{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T10:44:02Z","timestamp":1698403442071},"reference-count":9,"publisher":"Akademiai Kiado Zrt.","issue":"44","license":[{"start":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T00:00:00Z","timestamp":1667088000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,10,30]]},"abstract":"<jats:p>A hypereosinophil szindr\u00f3ma tart\u00f3s eosinophil-t\u00faltermel\u00e9ssel j\u00e1r\u00f3, a\n                    k\u00f6vetkezm\u00e9nyes eosinophilinfiltr\u00e1ci\u00f3 \u00e9s medi\u00e1torfelszabadul\u00e1s miatt t\u00f6bbszervi\n                    k\u00e1rosod\u00e1st okoz\u00f3 k\u00f3rk\u00e9p. Etiol\u00f3gia szerint megk\u00fcl\u00f6nb\u00f6ztet\u00fcnk myeloproliferativ\n                    eredet\u0171, parazitafert\u0151z\u00e9shez, solid tumorhoz \u00e9s T-sejtes lymphom\u00e1hoz t\u00e1rsul\u00f3,\n                    valamint idiopathi\u00e1s form\u00e1t. Esetismertet\u00e9s\u00fcnkben a 49 \u00e9ves f\u00e9rfit fogy\u00e1s,\n                    alsz\u00e1ri oedema, tachycardia miatt vett\u00fck fel oszt\u00e1lyunkra. Laborj\u00e1b\u00f3l jelent\u0151sen\n                    emelkedett epe\u00fati obstrukci\u00f3s param\u00e9terek, valamint extr\u00e9m leukocytosis,\n                    eosinophilia volt kiemelhet\u0151. Hematol\u00f3giai malignus betegs\u00e9g er\u0151s gyan\u00faj\u00e1val\n                    kezdt\u00fck vizsg\u00e1lni. Az elv\u00e9gzett mellkasi, hasi \u00e9s kismedencei CT\n                    hepatosplenomegali\u00e1t, multiplex intrahepaticus laesi\u00f3kat \u00e9s egy bizonytalan\n                    solitaer cystosus k\u00e9pletet \u00edrt le a pancreas farki r\u00e9sz\u00e9ben, k\u00f3ros\n                    nyirokcsom\u00f3kkal \u00e9s pleuralis folyad\u00e9kgy\u00fclemmel. A le\u00edrt CT-k\u00e9p a klinikum\n                    ismeret\u00e9ben els\u0151sorban kr\u00f3nikus myeloid leukaemia manifeszt\u00e1ci\u00f3j\u00e1nak volt\n                    megfeleltethet\u0151, de a diagn\u00f3zist a perif\u00e9ri\u00e1s kenet, az \u00e1raml\u00e1si citometria, a\n                    csontvel\u0151-biopszia \u00e9s a genetikai vizsg\u00e1lat sem igazolta. Mindezek f\u00e9ny\u00e9ben\n                    solid tumorhoz t\u00e1rsul\u00f3 leukaemoid reakci\u00f3 ir\u00e1ny\u00e1ba folytattuk a kivizsg\u00e1l\u00e1st, a\n                    m\u00e1jlaesi\u00f3k pontos verifik\u00e1l\u00e1sa \u00e9rdek\u00e9ben vastagt\u0171-biopszia t\u00f6rt\u00e9nt. A sz\u00f6vettani\n                    eredm\u00e9ny pancreatobiliaris carcinoma \u00e1tt\u00e9t\u00e9nek megfeleltethet\u0151, alacsonyan\n                    differenci\u00e1lt h\u00e1mtumor infiltr\u00e1ci\u00f3j\u00e1t mutatta. A diagn\u00f3zis fel\u00e1ll\u00edt\u00e1s\u00e1nak\n                    m\u00e1snapj\u00e1n kezel\u00e9s\u00fcnk ellen\u00e9re a beteg exit\u00e1lt. A gastrointestinalis solid\n                    tumorokhoz kapcsol\u00f3d\u00f3 hypereosinophil szindr\u00f3ma rendk\u00edv\u00fcl ritka k\u00f3rk\u00e9p.\n                    Tudom\u00e1sunk szerint ez a magyar orvosi irodalomban k\u00f6z\u00f6lt els\u0151 ilyen eset, mely\n                    felh\u00edvja a figyelmet a magas feh\u00e9rv\u00e9rsejtsz\u00e1m \u00e9s eosinophilar\u00e1ny\n                    differenci\u00e1ldiagnosztikai k\u00e9rd\u00e9seire, valamint arra, hogy nem korrel\u00e1l\u00f3\n                    hematol\u00f3giai leletek eset\u00e9n nem k\u00e9slekedhet\u00fcnk a solid elt\u00e9r\u00e9sek sz\u00f6vettani\n                    mintav\u00e9tel\u00e9vel. Orv Hetil. 2022; 163(44): 1758\u20131762.<\/jats:p>","DOI":"10.1556\/650.2022.32606","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T04:55:31Z","timestamp":1668833731000},"page":"1758-1762","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Malignus solid tumorhoz t\u00e1rsul\u00f3 hypereosinophil szindr\u00f3ma"],"prefix":"10.1556","volume":"163","author":[{"given":"Livia","family":"Lontai","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika Budapest, Kor\u00e1nyi S. u. 2\/a, 1083 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorottya","family":"Angyal","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anik\u00f3","family":"Folhoffer","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika Budapest, Kor\u00e1nyi S. u. 2\/a, 1083 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildik\u00f3","family":"Istenes","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika Budapest, Kor\u00e1nyi S. u. 2\/a, 1083 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildik\u00f3","family":"Szirtes","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai, Igazs\u00e1g\u00fcgyi \u00e9s Biztos\u00edt\u00e1si Orvostani Int\u00e9zet Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1kos","family":"Ili\u00e1s","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika Budapest, Kor\u00e1nyi S. u. 2\/a, 1083 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1097\/COC.0b013e3182a530dd","article-title":"Paraneoplastic leukemoid reaction in solid tumors","volume":"38","author":"1 Chakraborty","year":"2015","unstructured":"1 Chakraborty S, Keenportz B, Woodward S, et al. 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