{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:43:07Z","timestamp":1770291787014,"version":"3.49.0"},"reference-count":57,"publisher":"Akademiai Kiado Zrt.","issue":"35","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,8,28]]},"abstract":"<jats:p>A k\u00f6zel k\u00e9tsz\u00e1z \u00e9ve ismert, valamennyi hum\u00e1n sejtben megtal\u00e1lhat\u00f3 mitochondriumok\n                    morfol\u00f3giai le\u00edr\u00e1s\u00e1t csak lassan k\u00f6vette m\u0171k\u00f6d\u00e9s\u00fck alaposabb megismer\u00e9se \u00e9p \u00e9s\n                    k\u00f3ros viszonyok k\u00f6z\u00f6tt. Az ut\u00f3bbi \u00e9vtizedekben felgyorsult ennek a kiterjedt\n                    h\u00e1l\u00f3zatnak a megismer\u00e9se mind elm\u00e9leti t\u00e9ren, mind a klinikai gyakorlatban.\n                    C\u00e9lunk a mitochondriumok biogenezis\u00e9nek \u00e9s a diszfunkci\u00f3s m\u0171k\u00f6d\u00e9s\u00fck okozta\n                    megbeteged\u00e9seknek az \u00e1ttekint\u00e9se a jelenlegi legkorszer\u0171bb ismeretek alapj\u00e1n. Az\n                    irodalom tanulm\u00e1nyoz\u00e1sa sor\u00e1n ismertetj\u00fck a mitochondriumok m\u0171k\u00f6d\u00e9s\u00e9nek\n                    fontosabb ter\u00fcleteit, mint a szervezet energiaell\u00e1t\u00e1s\u00e1ban meghat\u00e1roz\u00f3 fontoss\u00e1g\u00fa\n                    ATP termel\u00e9s\u00e9t, kit\u00e9r\u00fcnk a piruv\u00e1t \u00e9s citromsavciklus, az elektronsz\u00e1ll\u00edt\u00f3 l\u00e1nc,\n                    az oxidat\u00edv foszforil\u00e1ci\u00f3 \u00e9s a ROS-k\u00e9pz\u0151d\u00e9s jelent\u0151s\u00e9g\u00e9re. Ismertetj\u00fck a\n                    szervezet v\u00e9dekez\u0151k\u00e9pess\u00e9g\u00e9hez hozz\u00e1j\u00e1rul\u00f3 mitohormesis m\u0171k\u00f6d\u00e9s\u00e9t. A\n                    mitochondrialis diszfunkci\u00f3 ismertet\u00e9se ut\u00e1n r\u00e1t\u00e9r\u00fcnk az egyes mitochondrialis\n                    k\u00f3rk\u00e9pek jellemz\u00e9s\u00e9re. A velesz\u00fcletett, mitochondrialis eredet\u0171 k\u00f3rk\u00e9pek ut\u00e1n\n                    kiemelj\u00fck az egyes parenchym\u00e1s szervek, a sz\u00edv, a m\u00e1j, a ves\u00e9k, a t\u00fcd\u0151k\n                    m\u0171k\u00f6d\u00e9s\u00e9t s\u00falyosan k\u00e1ros\u00edt\u00f3 fibrosist. Hangs\u00falyozzuk a cardialis fibrosis,\n                    k\u00fcl\u00f6n\u00f6sen a mitochondrialis diszfunkci\u00f3val \u00f6sszef\u00fcgg\u0151 sz\u00edvritmuszavarok\n                    jelent\u0151s\u00e9g\u00e9t, r\u00f6viden kit\u00e9rve a leg\u00fajabb ter\u00e1pi\u00e1s aj\u00e1nl\u00e1sokra. Ebben az\n                    \u00f6sszef\u00fcgg\u00e9sben eredm\u00e9ny v\u00e1rhat\u00f3 az SGLT2-, illetve a kombin\u00e1lt SGLT1\/2-g\u00e1tl\u00f3\n                    alkalmaz\u00e1s\u00e1t\u00f3l. \u00c9rintj\u00fck e rendszer szerep\u00e9t az 1-es t\u00edpus\u00fa diabetes\n                    mellitusban, valamint az inzulinrezisztencia \u00e9s a 2-es t\u00edpus\u00fa diabetes\n                    kialakul\u00e1s\u00e1ban. V\u00e1zoljuk a mitochondrium-diszfunkci\u00f3 szerep\u00e9t a neurodegenerat\u00edv\n                    betegs\u00e9gek kialakul\u00e1s\u00e1ban. E k\u00f3rk\u00e9pek kezel\u00e9s\u00e9ben kit\u00e9r\u00fcnk a testmozg\u00e1s\n                    fontoss\u00e1g\u00e1ra, az antioxid\u00e1ns ter\u00e1pi\u00e1ra, a kardiolipin-v\u00e9delemre, a\n                    mitochondrialis biogenezis fokoz\u00e1s\u00e1ra, a n\u00e1trium-gl\u00fck\u00f3z-kotranszporter-g\u00e1tl\u00f3k\n                    alkalmaz\u00e1s\u00e1ra \u00e9s \u2013 al\u00e1h\u00fazva \u2013 a nemr\u00e9gen bevezetett, rem\u00e9nyt kelt\u0151\n                    mitochondrialis transzplant\u00e1ci\u00f3ra. A mitochondrialis rendszer nemcsak\n                    energiak\u00f6zpont, de valamennyi \u00e9letfontos szerv\u00fcnk m\u0171k\u00f6d\u00e9s\u00e9t is szab\u00e1lyozza.\n                    Mitochondrialis diszfunkci\u00f3 eset\u00e9n \u00e9letfontos szerveink m\u0171k\u00f6d\u00e9se kritikuss\u00e1\n                    v\u00e1lik a kialakul\u00f3 fibrosis k\u00f6vetkezt\u00e9ben. Ugyanakkor nem foglalkozunk a\n                    mitochondriumok \u00e9s a mitochondrialis diszfunkci\u00f3 onkol\u00f3giai vonatkoz\u00e1saival,\n                    mert ez m\u00e1r meghaladn\u00e1 e cikk kereteit. C\u00e9lunk e munk\u00e1val els\u0151sorban e sziszt\u00e9ma\n                    sokr\u00e9t\u0171 \u00f6sszef\u00fcgg\u00e9seinek felt\u00e1r\u00e1sa, ismereteink elm\u00e9ly\u00edt\u00e9se \u00e9s hasznos\u00edt\u00e1sa\n                    betegeink jobb ell\u00e1t\u00e1sa \u00e9rdek\u00e9ben. Egyesek \u00fagy v\u00e9lik, hogy a medicina j\u00f6v\u0151j\u00e9t a\n                    mitochondriumok fogj\u00e1k meghat\u00e1rozni. Orv Hetil. 2022; 163(35): 1383\u20131393.<\/jats:p>","DOI":"10.1556\/650.2022.32552","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T01:41:14Z","timestamp":1668822074000},"page":"1383-1393","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":3,"title":["Mitochondrialis diszfunkci\u00f3 okozta betegs\u00e9gek"],"prefix":"10.1556","volume":"163","author":[{"given":"Tam\u00e1s","family":"Halmos","sequence":"first","affiliation":[{"name":"MAZSIHISZ Szeretetk\u00f3rh\u00e1z, Metabolikus Ambulancia Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Suba","sequence":"additional","affiliation":[{"name":"Bajcsy-Zsilinszky K\u00f3rh\u00e1z \u00e9s Rendel\u0151int\u00e9zet, X. 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