{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:15:51Z","timestamp":1787022951086,"version":"build-2736575974"},"reference-count":53,"publisher":"Akademiai Kiado Zrt.","issue":"25","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,6,25]]},"abstract":"<jats:p>Az intestinalis mikrobiom fontos szerepet t\u00f6lt be a szervezet \u00e9lettani\n                    folyamataiban. Egyik legfontosabb szerepe a r\u00f6vid sz\u00e9nl\u00e1nc\u00fa zs\u00edrsavak termel\u00e9se,\n                    ami meghat\u00e1roz\u00f3 jelent\u0151s\u00e9g\u0171 az \u00e9p b\u00e9lbarrier \u00e9s immunhomeostasis fenntart\u00e1s\u00e1ban\n                    A mikrobiomban bek\u00f6vetkez\u0151 \u2013 t\u00e1pl\u00e1lkoz\u00e1si szok\u00e1sok, rendszeres\n                    gy\u00f3gyszerhaszn\u00e1lat, egy\u00e9b t\u00e9nyez\u0151k okozta \u2013 dysbiosis a barrierfunkci\u00f3\n                    k\u00e1rosod\u00e1s\u00e1val j\u00e1rhat, ami lipopoliszacharidok portalis kering\u00e9sbe val\u00f3\n                    transzlok\u00e1ci\u00f3j\u00e1t v\u00e1ltja ki. Ezek szubklinikai gyullad\u00e1s fenntart\u00e1s\u00e1val elh\u00edz\u00e1s,\n                    inzulinrezisztencia, zs\u00edrm\u00e1j kialakul\u00e1s\u00e1hoz vezethetnek. Patog\u00e9n k\u00f3rokoz\u00f3k\n                    portalis kering\u00e9sbe jut\u00e1sa molekul\u00e1ris mimikrit, k\u00f6vetkezm\u00e9nyes autoimmunit\u00e1s\n                    r\u00e9v\u00e9n b\u00e9ta-sejt-destrukci\u00f3t okozhat. Mindk\u00e9t mechanizmus diabetes mellitushoz\n                    vezethet. A dolgozat \u00e1ttekinti az intestinalis mikrobiom 1-es \u00e9s 2-es t\u00edpus\u00fa\n                    cukorbetegs\u00e9gben bek\u00f6vetkez\u0151 v\u00e1ltoz\u00e1sait, a k\u00eds\u00e9rletes \u00e9s klinikai adatokat.\n                    Kiemeli, hogy noha ismereteink ma m\u00e9g nem el\u00e9gs\u00e9gesek a napi klinikai gyakorlat\n                    seg\u00edt\u00e9s\u00e9re, b\u0151v\u00fcl\u00e9s\u00fck seg\u00edtheti egyes adatok prognosztikai hasznos\u00edt\u00e1s\u00e1t.\n                    Mindehhez azonban m\u00e9g tov\u00e1bbi vizsg\u00e1latok \u00e9s megfigyel\u00e9sek sz\u00fcks\u00e9gesek. Orv\n                    Hetil. 2023; 164(25): 981\u2013987.<\/jats:p>","DOI":"10.1556\/650.2023.32788","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T10:06:37Z","timestamp":1687773997000},"page":"981-987","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":6,"title":["A diabetes mellitus \u00e9s a b\u00e9lmikrobiom"],"prefix":"10.1556","volume":"164","author":[{"given":"Gyula","family":"Tomasics","sequence":"first","affiliation":[{"name":"\u00c9szak-budai Szent J\u00e1nos Centrumk\u00f3rh\u00e1z, II. Belgy\u00f3gy\u00e1szat-Diabetol\u00f3gia Budapest, Di\u00f3s \u00e1rok 1\u20133., 1125 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Schandl","sequence":"additional","affiliation":[{"name":"\u00c9szak-budai Szent J\u00e1nos Centrumk\u00f3rh\u00e1z, II. 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