{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T10:43:28Z","timestamp":1698403408048},"reference-count":31,"publisher":"Akademiai Kiado Zrt.","issue":"36","license":[{"start":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:00:00Z","timestamp":1662249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,9,4]]},"abstract":"<jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> A fotodin\u00e1mi\u00e1s ter\u00e1pia a superficialis basalsejtes\n                    carcinoma, a Bowen-k\u00f3r \u00e9s az aktinikus keratosis kezel\u00e9s\u00e9re alkalmas elj\u00e1r\u00e1s. A\n                    m\u00f3dszer l\u00e9nyege, hogy a kezelend\u0151 b\u0151rfel\u00fcletre felvitt f\u00e9ny\u00e9rz\u00e9keny\u00edt\u0151 anyag\n                    metabolitj\u00e1b\u00f3l f\u00e9ny hat\u00e1s\u00e1ra reakt\u00edvoxig\u00e9n-gy\u00f6k\u00f6k szabadulnak fel, melyek\n                    szelekt\u00edven a tumorsejtek pusztul\u00e1s\u00e1hoz vezetnek. Az elj\u00e1r\u00e1s mesters\u00e9ges\n                    f\u00e9nyforr\u00e1ssal vagy a napf\u00e9ny alkalmaz\u00e1s\u00e1val v\u00e9gezhet\u0151. Ez ut\u00f3bbi a \u201edaylight\u201d\n                    fotodin\u00e1mi\u00e1s ter\u00e1pia, melynek hat\u00e9konys\u00e1ga mellett el\u0151nye, hogy nem j\u00e1r\n                    f\u00e1jdalommal. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> Munk\u00e1nk c\u00e9lkit\u0171z\u00e9se a napf\u00e9nnyel\n                    v\u00e9gzett fotodin\u00e1mi\u00e1s ter\u00e1pia bevezet\u00e9se volt klinik\u00e1nkon aktinikus keratosis\n                    indik\u00e1ci\u00f3j\u00e1ban \u00e9s a kezel\u00e9si protokoll optimaliz\u00e1l\u00e1sa a helyi \u00e9ghajlati\n                    viszonyokhoz. <jats:italic>M\u00f3dszer:<\/jats:italic> Klinikai vizsg\u00e1latunk h\u00e1rom r\u00e9szb\u0151l\n                    \u00e1llt. A kezel\u00e9si protokollok k\u00f6z\u00f6tt k\u00fcl\u00f6nbs\u00e9g a f\u00e9ny\u00e9rz\u00e9keny\u00edt\u0151 anyag inkub\u00e1ci\u00f3s\n                    idej\u00e9ben \u00e9s a napf\u00e9nyen t\u00f6rt\u00e9n\u0151 kezel\u00e9s id\u0151tartam\u00e1ban volt.\n                        <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A nemzetk\u00f6zi protokoll alapj\u00e1n v\u00e9gzett\n                    vizsg\u00e1latban az aktinikus keratosisok 73%-\u00e1ban komplett, 27%-\u00e1ban r\u00e9szleges\n                    remisszi\u00f3t \u00e9rt\u00fcnk el. A szabadban elt\u00f6lt\u00f6tt id\u0151 ar\u00e1ny\u00e1t cs\u00f6kkentve a lasi\u00f3k\n                    k\u00e9tharmad\u00e1n\u00e1l teljes, egyharmad\u00e1n\u00e1l r\u00e9szleges remisszi\u00f3t \u00e9rt\u00fcnk el. 100 J\/cm\u00b2\n                    feletti kezel\u00e9si d\u00f3zis eset\u00e9n s\u00falyos erythema megjelen\u00e9s\u00e9t \u00e9szlelt\u00fck a kezel\u00e9st\n                    k\u00f6vet\u0151 24 \u00f3r\u00e1ban. Ennek elker\u00fcl\u00e9s\u00e9re dozimetria seg\u00edts\u00e9g\u00e9vel hat\u00e1roztuk meg a\n                    szabadban elt\u00f6lt\u00f6tt kezel\u00e9si id\u0151t. A betegek a kezel\u00e9st j\u00f3l toler\u00e1lt\u00e1k, a lasi\u00f3k\n                    15%-\u00e1ban r\u00e9szleges, 85%-\u00e1ban teljes remisszi\u00f3t \u00e9rt\u00fcnk el.\n                        <jats:italic>Megbesz\u00e9l\u00e9s:<\/jats:italic> A m\u00f3dos\u00edtott nemzetk\u00f6zi protokoll alapj\u00e1n\n                    v\u00e9gzett \u201edaylight\u201d fotodin\u00e1mi\u00e1s ter\u00e1pia hat\u00e9kony \u00e9s j\u00f3l toler\u00e1lhat\u00f3 kezel\u00e9si\n                    elj\u00e1r\u00e1s az aktinikus keratosis indik\u00e1ci\u00f3j\u00e1ban. <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> A\n                    napf\u00e9nnyel v\u00e9gzett fotodin\u00e1mi\u00e1s kezel\u00e9st sikerrel adapt\u00e1ltuk \u00e9s alkalmazzuk\n                    klinik\u00e1nkon a mindennapi gyakorlatban aktinikus keratosisok kezel\u00e9s\u00e9ben. Orv\n                    Hetil. 2022; 163(36): 1422\u20131429.<\/jats:p>","DOI":"10.1556\/650.2022.32554","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T02:04:22Z","timestamp":1668823462000},"page":"1422-1429","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["\u00daj elj\u00e1r\u00e1s a nem melanoma t\u00edpus\u00fa b\u0151rdaganatok kezel\u00e9s\u00e9ben: \u201edaylight\u201d fotodin\u00e1mi\u00e1s ter\u00e1pia"],"prefix":"10.1556","volume":"163","author":[{"given":"D\u00f3ra","family":"\u00c1goston","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged, Kor\u00e1nyi fasor 6., 6720 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriette","family":"\u00d3csai","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged, Kor\u00e1nyi fasor 6., 6720 Magyarorsz\u00e1g"},{"name":"B\u00e9k\u00e9s Megyei K\u00f6zponti K\u00f3rh\u00e1z, P\u00e1ndy K\u00e1lm\u00e1n Tagk\u00f3rh\u00e1z Gyula Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Ign\u00e1cz","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Term\u00e9szettudom\u00e1nyi \u00e9s Informatikai Kar, Optikai \u00e9s Kvantumelektronikai Tansz\u00e9k Szeged Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Viharosn\u00e9 D\u00f3sa-R\u00e1cz","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged, Kor\u00e1nyi fasor 6., 6720 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"R\u00e1rosi","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Orvosi Fizikai \u00e9s Orvosi Informatikai Int\u00e9zet Szeged Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged, Kor\u00e1nyi fasor 6., 6720 Magyarorsz\u00e1g"},{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Onkoter\u00e1pi\u00e1s Klinika Szeged Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged, Kor\u00e1nyi fasor 6., 6720 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Balt\u00e1s","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged, Kor\u00e1nyi fasor 6., 6720 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.1365-2133.1994.tb08544.x","article-title":"Epidemiology of solar keratoses","volume":"131","author":"Frost CA","year":"1994","unstructured":"1 Frost CA, Green AC. 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