{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T05:08:11Z","timestamp":1697778491563},"reference-count":17,"publisher":"Akademiai Kiado Zrt.","issue":"27","license":[{"start":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T00:00:00Z","timestamp":1688860800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,7,9]]},"abstract":"<jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> A congenitalis aniridia ritka panocularis betegs\u00e9g,\n                    amelyben a szem csaknem minden strukt\u00far\u00e1ja \u00e9rintett, \u00e9s a betegek t\u00f6bbs\u00e9g\u00e9nek\n                    jelent\u0151sen cs\u00f6kkent a l\u00e1t\u00f3\u00e9less\u00e9ge. A congenitalis aniridia szem\u00e9szeti jelei\n                    lehetnek az aniridi\u00e1hoz t\u00e1rsult keratopathia, m\u00e1sodlagos z\u00f6ld h\u00e1lyog, sz\u00fcrke\n                    h\u00e1lyog, macula- \u00e9s opticus-hypoplasia, nystagmus. Noha az aniridi\u00e1hoz t\u00e1rsult\n                    keratopathia kifejez\u00e9s r\u00e9g\u00f3ta elterjedt az irodalomban, sokf\u00e9le st\u00e1diumbeoszt\u00e1si\n                    javaslata ker\u00fclt m\u00e1r le\u00edr\u00e1sra. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> Az aniridi\u00e1hoz\n                    t\u00e1rsult keratopathia egyes st\u00e1diumainak vizsg\u00e1lata az irodalomban el\u00e9rhet\u0151\n                    st\u00e1diumbeoszt\u00e1sok szerint, magyarorsz\u00e1gi aniridi\u00e1s betegekn\u00e9l. <jats:italic>Betegek\n                        \u00e9s m\u00f3dszerek:<\/jats:italic> 33, congenitalis aniridi\u00e1s beteg 65 szem\u00e9t vizsg\u00e1ltuk\n                    (e\u0301letkor: 25,69 \u00b1 17,49 [5\u201359] e\u0301v, 17 no\u030b [51,51%]). R\u00e9sl\u00e1mp\u00e1s vizsg\u00e1lattal\n                    r\u00f6gz\u00edtett\u00fck a szaruh\u00e1rtya \u00e1llapot\u00e1t, majd Mackman, Mayer, L\u00f3pez-Garc\u00eda, Lagali\n                    st\u00e1diumbeoszt\u00e1sa alapj\u00e1n oszt\u00e1lyoztuk a corneaelt\u00e9r\u00e9seket.\n                        <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A Mackman beoszt\u00e1sa szerinti 0. st\u00e1diumba 8\n                    szem (12,3%), az 1A st\u00e1diumba 0 szem, az 1B st\u00e1diumba 38 szem (58,46%), v\u00e9g\u00fcl a\n                    2. st\u00e1diumba 19 szem (29,23%) ker\u00fclt. Mayer szerint az I. st\u00e1diumba 8 szem\n                    (12,3%), a II. st\u00e1diumba 38 szem (58,46%), a III. st\u00e1diumba 5 szem (7,7%), a IV.\n                    st\u00e1diumba 7 szem (10,77%), az V. st\u00e1diumba pedig 7 szem (10,77%) tartozott.\n                    L\u00f3pez-Garc\u00eda csoportos\u00edt\u00e1sa alapj\u00e1n nem ker\u00fclt beoszt\u00e1sra 8 szem (12,3%), az 1.\n                    st\u00e1diumba 20 szem (30,77%), a 2. st\u00e1diumba 18 szem (27,7%), a 3. st\u00e1diumba pedig\n                    19 szem (29,23%) ker\u00fclt. Lagali oszt\u00e1lyoz\u00e1sa szerint a 0. st\u00e1diumba 8 szem\n                    (12,3%), az 1. st\u00e1diumba 20 szem (30,77%), a 2. st\u00e1diumba 18 szem (27,7%), a 3.\n                    st\u00e1diumba 5 szem (7,7%), a 4. st\u00e1diumba pedig 14 szem (21,54%) tartozott.\n                        <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> Jelenleg a <jats:italic>Lagali \u00e9s mtsai<\/jats:italic>\n                    \u00e1ltal kialak\u00edtott, aniridi\u00e1hoz t\u00e1rsult keratopathia st\u00e1diumbeoszt\u00e1si haszn\u00e1lat\u00e1t\n                    javasoljuk, hiszen a st\u00e1diumbesorol\u00e1shoz sz\u00fcks\u00e9ges vizsg\u00e1lat k\u00f6nnyen\n                    kivitelezhet\u0151, a st\u00e1diumok kell\u0151 r\u00e9szletess\u00e9ggel k\u00f6vetik az \u00e1llapot\n                    el\u0151rehalad\u00e1s\u00e1t, seg\u00edtve a progn\u00f3zis meg\u00edt\u00e9l\u00e9s\u00e9t, a ter\u00e1pi\u00e1s terv fel\u00e1ll\u00edt\u00e1s\u00e1t. A\n                    Lagali szerinti 1. st\u00e1diumban az erek legfeljebb 1 mm-rel l\u00e9pik \u00e1t a limbust, a\n                    2. st\u00e1diumban a centr\u00e1lis 2\u20133 mm szaruh\u00e1rtya-ter\u00fclet erekt\u0151l megk\u00edm\u00e9lt. Amikor\n                    az erek el\u00e9rik a szaruh\u00e1rtya centrum\u00e1t, 3. st\u00e1diumr\u00f3l, majd az \u00e1tl\u00e1tszatlan,\n                    vaskos, egyenetlen cornealis pannus eset\u00e9n 4. st\u00e1diumr\u00f3l besz\u00e9l\u00fcnk. Orv Hetil.\n                    2023; 164(27): 1063\u20131069.<\/jats:p>","DOI":"10.1556\/650.2023.32803","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T15:54:26Z","timestamp":1689004466000},"page":"1063-1069","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Az aniridi\u00e1hoz t\u00e1rsult keratopathia st\u00e1diumbeoszt\u00e1sa"],"prefix":"10.1556","volume":"164","author":[{"given":"Annam\u00e1ria","family":"N\u00e1ray","sequence":"first","affiliation":[{"name":"Dr. Rolf M. 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Am J Ophthalmol. 1979; 87: 497-502.","journal-title":"Am J Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/S1542-0124(12)70130-1","article-title":"Keratopathy in congenital aniridia","volume":"1","author":"3 Mayer","year":"2003","unstructured":"3 Mayer KL, Nordlund ML, Schwartz GS, et al. Keratopathy in congenital aniridia. Ocul Surf. 2003; 1: 74-79.","journal-title":"Ocul Surf"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ajo.2019.11.003","article-title":"Management of congenital aniridia-associated keratopathy: long-term outcomes from a tertiary referral center","volume":"210","author":"4 Yazdanpanah","year":"2020","unstructured":"4 Yazdanpanah G, Bohm KJ, Hassan OM, et al. Management of congenital aniridia-associated keratopathy: long-term outcomes from a tertiary referral center. 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Int Ophthalmol. 2021; 41: 4091-4098.","journal-title":"Int Ophthalmol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jtos.2020.04.014","article-title":"Abnormal neovascular and proliferative conjunctival phenotype in limbal stem cell deficiency is associated with altered microRNA and gene expression modulated by PAX6 mutational status in congenital aniridia","volume":"19","author":"11 Latta","year":"2021","unstructured":"11 Latta L, Ludwig N, Krammes L, et al. Abnormal neovascular and proliferative conjunctival phenotype in limbal stem cell deficiency is associated with altered microRNA and gene expression modulated by PAX6 mutational status in congenital aniridia. Ocul Surf. 2021; 19: 115-127.","journal-title":"Ocul Surf"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/ICO.0000000000002729","article-title":"Outcomes of human leukocyte antigen-matched allogeneic cultivated limbal epithelial transplantation in aniridia-associated keratopathy - a single-center retrospective analysis","volume":"41","author":"12 Behaegel","year":"2022","unstructured":"12 Behaegel J, Tassignon MJ, Lagali N, et al. Outcomes of human leukocyte antigen-matched allogeneic cultivated limbal epithelial transplantation in aniridia-associated keratopathy - a single-center retrospective analysis. Cornea 2022; 41: 69-77.","journal-title":"Cornea"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13 M\u00f3dis L, T\u00f3th E, Berta A. Surgical treatment of ocular surface diseases. [A szemfelsz\u00edn betegs\u00e9geinek seb\u00e9szi kezel\u00e9se.] Orv Hetil. 2009; 150: 1599-1606. [Hungarian]","DOI":"10.1556\/oh.2009.28684"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.exer.2018.10.002","article-title":"Expression of retinoic acid signaling components ADH7 and ALDH1A1 is reduced in aniridia limbal epithelial cells and a siRNA primary cell based aniridia model","volume":"179","author":"14 Latta","year":"2019","unstructured":"14 Latta L, Nordstr\u00f6m K, Stachon T, et al. Expression of retinoic acid signaling components ADH7 and ALDH1A1 is reduced in aniridia limbal epithelial cells and a siRNA primary cell based aniridia model. Exp Eye Res. 2019; 179: 8-17.","journal-title":"Exp Eye Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"108904","DOI":"10.1016\/j.exer.2021.108904","article-title":"Decreased FABP5 and DSG1 protein expression following PAX6 knockdown of differentiated human limbal epithelial cells","volume":"215","author":"15 Katiyar","year":"2022","unstructured":"15 Katiyar P, Stachon T, Fries FN et al. Decreased FABP5 and DSG1 protein expression following PAX6 knockdown of differentiated human limbal epithelial cells. Exp Eye Res. 2022; 215: 108904.","journal-title":"Exp Eye Res"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16 Latta L, Knebel I, Bleil C, et al. Similarities in DSG1 and KRT3 downregulation through retinoic acid treatment and PAX6 knockdown related expression profiles: does PAX6 affect RA signaling in limbal epithelial cells? Biomolecules 2021; 11: 1651.","DOI":"10.3390\/biom11111651"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jtos.2021.06.002","article-title":"Dysfunction of the limbal epithelial stem cell niche in aniridia-associated keratopathy","volume":"21","author":"17 Schl\u00f6tzer-Schrehardt","year":"2021","unstructured":"17 Schl\u00f6tzer-Schrehardt U, Latta L, Gie\u00dfl A, et al. Dysfunction of the limbal epithelial stem cell niche in aniridia-associated keratopathy. 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