagnostic methods, and available therapies.\n                    Furthermore, the authors conclude the molecular genetic background and the\n                    currently known pathomechanism of the disorder. Orv Hetil 2022; 163(5):\n                    171\u2013180.<\/jats:p>","DOI":"10.1556\/650.2022.32409","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T19:51:25Z","timestamp":1668801085000},"page":"171-180","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":4,"title":["Kr\u00f3nikus mucocutan candidiasis"],"prefix":"10.1556","volume":"163","author":[{"given":"Bernadett","family":"Hon-Balla","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"},{"name":"R\u00e1cz K\u00e1roly Klinikai Orvostudom\u00e1nyi Doktori Iskola Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Erd\u0151s","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Primer Immundeficientia Klinikai R\u00e9szleg \u00e9s Laborat\u00f3rium Budapest Magyarorsz\u00e1g"},{"name":"The Rockefeller University 1230 York Avenue, Box 163, New York, NY 10065 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1 Erd\u0151s M. 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