{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T11:45:01Z","timestamp":1698493501729},"reference-count":16,"publisher":"Akademiai Kiado Zrt.","issue":"52","license":[{"start":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T00:00:00Z","timestamp":1671926400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2022,12,25]]},"abstract":"<jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> A COVID\u201319-fert\u0151z\u00e9s vagy a v\u00e9d\u0151olt\u00e1s hat\u00e1s\u00e1t\n                    vizsg\u00e1ltuk a csecsem\u0151mirigyben zajl\u00f3 T-sejtek differenci\u00e1l\u00f3d\u00e1s\u00e1ra, illetve hogy\n                    a T-sejtek sz\u00e1m\u00e1nak a fert\u0151z\u00f6ttek v\u00e9r\u00e9ben \u00e9szlelhet\u0151 cs\u00f6kken\u00e9se a thymusban is\n                    \u00e9szlelhet\u0151-e. <jats:italic>M\u00f3dszer:<\/jats:italic> \u00d6sszesen 55, thymectomi\u00e1n \u00e1tesett beteg\n                    adatainak feldolgoz\u00e1sa sor\u00e1n h\u00e1rom csoportot alak\u00edtottunk ki: 1) a pre-COVID\u201319\n                    (PC)-csoportban szerepel 22 beteg, 12 n\u0151 \u00e9s 10 f\u00e9rfi, akikn\u00e9l 2008 \u00e9s 2013\n                    k\u00f6z\u00f6tt t\u00f6rt\u00e9nt thymectomia; a 2) no-COVID\u201319 (NC)-csoportban (v\u00e9d\u0151olt\u00e1st nem\n                    kapott, fert\u0151z\u00e9sen \u00e1t nem esett) 20 betegn\u00e9l (11 n\u0151 \u00e9s 9 f\u00e9rfi) 2020\u20132021-ben, a\n                    3) COVID\u201319-v\u00e9d\u0151olt\u00e1st kapott vagy -infekci\u00f3n \u00e1tesett (VIC-) csoportban 13\n                    betegn\u00e9l (4 n\u0151 \u00e9s 9 f\u00e9rfi) szint\u00e9n 2020\u20132021-ben t\u00f6rt\u00e9nt thymectomia. A\n                    patol\u00f3giai mint\u00e1kon CD4, CD8, CD25 \u00e9s FOXP3 immunhisztok\u00e9miai vizsg\u00e1latok\n                    t\u00f6rt\u00e9ntek a \u2019helper\u2019, a citotoxikus \u00e9s a regul\u00e1ci\u00f3s T-sejtek igazol\u00e1s\u00e1ra.\n                        <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A VIC-csoportban a CD4-sejtek el\u0151fordul\u00e1sa\n                    szignifik\u00e1nsan alacsonyabb volt a PC- \u00e9s az NC-csoporthoz k\u00e9pest. A FOXP3 a VIC-\n                    \u00e9s az NC-csoportban szignifik\u00e1nsan kisebb el\u0151fordul\u00e1st mutatott a PC-csoporthoz\n                    k\u00e9pest. A CD8, CD25 eset\u00e9ben szignifik\u00e1ns k\u00fcl\u00f6nbs\u00e9get a vizsg\u00e1lt csoportok\n                    k\u00f6z\u00f6tt nem tal\u00e1ltunk. <jats:italic>Megbesz\u00e9l\u00e9s:<\/jats:italic> A COVID\u201319-fert\u0151z\u00e9s vagy a\n                    v\u00e9d\u0151olt\u00e1s hat\u00e1ssal van a thymus T-sejtes \u00f6sszet\u00e9tel\u00e9re. A VIC-csoportban \u00e9szlelt\n                    CD4-expresszi\u00f3-cs\u00f6kken\u00e9s igazolja a T-sejtek sz\u00e1m\u00e1nak a thymusban is bek\u00f6vetkez\u0151\n                    cs\u00f6kken\u00e9s\u00e9t. A COVID\u201319-\u00e9ra alatt az NC-csoportban a PC-csoporthoz k\u00e9pest\n                    \u00e9szlelt alacsony FOXP3-szint a t\u00fcnetmentes COVID\u201319-fert\u0151z\u00e9s nagy ar\u00e1ny\u00e1ra\n                    utalhat, \u00e9s az immuntolerancia roml\u00e1s\u00e1t jelzi. <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n                    Az \u00e1ltalunk hozz\u00e1f\u00e9rhet\u0151 irodalomban el\u0151sz\u00f6r igazoltuk, hogy a COVID\u201319-fert\u0151z\u00e9s\n                    hat\u00e1s\u00e1ra a csecsem\u0151mirigyben cs\u00f6kken a \u2019helper\u2019 T-sejtek el\u0151fordul\u00e1sa, \u00e9s\n                    t\u00fcnetmentes betegekn\u00e9l is cs\u00f6kken az immunv\u00e9dekez\u00e9s. Orv Hetil. 2022; 163(52):\n                    2062\u20132066.<\/jats:p>","DOI":"10.1556\/650.2022.32664","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T12:53:01Z","timestamp":1672145581000},"page":"2062-2066","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["A csecsem\u0151mirigy T-sejtjeinek \u00f6sszet\u00e9tel\u00e9ben l\u00e9trej\u00f6v\u0151 v\u00e1ltoz\u00e1sok a COVID\u201319-pand\u00e9mia alatt"],"prefix":"10.1556","volume":"163","author":[{"given":"Judit","family":"Lantos","sequence":"first","affiliation":[{"name":"B\u00e1cs-Kiskun Megyei K\u00f3rh\u00e1z, Neurol\u00f3giai \u00e9s Stroke Oszt\u00e1ly Kecskem\u00e9t Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Fur\u00e1k","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Seb\u00e9szeti Klinika Szeged Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mi","family":"Zombori-T\u00f3th","sequence":"additional","affiliation":[{"name":"Csongr\u00e1d-Csan\u00e1d Megyei Mellkasi Betegs\u00e9gek Szakk\u00f3rh\u00e1za Deszk Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Zombori","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet Szeged Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Bihari","sequence":"additional","affiliation":[{"name":"B\u00e1cs-Kiskun Megyei K\u00f3rh\u00e1z, Neurol\u00f3giai \u00e9s Stroke Oszt\u00e1ly Kecskem\u00e9t Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Endre","family":"Varga","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Traumatol\u00f3giai Klinika Szeged Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Traumatol\u00f3giai Klinika Szeged Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1034\/j.1600-065X.2002.18502.x","article-title":"The discovery of thymus function and of thymus-derived lymphocytes","volume":"185","author":"1 Miller","year":"2002","unstructured":"1 Miller JF. 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