{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:44:21Z","timestamp":1790876661084,"version":"4.1.0"},"reference-count":60,"publisher":"Akademiai Kiado Zrt.","issue":"24","license":[{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,6,18]]},"abstract":"<jats:p>A h\u00fcvelyi mikrobiom fontos t\u00e9nyez\u0151 a patog\u00e9n mikroorganizmusokkal szembeni\n                    v\u00e9dekez\u00e9sben, az eg\u00e9szs\u00e9ges h\u00fcvelyi mili\u0151 fenntart\u00e1s\u00e1ban. A h\u00fcvelyi mikrobiom\n                    \u00f6sszet\u00e9tel\u00e9r\u0151l, funkci\u00f3ir\u00f3l, v\u00e1ltoz\u00e1sair\u00f3l az \u00fajgener\u00e1ci\u00f3s szekven\u00e1l\u00e1si\n                    technik\u00e1k r\u00e9v\u00e9n rendelkez\u00fcnk alapvet\u0151n \u00faj, sz\u00e9les k\u00f6r\u0171 ismeretekkel. Az\n                    \u00f6sszefoglal\u00f3 tanulm\u00e1ny c\u00e9lja a k\u00e9rd\u00e9s alapismereteinek \u00f6sszefoglal\u00e1sa. A h\u00fcvelyi\n                    mikrobiom az \u00e9letkorral p\u00e1rhuzamosan v\u00e1ltozik, reprodukt\u00edv korban \u00e9ri el\n                    funkcion\u00e1lis kiteljesed\u00e9s\u00e9t. Alkot\u00f3i a reprodukt\u00edv korban els\u0151sorban\n                        <jats:italic>Lactobacillus<\/jats:italic> speciesek, f\u0151k\u00e9nt <jats:italic>L. crispatus, L.\n                        iners, L. gasseri, L. jensenii,<\/jats:italic> melyek a fiziol\u00f3gi\u00e1s stabilit\u00e1s\u00e1t\n                    biztos\u00edtj\u00e1k. A h\u00fcvelyi mikrobiom a szervezet t\u00f6bbi mikrobiomj\u00e1val szemben\n                    alacsony diverzit\u00e1s\u00fa, a diverzit\u00e1s sz\u00e9lesed\u00e9se patog\u00e9n \u00e1llapothoz vezet. A\n                    hagyom\u00e1nyos, teny\u00e9szt\u00e9ses technik\u00e1k kor\u00e1ban is ismert volt a\n                        <jats:italic>Lactobacillus<\/jats:italic>ok szerepe a tejsavferment\u00e1l\u00e1s sor\u00e1n kialakul\u00f3\n                    savas h\u00fcvelyi pH fenntart\u00e1s\u00e1ban \u00e9s antimikrob\u00e1s anyagok termel\u00e9s\u00e9ben. A\n                    k\u00f6zlem\u00e9nyben r\u00e9szletesen t\u00e1rgyaljuk az 5 t\u00edpus\u00fa, k\u00fcl\u00f6nb\u00f6z\u0151 bakteri\u00e1lis\n                    \u00f6sszet\u00e9tel\u0171 h\u00fcvelyi k\u00f6z\u00f6ss\u00e9get, \u00f6sszet\u00e9tel\u00fcket, demogr\u00e1fiai el\u0151fordul\u00e1sukat, a\n                    t\u00edpusv\u00e1lt\u00e1sokat, a domin\u00e1l\u00f3 fl\u00f3ra \u00e1tmeneti v\u00e1ltoz\u00e1sait, annak jelent\u0151s\u00e9g\u00e9t,\n                    \u00f6sszehasonl\u00edtva a nem <jats:italic>Lactobacillus<\/jats:italic> domin\u00e1lta, fiziol\u00f3gi\u00e1snak\n                    tekinthet\u0151 fl\u00f3r\u00e1val. A mikrobiomnak l\u00e9nyeges szerepe van a lok\u00e1lis\n                    ny\u00e1lkah\u00e1rtya-immunit\u00e1sban, a patog\u00e9nekkel szembeni v\u00e9dekez\u00e9sben, a fiziol\u00f3gi\u00e1s\n                    v\u00e1ltoz\u00e1sokkal szembeni immuntolerancia kialak\u00edt\u00e1s\u00e1ban. A bakteri\u00e1lis vaginosis a\n                    nem eg\u00e9szs\u00e9ges fl\u00f3ra domin\u00e1l\u00f3 szerep\u00e9nek klasszikus p\u00e9ld\u00e1ja. Bakteri\u00e1lis\n                    vaginosisban a <jats:italic>Lactobacillus<\/jats:italic>-fl\u00f3ra dr\u00e1maian cs\u00f6kken, \u00e9s hely\u00e9t\n                    nagy diverzit\u00e1s\u00fa anaerob bakt\u00e9riumok foglalj\u00e1k el. Az \u00e1llapot az aktu\u00e1lis\n                    kellemetlens\u00e9gek mellett s\u00falyos n\u0151gy\u00f3gy\u00e1szati, sz\u00fcl\u00e9szeti k\u00f6vetkezm\u00e9nyekkel\n                    j\u00e1rhat: medd\u0151s\u00e9g, vet\u00e9l\u00e9s, korasz\u00fcl\u00e9s, chorioamnionitis, endometritis, n\u00f6vekszik\n                    a fog\u00e9konys\u00e1g a fels\u0151 genitalis traktusi \u00e9s h\u00fagy\u00fati infekci\u00f3k, valamint a\n                    szexu\u00e1lis \u00faton terjed\u0151 fert\u0151z\u00e9sek, HIV-akvir\u00e1ci\u00f3 ir\u00e1nt, emellett a bakteri\u00e1lis\n                    vaginosisban szenved\u0151 n\u0151k HIV-v\u00edrus-\u00e1tad\u00e1si k\u00e9pess\u00e9ge partner\u00fck \u00e9s az \u00fajsz\u00fcl\u00f6tt\n                    sz\u00e1m\u00e1ra n\u00f6vekedett. Orv Hetil. 2023; 164(24): 923\u2013930.<\/jats:p>","DOI":"10.1556\/650.2023.32791","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T04:02:37Z","timestamp":1687147357000},"page":"923-930","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":8,"title":["A n\u0151i als\u00f3 genitalis traktus mikrobiom tulajdons\u00e1gai \u00e9s szerepe"],"prefix":"10.1556","volume":"164","author":[{"given":"M\u00e1rta","family":"Marschalk\u00f3","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ambrus","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest, M\u00e1ria u. 41., 1085 Magyarorsz\u00e1g"},{"name":"Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Dermatoonkol\u00f3giai Oszt\u00e1ly Budapest, R\u00e1th Gy\u00f6rgy u. 7\u20139., 1122 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1471-0528.2010.02840.x","article-title":"The vaginal microbiome: new information about genital tract flora using molecular based techniques","volume":"118","author":"1 Lamont","year":"2011","unstructured":"1 Lamont RF, Sobel JD, Akins RA, et al. 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