{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:40:10Z","timestamp":1771663210958,"version":"3.50.1"},"reference-count":24,"publisher":"Akademiai Kiado Zrt.","issue":"20","license":[{"start":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T00:00:00Z","timestamp":1652572800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,5,15]]},"abstract":"<jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> A terhess\u00e9gi cholestasis a terhess\u00e9gek 1%-\u00e1ban\n                    el\u0151fordul\u00f3 k\u00f3rk\u00e9p. Fenn\u00e1ll\u00e1sa nagym\u00e9rt\u00e9kben n\u00f6veli a s\u00falyos magzati sz\u00f6v\u0151dm\u00e9nyek\n                    kialakul\u00e1s\u00e1nak, \u00edgy a korasz\u00fcl\u00e9snek \u00e9s a terminusk\u00f6zelben v\u00e1ratlanul\n                    bek\u00f6vetkez\u0151, m\u00e9hen bel\u00fcli magzati elhal\u00e1snak a rizik\u00f3j\u00e1t.\n                        <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> A haz\u00e1nkban a klinikum sz\u00e1m\u00e1ra a k\u00f6zelm\u00faltban\n                    el\u00e9rhet\u0151v\u00e9 v\u00e1lt sz\u00e9rum\u00f6sszepesavszint-m\u00e9r\u00e9ssel kapcsolatos eddigi\n                    tapasztalataink \u00f6sszegz\u00e9se \u00e9s a terhess\u00e9gi cholestasis ell\u00e1t\u00e1sa debreceni\n                    gyakorlat\u00e1nak bemutat\u00e1sa. <jats:italic>Betegek \u00e9s m\u00f3dszer:<\/jats:italic> Retrospekt\u00edv\n                    esetsorozatban vizsg\u00e1ltuk a debreceni Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinik\u00e1n 2020.\n                    szeptember \u00e9s 2021. szeptember k\u00f6z\u00f6tt kezelt s\u00falyos cholestasisos v\u00e1rand\u00f3sok\n                    adatait. Meghat\u00e1roztuk az epesav-, a m\u00e1jenzim- \u00e9s a bilirubinszintek\n                    statisztikai korrel\u00e1ci\u00f3j\u00e1t is. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> 758 v\u00e1rand\u00f3s 1258\n                    sz\u00e9rummint\u00e1j\u00e1b\u00f3l t\u00f6rt\u00e9nt epesav-meghat\u00e1roz\u00e1s. 5 esetben (az \u00f6sszes eset 0,7%-a,\n                    a cholestasisos esetek 6,4%-a) s\u00falyos (epesav 40\u201399 \u03bcmol\/l), 7 esetben (0,9%,\n                    illetve 9,0%) igen s\u00falyos (epesav \u2265100 \u03bcmol\/l) epepang\u00e1s volt igazolhat\u00f3. A 12\n                    s\u00falyos cholestasisos v\u00e1rand\u00f3s \u00e1tlag\u00e9letkora 30,6 (21\u201343) \u00e9v volt, k\u00f6z\u00fcl\u00fck 7 volt\n                    primigravida. A betegek k\u00f6z\u00fcl 5-n\u00e9l \u00e1llt fenn cholestasisra hajlamos\u00edt\u00f3\n                    el\u0151zm\u00e9nyi betegs\u00e9g. 6 beteg r\u00e9szes\u00fclt urzodezoxik\u00f3lsav-kezel\u00e9sben, amely az\n                    epesavszintek jelent\u0151s cs\u00f6kken\u00e9s\u00e9t eredm\u00e9nyezte. S\u00falyos cholestasisban az\n                    epesav\u2013GOT (R<jats:sup>2<\/jats:sup> = 0,14) \u00e9s az epesav\u2013GPT (R<jats:sup>2<\/jats:sup> = 0,17)\n                    korrel\u00e1ci\u00f3 gyeng\u00e9nek bizonyult (n = 45). Az epesavszintek postpartum hamar\n                    szignifik\u00e1nsan javultak. A 12 beteg k\u00f6z\u00fcl eddig 11 sz\u00fclt meg, \u00e9s 13 \u00fajsz\u00fcl\u00f6tt\n                    sz\u00fcletett, 2\/12 volt ikerterhess\u00e9g. Az \u00e1tlagos gestati\u00f3s kor a sz\u00fcl\u00e9skor 37\n                    (33\u201340) h\u00e9t volt. 3\/11 korasz\u00fcl\u00e9s t\u00f6rt\u00e9nt (27%). A terminusk\u00f6zeli sz\u00fcl\u00e9sek k\u00f6z\u00fcl\n                    7\/8 (88%) sz\u00fcl\u00e9sindukci\u00f3t k\u00f6vet\u0151en zajlott. Egyszer sem volt sz\u00fcks\u00e9g elekt\u00edv\n                    cs\u00e1sz\u00e1rmetsz\u00e9sre, \u00e9s a vaj\u00fad\u00e1s sor\u00e1n mind\u00f6ssze 2\/11 esetben kellett\n                    cs\u00e1sz\u00e1rmetsz\u00e9st v\u00e9gezni (18%). Intrauterin magzati elhal\u00e1s nem k\u00f6vetkezett be.\n                        <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> A sz\u00e9rumepesav-m\u00e9r\u00e9s hat\u00e9kony eszk\u00f6z a\n                    terhess\u00e9gi cholestasis diagnosztik\u00e1j\u00e1ban \u00e9s k\u00f6vet\u00e9s\u00e9ben, a protokollalap\u00fa\n                    sz\u00fcl\u00e9szeti ell\u00e1t\u00e1shoz pedig n\u00e9lk\u00fcl\u00f6zhetetlen. A k\u00f6zlem\u00e9nyben bemutatjuk\n                    klinik\u00e1nk epesavszinten alapul\u00f3 terhess\u00e9gi cholestasis ell\u00e1t\u00e1s\u00e1nak gyakorlat\u00e1t\n                    is. Orv Hetil. 2022; 163(20): 797\u2013805.<\/jats:p>","DOI":"10.1556\/650.2022.32474","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T13:04:20Z","timestamp":1668776660000},"page":"797-805","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["Az epesavm\u00e9r\u00e9s szerepe a s\u00falyos terhess\u00e9gi cholestasis sz\u00fcl\u00e9szeti ell\u00e1t\u00e1s\u00e1ban"],"prefix":"10.1556","volume":"163","author":[{"given":"Tam\u00e1s","family":"Deli","sequence":"first","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Laborat\u00f3riumi Medicina Int\u00e9zet Debrecen Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Cs\u00e9pes-Ruzicska","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zo\u00e1rd Tibor","family":"Krasznai","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Mosolyg\u00f3-Luk\u00e1cs","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Laborat\u00f3riumi Medicina Int\u00e9zet Debrecen Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Kappelmayer","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Laborat\u00f3riumi Medicina Int\u00e9zet Debrecen Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Lamp\u00e9","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.3748\/wjg.15.2049","article-title":"Intrahepatic cholestasis of pregnancy","volume":"15","author":"Geenes V","year":"2009","unstructured":"1 Geenes V, Williamson C. Intrahepatic cholestasis of pregnancy. World J Gastroenterol. 2009; 15: 2049-2066.","journal-title":"World J Gastroenterol"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1002\/hep.22139","article-title":"Sex hormones and bile acids in intrahepatic cholestasis of pregnancy","volume":"47","author":"2 Reyes","year":"2008","unstructured":"2 Reyes H. Sex hormones and bile acids in intrahepatic cholestasis of pregnancy. Hepatology 2008; 47: 376-379.","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/1471-0528.12174","article-title":"Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study","volume":"120","author":"3 Wikstr\u00f6m Shemer","year":"2013","unstructured":"3 Wikstr\u00f6m Shemer C, Marschall HU, Ludvigssun JF, et al. Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study. BJOG 2013; 120: 717-723.","journal-title":"BJOG"},{"key":"ref3","unstructured":"4 Ovadia C, Seed PT, Sklavounos A, et al. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet 2019; 393: 899-909. [Erratum: Lancet 2019; 393: 1100.]"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ejogrb.2017.09.012","article-title":"A retrospective cohort review of intrahepatic cholestasis of pregnancy in a South Australian population","volume":"218","author":"5 Marathe","year":"2017","unstructured":"5 Marathe JA, Lim WH, Metz MP, et al. A retrospective cohort review of intrahepatic cholestasis of pregnancy in a South Australian population. Eur J Obstet Gynecol Reprod Biol. 2017; 218: 33-38.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref5","unstructured":"6 Williamson C, Girling J. Obstetric cholestasis. In: James DK, Steer PJ, Weiner CP, et al. (eds.) High risk pregnancy: management options. Fourth edn. Elsevier Saunders, St. Louis, MO, 2011; pp. 843-846."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/j.1471-0528.2004.00167.x","article-title":"Clinical outcome in a series of cases of obstetric cholestasis identified via a patient support group","volume":"111","author":"7 Williamson","year":"2004","unstructured":"7 Williamson C, Hems LM, Goulis DG, et al. Clinical outcome in a series of cases of obstetric cholestasis identified via a patient support group. BJOG 2004; 111: 676-681.","journal-title":"BJOG"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8 Paternoster DM, Fabris F, Pal\u00f9 G, et al. Intra-hepatic cholestasis of pregnancy in hepatitis C virus infection. Acta Obstet Gynecol Scand. 2002; 81: 99-103.","DOI":"10.1080\/j.1600-0412.2002.810202.x"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ejogrb.2013.12.037","article-title":"Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes","volume":"176","author":"9 Martineau","year":"2014","unstructured":"9 Martineau M, Raker C, Powrie R, et al. Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes. Eur J Obstet Gynecol Reprod Biol. 2014; 176: 80-85.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1093\/hmg\/9.8.1209","article-title":"Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking","volume":"9","author":"10 Dixon","year":"2000","unstructured":"10 Dixon PH, Weerasekera N, Linton KJ, et al. Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. Hum Mol Genet. 2000; 9: 1209-1217.","journal-title":"Hum Mol Genet"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1111\/j.1365-2036.2006.02869.x","article-title":"Intrahepatic cholestasis of pregnancy: three novel MDR3 gene mutations","volume":"23","author":"11 Floreani","year":"2006","unstructured":"11 Floreani A, Carderi I, Paternoster D, et al. Intrahepatic cholestasis of pregnancy: three novel MDR3 gene mutations. Aliment Pharmacol Ther. 2006; 23: 1649-1653.","journal-title":"Aliment Pharmacol Ther"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12 Pa\u0159\u00edzek A, Du\u0161kov\u00e1 M, V\u00edtek L, et al. The role of steroid hormones in the development of intrahepatic cholestasis of pregnancy. Physiol Res. 2015; 64(Suppl 2): S203-S209.","DOI":"10.33549\/physiolres.933117"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/0168-8278(89)90079-2","article-title":"Intrahepatic cholestasis of pregnancy in twin pregnancies","volume":"9","author":"13 Gonzalez","year":"1989","unstructured":"13 Gonzalez MC, Reyes H, Arrese M, et al. Intrahepatic cholestasis of pregnancy in twin pregnancies. J Hepatol. 1989; 9: 84-90.","journal-title":"J Hepatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1080\/01443615.2017.1286302","article-title":"Two cases of first onset intrahepatic cholestasis of pregnancy associated with moderate ovarian hyperstimulation syndrome after IVF treatment and review of the literature","volume":"37","author":"14 Mutlu","year":"2017","unstructured":"14 Mutlu MF, Aslan K, Guler I, et al. Two cases of first onset intrahepatic cholestasis of pregnancy associated with moderate ovarian hyperstimulation syndrome after IVF treatment and review of the literature. J Obstet Gynaecol. 2017; 37: 547-549.","journal-title":"J Obstet Gynaecol"},{"key":"ref14","unstructured":"15 Department of Laboratory Medicine, Debrecen University. Analytical evaulation for measuring total bile acids. [Debreceni Egyetem, Klinikai K\u00f6zpont, Laborat\u00f3riumi Medicina: Tot\u00e1l epesav meghat\u00e1roz\u00e1s: M\u00f3dszerle\u00edr\u00e1s. MDL 09. LM. 2021. 10. 01.] [Hungarian]"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16 Danese E, Salvagno GL, Negrini D, et al. Analytical evaluation of three enzymatic assays for measuring total bile acids in plasma using a fully-automated clinical chemistry platform. PLoS ONE 2017; 12: e0179200.","DOI":"10.1371\/journal.pone.0179200"},{"key":"ref16","unstructured":"17 Obstetric cholestasis. Royal College of Obstetricians and Gynaecologists. RCOG green-top guideline No. 43: April, 2011."},{"key":"ref17","unstructured":"18 Department for Health and Wellbeing, Government of South Australia. South Australian Perinatal Practice Guideline: intrahepatic cholestasis of pregnancy. 11 August, 2021."},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19 American College of Obstetricians and Gynecologists' Committee on Obstetric Practice, Society for Maternal-Fetal Medicine. Medically indicated late-preterm and early-term deliveries: ACOG Committee Opinion, Number 831. Obstet Gynecol. 2021; 138: e35-e39.","DOI":"10.1097\/AOG.0000000000004447"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20 Tran TT, Ahn J, Reau NS. ACG clinical guideline: liver disease and pregnancy. Am J Gastroenterol. 2016; 111: 176-194. [Erratum: Am J Gastroenterol. 2016; 111: 1668.]","DOI":"10.1038\/ajg.2015.430"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21 European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol. 2009; 51: 237-267.","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"ref21","unstructured":"22 Lindor KD, Lee RH. Intrahepatic cholestasis of pregnancy. UpToDate. Available from: https:\/\/www.uptodate.com\/contents\/intrahepatic-cholestasis-of-pregnancy#H417223400 [accessed: December 19, 2021]."},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23 Manzotti C, Casazza G, Stimac T, et al. Total serum bile acids or serum bile acid profile, or both, for the diagnosis of intrahepatic cholestasis of pregnancy. Cochrane Database Syst Rev. 2019; 7: CD012546.","DOI":"10.1002\/14651858.CD012546.pub2"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24 Deli T, Lamp\u00e9 R, Juh\u00e1sz AG, et al. How the cesarean delivery rate decreased at the Department of Obstetrics and Gynecology, University of Debrecen during the COVID-19 pandemic. [Hogyan cs\u00f6kkent a cs\u00e1sz\u00e1rmetsz\u00e9sek ar\u00e1nya a debreceni Sz\u00fcl\u00e9szeti Klinik\u00e1n a koronav\u00edrus-pand\u00e9mia alatt?] Orv Hetil. 2021; 162: 811-823. 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