{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T11:44:50Z","timestamp":1698493490092},"reference-count":47,"publisher":"Akademiai Kiado Zrt.","issue":"46","license":[{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,11,13]]},"abstract":"<jats:p>A sikeres fogantat\u00e1s \u00e9s terhess\u00e9g elengedhetetlen \u00f6sszetev\u0151je a decidualiz\u00e1ci\u00f3,\n                    amely az endometrium szerkezeti \u00e9s funkcion\u00e1lis \u00e1talakul\u00e1s\u00e1t jelenti. A folyamat\n                    mag\u00e1ban foglalja a m\u00e9hny\u00e1lkah\u00e1rtya szerkezeti v\u00e1ltoz\u00e1sait, a spir\u00e1lis arteriol\u00e1k\n                    \u00e1talakul\u00e1s\u00e1t, az endometriumban fellelhet\u0151, illetve k\u00e9s\u0151bb oda v\u00e1ndorl\u00f3\n                    leukocyt\u00e1k sz\u00e1mbeli \u00e9s funkcion\u00e1lis adapt\u00e1ci\u00f3j\u00e1t \u00e9s a decidualis stromasejtek\n                    funkcion\u00e1lis \u00e9s morfol\u00f3giai v\u00e1ltoz\u00e1sait. A decidualiz\u00e1ci\u00f3 r\u00e9szek\u00e9nt az\n                    embrion\u00e1lis eredet\u0171 trophoblastsejtek szab\u00e1lyozott inv\u00e1zi\u00f3t hajtanak v\u00e9gre az\n                    anyai eredet\u0171 sz\u00f6vetben, l\u00e9trehozva a m\u00e9hlep\u00e9nyt. A folyamat siker\u00e9hez\n                    hozz\u00e1j\u00e1rul a trophoblastsejtek k\u00fcl\u00f6nleges antigenit\u00e1sa, illetve az immunol\u00f3giai\n                    \u00e9rtelemben vett graft (magzat) \u00e9s host (anya) k\u00f6z\u00f6tt hormonok, citokinek \u00e9s t\u00f6bb\n                    receptor-ligand kapcsolat r\u00e9v\u00e9n l\u00e9trej\u00f6v\u0151 kommunik\u00e1ci\u00f3. E folyamatok zavarai\n                    t\u00f6bb, a fogamz\u00e1st, be\u00e1gyaz\u00f3d\u00e1st \u00e9s sikeres terhess\u00e9get fenyeget\u0151 k\u00f3rk\u00e9p alapj\u00e1t\n                    k\u00e9pezik, \u00fagymint ism\u00e9tl\u0151d\u0151 vet\u00e9l\u00e9s, praeeclampsia, m\u00e9hen bel\u00fcli sorvad\u00e1s vagy\n                    korasz\u00fcl\u00e9s. Ebben a dolgozatunkban \u00e1ttekintj\u00fck az \u00e9lettani decidualiz\u00e1ci\u00f3\n                    anat\u00f3miai, immunol\u00f3giai \u00e9s molekul\u00e1ris alapjait, hogy azt\u00e1n kit\u00e9rj\u00fcnk a\n                    sz\u00fcl\u00e9szeti klinikumban el\u0151fordul\u00f3 gyakori k\u00f3rk\u00e9pekre, melyek h\u00e1tter\u00e9ben r\u00e9szben\n                    vagy eg\u00e9szen a decidualiz\u00e1ci\u00f3 valamely zavara \u00e1llhat. Orv Hetil. 2022; 163(46):\n                    1823\u20131833.<\/jats:p>","DOI":"10.1556\/650.2022.32626","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T05:27:35Z","timestamp":1668835655000},"page":"1823-1833","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["A decidualiz\u00e1ci\u00f3 klinikai vonatkoz\u00e1sai"],"prefix":"10.1556","volume":"163","author":[{"given":"Vilmos","family":"F\u00fcl\u00f6p","sequence":"first","affiliation":[{"name":"Magyar Honv\u00e9ds\u00e9g Eg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Molekul\u00e1ris Orvostudom\u00e1nyok Doktori Iskola Budapest, Di\u00f3s \u00e1rok 1\u20133., 1125 Magyarorsz\u00e1g"},{"name":"Miskolci Egyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar Miskolc Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korn\u00e9l","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Molekul\u00e1ris Orvostudom\u00e1nyok Doktori Iskola Budapest, Di\u00f3s \u00e1rok 1\u20133., 1125 Magyarorsz\u00e1g"},{"name":"Miskolci Egyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar Miskolc Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Demeter","sequence":"additional","affiliation":[{"name":"Magyar Honv\u00e9ds\u00e9g Eg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"V\u00e9gh","sequence":"additional","affiliation":[{"name":"\u00c9szak-K\u00f6z\u00e9p-budai Centrum, \u00daj Szent J\u00e1nos K\u00f3rh\u00e1z \u00e9s Szakrendel\u0151, Sz\u00fcl\u00e9szeti N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"P\u00e1llinger","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Genetikai, Sejt- \u00e9s Immunbiol\u00f3giai Int\u00e9zet Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/978-3-319-15856-3_4","article-title":"Transmembrane mucin expression and function in embryo implantation and placentation","volume":"216","author":"1 Constantinou","year":"2015","unstructured":"1 Constantinou PE, Morgado M, Carson DD. 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