{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:10:30Z","timestamp":1791231030762,"version":"4.1.0"},"reference-count":47,"publisher":"Akademiai Kiado Zrt.","issue":"32","license":[{"start":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T00:00:00Z","timestamp":1659830400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,8,7]]},"abstract":"<jats:p>A thrombocyt\u00e1k alapvet\u0151 szerepe a haemostasisban \u00e9s a thrombosisban j\u00f3l ismert.\n                    Ezen klasszikus funkci\u00f3kon t\u00fal azonban a thrombocyt\u00e1k kontroll\u00e1lt aktiv\u00e1ci\u00f3ja\n                    sz\u00fcks\u00e9ges a reprodukci\u00f3hoz \u00e9s egyes immunol\u00f3giai folyamatokhoz is.\n                    \u00d6sszefoglal\u00f3nkban \u00e1ttekintj\u00fck a thrombocyt\u00e1k szerep\u00e9t a reprodukci\u00f3ban. A\n                    leg\u00fajabb k\u00f6zlem\u00e9nyek seg\u00edts\u00e9g\u00e9vel bepillant\u00e1st nyerhet\u00fcnk a thrombocyt\u00e1k sokr\u00e9t\u0171\n                    \u00e9lettani szerep\u00e9be, \u00e9s \u00e1ttekintj\u00fck ezen ismeretek klinikai jelent\u0151s\u00e9g\u00e9t. A\n                    t\u00e9m\u00e1ban megjelent relev\u00e1ns nemzetk\u00f6zi irodalmi adatokat, valamint kor\u00e1bbi\n                    k\u00f6zlem\u00e9nyeinket felhaszn\u00e1lva \u00f6sszefoglaltuk az eddigi legfontosabb ismereteket.\n                    A thrombocytaaktiv\u00e1l\u00f3 faktor \u00e9s a thrombocyt\u00e1k kontroll\u00e1lt aktiv\u00e1ci\u00f3ja fontos\n                    szerepet j\u00e1tszik a folliculogenesisben, az ovul\u00e1ci\u00f3ban, a placenta\n                    kialakul\u00e1s\u00e1ban, az implant\u00e1ci\u00f3ban \u00e9s az embri\u00f3fejl\u0151d\u00e9sben. Az aktiv\u00e1lt\n                    thrombocyt\u00e1k szerepet j\u00e1tszanak az ovarialis hiperstimul\u00e1ci\u00f3s szindr\u00f3ma (OHSS)\n                    \u00e9s a praeeclampsia patogenezis\u00e9ben. A kis d\u00f3zis\u00fa aszpirin megg\u00e1tolja az OHSS\n                    kialakul\u00e1s\u00e1t az ovul\u00e1ci\u00f3indukci\u00f3 sor\u00e1n, m\u00edg a thrombocytad\u00fas plazma (PRP)\n                    intrauterin inf\u00fazi\u00f3ja el\u0151seg\u00edti az endometrium megvastagod\u00e1s\u00e1t, \u00e9s n\u00f6veli\n                    receptivit\u00e1s\u00e1t. A thrombocyt\u00e1k felsz\u00edn\u00e9n sokf\u00e9le adh\u00e9zi\u00f3s molekula \u00e9s receptor\n                    helyezkedik el, majd thrombocytaaktiv\u00e1ci\u00f3kor az intracellul\u00e1ris granulumokb\u00f3l\n                    k\u00fcl\u00f6nb\u00f6z\u0151, biol\u00f3giailag akt\u00edv medi\u00e1torok szabadulnak fel. A v\u00e9rlemezk\u00e9k sz\u00e1mos\n                    endokrin funkci\u00f3hoz n\u00e9lk\u00fcl\u00f6zhetetlenek, \u00edgy felt\u00e9telezz\u00fck egy thrombocyt\u00e1khoz\n                    t\u00e1rsult szab\u00e1lyoz\u00f3rendszer (PARS) m\u0171k\u00f6d\u00e9s\u00e9t a reprodukci\u00f3 sor\u00e1n. Sz\u00e1mos\n                    tanulm\u00e1ny igazolja a thrombocyt\u00e1k szerep\u00e9t a k\u00fcl\u00f6nb\u00f6z\u0151 \u00e9lettani folyamatokban,\n                    \u00edgy a reprodukci\u00f3ban is. B\u00e1r a szab\u00e1lyoz\u00e1si folyamatok teljes meg\u00e9rt\u00e9s\u00e9t\u0151l m\u00e9g\n                    messze j\u00e1runk, a PARS-sal kapcsolatos kutat\u00e1sok \u00e9s az <jats:italic>in vitro<\/jats:italic>\n                    fertiliz\u00e1ci\u00f3 sor\u00e1n alkalmazott aszpirin- \u00e9s PRP-kezel\u00e9s eredm\u00e9nyei biztat\u00f3ak.\n                    Orv Hetil. 2022; 163(32): 1254\u20131260.<\/jats:p>","DOI":"10.1556\/650.2022.32530","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T01:04:54Z","timestamp":1668819894000},"page":"1254-1260","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["A thrombocyt\u00e1k szerepe a reprodukci\u00f3ban"],"prefix":"10.1556","volume":"163","author":[{"given":"Bernadett","family":"Nagy","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs Magyarorsz\u00e1g"},{"name":"MTA-PTE Hum\u00e1n Reprodukci\u00f3s Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Sulyok","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"V\u00e1rnagy","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs Magyarorsz\u00e1g"},{"name":"MTA-PTE Hum\u00e1n Reprodukci\u00f3s Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Barab\u00e1s","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1lm\u00e1n","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs Magyarorsz\u00e1g"},{"name":"MTA-PTE Hum\u00e1n Reprodukci\u00f3s Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"B\u00f3dis","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Hum\u00e1n Reprodukci\u00f3s Nemzeti Laborat\u00f3rium P\u00e9cs, \u00c9desany\u00e1k \u00fatja 17., 7624 Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika P\u00e9cs Magyarorsz\u00e1g"},{"name":"MTA-PTE Hum\u00e1n Reprodukci\u00f3s Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.fertnstert.2019.10.014","article-title":"Evidence-based treatments for couples with unexplained infertility: a guideline","volume":"113","author":"1 Penzias","year":"2020","unstructured":"1 Penzias A, Bendikson K, Falcone T, et al. 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