{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:55:30Z","timestamp":1785200130724,"version":"3.55.0"},"reference-count":22,"publisher":"Akademiai Kiado Zrt.","issue":"5","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,2,5]]},"abstract":"<jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> A lupus erythematosus panniculitis (LEP) a cutan\n                    lupus erythematosus kr\u00f3nikus form\u00e1j\u00e1nak ritka vari\u00e1nsa, klinikailag t\u00f6m\u00f6tt,\n                    subcutan csom\u00f3k \u00e9s erythem\u00e1s plakkok jellemzik. Az akt\u00edv t\u00fcnetek az arcot \u00e9s\n                    testet torz\u00edt\u00f3 maradv\u00e1nyt\u00fcnetekkel gy\u00f3gyulhatnak, rontva a betegek\n                    \u00e9letmin\u0151s\u00e9g\u00e9t. A sziszt\u00e9m\u00e1s lupus erythematosus (SLE) r\u00e9szjelens\u00e9ge lehet, els\u0151\n                    t\u00fcnetek\u00e9nt is kialakulhat. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> A LEP klinikopatol\u00f3giai\n                    k\u00e9p\u00e9nek bemutat\u00e1sa saj\u00e1t beteganyagunk szeml\u00e9ltet\u00e9s\u00e9vel, a betegs\u00e9g lefoly\u00e1s\u00e1nak\n                    \u00e9rt\u00e9kel\u00e9se. <jats:italic>M\u00f3dszerek:<\/jats:italic> A Semmelweis Egyetem B\u0151r-, Nemik\u00f3rtani\n                    \u00e9s B\u0151ronkol\u00f3giai Klinik\u00e1j\u00e1n 2000 \u00e9s 2022 k\u00f6z\u00f6tt jelentkezett LEP-betegek\n                    \u00f6sszegy\u0171jt\u00e9se, adataik retrospekt\u00edv elemz\u00e9se. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A 17\n                    beteg k\u00f6z\u00fcl 1 f\u00e9rfi, 16 n\u0151, \u00e1tlag\u00e9letkoruk 37,8 \u00e9v volt. T\u00fcneteik a\n                    leggyakrabban a proximalis als\u00f3 \u00e9s fels\u0151 v\u00e9gtagokon jelentkeztek (als\u00f3: 8\/17,\n                    fels\u0151: 7\/17), az arc 4, az eml\u0151 3, a mellkas \u00e9s a farpof\u00e1k 2-2, a h\u00e1t \u00e9s a\n                    l\u00e1bsz\u00e1r 1-1 esetben volt \u00e9rintett. A leggyakrabban akt\u00edv csom\u00f3 (11\/17), illetve\n                    plakk jelentkezett (7\/17), 4 esetben lipoatrophia, 3-n\u00e1l kifek\u00e9lyesed\u00e9s, 1-n\u00e9l\n                    kalcifik\u00e1ci\u00f3. 6 betegn\u00e9l a subcutan t\u00fcnetet discoid plakk fedte. 10 betegn\u00e9l\n                    alakult ki sziszt\u00e9m\u00e1s t\u00fcnet: arthritis (4\/17), hematol\u00f3giai elt\u00e9r\u00e9s (5\/17),\n                    vese\u00e9rintetts\u00e9g (2\/17), antifoszfolipid-szindr\u00f3ma (2\/17). Az SLE diagn\u00f3zis\u00e1t 7\n                    esetben tudtuk fel\u00e1ll\u00edtani. A sz\u00f6vettani k\u00e9p 8 esetben kevert t\u00edpus\u00fa\n                    panniculitist, 3-n\u00e1l lobularist mutatott. \u00c1tlagosan 24,3 h\u00f3nap telt el a\n                    diagn\u00f3zis fel\u00e1ll\u00edt\u00e1s\u00e1ig. SLE-s betegeink b\u0151rt\u00fcnetei regredi\u00e1ltak az alkalmazott\n                    sziszt\u00e9m\u00e1s immunszuppressz\u00edv kezel\u00e9sekre. A kiz\u00e1r\u00f3lag b\u0151rmanifeszt\u00e1ci\u00f3t mutat\u00f3\n                    betegeink k\u00f6r\u00e9ben gyakori volt a ter\u00e1piarezisztencia a cutan lupus\n                    erythematosusban alkalmazott kezel\u00e9sekre. <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> A LEP\n                    diagnosztiz\u00e1l\u00e1sa t\u00f6bb h\u00f3napot, \u00e9vet vehet ig\u00e9nybe. Sz\u00e9lesebb k\u00f6r\u0171 ismerete\n                    seg\u00edtheti a gyorsabb diagn\u00f3zisalkot\u00e1st, megel\u0151zhet\u0151 a maradv\u00e1nyt\u00fcnetek, illetve\n                    az esetleges belszervi elv\u00e1ltoz\u00e1sok kialakul\u00e1sa. Megfigyel\u00e9seink alapj\u00e1n SLE\n                    n\u00e9lk\u00fcli LEP eset\u00e9n is korai immunszuppressz\u00edv ter\u00e1pi\u00e1t lenne \u00e9rdemes bevezetni.\n                    Orv Hetil. 2023; 164(5): 172\u2013178.<\/jats:p>","DOI":"10.1556\/650.2023.32692","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T16:38:58Z","timestamp":1675701538000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":3,"title":["A lupus erythematosus panniculitis lefoly\u00e1s\u00e1nak jellegzetess\u00e9gei 17 beteg\u00fcnk retrospekt\u00edv vizsg\u00e1lata alapj\u00e1n"],"prefix":"10.1556","volume":"164","author":[{"given":"Zs\u00f3fia","family":"Kir\u00e1ly","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik\u00f3","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Medvecz","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"R\u00f3bert","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bokor","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"Kuroli","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai \u00e9s K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gota","family":"Szepesi","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai \u00e9s K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Marschalk\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadett","family":"Hidv\u00e9gi","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1001\/archderm.1956.01550010017002","article-title":"Lupus erythematosus profundus; commentary and report of four more cases","volume":"73","author":"Arnold HL. 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