{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:25:42Z","timestamp":1775593542622,"version":"3.50.1"},"reference-count":32,"publisher":"Akademiai Kiado Zrt.","issue":"12","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,3,20]]},"abstract":"\u00d6sszefoglal\u00f3.<\/jats:bold>\n Bevezet\u00e9s:<\/jats:italic> A pajzsmirigy-alulm\u0171k\u00f6d\u00e9s gyakori betegs\u00e9g.\n Kezel\u00e9s\u00e9ben a levotiroxin (LT4)-p\u00f3tl\u00e1s a szok\u00e1sos elj\u00e1r\u00e1s, mely tabletta vagy\n g\u00e9lkapszula form\u00e1j\u00e1ban \u00e1ll rendelkez\u00e9sre Magyarorsz\u00e1gon. A nemzetk\u00f6zi trendeknek\n megfelel\u0151en az esetek korai felismer\u00e9se miatt m\u00e1r a kev\u00e9sb\u00e9 kifejezett\n hormon\u00e1lis elt\u00e9r\u00e9sek idej\u00e9n elindul a kezel\u00e9s. Az endokrinol\u00f3gusok\n hypothyreosiskezel\u00e9si szok\u00e1saival kapcsolatban Magyarorsz\u00e1gon \u00e9s Eur\u00f3p\u00e1ban\n felm\u00e9r\u00e9s eddig nem t\u00f6rt\u00e9nt. C\u00e9lkit\u0171z\u00e9s: A<\/jats:italic> THESIS\n (T<\/jats:italic>reatment of H<\/jats:italic>ypothyroidism in\n E<\/jats:italic>urope by S<\/jats:italic>pecialists: an\n I<\/jats:italic>nternational S<\/jats:italic>urvey) c\u00e9lja, hogy\n felm\u00e9rj\u00fck az eur\u00f3pai \u00e9s k\u00f6zte jelen munk\u00e1nkban a magyar endokrinol\u00f3gusok\n hypothyreosiskezel\u00e9si szok\u00e1sait \u00e9s az LT4 esetleges alkalmaz\u00e1s\u00e1t\n pajzsmirigy-m\u0171k\u00f6d\u00e9szavarral nem j\u00e1r\u00f3 \u00e1llapotokban. M\u00f3dszer:<\/jats:italic> A\n Magyar Endokrinol\u00f3giai \u00e9s Anyagcsere T\u00e1rsas\u00e1g (MEAT) tagjainak e-mailben\n megh\u00edv\u00f3t k\u00fcldt\u00fcnk az online k\u00e9rd\u0151\u00edves vizsg\u00e1lathoz. Eredm\u00e9nyek:<\/jats:italic>\n 165 magyar endokrinol\u00f3gus v\u00e1laszai alapj\u00e1n v\u00e9gezt\u00fck az elemz\u00e9st. A v\u00e1laszad\u00f3k\n t\u00f6bbs\u00e9ge, 99,4%-uk els\u0151 kezel\u00e9sk\u00e9nt LT4-p\u00f3tl\u00e1st alkalmaz. Az LT4 + LT3\n kombin\u00e1ci\u00f3t els\u0151sorban olyan betegekn\u00e9l alkalmazz\u00e1k, akik LT4 szed\u00e9se mellett\n euthyreoid hormon\u00e9rt\u00e9kek ellen\u00e9re hypothyreosisra jellemz\u0151 t\u00fcneteket mutatnak\n (36,1%). Euthyreoid hormon\u00e9rt\u00e9kek mellett, magas antitestszint \u00e9s infertilit\u00e1s\n eset\u00e9n 60,3% megfontoln\u00e1 LT4 ind\u00edt\u00e1s\u00e1t, amit evidenci\u00e1k jelenleg nem indokolnak.\n Sz\u00e1mos k\u00f3r\u00e1llapot befoly\u00e1solja az LT4 felsz\u00edv\u00f3d\u00e1s\u00e1t, ezekben az esetekben a\n magyar endokrinol\u00f3gusok 66,4%-a prefer\u00e1lja a l\u00e1gy kapszula alkalmaz\u00e1s\u00e1t, jobb\n eredm\u00e9nyt v\u00e1rva a gy\u00f3gyszerform\u00e1k k\u00f6z\u00f6tti v\u00e1lt\u00e1st\u00f3l.\n K\u00f6vetkeztet\u00e9s:<\/jats:italic> A pajzsmirigy-alulm\u0171k\u00f6d\u00e9s kezel\u00e9s\u00e9ben a\n magyar endokrinol\u00f3gusok els\u0151dlegesen az LT4-et v\u00e1lasztj\u00e1k. Az LT4 + LT3\n kombin\u00e1lt alkalmaz\u00e1s\u00e1t a pajzsmirigy-stimul\u00e1l\u00f3 hormon norm\u00e1lis szintj\u00e9nek\n el\u00e9r\u00e9se ut\u00e1n perziszt\u00e1l\u00f3 hypothyreosisos t\u00fcnetek eset\u00e9n fontolj\u00e1k meg. Az \u00fajabb\n gy\u00f3gyszerform\u00e1kat a t\u00f6bbs\u00e9g prefer\u00e1lja, ha az LT4 hagyom\u00e1nyos tablett\u00e1s\n form\u00e1j\u00e1nak alacsonyabb biohasznosul\u00e1sa v\u00e1rhat\u00f3. Orv Hetil. 2022; 163(12):\n 463\u2013472.<\/jats:p>\n Summary.<\/jats:bold>\n Introduction:<\/jats:italic> Hypothyroidism has a high prevalence in the adult\n population. Levothyroxine (LT4) supplementation is considered to be the\n gold-standard treatment method. In Hungary, LT4 tablets and soft gel capsules\n are the available formulations. Similarly to the international trends,\n hypothyroidism is earlier recognised, leading to early LT4 supplementation. Up\n till now, there has been no survey on the treatment of hypothyroidism among\n Hungarian endocrinologists. Objective:<\/jats:italic> THESIS\n (T<\/jats:italic>reatment of H<\/jats:italic>ypothyroidism in\n E<\/jats:italic>urope by S<\/jats:italic>pecialists: an\n I<\/jats:italic>nternational S<\/jats:italic>urvey) had been conducted\n to assess treatment preferences among European endocrinologists. Here we report\n the results on the use of thyroid hormones in hypothyroid patients and euthyroid\n individuals in Hungary. Method:<\/jats:italic> An e-mail invitation to\n participate, containing the link to the online survey was sent to members of the\n Hungarian Society for Endocrinology and Metabolism. Results:<\/jats:italic>\n There were 165 responses with full demographics which were included in the\n analysis. By the majority (99.4%) of them, LT4 was the first treatment of\n choice. LT4 + LT3 combination was considered an option in patients with\n persistent symptoms despite biochemical euthyroidism while on LT4 (36,1%). In\n euthyroid individuals, 60.3% of the respondents would consider starting LT4 in\n euthyroid infertile women with high antibody levels, which is hardly supported\n by evidence. In the presence of comorbidities and interfering medications which\n may hinder LT4 absorption, 66.4% of Hungarian endocrinologist anticipate\n significant improvement after switching from tablets to soft gel capsules.\n Conclusion:<\/jats:italic> The treatment of choice for hypothyroidism is\n LT4 in Hungary. Combination therapy with LT4 + LT3 was considered for patients\n with persistent symptoms. In the presence of diseases and interfering\n medications affecting bioavailability, a high number of Hungarian\n endocrinologists prefer the new LT4 formulation. The administration of LT4 in\n euthyroid conditions awaits explanation and calls for intensive discussions at\n local conferences and courses. Orv Hetil. 2022; 163(12): 463\u2013472.<\/jats:p>","DOI":"10.1556\/650.2022.32412","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T10:17:49Z","timestamp":1668766669000},"page":"463-472","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":15,"title":["Pajzsmirigyhormon-kezel\u00e9si szok\u00e1sok Magyarorsz\u00e1gon."],"prefix":"10.1556","volume":"163","author":[{"given":"Eszter","family":"Berta","sequence":"first","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvosi Kar, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Endokrinol\u00f3gia Tansz\u00e9k Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"},{"name":"Debreceni Egyetem, Gy\u00f3gyszer\u00e9sztudom\u00e1nyi Kar, Klinikai Farmakol\u00f3giai Tansz\u00e9k Debrecen Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inez Merc\u00e9desz","family":"Lengyel","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvosi Kar, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Endokrinol\u00f3gia Tansz\u00e9k Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Heged\u0171s","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Papini","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Opsedale Regina Apostolorum Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Perros","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Royal Victoria Infirmary Newcastle upon Tyne United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Negro","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, V. 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Eur Thyroid J. 2012; 1: 55-71.","journal-title":"Eur Thyroid J"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1210\/jc.2017-00166","article-title":"Excess mortality in treated and untreated hyperthyroidism is related to cumulative periods of low serum TSH","volume":"102","author":"18 Lillevang-Johansen","year":"2017","unstructured":"18 Lillevang-Johansen M, Abrahamsen B, J\u00f8rgensen HL, et al. Excess mortality in treated and untreated hyperthyroidism is related to cumulative periods of low serum TSH. 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Eur Thyroid J. 2020; 9: 25-31.","DOI":"10.1159\/000502057"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"462","DOI":"10.4183\/aeb.2020.462","article-title":"A THESIS* questionnaire survey of Romanian physicians *THESIS: treatment of hypothyroidism in Europe by specialists: an international survey","volume":"16","author":"21 Niculescu","year":"2020","unstructured":"21 Niculescu DA, Attanasio R, Heged\u00fcs L, et al. Use of thyroid hormones in hypothyroid and euthyroid patients. A THESIS* questionnaire survey of Romanian physicians *THESIS: treatment of hypothyroidism in Europe by specialists: an international survey. Acta Endocrinol (Buchar) 2020; 16: 462-469.","journal-title":"Acta Endocrinol (Buchar)"},{"key":"ref21","unstructured":"22 Galofr\u00e9 JC, Attanasio R, Heged\u00fcs L, et al. Use of thyroid hormone in hypothyroid patients and euthyroid subjects in Spain: a THESIS* questionnaire survey. Endocrinol Diabetes Nutr. 2021 Sep 8; S2530-0164(21)00190-7. 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