{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:19:09Z","timestamp":1780658349357,"version":"3.54.1"},"reference-count":50,"publisher":"Akademiai Kiado Zrt.","issue":"17","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,4,24]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> Eg\u00e9szs\u00e9ges terhess\u00e9gben mintegy k\u00e9t literrel n\u0151 a v\u00e9r\n                    mennyis\u00e9ge. A v\u00e9rvolumen n\u00f6veked\u00e9s\u00e9nek elmarad\u00e1sa, de extr\u00e9m m\u00e9rt\u00e9k\u0171 n\u00f6veked\u00e9se\n                    is s\u00falyos k\u00f6vetkezm\u00e9nyekkel sz\u00f6v\u0151dhet. Ma m\u00e1r nem k\u00e9ts\u00e9ges, hogy a\n                    praeeclampsia, mely a v\u00e1rand\u00f3ss\u00e1g m\u00e1sodik fel\u00e9ben magas v\u00e9rnyom\u00e1s \u00e9s proteinuria\n                    egy\u00fcttes megjelen\u00e9se, nem egys\u00e9ges k\u00f3rk\u00e9p. A korai kezdet\u0171 (34. h\u00e9t el\u0151tt\n                    jelentkez\u0151), hypovolaemi\u00e1val j\u00e1r\u00f3 praeeclampsia placentaris eredet\u0171, melyben az\n                    endothelium s\u00e9r\u00fcl\u00e9se vezet a magas v\u00e9rnyom\u00e1s\u00e9rt \u00e9s szervk\u00e1rosod\u00e1sok\u00e9rt felel\u0151s\n                    vasoconstricti\u00f3hoz \u00e9s microthrombosisok megjelen\u00e9s\u00e9hez. Magzati sorvad\u00e1s,\n                    oligohydramnion alakul ki a lep\u00e9nyi el\u00e9gtelens\u00e9g miatt. A k\u00f3rk\u00e9p v\u00e9gs\u0151\n                    st\u00e1dium\u00e1ban magzati elhal\u00e1s, eclampsia, lep\u00e9nylev\u00e1l\u00e1s v\u00e1rhat\u00f3. Az \u00e1llapot\n                    kezel\u00e9s\u00e9ben rendk\u00edv\u00fcl korl\u00e1tozottak a lehet\u0151s\u00e9gek; a c\u00e9l, k\u00f6r\u00fcltekint\u0151\n                    monitoriz\u00e1l\u00e1s \u00e9s az \u00e1llapot stabiliz\u00e1l\u00e1sa mellett, v\u00e1rakoz\u00e1s a magzati t\u00fcd\u0151\n                    \u00e9retts\u00e9g\u00e9nek fokoz\u00f3d\u00e1sa \u00e9rdek\u00e9ben. A k\u00e9s\u0151i kezdet\u0171, nagy perct\u00e9rfogattal j\u00e1r\u00f3\n                    praeeclampsia anyai betegs\u00e9g: ebben az obesitasnak kock\u00e1zati szerepe van, mivel\n                    \u00f6nmag\u00e1ban is hajlamos\u00edt fokozott folyad\u00e9k-visszatart\u00e1sra, magas v\u00e9rnyom\u00e1sra \u00e9s\n                    m\u00e9rs\u00e9kelt endothelk\u00e1rosod\u00e1sra. A kezdeti l\u00e1bsz\u00e1r-, majd generaliz\u00e1l\u00f3d\u00f3 oedema\n                    mellett nemritk\u00e1n jelentkezik magas v\u00e9rnyom\u00e1s \u00e9s az esetek egy r\u00e9sz\u00e9ben\n                    proteinuria is, mely ekkor m\u00e1r megfelel a praeeclampsia krit\u00e9rium\u00e1nak. A magzat\n                    s\u00falya norm\u00e1lis vagy \u00e1tlag feletti. Az extr\u00e9m fok\u00fa folyad\u00e9kretenci\u00f3, val\u00f3sz\u00edn\u0171leg\n                    a parenchymalis pang\u00e1s miatt, asciteshez, eclampsi\u00e1hoz, lep\u00e9nylev\u00e1l\u00e1shoz\n                    vezethet. A hypervolaemi\u00e1val j\u00e1r\u00f3 praeeclampsia kezel\u00e9s\u00e9ben a diuretikus\n                    furoszemidkezel\u00e9s \u00edg\u00e9retesnek t\u0171nik. Orv Hetil. 2022; 163(17): 663\u2013669.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> During normal pregnancy, blood volume increases by nearly\n                    two liters. Distinctively, the absence and also the extreme extent regarding the\n                    volume expansion are likely accompanied with serious conditions. Undoubtedly,\n                    preeclampsia, defined as the appearance of hypertension and proteinuria during\n                    the second half of pregnancy, is not a homogenous disease. The early onset which\n                    begins prior to the 34th week, is characteristically a hypovolemia-associated\n                    form and depicts the placental origination, in which endothelial damage leads to\n                    hypertension and organ damage due to vasoconstriction and microthrombosis. Fetal\n                    blood supply progressively worsens due to placental insufficiency. The outcome\n                    of this condition often leads to fetal death, eclampsia, or placental abruption.\n                    Management is confined to a diligent prolongation of pregnancy to accomplish\n                    improved neonatal pulmonary function. The late onset form, associated with high\n                    cardiac output, is a maternal disease, in which obesity is a risk factor since\n                    it predisposes individuals to enhanced water retention, hypertension, and a\n                    weakened endothelial dysfunction. Initially, low extremity edema oftentimes\n                    progresses to a generalized form and frequently results in hypertension. In\n                    several cases proteinuria appears. This condition entirely meets the\n                    preeclampsia criteria. Fetal weight is normal or frequently over the average. It\n                    is very likely, the increasing parenchymal stasis will lead to ascites,\n                    eclampsia, or placental abruption. During the management of this\n                    hypervolemia-associated preeclampsia, the administration of diuretic furosemide\n                    treatment seemingly offers promise. Orv Hetil. 2022; 163(17): 663\u2013669.<\/jats:p>","DOI":"10.1556\/650.2022.32427","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T21:34:00Z","timestamp":1668807240000},"page":"663-669","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["A praeeclampsia k\u00e9t arca"],"prefix":"10.1556","volume":"163","author":[{"given":"P\u00e9ter","family":"Tam\u00e1s","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, Doktori Iskola P\u00e9cs Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, S\u00fcrg\u0151ss\u00e9gi Ell\u00e1t\u00e1si \u00e9s Eg\u00e9szs\u00e9gpedag\u00f3giai Int\u00e9zet P\u00e9cs Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"Hum\u00e1n Nemzeti Reprodukci\u00f3s Tudom\u00e1nyos Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Betlehem","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, Doktori Iskola P\u00e9cs Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, S\u00fcrg\u0151ss\u00e9gi Ell\u00e1t\u00e1si \u00e9s Eg\u00e9szs\u00e9gpedag\u00f3giai Int\u00e9zet P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Szekeres-Barth\u00f3","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Orvosi Mikrobiol\u00f3giai \u00e9s Immunit\u00e1stani Int\u00e9zet P\u00e9cs Magyarorsz\u00e1g"},{"name":"Hum\u00e1n Nemzeti Reprodukci\u00f3s Tudom\u00e1nyos Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"},{"name":"MTA\u2212PTE Hum\u00e1n Reprodukci\u00f3s Tudom\u00e1nyos Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1lm\u00e1n","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"Hum\u00e1n Nemzeti Reprodukci\u00f3s Tudom\u00e1nyos Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"},{"name":"MTA\u2212PTE Hum\u00e1n Reprodukci\u00f3s Tudom\u00e1nyos Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girma Alemu","family":"Wami","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, Doktori Iskola P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"V\u00e9rtes","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"Hum\u00e1n Nemzeti Reprodukci\u00f3s Tudom\u00e1nyos Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"},{"name":"MTA\u2212PTE Hum\u00e1n Reprodukci\u00f3s Tudom\u00e1nyos Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"B\u00f3dis","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, Doktori Iskola P\u00e9cs Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"Hum\u00e1n Nemzeti Reprodukci\u00f3s Tudom\u00e1nyos Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"},{"name":"MTA\u2212PTE Hum\u00e1n Reprodukci\u00f3s Tudom\u00e1nyos Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","unstructured":"1 Paulin F, Pajor A. Gestational hypertensions. In: Papp Z. (ed.) Textbook of obstetrics and gynecology. [Terhess\u00e9gi hypertoni\u00e1k. In: Papp Z. (szerk.) A sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szat tank\u00f6nyve.] Semmelweis Kiad\u00f3, Budapest, 2009; pp. 208-209. [Hungarian]"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1001\/jama.287.24.3183","article-title":"Contemporary concepts of the pathogenesis and management of preeclampsia","volume":"287","author":"Lain KY","year":"2002","unstructured":"2 Lain KY, Roberts JM. Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA 2002; 287: 1383-1386.","journal-title":"JAMA"},{"key":"ref2","unstructured":"3 Easterling TR, Benedetti TJ, Schmucker BC, et al. Maternal hemodynamics in normal and preeclamptic pregnancies: a longitudinal study. Obstet Gynecol. 1990; 76: 1061-1069."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4 Vatten LJ, Skjaerven R. Is pre-eclampsia more than one disease? BJOG 2004; 111: 298-302.","DOI":"10.1111\/j.1471-0528.2004.00071.x"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1034\/j.1600-0412.1999.780705.x","article-title":"Preeclampsia may cause both overperfusion and underperfusion of the brain: a cerebral perfusion-based model","volume":"78","author":"5 Belfort","year":"1999","unstructured":"5 Belfort MA, Grunewald C, Saade GR, et al. Preeclampsia may cause both overperfusion and underperfusion of the brain: a cerebral perfusion-based model. Acta Obstet Gynecol Scand. 1999; 78: 586-591.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/S0002-9378(96)70056-X","article-title":"Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications","volume":"175","author":"Ness RB","year":"1996","unstructured":"6 Ness RB, Roberts JM. Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications. Am J Obstet Gynecol. 1996; 175: 1365-1370.","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","unstructured":"7 Tam\u00e1s P, Veszpr\u00e9mi B, Szab\u00f3 I. Distinct fetal growth is associated with distinct gestational indices in preeclampsia. [Elt\u00e9r\u0151 magzati n\u00f6veked\u00e9s \u00e9s terhess\u00e9gi mutat\u00f3k praeeclampsi\u00e1ban.] Magy N\u0151orv L. 2003; 66: 211-215. [Hungarian]"},{"key":"ref7","unstructured":"8 Tam\u00e1s P, Hantosi E, B\u00f3dis J. Hypertensive disorders of pregnancy. Theory of hypoperfusion and hyperperfusion types of preeclampsia. Gynecol Perinatol. 2010; 19: 255-260."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1081\/PRG-120021060","article-title":"Subclassification of preeclampsia","volume":"22","author":"9 von Dadelszen","year":"2003","unstructured":"9 von Dadelszen P, Magee LA, Roberts JM. Subclassification of preeclampsia. Hypertens Pregnancy 2003; 22: 143-148.","journal-title":"Hypertens Pregnancy"},{"key":"ref9","unstructured":"10 Tam\u00e1s P, Ifi Z, Szil\u00e1gyi A. Discordant clinical characteristics suggest different pathogesesis of preeclampsia. J Perinat Med. 2007; 35(Suppl. 2): 278."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3109\/14767050903258746","article-title":"Evidence for distinct preterm and term phenotypes of preeclampsia","volume":"23","author":"11 Phillips","year":"2010","unstructured":"11 Phillips JK, Janowiak M, Badger GJ, et al. Evidence for distinct preterm and term phenotypes of preeclampsia. J Matern Fetal Neonatal Med. 2010; 23: 622-626.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/OGX.0b013e3182331028","article-title":"A critical review of early-onset and late-onset preeclampsia","volume":"66","author":"Raymond D","year":"2011","unstructured":"12 Raymond D, Peterson E. A critical review of early-onset and late-onset preeclampsia. Obstet Gynecol Surv. 2011; 66: 497-507.","journal-title":"Obstet Gynecol Surv"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13 Masini G, Foo LF, Tay J, et al. Preeclampsia has two phenotypes which require different treatment strategies. Am J Obstet Gynecol. 2022; 226(2 Suppl): S1006-S1018.","DOI":"10.1016\/j.ajog.2020.10.052"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1161\/HYPERTENSIONAHA.108.117358","article-title":"Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease","volume":"52","author":"14 Valensise","year":"2008","unstructured":"14 Valensise H, Vasapollo B, Gagliardi G, et al. Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease. Hypertension 2008; 52: 873-880.","journal-title":"Hypertension"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.placenta.2014.01.008","article-title":"Placental perfusion in normal pregnancy and early and late preeclampsia: a magnetic resonance imaging study","volume":"35","author":"15 Sohlberg","year":"2014","unstructured":"15 Sohlberg S, Mulic-Lutvica A, Lindgren P, et al. Placental perfusion in normal pregnancy and early and late preeclampsia: a magnetic resonance imaging study. Placenta 2014; 35: 202-206.","journal-title":"Placenta"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.placenta.2016.11.014","article-title":"Impact of early- and late-onset preeclampsia on features of placental and newborn vascular health","volume":"49","author":"16 Herzog","year":"2017","unstructured":"16 Herzog EM, Eggink AJ, Reijnierse A, et al. Impact of early- and late-onset preeclampsia on features of placental and newborn vascular health. Placenta 2017; 49: 72-79.","journal-title":"Placenta"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"5637","DOI":"10.2147\/IJN.S208865","article-title":"Exosomal microRNA profiling in early and late onset preeclamptic pregnant women reflects pathophysiology","volume":"14","author":"17 Pillay","year":"2019","unstructured":"17 Pillay P, Vatish M, Duarte R, et al. Exosomal microRNA profiling in early and late onset preeclamptic pregnant women reflects pathophysiology. Int J Nanomedicine 2019; 14: 5637-5657.","journal-title":"Int J Nanomedicine"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.placenta.2015.07.001","article-title":"Serum HtrA1 is differentially regulated between early-onset and late-onset preeclampsia","volume":"36","author":"18 Teoh","year":"2015","unstructured":"18 Teoh SS, Zhao M, Wang Y, et al. Serum HtrA1 is differentially regulated between early-onset and late-onset preeclampsia. Placenta 2015; 36: 990-995.","journal-title":"Placenta"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ejogrb.2016.03.011","article-title":"Comparison of plasma fetuin A levels in patients with early-onset pre-eclampsia vs late-onset pre-eclampsia","volume":"200","author":"19 Sanhal","year":"2016","unstructured":"19 Sanhal CY, Can Kavcar M, Yucel A, et al. Comparison of plasma fetuin A levels in patients with early-onset pre-eclampsia vs late-onset pre-eclampsia. Eur J Obstet Gynecol Reprod Biol. 2016; 200: 108-112.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"5212","DOI":"10.1073\/pnas.91.11.5212","article-title":"Induction of calcium-dependent nitric oxide synthases by sex hormones","volume":"91","author":"20 Weiner","year":"1994","unstructured":"20 Weiner CP, Lizasoain I, Baylis SA, et al. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA 1994; 91: 5212-5216.","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1093\/humrep\/deh803","article-title":"Progestogens stimulate prostacyclin production by human endothelial cells","volume":"20","author":"21 Hermenegildo","year":"2005","unstructured":"21 Hermenegildo C, Oviedo PJ, Garc\u00eda-Mart\u00ednez MC, et al. Progestogens stimulate prostacyclin production by human endothelial cells. Hum Reprod. 2005; 20: 1554-1561.","journal-title":"Hum Reprod"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1093\/biolre\/ioz038","article-title":"Gasotransmitters in pregnancy: from conception to uterine involution","volume":"101","author":"Guerra DD","year":"2019","unstructured":"22 Guerra DD, Hurt KJ. Gasotransmitters in pregnancy: from conception to uterine involution. Biol Reprod. 2019; 101: 4-25.","journal-title":"Biol Reprod"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1210\/jcem-54-5-1010","article-title":"Changes in active and inactive renin throughout pregnancy","volume":"54","author":"23 Hsueh","year":"1982","unstructured":"23 Hsueh WA, Luetscher JA, Carlson EJ, et al. Changes in active and inactive renin throughout pregnancy. J Clin Endocrinol Metab. 1982; 54: 1010-1016.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24 Larciprete G, Valensise H, Vasapollo B, et al. Body composition during normal pregnancy: reference ranges. Acta Diabetol. 2003; 40(Suppl 1): S225-S232.","DOI":"10.1007\/s00592-003-0072-4"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"113976","DOI":"10.1016\/j.bcp.2020.113976","article-title":"Progesterone: an enigmatic ligand for the mineralocorticoid receptor","volume":"177","author":"Baker ME","year":"2020","unstructured":"25 Baker ME, Katsu Y. Progesterone: an enigmatic ligand for the mineralocorticoid receptor. Biochem Pharmacol. 2020; 177: 113976.","journal-title":"Biochem Pharmacol"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26 Meah VL, Cockcroft JR, Backx K, et al. Cardiac output and related haemodynamics during pregnancy: a series of meta-analyses. Heart 2016: 102: 518-526.","DOI":"10.1136\/heartjnl-2015-308476"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.3389\/fimmu.2019.02729","article-title":"Editorial: Fetal-maternal immune interactions in pregnancy","volume":"10","author":"27 Than","year":"2019","unstructured":"27 Than NG, Hahn S, Rossi SW, et al. Editorial: Fetal-maternal immune interactions in pregnancy. Front Immunol. 2019; 10: 2729.","journal-title":"Front Immunol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3390\/ijms20030583","article-title":"Involvement of the PD-1\/PD-L1 co-inhibitory pathway in the pathogenesis of the inflammatory stage of early-onset preeclampsia","volume":"20","author":"28 Meggyes","year":"2019","unstructured":"28 Meggyes M, Miko E, Lajko A, et al. Involvement of the PD-1\/PD-L1 co-inhibitory pathway in the pathogenesis of the inflammatory stage of early-onset preeclampsia. Int J Mol Sci. 2019; 20: 583-592.","journal-title":"Int J Mol Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"Pathophysiology and clinical presentations: JACC state-of-the-art review","volume":"76","author":"29 Ives","year":"2020","unstructured":"29 Ives CW, Sinkey R, Rajapreyar I, et al. Preeclampsia. Pathophysiology and clinical presentations: JACC state-of-the-art review. J Am Coll Cardiol. 2020; 76: 1690-1702.","journal-title":"J Am Coll Cardiol"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30 Weissgerber TL, Garcia-Valencia O, Milic NM, et al. Early onset preeclampsia is associated with glycocalyx degradation and reduced microvascular perfusion. J Am Heart Assoc. 2019; 8: e010647.","DOI":"10.1161\/JAHA.118.010647"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.mam.2016.12.003","article-title":"Adenosine and preeclampsia","volume":"55","author":"31 Salsoso","year":"2017","unstructured":"31 Salsoso R, Far\u00edas M, Guti\u00e9rrez J, et al. Adenosine and preeclampsia. Mol Aspects Med. 2017; 55: 126-139.","journal-title":"Mol Aspects Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s11906-015-0575-8","article-title":"Cerebrovascular dyspution in preeclamptic pregnancies","volume":"17","author":"Hammer ES","year":"2015","unstructured":"32 Hammer ES, Cipolla MJ. Cerebrovascular dyspution in preeclamptic pregnancies. Curr Hypertens Rep. 2015; 17: 64-76.","journal-title":"Curr Hypertens Rep"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"33 Boeldt DS, Bird IM. Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia. J Endocrinol. 2017; 232: R27-R44.","DOI":"10.1530\/JOE-16-0340"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/0002-9378(91)90436-U","article-title":"The effect of hemodynamics on fetal growth in hypertensive pregnancies","volume":"165","author":"34 Easterling","year":"1991","unstructured":"34 Easterling TR, Benedetti TJ, Carlson KC, et al. The effect of hemodynamics on fetal growth in hypertensive pregnancies. Am J Obstet Gynecol. 1991; 165: 902-906.","journal-title":"Am J Obstet Gynecol"},{"key":"ref34","unstructured":"35 Tam\u00e1s P, Hantosi E, Menyh\u00e1rt Cs, et al. Fetal birth weight correlates to maternal cardiac output. J Matern Fetal Neonatal Med. 2010; 23: 633."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/sdi.12838","article-title":"The relationship of volume overload and its control to hypertension in hemodialysis patients","volume":"32","author":"Flythe JE","year":"2019","unstructured":"36 Flythe JE, Bansal N.The relationship of volume overload and its control to hypertension in hemodialysis patients. Semin Dial. 2019; 32: 500-506.","journal-title":"Semin Dial"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.bbadis.2010.02.005","article-title":"Marinobufagenin, resibufogenin and preeclampsia","volume":"1802","author":"37 Puschett","year":"2010","unstructured":"37 Puschett JB, Agunanne E, Uddin MN. Marinobufagenin, resibufogenin and preeclampsia. Biochim Biophys Acta 2010; 1802: 1246-1253.","journal-title":"Biochim Biophys Acta"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1055\/s-0036-1585581","article-title":"The effect of early excessive weight gain on the development of hypertension in pregnancy","volume":"33","author":"38 Ruhstaller","year":"2016","unstructured":"38 Ruhstaller KE, Bastek JA, Thomas A, et al. The effect of early excessive weight gain on the development of hypertension in pregnancy. Am J Perinatol. 2016; 33: 1205-1210.","journal-title":"Am J Perinatol"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"39 Macdonald-Wallis C, Tilling K, Fraser A, et al. Gestational weight gain as a risk factor for hypertensive disorders of pregnancy. Am J Obstet Gynecol. 2013; 209: 327.e1-e17.","DOI":"10.1016\/j.ajog.2013.05.042"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","article-title":"Obesity","volume":"366","author":"Haslam DW","year":"2005","unstructured":"40 Haslam DW, James WP. Obesity. Lancet 2005; 366: 1197-1209.","journal-title":"Lancet"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"41 Poirier P, Giles TD, Bray GA, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol. 2006, 26: 968-976.","DOI":"10.1161\/01.ATV.0000216787.85457.f3"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"42 Eckel","year":"2005","unstructured":"42 Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005; 365: 1415-1428.","journal-title":"Lancet"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3390\/jcm8030335","article-title":"Maternal venous hemodynamic dysfunction in proteinuric gestational hypertension: evidence and implications","volume":"8","author":"43 Gyselaers","year":"2019","unstructured":"43 Gyselaers W. Maternal venous hemodynamic dysfunction in proteinuric gestational hypertension: evidence and implications. J Clin Med. 2019; 8: 335.","journal-title":"J Clin Med"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"44 Roberge S, Bujold E, Nicolaides KH. Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis. Am J Obstet Gynecol. 2018; 218: 287-293.e1.","DOI":"10.1016\/j.ajog.2017.11.561"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"45 Webster K, Fishburn S, Maresh M, et al. Diagnosis and management of hypertension in pregnancy: summary of updated NICE guidance. BMJ 2019; 366: I5119.","DOI":"10.1136\/bmj.l5119"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"46 Di Pasquo E, Ghi T, Dall'Asta A, et al. Maternal cardiac parameters can help in differentiating the clinical profile of preeclampsia and in predicting progression from mild to severe forms. Am J Obstet Gynecol. 2019; 221: 633.e1-633.e9.","DOI":"10.1016\/j.ajog.2019.06.029"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"47 McLaughlin K, Scholten RR, Kingdom JC, et al. Should maternal hemodynamics guide antihypertensive therapy in preeclampsia? Hypertension 2018; 71: 550-556.","DOI":"10.1161\/HYPERTENSIONAHA.117.10606"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/S1701-2163(15)30588-0","article-title":"Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary","volume":"36","author":"48 Magee","year":"2014","unstructured":"48 Magee LA, Pels A, Helewa M, et al. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. J Obstet Gynaecol Can. 2014; 36: 416-441.","journal-title":"J Obstet Gynaecol Can"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"49 Tay J, Foo L, Masini G, et al. Early and late preeclampsia are characterized by high cardiac output, but in the presence of fetal growth restriction, cardiac output is low: insights from a retrospective study. Am J Obstet Gynecol. 2018; 218: 517.e1-517.e12.","DOI":"10.1016\/j.ajog.2018.02.007"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/ijgo.12019","article-title":"Preliminary study of the effects of furosemide on blood pressure during late-onset preeclampsia in patients with high cardiac output","volume":"136","author":"50 Tam\u00e1s","year":"2017","unstructured":"50 Tam\u00e1s P, Hantosi E, Farkas B, et al. Preliminary study of the effects of furosemide on blood pressure during late-onset preeclampsia in patients with high cardiac output. Int J Gynaecol Obstet. 2017; 136: 87-90.","journal-title":"Int J Gynaecol Obstet"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/163\/17\/article-p663.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/163\/17\/article-p663.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/163\/17\/article-p663.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T15:12:02Z","timestamp":1698246722000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/163\/17\/article-p663.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,24]]},"references-count":50,"journal-issue":{"issue":"17"},"URL":"https:\/\/doi.org\/10.1556\/650.2022.32427","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,24]]}}}