{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:26:23Z","timestamp":1774326383812,"version":"3.50.1"},"reference-count":36,"publisher":"Akademiai Kiado Zrt.","issue":"22","license":[{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,6,4]]},"abstract":"<jats:p>Az anafilaxia egy generaliz\u00e1lt s\u00falyos, \u00e9letvesz\u00e9lyes reakci\u00f3. A legt\u00f6bb esetben\n                    allergi\u00e1s eredetre vezethet\u0151 vissza. A kiv\u00e1lt\u00f3 okok k\u00f6z\u00f6tt a legt\u00f6bbsz\u00f6r\n                    gy\u00f3gyszerek, cs\u00edp\u00e9s, m\u00e9rgek, \u00e9lelmiszer, kontrasztanyag szerepel. A\n                    h\u00edz\u00f3sejtekb\u0151l, basophil granulocyt\u00e1kb\u00f3l felszabadul\u00f3 k\u00fcl\u00f6nb\u00f6z\u0151 medi\u00e1torok\n                    (hisztamin, prosztaglandinok, leukotri\u00e9nek, tript\u00e1z, v\u00e9rlemezke-aktiv\u00e1l\u00f3 faktor,\n                    citokinek, kemokinek) okozz\u00e1k. L\u00e9trej\u00f6tt\u00e9ben a hisztamin k\u00f6zponti szerepet\n                    j\u00e1tszik. A s\u00falyos anafilaxia azonnali felismer\u00e9se, k\u00e9sleked\u00e9s n\u00e9lk\u00fcli specifikus\n                    kezel\u00e9se elengedhetetlen a sikeres ell\u00e1t\u00e1shoz. A s\u00falyos t\u00fcnetekkel j\u00e1r\u00f3\n                    anafilaxi\u00e1ban a klinikai jellemz\u0151k nagyon hasonl\u00f3ak, allergi\u00e1s vagy nem\n                    allergi\u00e1s eredet\u00e9t\u0151l f\u00fcggetlen\u00fcl. A perioperat\u00edv anafilaxia el\u0151fordul\u00e1sa\n                    k\u00fcl\u00f6nb\u00f6z\u0151 lehet, id\u0151ben \u00e9s betegpopul\u00e1ci\u00f3k k\u00f6z\u00f6tt v\u00e1ltozhat. El\u0151fordul\u00e1si\n                    gyakoris\u00e1ga rendk\u00edv\u00fcl v\u00e1ltoz\u00f3, megk\u00f6zel\u00edt\u0151leg 1\/10\u00a0000 \u00e9rz\u00e9stelen\u00edt\u00e9s. A legt\u00f6bb\n                    tanulm\u00e1ny a neuromuscularis blokkol\u00f3szereket eml\u00edti meg a leggyakoribb oki\n                    t\u00e9nyez\u0151k\u00e9nt. A Royal College of Anaesthetists (Anglia) \u00e1ltal elv\u00e9gzett \u201e6th\n                    National Audit Project\u201d prospekt\u00edv felm\u00e9r\u00e9s a perioperat\u00edv anafilaxia\n                    leggyakoribb okai k\u00f6z\u00f6tt az antibiotikumok (1\/26\u00a0845), a neuromuscularis\n                    juncti\u00f3t blokkol\u00f3 gy\u00f3gyszerek (1\/19\u00a0070) a kl\u00f3rhexidin (1\/127\u00a0698) \u00e9s a \u201ePatent\n                    Blue\u201d fest\u00e9k (1\/6863) haszn\u00e1lat\u00e1t teszi felel\u0151ss\u00e9. Kialakul\u00e1sa az esetek\n                    66%-\u00e1ban 5 percen bel\u00fcl, 17%-\u00e1ban 6\u201310 perc, 5%-\u00e1ban 11\u201315 perc, 2%-\u00e1ban 16\u201330\n                    perc k\u00f6z\u00f6tt mutatkozik, de a legt\u00f6bbsz\u00f6r \u00e1ltal\u00e1ban 30 percen bel\u00fcl. Az\n                    antibiotikumallergia egyre nagyobb probl\u00e9ma, k\u00fcl\u00f6n\u00f6sen a teikoplaninnal\n                    (16,4\/100\u00a0000) \u00e9s az amoxicillin\/klavul\u00e1nsavval (8,7\/100\u00a0000) szemben. Ha\n                    kor\u00e1bbi anafilaxi\u00e1s sokk el\u0151fordul\u00e1sa nem ismert, az izomrelax\u00e1ns t\u00edpus\u00e1nak\n                    megv\u00e1laszt\u00e1sa nem meghat\u00e1roz\u00f3 t\u00e9nyez\u0151. A betegek aneszt\u00e9ziabesorol\u00e1sa, fizikai\n                    \u00e1llapota, az elh\u00edz\u00e1s, a b\u00e9ta-blokkol\u00f3k \u00e9s az ACE-g\u00e1tl\u00f3k alkalmaz\u00e1sa befoly\u00e1solja\n                    a perioperat\u00edv anafilaxia klinikai jellemz\u0151it. A kezdeti t\u00fcnetek rendk\u00edv\u00fcl\n                    v\u00e1ltozatosak lehetnek, a kezel\u00e9s hat\u00e9konys\u00e1g\u00e1hoz a korai felismer\u00e9s \u00e9s\n                    ter\u00e1piakezd\u00e9s a siker kulcsa. A preoperat\u00edv allergiat\u00f6rt\u00e9net kik\u00e9rdez\u00e9se\n                    cs\u00f6kkentheti az anafilaxi\u00e1s reakci\u00f3k kock\u00e1zat\u00e1t \u00e9s el\u0151fordul\u00e1s\u00e1t. Orv Hetil.\n                    2023; 164(22): 871\u2013877.<\/jats:p>","DOI":"10.1556\/650.2023.32789","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T05:56:46Z","timestamp":1685944606000},"page":"871-877","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":6,"title":["Az anafilaxia perioperat\u00edv vonatkoz\u00e1sai"],"prefix":"10.1556","volume":"164","author":[{"given":"Bal\u00e1zs","family":"S\u00fct\u0151","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs, Ifj\u00fas\u00e1g u. 13., 7624 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamilla","family":"Domokos","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs, Ifj\u00fas\u00e1g u. 13., 7624 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","unstructured":"1 Cook T, Harper N. 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