{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T17:13:37Z","timestamp":1721927617109},"reference-count":46,"publisher":"Akademiai Kiado Zrt.","issue":"19","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,5,8]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic> Az extrapulmonalis tuberculosis incidenci\u00e1ja n\u00f6vekv\u0151\n                    tendenci\u00e1t mutat annak ellen\u00e9re, hogy az elm\u00falt \u00e9vekben vil\u00e1gszerte cs\u00f6kkent a\n                    tuberculosisos esetek sz\u00e1ma. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> Az extrapulmonalis\n                    tuberculosisra hajlamos\u00edt\u00f3 t\u00e9nyez\u0151k felm\u00e9r\u00e9se \u00e9s a bakteriol\u00f3giai \u00e9s sz\u00f6vettani\n                    diagnosztiz\u00e1l\u00e1si ar\u00e1nyok meghat\u00e1roz\u00e1sa az egyes form\u00e1k eset\u00e9n.\n                        <jats:italic>M\u00f3dszer:<\/jats:italic> A region\u00e1lis ell\u00e1t\u00e1si ter\u00fclet\u00fcnkh\u00f6z tartoz\u00f3\n                    ter\u00fcletr\u0151l h\u00e1rom \u00e9v alatt (2018. janu\u00e1rt\u00f3l 2020. decemberig) hozz\u00e1nk ker\u00fclt 63,\n                    extrapulmonalis tuberculosisos eset retrospekt\u00edv elemz\u00e9s\u00e9t v\u00e9gezt\u00fck. A\n                    bakteriol\u00f3giai vizsg\u00e1lat alapj\u00e1t a k\u00fcl\u00f6nb\u00f6z\u0151 mint\u00e1k Ziehl\u2013Neelsen-fest\u00e9se \u00e9s\n                    L\u00f6wenstein\u2013Jensen-t\u00e1ptalajon t\u00f6rt\u00e9n\u0151 teny\u00e9szt\u00e9se k\u00e9pezte. Egyes esetekben\n                    GeneXpert- \u00e9s sz\u00f6vettani vizsg\u00e1latra is sor ker\u00fclt. <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    Az esetek t\u00f6bbs\u00e9g\u00e9ben a mint\u00e1k vid\u00e9ki k\u00f6rnyezetb\u0151l, k\u00f6z\u00e9pkor\u00fa egy\u00e9nekt\u0151l\n                    sz\u00e1rmaztak. A legf\u0151bb kock\u00e1zati t\u00e9nyez\u0151kk\u00e9nt a rossz \u00e9letk\u00f6r\u00fclm\u00e9nyeket, a\n                    munkan\u00e9lk\u00fclis\u00e9get, a doh\u00e1nyz\u00e1st \u00e9s a kr\u00f3nikus alkoholizmust eml\u00edthetj\u00fck. 18\n                    esetben a k\u00f3rism\u00e9z\u00e9s bakteriol\u00f3giai, 17 esetben pedig sz\u00f6vettani vizsg\u00e1lattal\n                    t\u00f6rt\u00e9nt. A bakteriol\u00f3giai vagy sz\u00f6vettani vizsg\u00e1latokkal nem igazolt esetekn\u00e9l a\n                    k\u00f3rism\u00e9z\u00e9shez val\u00f3sz\u00edn\u0171s\u00e9gi krit\u00e9riumokra t\u00e1maszkodtunk, azaz epidemiol\u00f3giai,\n                    klinikai \u00e9s k\u00e9palkot\u00e1si m\u00f3dszerekre. Az extrapulmonalis tuberculosisos form\u00e1inak\n                    megoszl\u00e1sa a k\u00f6vetkez\u0151: 25 mellh\u00e1rtya-, 13 csont-\u00edz\u00fcleti, 11 nyirokcsom\u00f3-, 7\n                    agyh\u00e1rtya-, 4 vese-, 2 b\u0151r- \u00e9s 1 gyomor-b\u00e9l rendszeri tuberculosis. A\n                    tuberculosisos mellh\u00e1rtyagyullad\u00e1s bakteriol\u00f3giai meger\u0151s\u00edt\u00e9se 3 esetben t\u00f6rt\u00e9nt\n                    meg. A csont-\u00edz\u00fcleti tuberculosist 6 esetben bakterol\u00f3giailag, 4-ben pedig\n                    sz\u00f6vettanilag igazoltuk. A tuberculosisos agyh\u00e1rtyagyullad\u00e1st 5 esetben\n                    bakteriol\u00f3giai vizsg\u00e1lattal k\u00f3rism\u00e9zt\u00fck. A nyirokcsom\u00f3-, illetve\n                    b\u0151rtuberculosist sz\u00f6vettani vizsg\u00e1lattal igazoltuk. A tuberculosis elleni\n                    kezel\u00e9st a betegek j\u00f3l toler\u00e1lt\u00e1k, de a compliance a kezel\u00e9s sor\u00e1n alacsony volt\n                    (92%). <jats:italic>Megbesz\u00e9l\u00e9s:<\/jats:italic> A bakteriol\u00f3giai \u00e9s sz\u00f6vettani\n                    meger\u0151s\u00edt\u00e9ssel j\u00e1r\u00f3 neh\u00e9zs\u00e9gek miatt az extrapulmonalis tuberculosis tov\u00e1bbra is\n                    diagnosztikai kih\u00edv\u00e1st jelent. <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> Az esetek korai\n                    felismer\u00e9se \u00e9s szoros megfigyel\u00e9se cs\u00f6kkentheti a sz\u00f6v\u0151dm\u00e9nyeket, \u00e9s\n                    hozz\u00e1j\u00e1rulhat a compliance n\u00f6vel\u00e9s\u00e9hez. Orv Hetil. 2022; 163(19): 750\u2013757.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold>\n                    <jats:italic>Introduction:<\/jats:italic> The incidence of extrapulmonary tuberculosis is\n                    still high despite of the decrease in global tuberculosis cases during the last\n                    years. <jats:italic>Objective:<\/jats:italic> Evaluation of predisposing factors and\n                    determination of bacteriological and histopathological confirmation rates for\n                    extrapulmonary tuberculosis. <jats:italic>Method:<\/jats:italic> We performed a\n                    retrospective study of 63 cases of extrapulmonary tuberculosis diagnosed in\n                    regional supply area between January 2018 and December 2020. The bacteriological\n                    examination included Ziehl\u2013Neelsen staining and L\u00f6wenstein\u2013Jensen culture from\n                    various pathological specimens. In some cases, we also performed GeneXpert and\n                    histopathological examination. <jats:italic>Results:<\/jats:italic> Cases were\n                    predominantly from rural areas and in middle-aged people. The major risk factors\n                    were precarious living conditions, unemployment, smoking and alcohol abuse. In\n                    18 cases, the diagnosis was confirmed by bacteriological and in 17 by\n                    histopathological examination. In cases without bacteriological or\n                    histopathological confirmation, we corroborated the probability criteria as\n                    epidemiological, clinical, and imaging findings. Extrapulmonary tuberculosis\n                    manifested as pleural (25), osteoarticular (13), nodal (11), meningeal (7),\n                    renal (4), cutaneous (2) and gastrointestinal (1) tuberculosis. Bacteriological\n                    confirmation of tuberculous pleurisy was made in 3 cases. Osteoarticular\n                    tuberculosis had bacteriological confirmation in 6 cases and histopathological\n                    in 4. Tuberculosis meningitis was diagnosed in 5 cases by bacteriological\n                    examination. Lymph node and cutaneous tuberculosis were confirmed by\n                    histopathological examination. Antituberculotic treatment was well tolerated by\n                    patients, but the compliance was low (92%). <jats:italic>Discussion:<\/jats:italic>\n                    Extrapulmonary tuberculosis is a diagnostic challenge due to the difficulty of\n                    bacteriological and histopathological confirmation. <jats:italic>Conclusion:<\/jats:italic>\n                    Increasing early confirmation and careful monitoring of cases can reduce\n                    complications and increase treatment compliance. Orv Hetil. 2022; 163(19):\n                    750\u2013757.<\/jats:p>","DOI":"10.1556\/650.2022.32437","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T16:10:06Z","timestamp":1668787806000},"page":"750-757","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["Extrapulmonalis tuberculosis \u2013 diagnosztikai \u00e9s ter\u00e1pi\u00e1s kih\u00edv\u00e1s"],"prefix":"10.1556","volume":"163","author":[{"given":"H\u00e9di-Katalin","family":"S\u00e1rk\u00f6zi","sequence":"first","affiliation":[{"name":"Marosv\u00e1s\u00e1rhelyi \u201eGeorge Emil Palade\u201d Orvosi, Gy\u00f3gyszer\u00e9szeti, Tudom\u00e1ny- \u00e9s Technol\u00f3giai Egyetem, T\u00fcd\u0151gy\u00f3gy\u00e1szati Tansz\u00e9k Marosv\u00e1s\u00e1rhely Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Beatrice","family":"Iano\u0219i","sequence":"additional","affiliation":[{"name":"Marosv\u00e1s\u00e1rhelyi \u201eGeorge Emil Palade\u201d Orvosi, Gy\u00f3gyszer\u00e9szeti, Tudom\u00e1ny- \u00e9s Technol\u00f3giai Egyetem K\u00e1rp\u00e1tok s\u00e9t\u00e1ny, 43\/A, 3\/11., 540296, Marosv\u00e1s\u00e1rhely, Maros megye Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca-Emilia","family":"Ciurba","sequence":"additional","affiliation":[{"name":"Maros Megyei Klinikai K\u00f3rh\u00e1z, T\u00fcd\u0151gy\u00f3gy\u00e1szati Klinika Marosv\u00e1s\u00e1rhely Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimr\u00f3d","family":"L\u00e1szl\u00f3","sequence":"additional","affiliation":[{"name":"Maros Megyei Klinikai K\u00f3rh\u00e1z, T\u00fcd\u0151gy\u00f3gy\u00e1szati Klinika Marosv\u00e1s\u00e1rhely Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"S\u00e1rk\u00f6zi","sequence":"additional","affiliation":[{"name":"Maros Megyei S\u00fcrg\u0151ss\u00e9gi K\u00f3rh\u00e1z, Aneszteziol\u00f3gia \u00e9s Intenz\u00edv Ter\u00e1pia Oszt\u00e1ly Marosv\u00e1s\u00e1rhely Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Jimborean","sequence":"additional","affiliation":[{"name":"Marosv\u00e1s\u00e1rhelyi \u201eGeorge Emil Palade\u201d Orvosi, Gy\u00f3gyszer\u00e9szeti, Tudom\u00e1ny- \u00e9s Technol\u00f3giai Egyetem, T\u00fcd\u0151gy\u00f3gy\u00e1szati Tansz\u00e9k Marosv\u00e1s\u00e1rhely Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","unstructured":"1 World Health Organization. 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