{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T08:31:34Z","timestamp":1723192294379},"reference-count":40,"publisher":"Akademiai Kiado Zrt.","issue":"30","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,7,24]]},"abstract":"<jats:p>A G4-immunglobulinnal t\u00e1rsult betegs\u00e9g az elm\u00falt \u00e9vekben ker\u00fclt az \u00e9rdekl\u0151d\u00e9s\n                    k\u00f6z\u00e9ppontj\u00e1ba. A k\u00f3rk\u00e9pre jellemz\u0151 az \u00e9rintett szervek gyullad\u00e1s\u00e1val j\u00e1r\u00f3\n                    \u00e1llapot, gyakran daganat gyan\u00faj\u00e1t kelt\u0151 makroszk\u00f3pos megjelen\u00e9s, emelkedett\n                    immunglobulin-G4-szint, sz\u00f6vettani vizsg\u00e1lat sor\u00e1n immunglobulin-G4-pozit\u00edv\n                    plazmasejtes besz\u0171r\u0151d\u00e9s, fibrosis, obliterativ phlebitis \u00e9s t\u00edpusos esetben\n                    kortikoszteroidra adott gyors ter\u00e1pi\u00e1s v\u00e1lasz. A betegs\u00e9g v\u00e1ltozatos szervi\n                    manifeszt\u00e1ci\u00f3t mutathat, gyakori az exokrin mirigyek \u00e9rintetts\u00e9ge. Az endokrin\n                    szervek k\u00f6z\u00fcl a pajzsmirigyben \u00e9s az agyalapi mirigyben jelenhetnek meg a\n                    t\u00fcnetek. A G4-immunglobulinnal t\u00e1rsult hypophysitis krit\u00e9riumrendszer\u00e9t 2011-ben\n                    fogalmazt\u00e1k meg. A G4-immunglobulinnal t\u00e1rsult pajzsmirigybetegs\u00e9g \u00e9vekig\n                    kiz\u00e1r\u00f3lag a Riedel-thyreoiditist jelentette, majd n\u00e9h\u00e1ny \u00e9vvel ezel\u0151tt v\u00e1ltozott\n                    az ezzel kapcsolatos szeml\u00e9let. A 2021-ben megjelent krit\u00e9riumrendszer alapj\u00e1n a\n                    Hashimoto-thyreoiditisben \u00e9s Graves\u2013Basedow-k\u00f3rban szenved\u0151 betegek egy r\u00e9sze is\n                    a G4-immunglobulinnal t\u00e1rsult pajzsmirigybetegs\u00e9g kateg\u00f3ri\u00e1j\u00e1ba sorolhat\u00f3. Az\n                    irodalmi adatokat alapul v\u00e9ve a G4-immunglobulinnal t\u00e1rsult endokrin betegs\u00e9gek\n                    azonos\u00edt\u00e1sa, a pontos diagn\u00f3zis fel\u00e1ll\u00edt\u00e1sa a beteg kezel\u00e9s\u00e9t m\u00f3dos\u00edthatja, a\n                    betegs\u00e9g lefoly\u00e1s\u00e1t meghat\u00e1rozhatja. A G4-immunglobulinnal t\u00e1rsult endokrin\n                    k\u00f3rk\u00e9pben szenved\u0151 betegek eset\u00e9ben egy\u00e9b szervi manifeszt\u00e1ci\u00f3kat is keresni\n                    kell, \u00e9s a betegek \u00e9lethosszig tart\u00f3 immunol\u00f3giai k\u00f6vet\u00e9se indokolt. Orv Hetil.\n                    2022; 163(30): 1175\u20131180.<\/jats:p>","DOI":"10.1556\/650.2022.32527","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:13:50Z","timestamp":1668816830000},"page":"1175-1180","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":2,"title":["G4-immunglobulinnal t\u00e1rsult endokrin betegs\u00e9gek"],"prefix":"10.1556","volume":"163","author":[{"given":"Annam\u00e1ria","family":"Erdei","sequence":"first","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Endokrinol\u00f3gia Tansz\u00e9k Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3960\/jslrt.51.13","article-title":"IgG4-related disease: a novel lymphoproliferative disorder discovered and established in Japan in the 21st century","volume":"51","author":"1 Masaki","year":"2011","unstructured":"1 Masaki Y, Kurose N, Umehara H. 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