{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:15:48Z","timestamp":1787022948593,"version":"build-2736575974"},"reference-count":50,"publisher":"Akademiai Kiado Zrt.","issue":"39","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,9,25]]},"abstract":"<jats:p>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic>\n                    A propolisz m\u00e9hek \u00e1ltal gy\u0171jt\u00f6tt gyant\u00e1s anyag,\n                    melynek k\u00fcl\u00f6nf\u00e9le term\u00e9kekben t\u00f6rt\u00e9n\u0151 k\u00fcls\u0151 \u00e9s bels\u0151 alkalmaz\u00e1sa j\u00f3t\u00e9kony\n                    hat\u00e1sai miatt sz\u00e9les k\u00f6rben elterjedt. Ismert allerg\u00e9n, a n\u00f6vekv\u0151 expoz\u00edci\u00f3s\n                    lehet\u0151s\u00e9gek szenzibiliz\u00e1l\u00f3 hat\u00e1s\u00e1t is el\u0151t\u00e9rbe hozt\u00e1k.\n                    <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n                    A szerz\u0151k 30 \u00e9ves peri\u00f3dusban epicutan\n                    tesztelt, propolisz\u00e9rz\u00e9keny betegek adatait dolgozt\u00e1k fel az irodalmi adatok\n                    t\u00fckr\u00e9ben.\n                    <jats:italic>M\u00f3dszer:<\/jats:italic>\n                    A Semmelweis Egyetem B\u0151r-, Nemik\u00f3rtani \u00e9s\n                    B\u0151ronkol\u00f3giai Klinik\u00e1j\u00e1nak Allergol\u00f3giai Laborat\u00f3rium\u00e1ban 1992 \u00e9s 2021 k\u00f6z\u00f6tt\n                    epicutan tesztelt 17\u00a0784 beteg k\u00f6z\u00fcl annak a 464 betegnek az eredm\u00e9nyeit\n                    elemezt\u00fck retrospekt\u00edven, akikn\u00e9l propolisz-t\u00fal\u00e9rz\u00e9kenys\u00e9g igazol\u00f3dott.\n                    Vizsg\u00e1ltuk a szenzibiliz\u00e1ci\u00f3s gyakoris\u00e1gok v\u00e1ltoz\u00e1s\u00e1t, a jellemz\u0151 diagn\u00f3zisokat,\n                    a betegek \u00e9letkori megoszl\u00e1s\u00e1t, a klinikai t\u00fcnetek leggyakoribb lokaliz\u00e1ci\u00f3it \u00e9s\n                    a t\u00e1rsult allerg\u00e9n\u00e9rz\u00e9kenys\u00e9geket.\n                    <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    A 30 \u00e9ves\n                    peri\u00f3dusban a propolisz szenzibiliz\u00e1ci\u00f3s gyakoris\u00e1ga \u00e1tlagosan 2,6% volt,\n                    2019\u20132021-ben a vizsg\u00e1lt peri\u00f3dusban kor\u00e1bban nem \u00e9szlelt jelent\u0151s emelked\u00e9s\n                    mutatkozott (6,2%, 8,4%, 6,9%). Jellemz\u0151 volt a n\u0151i dominancia (70,7%). A\n                    propolisz-t\u00fal\u00e9rz\u00e9kenys\u00e9g az 51\u201360 \u00e9vesek k\u00f6r\u00e9ben fordult el\u0151 a leggyakrabban\n                    (24,6%), a betegek \u00e1tlag\u00e9letkora 52,5 \u00e9v volt. A legt\u00f6bb t\u00fcnet kezeken (34,2%),\n                    l\u00e1bakon (18,4%), arcon (17,5%) jelent meg. A t\u00e1rsult \u00e9rz\u00e9kenys\u00e9gek k\u00f6z\u00fcl az\n                    illatanyagok, a fragrance mix I (27,7%), a perubalzsam (26,8%) \u00e9s a fak\u00e1tr\u00e1ny\n                    (23,0%) emelhet\u0151 ki.\n                    <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n                    Az alternat\u00edv gy\u00f3gy\u00e1szati\n                    antibakteri\u00e1lis \u00e9s antivir\u00e1lis k\u00e9sz\u00edtm\u00e9nyek, valamint a bioterm\u00e9kek ir\u00e1nti nagy\n                    kereslet n\u00f6veli a propoliszexpoz\u00edci\u00f3s lehet\u0151s\u00e9gek sz\u00e1m\u00e1t. A szenzibiliz\u00e1ci\u00f3\n                    es\u00e9ly\u00e9t fokozza, hogy a propolisztartalm\u00fa term\u00e9keket sokszor ellen\u0151rizetlen\n                    mennyis\u00e9gben \u00e9s form\u00e1ban, a b\u0151r\u00f6n gyulladt, fokozott allerg\u00e9npenetr\u00e1ci\u00f3t\n                    biztos\u00edt\u00f3 ter\u00fcleteken alkalmazz\u00e1k. Eredm\u00e9nyeink alapj\u00e1n a propolisz \u2013 j\u00f3t\u00e9kony\n                    hat\u00e1sai mellett \u2013 jelent\u0151s k\u00f6rnyezeti allerg\u00e9n, els\u0151sorban az id\u0151sebb n\u0151k\n                    k\u00f6r\u00e9ben. Expoz\u00edci\u00f3inak ismerete hasznos, szenzibiliz\u00e1ci\u00f3ja \u00e9s t\u00e1rsult\n                    allerg\u00e9njei epicutan tesztsor seg\u00edts\u00e9g\u00e9vel kimutathat\u00f3k. Orv Hetil. 2022;\n                    163(39): 1559\u20131567.\n                  <\/jats:p>","DOI":"10.1556\/650.2022.32594","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T22:04:24Z","timestamp":1668809064000},"page":"1559-1567","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":4,"title":["Egy r\u00e9gi-\u00faj allerg\u00e9n \u2013 a propolisz szenzibiliz\u00e1l\u00f3 hat\u00e1s\u00e1nak vizsg\u00e1lata 1992 \u00e9s 2021 k\u00f6z\u00f6tt"],"prefix":"10.1556","volume":"163","author":[{"given":"D\u00f3ra","family":"Mezei","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, R\u00e1cz K\u00e1roly Klinikai Orvostudom\u00e1nyok Doktori Iskola Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzs\u00e9bet","family":"Temesv\u00e1ri","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgyi","family":"P\u00f3nyai","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/DER.0000000000000011","article-title":"Propolis: a review of properties, applications, chemical composition, contact allergy, and other adverse effects","volume":"24","author":"Groot AC","year":"2013","unstructured":"1 de Groot AC. 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