{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T01:20:34Z","timestamp":1769908834324,"version":"3.49.0"},"reference-count":38,"publisher":"Akademiai Kiado Zrt.","issue":"23","license":[{"start":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T00:00:00Z","timestamp":1686441600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,6,11]]},"abstract":"<jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> Haz\u00e1nkban az obesitas, a 2-es t\u00edpus\u00fa diabetes \u00e9s a\n                    rosszindulat\u00fa daganatok egyar\u00e1nt n\u00e9pbetegs\u00e9gnek sz\u00e1m\u00edtanak. Hasonl\u00f3\n                    epidemiol\u00f3gi\u00e1juk alapj\u00e1t a r\u00e9szben k\u00f6z\u00f6s anyagcsere k\u00e9pezheti.\n                        <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> A daganatos betegek glykaemi\u00e1s \u00e9s t\u00e1pl\u00e1lts\u00e1gi\n                    \u00e1llapota, valamint a r\u00e1kbetegs\u00e9g k\u00f3rlefoly\u00e1sa k\u00f6zti metabolikus kapcsolat\n                    bizony\u00edt\u00e1sa, illetve a noninzulin-antidiabetikumok \u2013 els\u0151sorban a metformin \u2013\n                    tumorellenes effektus\u00e1nak meger\u0151s\u00edt\u00e9se. <jats:italic>M\u00f3dszer:<\/jats:italic> B\u00e9k\u00e9s v\u00e1rmegye\n                    onkol\u00f3giai ell\u00e1t\u00e1s\u00e1ban 1224 beteg adatait dolgoztuk fel. A testt\u00f6megindex \u00e9s\n                    v\u00e9rcukorszint \u00e9rt\u00e9k\u00e9nek, valamint a 2-es t\u00edpus\u00fa diabetes jelenl\u00e9t\u00e9nek \u00e9s\n                    ter\u00e1pi\u00e1j\u00e1nak f\u00fcggv\u00e9ny\u00e9ben vizsg\u00e1ltuk a tumorprogresszi\u00f3t, illetve a\n                    daganatst\u00e1dium viszony\u00e1ban elemezt\u00fck a glykaemi\u00e1s \u00e9s t\u00e1pl\u00e1lts\u00e1gi \u00e1llapot\n                    v\u00e1ltoz\u00e1s\u00e1t, valamint a cukorbetegs\u00e9g el\u0151fordul\u00e1s\u00e1t. <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    A malignus cachexia ellen\u00e9re relat\u00edve nagy ar\u00e1nyban (23,28%) tapasztaltunk\n                    obesitast vagy annak megfelel\u0151 testt\u00f6megindex-\u00e9rt\u00e9ket, melyhez gyakrabban\n                    t\u00e1rsult \u00e1tt\u00e9tes tumorst\u00e1dium. A feln\u0151tt n\u00e9pess\u00e9ghez viszony\u00edtva a 2-es t\u00edpus\u00fa\n                    diabetes gyakoribb el\u0151fordul\u00e1s\u00e1t (20,34%) tapasztaltuk. Primer m\u00e1jsejtes (60%,\n                    p&lt;0,001), hasny\u00e1lmirigy- (50%, p&lt;0,001), h\u00fagyh\u00f3lyag- (50%, p&lt;0,001),\n                    prosztata- (50%, p&lt;0,002) \u00e9s endometriumr\u00e1k (50%, p&lt;0,02), valamint\n                    postmenopausalis eml\u0151r\u00e1k (30%, p&lt;0,006) eset\u00e9ben a vizsg\u00e1lt popul\u00e1ci\u00f3 t\u00f6bbi\n                    r\u00e9sz\u00e9hez k\u00e9pest enn\u00e9l is magasabb diabetesar\u00e1nyt \u00e9szlelt\u00fcnk. A\n                    noninzulin-antidiabetikumokkal kezeltek k\u00f6r\u00e9ben metformin alkalmaz\u00e1sa eset\u00e9n\n                    volt a legalacsonyabb a metasztatikus st\u00e1dium gyakoris\u00e1ga, illetve a legmagasabb\n                    a testt\u00f6megindex \u00e9s a v\u00e9rcukorszint. <jats:italic>Megbesz\u00e9l\u00e9s:<\/jats:italic>\n                    Vizsg\u00e1latunkban a 2-es t\u00edpus\u00fa cukorbetegs\u00e9ggel leggyakrabban t\u00e1rsul\u00f3 daganatok\n                    sorrendje \u00f6sszhangban \u00e1llt az irodalmi adatokkal. A tumorprogresszi\u00f3t k\u00eds\u00e9r\u0151\n                    inzulinrezisztencia kialakul\u00e1s\u00e1t az anyagcseregy\u00f3gyszerek hat\u00e9konyan\n                    k\u00e9sleltetik. A metformin \u00f6sszetett antimetasztatikus hat\u00e1sa a gl\u00fck\u00f3z- \u00e9s\n                    s\u00falykontrollt\u00f3l f\u00fcggetlen\u00fcl is \u00e9rv\u00e9nyes\u00fclhet. <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n                    Eredm\u00e9nyeink alapj\u00e1n szakmailag javasolhat\u00f3 a diabetesesek c\u00e9lzott r\u00e1ksz\u0171r\u00e9se,\n                    illetve az egyes daganatokat k\u00eds\u00e9r\u0151 gl\u00fckometabolikus zavarok keres\u00e9se, megfelel\u0151\n                    antidiabetikus ter\u00e1pi\u00e1ja, els\u0151sorban a metformin \u00e9s az \u00fajabb\n                    noninzulin-antidiabetikumok alkalmaz\u00e1sa. Mindezek r\u00e9v\u00e9n a r\u00e1kellenes k\u00fczdelem\n                    m\u00e9g hat\u00e9konyabb\u00e1 tehet\u0151. Orv Hetil. 2023; 164(23): 900\u2013910.<\/jats:p>","DOI":"10.1556\/650.2023.32796","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T12:41:02Z","timestamp":1686573662000},"page":"900-910","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["Daganatos betegek glykaemi\u00e1s \u00e9s t\u00e1pl\u00e1lts\u00e1gi \u00e1llapot\u00e1nak vizsg\u00e1lata."],"prefix":"10.1556","volume":"164","author":[{"given":"R\u00f3bert J\u00e1nos","family":"B\u00e1nhegyi","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, Doktori Iskola P\u00e9cs Magyarorsz\u00e1g"},{"name":"B\u00e9k\u00e9s V\u00e1rmegyei K\u00f6zponti K\u00f3rh\u00e1z P\u00e1ndy K\u00e1lm\u00e1n Tagk\u00f3rh\u00e1za, Onkol\u00f3giai Centrum Gyula, Semmelweis u. 1., 5700 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanka","family":"Ver\u00e9b","sequence":"additional","affiliation":[{"name":"B\u00e9k\u00e9s V\u00e1rmegyei K\u00f6zponti K\u00f3rh\u00e1z P\u00e1ndy K\u00e1lm\u00e1n Tagk\u00f3rh\u00e1za, Onkol\u00f3giai Centrum Gyula, Semmelweis u. 1., 5700 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1d\u00e1m Attila","family":"M\u00e1trai","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Seb\u00e9szeti M\u0171t\u00e9ttani Tansz\u00e9k Debrecen Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrix","family":"R\u00e1cz","sequence":"additional","affiliation":[{"name":"B\u00e9k\u00e9s V\u00e1rmegyei K\u00f6zponti K\u00f3rh\u00e1z P\u00e1ndy K\u00e1lm\u00e1n Tagk\u00f3rh\u00e1za, III. Belgy\u00f3gy\u00e1szati Oszt\u00e1ly Gyula Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szilvia","family":"Beke","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, Doktori Iskola P\u00e9cs Magyarorsz\u00e1g"},{"name":"G\u00e1l Ferenc Egyetem, Eg\u00e9szs\u00e9g- \u00e9s Szoci\u00e1lis Tudom\u00e1nyi Kar Gyula Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1 Kaplan, G.G. and J.W. Windsor, The four epidemiological stages in the global evolution of inflammatory bowel disease. Nature Reviews Gastroenterology & Hepatology, 2021. 18(1): p. 56-66. [DOI:10.1038\/s41575-020-00360-x]","DOI":"10.1038\/s41575-020-00360-x"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2 Mak, W.Y., et al, The epidemiology of inflammatory bowel disease: East meets west. 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