{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:09:19Z","timestamp":1774076959791,"version":"3.50.1"},"reference-count":37,"publisher":"Akademiai Kiado Zrt.","issue":"21","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,5,28]]},"abstract":"<jats:p>A gestati\u00f3s diabetes mellitus az egyik leggyakrabban el\u0151fordul\u00f3 terhespatol\u00f3giai\n                    k\u00f3rk\u00e9p, mely a v\u00e1rand\u00f3ss\u00e1gok 5\u201314%-\u00e1ban jelenik meg. A terhess\u00e9gi intrahepaticus\n                    cholestasis a v\u00e1rand\u00f3ss\u00e1g alatt el\u0151fordul\u00f3 m\u00e1jbetegs\u00e9gek k\u00f6z\u00f6tt foglalja el az\n                    els\u0151 helyet, 0,2\u201327%-os gyakoris\u00e1ggal. Irodalmi adatok alapj\u00e1n a k\u00e9t terhess\u00e9gi\n                    k\u00f3r\u00e1llapot egym\u00e1shoz val\u00f3 viszony\u00e1t vizsg\u00e1ltuk meg \u00f6sszefoglal\u00f3 k\u00f6zlem\u00e9ny\u00fcnkben\n                    abb\u00f3l a szempontb\u00f3l, hogy egy\u00fcttes jelenl\u00e9t\u00fck hogyan befoly\u00e1solja a v\u00e1rand\u00f3ss\u00e1g\n                    kimenetel\u00e9t. A rendelkez\u00e9sre \u00e1ll\u00f3 kutat\u00e1sok azt igazolt\u00e1k, hogy a terhess\u00e9gi\n                    intrahepaticus cholestasis szoros \u00f6sszef\u00fcgg\u00e9st mutat a gestati\u00f3s diabetes\n                    mellitusszal. Az \u00f6sszef\u00fcgg\u00e9s h\u00e1tter\u00e9ben a sz\u00e9rumepesavak gl\u00fck\u00f3z-, illetve\n                    lipidhomeostasist modul\u00e1l\u00f3 szerepe h\u00faz\u00f3dik, a farnezoid X-receptorhoz \u00e9s a\n                    Takeda G-feh\u00e9rj\u00e9hez kapcsolt receptor-5 regul\u00e1ci\u00f3ja r\u00e9v\u00e9n. Mind a gestati\u00f3s\n                    diabetesnek, mind a terhess\u00e9gi cholestasisnak lehets\u00e9ges magzati sz\u00f6v\u0151dm\u00e9nye a\n                    korasz\u00fcl\u00e9s, az akut l\u00e9gz\u00e9si distressz szindr\u00f3ma \u00e9s a m\u00e9hen bel\u00fcli elhal\u00e1s. A\n                    terhess\u00e9gi intrahepaticus cholestasisban szenved\u0151 betegek k\u00f6r\u00e9ben a gestati\u00f3s\n                    diabetes mellitus el\u0151fordul\u00e1sa gyakoribb lehet, \u00e9s a k\u00e9t k\u00f3rk\u00e9p egy\u00fcttes\n                    jelenl\u00e9te n\u00f6velheti a magzati \u00e9s az anyai sz\u00f6v\u0151dm\u00e9nyek kock\u00e1zat\u00e1t, ez\u00e9rt ezek\n                    megel\u0151z\u00e9s\u00e9re \u00e9s kezel\u00e9s\u00e9re kiemelt figyelmet kell, hogy ford\u00edtson a\n                    v\u00e1rand\u00f3sgondoz\u00e1st v\u00e9gz\u0151 szakember. Orv Hetil. 2023; 164(21): 831\u2013835.<\/jats:p>","DOI":"10.1556\/650.2023.32778","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T09:46:00Z","timestamp":1685267160000},"page":"831-835","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":3,"title":["A terhess\u00e9gi intrahepaticus cholestasis \u00e9s a gestati\u00f3s diabetes mellitus \u00f6sszef\u00fcgg\u00e9se"],"prefix":"10.1556","volume":"164","author":[{"given":"Magdolna","family":"Ozsv\u00e1ri-Vid\u00e1kovich","sequence":"first","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anik\u00f3","family":"Somogyi","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kl\u00e1ra","family":"Rosta","sequence":"additional","affiliation":[{"name":"B\u00e9csi Orvostudom\u00e1nyi Egyetem, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika 18\u201320 W\u00e4hringer G\u00fcrtel, A-1090 Wien Ausztria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/S0140-6736(09)61495-1","article-title":"Liver disease in pregnancy","volume":"375","author":"1 Joshi","year":"2010","unstructured":"1 Joshi D, James A, Quaglia A, et al. 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