{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T04:28:21Z","timestamp":1698208101573},"reference-count":24,"publisher":"Akademiai Kiado Zrt.","issue":"6","license":[{"start":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T00:00:00Z","timestamp":1676160000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,2,12]]},"abstract":"<jats:p>A primer szklerotiz\u00e1l\u00f3 cholangitis (PSC) n\u0151kben k\u00fcl\u00f6n\u00f6sen ritka, progredi\u00e1l\u00f3,\n                    cholestasissal \u00e9s gyakran colitis ulceros\u00e1val j\u00e1r\u00f3, s\u00falyos form\u00e1j\u00e1ban\n                    szerv\u00e1t\u00fcltet\u00e9st ig\u00e9nyl\u0151 m\u00e1jbetegs\u00e9g. A teherbe es\u00e9s es\u00e9ly\u00e9re \u00e9s a v\u00e1rand\u00f3ss\u00e1g\n                    kivisel\u00e9s\u00e9re gyakorolt hat\u00e1s\u00e1t hazai k\u00f6zlem\u00e9ny eddig nem elemezte. K\u00f6zlem\u00e9ny\u00fcnk\n                    c\u00e9lja a s\u00falyos colitis ulceros\u00e1val \u00e9s cholestasissal sz\u00f6v\u0151d\u00f6tt PSC mellett\n                    fogant v\u00e1rand\u00f3ss\u00e1g lefoly\u00e1s\u00e1val foglalkoz\u00f3 irodalom \u00e1ttekint\u00e9se, egy fiatal,\n                    el\u0151sz\u00f6r v\u00e1rand\u00f3s sikeres sz\u00fcl\u00e9se, majd postpartum colectomi\u00e1ja kapcs\u00e1n. A 37\n                    \u00e9ves, m\u00e1j\u00e1t\u00fcltet\u00e9sre v\u00e1r\u00f3 primigravida v\u00e1rand\u00f3ss\u00e1ga spont\u00e1n fogant, \u00e9s s\u00falyos\n                    m\u00e1jbetegs\u00e9ge mellett, a gy\u00f3gyszeresen kezelhet\u0151 magas v\u00e9rnyom\u00e1s ellen\u00e9re,\n                    zavartalan lefoly\u00e1s\u00fa volt. A harmadik trimeszterben cholestasisa jelent\u0151sen\n                    fokoz\u00f3dott, a sz\u00e9rum-\u00f6sszepesavszint 100 \u03bcmol\/l f\u00f6l\u00e9 emelkedett, de napi 8 g\n                    kolesztiramin ad\u00e1s\u00e1val az \u00e9rt\u00e9k r\u00f6vid id\u0151n bel\u00fcl a norm\u00e1ltartom\u00e1nyba cs\u00f6kkent.\n                    K\u00e9s\u0151i korasz\u00fcl\u00e9se a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s akut fell\u00e1ngol\u00e1sa k\u00f6vetkezt\u00e9ben\n                    kialakult chorioamnionitis miatt indult meg. Cs\u00e1sz\u00e1rmetsz\u00e9ssel eutr\u00f3fi\u00e1s, j\u00f3\n                    \u00e1ltal\u00e1nos \u00e1llapot\u00fa gyermek sz\u00fcletett, aki az\u00f3ta is eg\u00e9szs\u00e9ges. A korai\n                    gyermek\u00e1gyban a colitis ulcerosa tov\u00e1bb s\u00falyosbodott, gy\u00f3gyszeres kezel\u00e9ssel a\n                    beteg szeptikus \u00e1llapota nem volt kezelhet\u0151. G\u00f3ctalan\u00edt\u00e1s \u00e9rdek\u00e9ben subtotalis\n                    colectomi\u00e1ra ker\u00fclt sor, amely ut\u00e1n 12 nappal a beteg j\u00f3 \u00e1llapotban otthon\u00e1ba\n                    ker\u00fclt. A m\u0171t\u00e9t ut\u00e1n 3 h\u00f3nappal a tehermentes\u00edt\u0151 ileostoma z\u00e1r\u00e1sra ker\u00fclt. A m\u00e1j\n                    \u00e1llapota miatt a gyermek\u00e1gyas ism\u00e9t m\u00e1j\u00e1t\u00fcltet\u00e9sre v\u00e1r. Eset\u00fcnk az irodalmi\n                    adatokkal egyez\u0151en arra utal, hogy a colitis ulceros\u00e1val sz\u00f6v\u0151d\u00f6tt PSC mellett\n                    fogant v\u00e1rand\u00f3ss\u00e1g \u2013 szoros belgy\u00f3gy\u00e1szati \u00e9s sz\u00fcl\u00e9szeti ellen\u0151rz\u00e9s mellett \u2013\n                    v\u00e1llalhat\u00f3, de a b\u00e9l- \u00e9s a m\u00e1jbetegs\u00e9g mind a v\u00e1rand\u00f3ss\u00e1g alatt, mind a\n                    gyermek\u00e1gyas id\u0151szakban progredi\u00e1lhat. Kolesztiramin ad\u00e1sa alkalmas lehet a\n                    magas \u00f6sszepesavszint gyors, jelent\u0151s \u00e9s biztons\u00e1gos cs\u00f6kkent\u00e9s\u00e9re. Orv Hetil.\n                    2023; 164(6): 234\u2013240.<\/jats:p>","DOI":"10.1556\/650.2023.32707","type":"journal-article","created":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T12:46:45Z","timestamp":1676206005000},"page":"234-240","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Primer szklerotiz\u00e1l\u00f3 cholangitisben szenved\u0151, m\u00e1jtranszplant\u00e1ci\u00f3ra v\u00e1r\u00f3 beteg sikeres v\u00e1rand\u00f3ss\u00e1ga"],"prefix":"10.1556","volume":"164","author":[{"given":"Magdolna","family":"Ozsv\u00e1ri-Vid\u00e1kovich","sequence":"first","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest, T\u00e9t\u00e9nyi \u00fat 12\u201316., 1115 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"P\u00e9ter","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Seb\u00e9szeti, Traszplant\u00e1ci\u00f3s \u00e9s Gasztroenterol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fruzsina","family":"Vilmos","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Seb\u00e9szeti, Traszplant\u00e1ci\u00f3s \u00e9s Gasztroenterol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Szij\u00e1rt\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Seb\u00e9szeti, Traszplant\u00e1ci\u00f3s \u00e9s Gasztroenterol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1d\u00e1m","family":"D\u00e1niel","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Seb\u00e9szeti, Traszplant\u00e1ci\u00f3s \u00e9s Gasztroenterol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00f3r\u00e1nd","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Seb\u00e9szeti, Traszplant\u00e1ci\u00f3s \u00e9s Gasztroenterol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"S\u00e1ra","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szilvia","family":"Szakony","sequence":"additional","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest, T\u00e9t\u00e9nyi \u00fat 12\u201316., 1115 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Sziller","sequence":"additional","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest, T\u00e9t\u00e9nyi \u00fat 12\u201316., 1115 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1136\/gutjnl-2018-317993","article-title":"British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis","volume":"68","author":"1 Chapman","year":"2019","unstructured":"1 Chapman MH, Thorburn D, Hirschfield GM, et al. 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