{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T10:43:18Z","timestamp":1698316998549},"reference-count":27,"publisher":"Akademiai Kiado Zrt.","issue":"6","license":[{"start":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T00:00:00Z","timestamp":1644105600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,2,6]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> A SARS-CoV-2-infekci\u00f3 v\u00e1ltozatos k\u00f3rlefoly\u00e1s\u00fa, a\n                    gyermekpopul\u00e1ci\u00f3ban n\u00f6vekv\u0151 incidenci\u00e1t mutat\u00f3 fert\u0151z\u00e9s. Ebben a korcsoportban a\n                    feln\u0151ttekkel szemben sokkal gyakrabban tapasztalhat\u00f3k gasztroenterol\u00f3giai\n                    t\u00fcnetek a betegs\u00e9g sor\u00e1n, 18\u201332%-ban jelentkezik legal\u00e1bb egy szimpt\u00f3ma. Ezek\n                    nem specifikusak, gyakran megegyezhetnek a vir\u00e1lis enteritisek, a gyullad\u00e1sos\n                    b\u00e9lbetegs\u00e9gek vagy a vakb\u00e9lgyullad\u00e1s t\u00fcneteivel. A gyermekkori\n                    SARS-CoV-2-infekci\u00f3nak egy viszonylag ritk\u00e1n megjelen\u0151, de s\u00falyos, ak\u00e1r\n                    \u00e9letvesz\u00e9lyes sz\u00f6v\u0151dm\u00e9nye a gyermekkori sokszervi gyullad\u00e1sos szindr\u00f3ma\n                    (multisystem inflammatory syndrome in children, MIS-C). Ilyenkor a\n                    gastrointestinalis t\u00fcnetek gyakoris\u00e1ga 60\u2013100%-ra n\u0151, sok esetben akut has\n                    benyom\u00e1s\u00e1t keltve. A jelenlegi kutat\u00e1sok eredm\u00e9nyei alapj\u00e1n a gyullad\u00e1sos\n                    b\u00e9lbeteg gyerekek az alapbetegs\u00e9g\u00fck miatt nincsenek nagyobb vesz\u00e9lynek kit\u00e9ve az\n                    \u00e1tlagpopul\u00e1ci\u00f3hoz k\u00e9pest a COVID\u201319-fert\u0151z\u00e9s szempontj\u00e1b\u00f3l. A ter\u00e1pi\u00e1jukban\n                    alkalmazott gy\u00f3gyszereik k\u00f6z\u00fcl a nagy d\u00f3zis\u00fa szteroidkezel\u00e9s okoz nagyobb\n                    kock\u00e1zatot a megfert\u0151z\u0151d\u00e9sre, illetve ebben az esetben a s\u00falyosabb\n                    k\u00f3rlefoly\u00e1sra. Az \u00e9ppen remisszi\u00f3ban l\u00e9v\u0151 gyullad\u00e1sos b\u00e9lbetegek fenntart\u00f3\n                    ter\u00e1pi\u00e1j\u00e1nak m\u00f3dos\u00edt\u00e1sok n\u00e9lk\u00fcli folytat\u00e1sa javasolt, kiemelt figyelmet ford\u00edtva\n                    a biol\u00f3giai ter\u00e1pi\u00e1k id\u0151ben t\u00f6rt\u00e9n\u0151, megszak\u00edt\u00e1s n\u00e9lk\u00fcli alkalmaz\u00e1s\u00e1ra.\n                    T\u00f6rekedni kell a szem\u00e9lyes vizitek sz\u00e1m\u00e1nak cs\u00f6kkent\u00e9s\u00e9re a pand\u00e9mia idej\u00e9n,\n                    ezek telemedicin\u00e1val t\u00f6rt\u00e9n\u0151 helyettes\u00edt\u00e9se javasolt. A halaszthat\u00f3 endoszk\u00f3pos\n                    vizsg\u00e1latok noninvaz\u00edv vizsg\u00e1l\u00f3m\u00f3dszerekkel t\u00f6rt\u00e9n\u0151 \u00e1tmeneti kiv\u00e1lt\u00e1sa\n                    r\u00e9szes\u00edtend\u0151 el\u0151nyben a betegs\u00e9g aktivit\u00e1s\u00e1nak, a ter\u00e1pia hat\u00e9konys\u00e1g\u00e1nak\n                    meg\u00edt\u00e9l\u00e9s\u00e9re. A gyullad\u00e1sos b\u00e9lbetegs\u00e9gben szenved\u0151 gyermekek COVID\u201319 elleni\n                    v\u00e9d\u0151olt\u00e1sa javasolt, jelenleg minden el\u00e9rhet\u0151 olt\u00f3anyag alkalmazhat\u00f3 n\u00e1luk (az\n                    \u00e9l\u0151 \u00e1genst tartalmaz\u00f3 vakcin\u00e1k ellenjavalltak). Immunmodul\u00e1ns, szteroid- vagy\n                    anti-tumornekr\u00f3zisfaktor (TNF)-alfa-ter\u00e1pia eset\u00e9n az olt\u00e1s lehets\u00e9ges cs\u00f6kkent\n                    hat\u00e9konys\u00e1g\u00e1val kell sz\u00e1molni. Orv Hetil. 2022; 163(6): 214\u2013221.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> The SARS-CoV-2 infection is showing high variety in the\n                    disease course, with a constantly increasing incidence among the pediatric\n                    population. In this age group, at least one gastrointestinal symptom appears in\n                    18\u201332% of the cases, showing a significant difference compared to the adult\n                    population. The gastrointestinal signs of COVID\u201319 are not specific, can mimic\n                    the symptoms of viral enteritis, inflammatory bowel diseases or acute\n                    appendicitis. The multisystem inflammatory syndrome in children (MIS-C) is a\n                    rather rare, but serious complication of the pediatric COVID\u201319 disease: in\n                    these cases, the incidence of the gastrointestinal symptoms is increased up to\n                    60\u2013100%, often observed as acute abdomen. Based on recent researches, patients\n                    with inflammatory bowel diseases (IBD) are shown to have the same risk in\n                    developing COVID\u201319 infection compared to the normal population: in their\n                    medications, the high dose steroid treatment is proved to increase the risk of\n                    infection or to make the disease course more serious. The treatment of patients\n                    with IBD should be continued without any changes (when the disease is in\n                    remission). The use of biologics should be done with special care, with more\n                    attention keeping the schedule and the continuity. It is advised to minimise the\n                    number of personal visits during the pandemic, they should be substituted with\n                    telemedicine. The postponable endoscopic examinations should be temporarily\n                    redeemed by non-invasive methods for screening the disease activity and the\n                    efficacy of the treatment. The vaccination against COVID\u201319 is advised in the\n                    population with IBD. All vaccines currently available are usable in this patient\n                    group (the use of vaccines containing live agents are contraindicated). In the\n                    case of patients treated with immunmodulators, steroids or anti-tumor necrosis\n                    factor (TNF) alpha, a possible lower efficacy can be expected after the\n                    vaccination. Orv Hetil. 2022; 163(6): 214\u2013221.<\/jats:p>","DOI":"10.1556\/650.2022.32443","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T09:47:52Z","timestamp":1645004872000},"page":"214-221","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":2,"title":["A COVID\u201319-fert\u0151z\u00e9s gastrointestinalis hat\u00e1sai gyermekkorban \u00e9s a gyullad\u00e1sos b\u00e9lbeteg gyermekekben"],"prefix":"10.1556","volume":"163","author":[{"given":"Luca","family":"T\u00f3bi","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Gyermekgy\u00f3gy\u00e1szati Klinika 1428 Budapest, Pf. 2. Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bence","family":"Prehoda","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. 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[Hungarian]","DOI":"10.1556\/650.2020.31871"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.dld.2020.10.024","article-title":"Management of paediatric IBD after the peak of COVID-19 pandemic in Italy: a position paper on behalf of the SIGENP IBD working group","volume":"53","author":"27 Arrigo","year":"2021","unstructured":"27 Arrigo S, Alvisi P, Banzato C, et al. Management of paediatric IBD after the peak of COVID-19 pandemic in Italy: a position paper on behalf of the SIGENP IBD working group. Dig Liver Dis. 2021; 53: 183-189.","journal-title":"Dig Liver Dis"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/163\/6\/article-p214.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/163\/6\/article-p214.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/163\/6\/article-p214.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T09:11:25Z","timestamp":1698225085000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/163\/6\/article-p214.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,6]]},"references-count":27,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1556\/650.2022.32443","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,6]]}}}