{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T11:45:02Z","timestamp":1698493502179},"reference-count":45,"publisher":"Akademiai Kiado Zrt.","issue":"46","license":[{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,11,13]]},"abstract":"<jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> A parci\u00e1lis aponeurectomia a Dupuytren-kontrakt\u00fara\n                    kezel\u00e9s\u00e9re leggyakrabban v\u00e9gzett m\u0171t\u00e9ti elj\u00e1r\u00e1s. A betegs\u00e9gben kialakul\u00f3\n                    patol\u00f3gi\u00e1s sz\u00f6vet megv\u00e1ltoztathatja a digit\u00e1lis ideg anat\u00f3miai elhelyezked\u00e9s\u00e9t,\n                    ami megnehez\u00edti az ideg m\u0171t\u00e9t k\u00f6zbeni lokaliz\u00e1ci\u00f3j\u00e1t \u00e9s dissecti\u00f3j\u00e1t, \u00e9s n\u00f6veli\n                    a iatrog\u00e9n idegs\u00e9r\u00fcl\u00e9s kock\u00e1zat\u00e1t. Intraoperat\u00edv idegfest\u00e9si elj\u00e1r\u00e1ssal az ideg\n                    lokaliz\u00e1ci\u00f3ja megk\u00f6nny\u00edthet\u0151 lenne, ez\u00e1ltal a iatrog\u00e9n idegs\u00e9r\u00fcl\u00e9s kock\u00e1zata is\n                    cs\u00f6kkenne. \u00c1llatk\u00eds\u00e9rleteinkben kor\u00e1bban igazoltuk, hogy metil\u00e9nk\u00e9koldattal a\n                    perif\u00e9ri\u00e1s ideg <jats:italic>in vivo<\/jats:italic> megfesthet\u0151 az ideg strukt\u00far\u00e1j\u00e1nak \u00e9s\n                    funkci\u00f3j\u00e1nak k\u00e1ros\u00edt\u00e1sa n\u00e9lk\u00fcl. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> A patk\u00e1ny nervus\n                    ischiadicus modellen m\u00e1r sikeresen alkalmazott metil\u00e9nk\u00e9koldattal v\u00e9gzett\n                    idegfest\u00e9si elj\u00e1r\u00e1s hat\u00e9konys\u00e1g\u00e1nak vizsg\u00e1lata hum\u00e1n kad\u00e1ver digit\u00e1lis idegen.\n                        <jats:italic>M\u00f3dszer:<\/jats:italic> Vizsg\u00e1latunk els\u0151 f\u00e1zis\u00e1ban formalinnal fix\u00e1lt\n                    k\u00e9zen n\u00e9gy digit\u00e1lis ideg epineuralis fest\u00e9s\u00e9t v\u00e9gezt\u00fck el 40 \u00b5l 1 : 80-as\n                    h\u00edg\u00edt\u00e1s\u00fa metil\u00e9nk\u00e9koldattal. A m\u00e1sodik vizsg\u00e1latban fix\u00e1ci\u00f3n \u00e1t nem esett\n                    kad\u00e1verk\u00e9zen hat digit\u00e1lis ideg fest\u00e9s\u00e9t v\u00e9gezt\u00fck. A megfesthet\u0151 idegszakasz\n                    hossz\u00e1nak n\u00f6vel\u00e9s\u00e9re k\u00e9t ideg fest\u00e9s\u00e9hez 200 \u00b5l metil\u00e9nk\u00e9koldatot haszn\u00e1ltunk.\n                        <jats:italic>Eredm\u00e9nyek:<\/jats:italic> Az epineuralis idegjel\u00f6l\u00e9s formalinfix\u00e1lt\n                    idegeken nem m\u0171k\u00f6d\u00f6tt ide\u00e1lisan. Friss, formalinos fix\u00e1l\u00e1son \u00e1t nem esett hum\u00e1n\n                    kad\u00e1ver digit\u00e1lis idegen az idegfest\u00e9si elj\u00e1r\u00e1st sikeresen alkalmaztuk, a\n                    megfestett idegszakasz tekintet\u00e9ben \u00e1llatk\u00eds\u00e9rletes eredm\u00e9nyeinket reproduk\u00e1lni\n                    tudtuk. 40 \u00b5l 1 : 80-as h\u00edg\u00edt\u00e1s\u00fa metil\u00e9nk\u00e9koldattal \u00e1tlagosan 13 mm-es, m\u00edg 200\n                    \u00b5l oldat haszn\u00e1lat\u00e1val 18 mm-es idegszakaszt siker\u00fclt megfesteni.\n                        <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> Formalinnal fix\u00e1lt digit\u00e1lis ideg fest\u00e9se a\n                    fix\u00e1ci\u00f3 k\u00f6vetkezt\u00e9ben fell\u00e9p\u0151 sz\u00f6veti zsugorod\u00e1s miatt korl\u00e1tozottan lehets\u00e9ges.\n                    Formalinos fix\u00e1l\u00e1son \u00e1t nem esett digit\u00e1lis idegek eset\u00e9n a megtartott anat\u00f3miai\n                    viszonyok mellett 18 mm-es idegszakasz megfesthet\u0151. Tov\u00e1bbi vizsg\u00e1latokat\n                    tervez\u00fcnk Dupuytren-sz\u00f6vettel \u00e9s hegsz\u00f6vettel k\u00f6r\u00fclvett digit\u00e1lis idegen, a\n                    technika k\u00e9zseb\u00e9szeti m\u0171t\u00e9tek sor\u00e1n t\u00f6rt\u00e9n\u0151 alkalmazhat\u00f3s\u00e1g\u00e1nak meg\u00edt\u00e9l\u00e9s\u00e9re.\n                    Orv Hetil. 2022; 163(46): 1834\u20131839<\/jats:p>","DOI":"10.1556\/650.2022.32617","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T05:27:35Z","timestamp":1668835655000},"page":"1834-1839","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Perif\u00e9ri\u00e1s ideg epineuralis metil\u00e9nk\u00e9kfest\u00e9se kad\u00e1verk\u00e9zen"],"prefix":"10.1556","volume":"163","author":[{"given":"Tam\u00e1s","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Klinikai K\u00f6zpont, Traumatol\u00f3giai \u00e9s K\u00e9zseb\u00e9szeti Klinika P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 13., 7624 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikt\u00f3ria","family":"Kormos","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Farmakol\u00f3giai \u00e9s Farmakoter\u00e1piai Int\u00e9zet P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Gaszner","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Anat\u00f3miai Int\u00e9zet, P\u00e9cs Hangulatzavarok Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Anat\u00f3miai Int\u00e9zet P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"R\u00e9k\u00e1si","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Anat\u00f3miai Int\u00e9zet, P\u00e9cs Hangulatzavarok Kutat\u00f3csoport P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jbspin.2011.05.027","article-title":"Genetics of Dupuytren's disease","volume":"79","author":"1 Michou","year":"2012","unstructured":"1 Michou L, Lermusiaux JL, Teyssedou JP, et al. 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