{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T10:43:56Z","timestamp":1698403436024},"reference-count":30,"publisher":"Akademiai Kiado Zrt.","issue":"26","license":[{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,6,26]]},"abstract":"<jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> A malignus pleuralis effusio a daganatos betegek\n                    rossz progn\u00f3zist jelent\u0151 k\u00f3r\u00e1llapota, mely akutan \u00e9letvesz\u00e9lyes is lehet,\n                    el\u0151rehaladott esetben onkol\u00f3giai s\u00fcrg\u0151ss\u00e9gi kezel\u00e9st ig\u00e9nyel.\n                        <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> A P\u00e9csi Tudom\u00e1nyegyetem Onkoter\u00e1pi\u00e1s\n                    Int\u00e9zet\u00e9ben arra tett\u00fcnk k\u00eds\u00e9rletet, hogy a COVID\u201319-pand\u00e9mia alatt is komplex\n                    ell\u00e1t\u00e1st ny\u00fajtsunk a malignus pleuralis effusi\u00f3val terhelt betegeknek. Az\n                    int\u00e9zet\u00fcnk rutin betegell\u00e1t\u00f3 profilj\u00e1t nem k\u00e9pez\u0151 thoracocentesist a pand\u00e9mia\n                    idej\u00e9n bevezett\u00fck elj\u00e1r\u00e1saink k\u00f6z\u00e9. <jats:italic>M\u00f3dszer:<\/jats:italic> Tanulm\u00e1nyunkban\n                    2020. m\u00e1rcius 18. \u00e9s 2021. m\u00e1jus 31. k\u00f6z\u00f6tt az int\u00e9zet\u00fcnkben kezelt betegek\n                    eset\u00e9ben az \u00fajonnan megjelent mell\u0171ri folyad\u00e9k kivizsg\u00e1l\u00e1s\u00e1nak, kezel\u00e9s\u00e9nek \u00e9s a\n                    panaszt okoz\u00f3 mell\u0171ri folyad\u00e9k ell\u00e1t\u00e1s\u00e1nak eredm\u00e9nyeit vizsg\u00e1ltuk meg.\n                        <jats:italic>Eredm\u00e9nyek:<\/jats:italic> Feldolgoz\u00e1sunkban 45 beteg adatait jelen\u00edtett\u00fck\n                    meg, t\u00f6bbs\u00e9g\u00fck (66,7%) n\u0151, a betegek medi\u00e1n \u00e9letkora 67 \u00e9v volt. A vizsg\u00e1lat\n                    alatt akt\u00edv sziszt\u00e9m\u00e1s t\u00edpus\u00fa daganatellenes kezel\u00e9sben a betegek 57,8%-a\n                    r\u00e9szes\u00fclt. A thoracocentesisek sz\u00e1ma 120 feletti volt, a betegek harmad\u00e1ban\n                    5-n\u00e9l t\u00f6bbsz\u00f6r volt sz\u00fcks\u00e9g beavatkoz\u00e1sra. Mind\u00f6ssze 3 alkalommal fordult el\u0151\n                    iatrog\u00e9n pneumothorax, m\u00e1s s\u00falyos sz\u00f6v\u0151dm\u00e9nyt nem \u00e9szlelt\u00fcnk. A beavatkoz\u00e1sok,\n                    melyek f\u0151k\u00e9pp a panaszok enyh\u00edt\u00e9s\u00e9re ir\u00e1nyultak (80%-ban), sikeresnek\n                    tekinthet\u0151k. A pleuralis carcinosis rossz prognosztikai jelleg\u00e9t bizony\u00edtja,\n                    hogy az alig t\u00f6bb mint egy\u00e9ves feldolgozott id\u0151szak v\u00e9g\u00e9n\u00e9l a betegek 48,9%-a\n                    m\u00e1r nem volt \u00e9letben. <jats:italic>Megbesz\u00e9l\u00e9s \u00e9s k\u00f6vetkeztet\u00e9s:<\/jats:italic> A j\u00e1rv\u00e1ny\n                    alatt az onkol\u00f3giai betegek ell\u00e1t\u00e1sa nem sz\u00fcnetelt, s\u00fcrg\u0151ss\u00e9gi betegell\u00e1t\u00e1s\n                    keret\u00e9ben azonban sokszor el\u0151rehaladottabb k\u00f3r\u00e1llapotban \u00e9szlelt\u00fck \u0151ket. A\n                    malignus mell\u0171ri effusio kezel\u00e9se onkol\u00f3giai el\u0151regondolkod\u00e1st \u00e9s invaz\u00edv\n                    beavatkoz\u00e1si k\u00e9pess\u00e9geket is felt\u00e9telez. Jelen tanulm\u00e1nyunk r\u00e1vil\u00e1g\u00edtott a\n                    neh\u00e9zs\u00e9gekre \u00e9s az el\u0151remutat\u00f3 l\u00e9p\u00e9sek sz\u00fcks\u00e9gess\u00e9g\u00e9re. Megfigyel\u00e9seink a\n                    szakirodalmi adatokkal egybev\u00e1gnak, s\u0151t a beavatkoz\u00e1sokhoz t\u00e1rsul\u00f3 sz\u00f6v\u0151dm\u00e9nyek\n                    tekintet\u00e9ben jobbak az eredm\u00e9nyeink. Orv Hetil. 2022; 163(26): 1015\u20131022.<\/jats:p>","DOI":"10.1556\/650.2022.32503","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T23:20:06Z","timestamp":1668813606000},"page":"1015-1022","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["Malignus pleuralis effusi\u00f3kkal k\u00fczd\u0151 betegek ell\u00e1t\u00e1sa egy region\u00e1lis onkol\u00f3giai k\u00f6zpontban a COVID\u201319-pand\u00e9mia id\u0151szak\u00e1ban"],"prefix":"10.1556","volume":"163","author":[{"given":"Em\u0151ke","family":"Papp","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Onkoter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Pusztai","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Onkoter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"Csongr\u00e1d-Csan\u00e1d Megyei Eg\u00e9szs\u00e9g\u00fcgyi Ell\u00e1t\u00f3 K\u00f6zpont, S\u00fcrg\u0151ss\u00e9gi Oszt\u00e1ly H\u00f3dmez\u0151v\u00e1s\u00e1rhely Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter Adrienne","family":"Herendi","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Onkoter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Mangel","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Onkoter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1 Lovell N, Etkind SN, Bajwah S, et al. Control and context are central for people with advanced illness experiencing breathlessness: a systematic review and thematic synthesis. J Pain Symptom Manage 2019; 57: 140-155.e2.","DOI":"10.1016\/j.jpainsymman.2018.09.021"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12245-020-00302-z","article-title":"Separating the wheat from the chaff-COVID-19 in a German emergency department: a case-control study","volume":"13","author":"2 Fistera","year":"2020","unstructured":"2 Fistera D, Pabst D, H\u00e4rtl A, et al. Separating the wheat from the chaff-COVID-19 in a German emergency department: a case-control study. Int J Emerg Med. 2020; 13: 44.","journal-title":"Int J Emerg Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jss.2019.06.068","article-title":"Gender disparity in referral for definitive care of malignant pleural effusions","volume":"244","author":"3 Foote","year":"2019","unstructured":"3 Foote DC, Burke CR, Pandian B, et al. Gender disparity in referral for definitive care of malignant pleural effusions. J Surg Res. 2019; 244: 409-416.","journal-title":"J Surg Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2147\/OAEM.S29942","article-title":"Pleural effusion: diagnosis, treatment, and management","volume":"4","author":"Karkhanis VS","year":"2012","unstructured":"4 Karkhanis VS, Joshi JM. Pleural effusion: diagnosis, treatment, and management. Open Access Emerg Med. 2012; 4: 31-52.","journal-title":"Open Access Emerg Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"98","DOI":"10.4103\/0973-1075.84529","article-title":"An update in the management of malignant pleural effusion","volume":"17","author":"5 Muduly","year":"2011","unstructured":"5 Muduly D, Deo S, Subi Ts, et al. An update in the management of malignant pleural effusion. Indian J Palliat Care 2011; 17: 98-103.","journal-title":"Indian J Palliat Care"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6 Hui D, Maddocks M, Johnson MJ, et al. Management of breathlessness in patients with cancer: ESMO Clinical Practice Guidelines. ESMO Open 2020; 5: e001038.","DOI":"10.1136\/esmoopen-2020-001038"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1056\/NEJMra1403503","article-title":"Pleural disease","volume":"378","author":"Feller-Kopman D","year":"2018","unstructured":"7 Feller-Kopman D, Light R. Pleural disease. N Engl J Med. 2018; 378: 740-751.","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.2214\/ajr.156.6.2028857","article-title":"Imaging the pleura: sonography, CT, and MR imaging","volume":"156","author":"McLoud TC","year":"1991","unstructured":"8 McLoud TC, Flower CD. Imaging the pleura: sonography, CT, and MR imaging. Am J Roentgenol. 1991; 156: 1145-1153.","journal-title":"Am J Roentgenol"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9 Beaudoin S, Gonzalez AV. Evaluation of the patient with pleural effusion. CMAJ 2018; 190: E291-E295.","DOI":"10.1503\/cmaj.170420"},{"key":"ref9","unstructured":"10 [10 ] Protocol for thoracocentesis at the Department of Oncotherapy in P\u00e9cs University. [Szakmai ir\u00e1nyelv PTE Onkoter\u00e1pi\u00e1s Int\u00e9zet - ER-OI 13 A mellkaspunctio elj\u00e1r\u00e1srendje.] [Hungarian]"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1164\/rccm.201807-1415ST","article-title":"An official ATS\/STS\/STR clinical practice guideline","volume":"198","author":"11 Feller-Kopman","year":"2018","unstructured":"11 Feller-Kopman DJ, Reddy CB, DeCamp MM, et al. Management of malignant pleural effusions. An official ATS\/STS\/STR clinical practice guideline. Am J Respir Crit Care Med. 2018; 198: 839-849.","journal-title":"Am J Respir Crit Care Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1016\/j.athoracsur.2007.06.038","article-title":"Large-volume thoracentesis and the risk of reexpansion pulmonary edema","volume":"84","author":"12 Feller-Kopman","year":"2007","unstructured":"12 Feller-Kopman D, Berkowitz D, Boiselle P, et al. Large-volume thoracentesis and the risk of reexpansion pulmonary edema. Ann Thorac Surg. 2007; 84: 1656-1661.","journal-title":"Ann Thorac Surg"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/jcu.20163","article-title":"Sonographically guided thoracentesis and rate of pneumothorax","volume":"33","author":"13 Barnes","year":"2005","unstructured":"13 Barnes TW, Morgenthaler TI, Olson EJ, et al. Sonographically guided thoracentesis and rate of pneumothorax. J Clin Ultrasound. 2005; 33: 442-446.","journal-title":"J Clin Ultrasound"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"490","DOI":"10.3390\/medicina55080490","article-title":"Malignant pleural effusion and its current management: a review","volume":"55","author":"14 Skok","year":"2019","unstructured":"14 Skok K, Hladnik G, Grm A. et al. Malignant pleural effusion and its current management: a review. Medicina (Kaunas) 2019; 55: 490.","journal-title":"Medicina (Kaunas)"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2147\/CMAR.S95663","article-title":"Management of malignant pleural effusion: challenges and solutions","volume":"9","author":"15 Penz","year":"2017","unstructured":"15 Penz E, Watt KN, Hergott CA, et al. Management of malignant pleural effusion: challenges and solutions. Cancer Manag Res. 2017; 9: 229-241.","journal-title":"Cancer Manag Res"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16 Hutchinson AH, Fakhouri EW, Raudales J. Recurrent large volume malignant pleural effusion in a patient with renal cell carcinoma. Cureus 2021; 13: e13593.","DOI":"10.7759\/cureus.13593"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"15205","DOI":"10.1038\/ncomms15205","article-title":"Mutant KRAS promotes malignant pleural effusion formation","volume":"8","author":"17 Agalioti","year":"2017","unstructured":"17 Agalioti T, Giannou AD, Krontira AC, et al. Mutant KRAS promotes malignant pleural effusion formation. Nat Commun. 2017; 8: 15205.","journal-title":"Nat Commun"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.path.2018.05.003","article-title":"Updates in effusion cytology","volume":"11","author":"Lepus CM","year":"2018","unstructured":"18 Lepus CM, Vivero M. Updates in effusion cytology. Surg Pathol Clin. 2018; 11: 523-544.","journal-title":"Surg Pathol Clin"},{"key":"ref18","unstructured":"19 Spella M, Giannou AD, Stathopoulos GT. Switching off malignant pleural effusion formation-fantasy or future? J Thorac Dis. 2015; 7: 1009-1020."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"6169","DOI":"10.1158\/1078-0432.CCR-11-3265","article-title":"Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers","volume":"18","author":"20 Dogan","year":"2012","unstructured":"20 Dogan S, Shen R, Ang DC, et al. Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers. Clin Cancer Res. 2012; 18: 6169-6177.","journal-title":"Clin Cancer Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1164\/rccm.201203-0465PP","article-title":"Malignant pleural effusion: tumor-host interactions unleashed","volume":"186","author":"Stathopoulos GT","year":"2012","unstructured":"21 Stathopoulos GT, Kalomenidis I. Malignant pleural effusion: tumor-host interactions unleashed. Am J Respir Crit Care Med. 2012; 186: 487-492.","journal-title":"Am J Respir Crit Care Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1093\/ejcts\/ezy258","article-title":"ERS\/EACTS statement on the management of malignant pleural effusion","volume":"55","author":"22 Bibby","year":"2019","unstructured":"22 Bibby AC, Dorn P, Psallidas I, et al. ERS\/EACTS statement on the management of malignant pleural effusion. Eur J Cardiothorac Surg. 2019; 55: 116-132.","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23 Chen Y, Mathy NW, Lu H. The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non-small cell lung cancer. Mol Med Rep. 2018; 17: 8019-8030.","DOI":"10.3892\/mmr.2018.8922"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/1759-7714.12582","article-title":"Outcomes of bevacizumab combined with chemotherapy in lung adenocarcinoma-induced malignant pleural effusion","volume":"9","author":"24 Tao","year":"2018","unstructured":"24 Tao H, Meng Q, Li M, et al. Outcomes of bevacizumab combined with chemotherapy in lung adenocarcinoma-induced malignant pleural effusion. Thorac Cancer 2018; 9: 298-304.","journal-title":"Thorac Cancer"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s12931-019-1204-x","article-title":"Chemical pleurodesis - a review of mechanisms involved in pleural space obliteration","volume":"20","author":"25 Mierzejewski","year":"2019","unstructured":"25 Mierzejewski M, Korczynski P, Krenke R, et al. Chemical pleurodesis - a review of mechanisms involved in pleural space obliteration. Respir Res. 2019; 20: 247.","journal-title":"Respir Res"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26 Iyer NP, Reddy CB, Wahidi MM, et al. Indwelling pleural catheter versus pleurodesis for malignant pleural effusions. A systematic review and meta-analysis. Ann Am Thorac Soc. 2019; 16: 124-131.","DOI":"10.1513\/AnnalsATS.201807-495OC"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.pulmoe.2020.07.007","article-title":"Recommendations for interventional pulmonology during COVID-19 outbreak: a consensus statement from the Portuguese Pulmonology Society","volume":"26","author":"27 Guedes","year":"2020","unstructured":"27 Guedes F, Bol\u00e9o-Tom\u00e9 JP, Rodrigues LV, et al. Recommendations for interventional pulmonology during COVID-19 outbreak: a consensus statement from the Portuguese Pulmonology Society. Pulmonology 2020; 26: 386-397.","journal-title":"Pulmonology"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28 Wahidi MM, Lamb C, Murgu S, et al. American Association for Bronchology and Interventional Pulmonology (AABIP) statement on the use of bronchoscopy and respiratory specimen collection in patients with suspected or confirmed COVID-19 infection. J Bronchology Interv Pulmonol. 2020; 27: e52-e54.","DOI":"10.1097\/LBR.0000000000000681"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29 Carvalho EA, Oliveira MV. Safety model for chest drainage in pandemic by COVID-19. Rev Col Bras Cir. 2020; 47: e20202568.","DOI":"10.1590\/0100-6991e-20202568"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30 Al-Shamsi HO, Alhazzani W, Alhuraiji A, et al. A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group. Oncologist 2020; 25: e936-e945.","DOI":"10.1634\/theoncologist.2020-0213"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/163\/26\/article-p1015.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/163\/26\/article-p1015.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/163\/26\/article-p1015.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:11:30Z","timestamp":1698307890000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/163\/26\/article-p1015.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,26]]},"references-count":30,"journal-issue":{"issue":"26"},"URL":"https:\/\/doi.org\/10.1556\/650.2022.32503","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,26]]}}}