{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:16:31Z","timestamp":1785363391689,"version":"3.55.0"},"reference-count":43,"publisher":"Akademiai Kiado Zrt.","issue":"38","license":[{"start":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:00:00Z","timestamp":1695513600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,9,24]]},"abstract":"<jats:p>Az alkoholhaszn\u00e1lati zavar egyik legjelent\u0151sebb sz\u00f6v\u0151dm\u00e9nye az alkoholmegvon\u00e1sos\n                    szindr\u00f3ma, amely olyan \u00f6sszetett neuropszichi\u00e1triai k\u00f3rk\u00e9p, melynek kezel\u00e9se\n                    haz\u00e1nkban els\u0151sorban nem szakspecifikus, m\u00e1sodsorban pszichi\u00e1triai\/addiktol\u00f3giai\n                    fekv\u0151- \u00e9s j\u00e1r\u00f3beteg-ell\u00e1t\u00e1si keretek k\u00f6z\u00f6tt zajlik. Az alkoholmegvon\u00e1sos\n                    szindr\u00f3ma egyr\u00e9szr\u0151l az alkoholhaszn\u00e1lat-zavar s\u00falyoss\u00e1g\u00e1nak egyik legfontosabb\n                    jelz\u0151je, m\u00e1sr\u00e9szr\u0151l olyan s\u00falyos klinikai \u00e1llapotok kialakul\u00e1s\u00e1hoz vezethet,\n                    mint a megvon\u00e1sos konvulz\u00edv rosszull\u00e9t \u00e9s a delirium tremens, melyeknek igen\n                    jelent\u0151s a mortalit\u00e1suk. Ily m\u00f3don az alkoholmegvon\u00e1sos szindr\u00f3ma korai\n                    felismer\u00e9se, megfelel\u0151 nyomon k\u00f6vet\u00e9se \u00e9s az optim\u00e1lis ter\u00e1pia megv\u00e1laszt\u00e1sa\n                    elengedhetetlen. A jelen \u00f6sszefoglal\u00f3 k\u00f6zlem\u00e9ny alapvet\u0151 c\u00e9lj\u00e1t az elm\u00falt k\u00e9t\n                    \u00e9vtized idevonatkoz\u00f3 szakirodalmi adatainak \u00e1ttekint\u00e9se \u00e9s egy korszer\u0171,\n                    egys\u00e9ges diagnosztikus \u00e9s ter\u00e1pi\u00e1s s\u00e9ma kialak\u00edt\u00e1sa k\u00e9pezte. Az\n                    alkoholmegvon\u00e1sos szindr\u00f3ma t\u00fcneteinek felismer\u00e9s\u00e9ben \u00e9s nyomon k\u00f6vet\u00e9s\u00e9ben\n                    kiemelten fontos az Alkohol Megvon\u00e1si Sk\u00e1la alkalmaz\u00e1sa, m\u00edg rizik\u00f3becsl\u00e9s\u00e9ben a\n                    Prediction of Alcohol Withdrawal Severity Scale m\u00e9r\u0151eszk\u00f6z javasolt. A\n                    gy\u00f3gyszeres ter\u00e1pia alapj\u00e1t a benzodiazepinek k\u00e9pezik. A vizsg\u00e1latok t\u00f6bbs\u00e9ge a\n                    diazep\u00e1mot, a kl\u00f3rdiazepoxidot, a lorezap\u00e1mot \u00e9s az oxazep\u00e1mot r\u00e9szes\u00edti\n                    el\u0151nyben elt\u00e9r\u0151 indik\u00e1ci\u00f3val. Az elm\u00falt \u00e9vekben ugyanakkor felmer\u00fclt a nem\n                    benzodiazepin t\u00edpus\u00fa ter\u00e1pia jelent\u0151s\u00e9ge is. A nem benzodiazepin t\u00edpus\u00fa\n                    farmakonok eset\u00e9n a propofol, a fenobarbit\u00e1l, az antiepileptikumok k\u00f6z\u00fcl a\n                    karbamazepin \u00e9s az oxkarbamazepin, m\u00edg az alfa-2-adrenerg-receptor-agonista\n                    szerek k\u00f6z\u00fcl a klonidin \u00e9s a dexmedetomidin hat\u00e1soss\u00e1ga emelend\u0151 ki. Tov\u00e1bb\u00e1\n                    meg\u00e1llap\u00edthat\u00f3, hogy megvon\u00e1sos konvulz\u00edv rosszull\u00e9t \u00e9s delirium tremens\n                    eset\u00e9ben is a benzodiazepin-ter\u00e1pia hat\u00e1soss\u00e1ga az els\u0151dleges. A jelen\n                    \u00f6sszefoglal\u00f3 k\u00f6zlem\u00e9nyben az elm\u00falt k\u00e9t \u00e9vtized szakirodalmi adatainak\n                    \u00e1ttekint\u00e9s\u00e9vel korszer\u0171, egys\u00e9ges diagnosztikus \u00e9s ter\u00e1pi\u00e1s s\u00e9ma kialak\u00edt\u00e1s\u00e1ra\n                    t\u00f6rekedt\u00fcnk , mely egyr\u00e9szr\u0151l el\u0151seg\u00edtheti az alkoholhaszn\u00e1lati zavarral k\u00fczd\u0151\n                    p\u00e1ciensek ell\u00e1t\u00e1si sz\u00ednvonal\u00e1nak n\u00f6vel\u00e9s\u00e9t, tov\u00e1bb\u00e1 lehet\u0151s\u00e9get teremt tov\u00e1bbi\n                    klinikai vizsg\u00e1latok megszervez\u00e9s\u00e9re. Orv Hetil. 2023; 164(38): 1487\u20131496.<\/jats:p>","DOI":"10.1556\/650.2023.32847","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T13:20:36Z","timestamp":1695648036000},"page":"1487-1496","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":3,"title":["Az alkoholmegvon\u00e1sos szindr\u00f3ma ell\u00e1t\u00e1sa: \u00faj perspekt\u00edv\u00e1k"],"prefix":"10.1556","volume":"164","author":[{"given":"Bettina Kata","family":"K\u00e1d\u00e1r","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pszichi\u00e1triai Klinika, Addiktol\u00f3giai Kutat\u00f3csoport Szeged, Kor\u00e1nyi fasor 8\u201310., 6720 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildik\u00f3 Katalin","family":"Prib\u00e9k","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pszichi\u00e1triai Klinika, Addiktol\u00f3giai Kutat\u00f3csoport Szeged, Kor\u00e1nyi fasor 8\u201310., 6720 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janka","family":"Gajdics","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pszichi\u00e1triai Klinika, Addiktol\u00f3giai Kutat\u00f3csoport Szeged, Kor\u00e1nyi fasor 8\u201310., 6720 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Szemely\u00e1cz","sequence":"additional","affiliation":[{"name":"INDIT K\u00f6zalap\u00edtv\u00e1ny P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"And\u00f3","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pszichi\u00e1triai Klinika, Addiktol\u00f3giai Kutat\u00f3csoport Szeged, Kor\u00e1nyi fasor 8\u201310., 6720 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence Andr\u00e1s","family":"L\u00e1z\u00e1r","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pszichi\u00e1triai Klinika, Addiktol\u00f3giai Kutat\u00f3csoport Szeged, Kor\u00e1nyi fasor 8\u201310., 6720 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","unstructured":"1. World Health Organization. Global status report on alcohol and health 2018. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789241565639."},{"key":"ref1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1093\/alcalc\/agp087","article-title":"Analysis of the factors determining survival of alcoholic withdrawal syndrome patients in a general hospital","volume":"45","author":"Monte","year":"2010","unstructured":"2. Monte R, Rabu\u00f1al R, Casariego E, et al. Analysis of the factors determining survival of alcoholic withdrawal syndrome patients in a general hospital. Alcohol Alcohol. 2010; 45: 151-158.","journal-title":"Alcohol Alcohol"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Suchyta MR, Beck CJ, Key CW, et al. Substance dependence and psychiatric disorders are related to outcomes in a mixed ICU population. Intensive Care Med. 2008; 34: 2264-2267. Erratum: Intensive Care Med. 2009; 35: 390.","DOI":"10.1007\/s00134-008-1263-9"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jemermed.2005.09.012","article-title":"Alcohol-related seizures","volume":"31","author":"Rathlev","year":"2006","unstructured":"4. Rathlev NK, Ulrich AS, Delanty N, et al. Alcohol-related seizures. J Emerg Med. 2006; 31: 157-163.","journal-title":"J Emerg Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1056\/NEJMra1407298","article-title":"Recognition and management of withdrawal delirium (delirium tremens)","volume":"371","author":"Schuckit","year":"2014","unstructured":"5. Schuckit MA. Recognition and management of withdrawal delirium (delirium tremens). N Engl J Med. 2014; 371: 2109-2113.","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Christoffersen S. Death from seizures induced by chronic alcohol abuse - does it exist? Seizure 2007; 16: 379-383.","DOI":"10.1016\/j.seizure.2007.02.013"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.alcohol.2014.01.004","article-title":"The \"Prediction of Alcohol Withdrawal Severity Scale\" (PAWSS): systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome","volume":"48","author":"Maldonado","year":"2014","unstructured":"7. Maldonado JR, Sher Y, Ashouri JF, et al. The \"Prediction of Alcohol Withdrawal Severity Scale\" (PAWSS): systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome. Alcohol 2014; 48: 375-390.","journal-title":"Alcohol"},{"key":"ref7","unstructured":"8. Ministry of Health, College of Psychiatrists. Alcohol disease 2006. Hungarian Protocol. [Pszichi\u00e1triai Szakmai Koll\u00e9gium. Az Eg\u00e9szs\u00e9g\u00fcgyi Miniszt\u00e9rium szakmai protokollja - Alkoholbetegs\u00e9g 2006.] Available from: https:\/\/kollegium.aeek.hu\/Iranyelvek\/Index. [Hungarian]."},{"key":"ref8","unstructured":"9. National Collaborating Centre for Mental Health (UK). Alcohol-use disorders: The NICE Guideline on Diagnosis, Assessment and Management of Harmful Drinking and Alcohol Dependence. British Psychological Society, Leicester, 2011."},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Swain S, Krause T, Laramee P, et al. Diagnosis and clinical management of alcohol related physical complications: summary of NICE guidance. BMJ 2010; 340: c2942.","DOI":"10.1136\/bmj.c2942"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1111\/add.15647","article-title":"Clinical management of the alcohol withdrawal syndrome","volume":"117","author":"Day","year":"2021","unstructured":"11. Day E, Daly C. Clinical management of the alcohol withdrawal syndrome. Addiction 2021; 117: 804-814.","journal-title":"Addiction"},{"key":"ref11","unstructured":"12. Littleton J. Neurochemical mechanisms underlying alcohol withdrawal. Alcohol Health Res World 1998; 22: 13-24."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1001\/archpsyc.63.9.957","article-title":"Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment","volume":"63","author":"Krystal","year":"2006","unstructured":"13. Krystal JH, Staley J, Mason G, et al. Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. Arch Gen Psychiatry 2006; 63: 957-968.","journal-title":"Arch Gen Psychiatry"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00213-009-1562-z","article-title":"The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress","volume":"205","author":"Kumar","year":"2009","unstructured":"14. Kumar S, Porcu P, Werner DF, et al. The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology (Berl). 2009; 205: 529-564.","journal-title":"Psychopharmacology (Berl)"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"12700","DOI":"10.1523\/JNEUROSCI.3371-07.2007","article-title":"Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement","volume":"27","author":"Volkow","year":"2007","unstructured":"15. Volkow ND, Wang GJ, Telang F, et al. Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. J Neurosci. 2007; 27: 12700-12706.","journal-title":"J Neurosci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1111\/j.1530-0277.2002.tb02637.x","article-title":"Increased ethanol excitation of dopaminergic neurons of the ventral tegmental area after chronic ethanol treatment","volume":"26","author":"Brodie","year":"2002","unstructured":"16. Brodie MS. Increased ethanol excitation of dopaminergic neurons of the ventral tegmental area after chronic ethanol treatment. Alcohol Clin Exp Res. 2002; 26: 1024-1030.","journal-title":"Alcohol Clin Exp Res"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Becker HC. Kindling in alcohol withdrawal. Alcohol Health Res World 1998; 22: 25-33.","DOI":"10.1093\/alcalc\/33.5.457"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1530-0277.2001.tb02231.x","article-title":"Mice that lack corticotropin-releasing factor (CRF) receptors type 1 show a blunted ACTH response to acute alcohol despite up-regulated constitutive hypothalamic CRF gene expression","volume":"25","author":"Lee","year":"2001","unstructured":"18. Lee S, Smith GW, Vale W, et al. Mice that lack corticotropin-releasing factor (CRF) receptors type 1 show a blunted ACTH response to acute alcohol despite up-regulated constitutive hypothalamic CRF gene expression. Alcohol Clin Exp Res. 2001; 25: 427-433.","journal-title":"Alcohol Clin Exp Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.ccc.2017.03.012","article-title":"Novel algorithms for the prophylaxis and management of alcohol withdrawal syndromes - beyond benzodiazepines","volume":"33","author":"Maldonado","year":"2017","unstructured":"19. Maldonado JR. Novel algorithms for the prophylaxis and management of alcohol withdrawal syndromes - beyond benzodiazepines. Crit Care Clin. 2017; 33: 559-599.","journal-title":"Crit Care Clin"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1016\/S0140-6736(97)04572-8","article-title":"The alcohol withdrawal syndrome","volume":"349","author":"Hall","year":"1997","unstructured":"20. Hall W, Zador D. The alcohol withdrawal syndrome. Lancet 1997; 349: 1897-1900.","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1093\/alcalc\/agm154","article-title":"Dose-response relation between volume of drinking and alcohol-related diseases in male general hospital inpatients","volume":"43","author":"Lau","year":"2008","unstructured":"21. Lau K, Freyer-Adam J, Coder B, et al. Dose-response relation between volume of drinking and alcohol-related diseases in male general hospital inpatients. Alcohol Alcohol. 2008; 43: 34-38.","journal-title":"Alcohol Alcohol"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22. Wood E, Albarqouni L, Tkachuk S, et al. Will this hospitalized patient develop severe alcohol withdrawal syndrome? The rational clinical examination systematic review. JAMA 2018; 320: 825-833. Erratum: JAMA 2019; 322: 369.","DOI":"10.1001\/jama.2018.10574"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1111\/acer.12529","article-title":"Predictors of severe alcohol withdrawal syndrome: a systematic review and meta-analysis","volume":"38","author":"Goodson","year":"2014","unstructured":"23. Goodson CM, Clark BJ, Douglas IS. Predictors of severe alcohol withdrawal syndrome: a systematic review and meta-analysis. Alcohol Clin Exp Res. 2014; 38: 2664-2677.","journal-title":"Alcohol Clin Exp Res"},{"key":"ref23","unstructured":"24. Alcohol withdrawal syndrome: how to predict, prevent, diagnose and treat it. Prescrire Int. 2007; 16: 24-31."},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. L\u00e1z\u00e1r BA, Prib\u00e9k IK, Kov\u00e1cs Cs, et al. The first step towards a unified approach: validation of the Hungarian version of the Clinical Institute Withdrawal Assessment of Alcohol, Revised in Hungarian general hospital settings. [Els\u0151 l\u00e9p\u00e9s egy egys\u00e9ges szeml\u00e9let fel\u00e9: az Alkohol Megvon\u00e1si Sk\u00e1la bevezet\u00e9se a hazai betegell\u00e1t\u00e1si gyakorlatba.] Orv Hetil. 2019; 160: 1184-1192. [Hungarian].","DOI":"10.1556\/650.2019.31424"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1097\/00004714-198111000-00006","article-title":"Assessment and effectiveness of supportive care","volume":"1","author":"Shaw","year":"1981","unstructured":"26. Shaw JM, Kolesar GS, Sellers EM, et al. Development of optimal treatment tactics for alcohol withdrawal. I. Assessment and effectiveness of supportive care. J Clin Psychopharmacol. 1981; 1: 382-389.","journal-title":"J Clin Psychopharmacol"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Prib\u00e9k IK, K\u00e1d\u00e1r BK, And\u00f3 B, et al. Detailed psychometric evaluation of the Clinical Institute Withdrawal Assessment of Alcohol, Revised: recommendation of a brief version. Abstracts of the ECNP Congress, Vienna, 2022.","DOI":"10.1016\/j.nsa.2022.100116"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1111\/j.1360-0443.1989.tb00737.x","article-title":"Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar)","volume":"84","author":"Sullivan","year":"1989","unstructured":"28. Sullivan JT, Sykora K, Schneiderman J, et al. Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict. 1989; 84: 1353-1357.","journal-title":"Br J Addict"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"108536","DOI":"10.1016\/j.drugalcdep.2021.108536","article-title":"Evaluation of the course and treatment of alcohol withdrawal syndrome with the Clinical Institute Withdrawal Assessment for Alcohol - Revised: a systematic review-based meta-analysis","volume":"220","author":"Prib\u00e9k","year":"2021","unstructured":"29. Prib\u00e9k IK, Kov\u00e1cs I, K\u00e1d\u00e1r BK, et al. Evaluation of the course and treatment of alcohol withdrawal syndrome with the Clinical Institute Withdrawal Assessment for Alcohol - Revised: a systematic review-based meta-analysis. Drug Alcohol Depend. 2021; 220: 108536.","journal-title":"Drug Alcohol Depend"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/alcalc\/agv043","article-title":"Prospective validation study of the Prediction of Alcohol Withdrawal Severity Scale (PAWSS) in medically ill inpatients: a new scale for the prediction of complicated alcohol withdrawal syndrome","volume":"50","author":"Maldonado","year":"2015","unstructured":"30. Maldonado JR, Sher Y, Das S, et al. Prospective validation study of the Prediction of Alcohol Withdrawal Severity Scale (PAWSS) in medically ill inpatients: a new scale for the prediction of complicated alcohol withdrawal syndrome. Alcohol Alcohol. 2015; 50: 509-518.","journal-title":"Alcohol Alcohol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1164\/rccm.2107138","article-title":"The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients","volume":"166","author":"Sessler","year":"2002","unstructured":"31. Sessler CN, Gosnell MS, Grap MJ, et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med. 2002; 166: 1338-1344.","journal-title":"Am J Respir Crit Care Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1136\/emermed-2011-200509","article-title":"Symptom-triggered benzodiazepine therapy for alcohol withdrawal syndrome in the emergency department: a comparison with the standard fixed dose benzodiazepine regimen","volume":"29","author":"Cassidy","year":"2011","unstructured":"32. Cassidy EM, O'Sullivan I, Bradshaw P, et al. Symptom-triggered benzodiazepine therapy for alcohol withdrawal syndrome in the emergency department: a comparison with the standard fixed dose benzodiazepine regimen. Emerg Med J. 2011; 29: 802-804.","journal-title":"Emerg Med J"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"33. Amato L, Minozzi S, Davoli M. Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome. Cochrane Database Syst Rev. 2011; 6: CD008537.","DOI":"10.1002\/14651858.CD008537.pub2"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"34. Minozzi S, Amato L, Vecchi S, et al. Anticonvulsants for alcohol withdrawal. Cochrane Database Syst Rev. 2010; 3: CD005064.","DOI":"10.1002\/14651858.CD005064.pub3"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1097\/00003246-200006000-00014","article-title":"Refractory delirium tremens treated with propofol: a case series","volume":"28","author":"McCowan","year":"2000","unstructured":"35. McCowan C, Marik P. Refractory delirium tremens treated with propofol: a case series. Crit Care Med. 2000; 28: 1781-1784.","journal-title":"Crit Care Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/phar.1726","article-title":"Propofol for treatment of refractory alcohol withdrawal syndrome: a review of the literature","volume":"36","author":"Brotherton","year":"2016","unstructured":"36. Brotherton AL, Hamilton EP, Kloss HG, et al. Propofol for treatment of refractory alcohol withdrawal syndrome: a review of the literature. Pharmacotherapy 2016; 36: 433-442.","journal-title":"Pharmacotherapy"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1176\/ajp.145.12.1501","article-title":"Critical review of liability for benzodiazepine abuse among alcoholics","volume":"145","author":"Ciraulo","year":"1988","unstructured":"37. Ciraulo DA, Sands BF, Shader RI. Critical review of liability for benzodiazepine abuse among alcoholics. Am J Psychiatry 1988; 145: 1501-1506.","journal-title":"Am J Psychiatry"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"38. Billioti de Gage S, B\u00e9gaud B, Bazin F, et al. Benzodiazepine use and risk of dementia: prospective population based study. BMJ 2012; 345: e6231.","DOI":"10.1136\/bmj.e6231"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/add.15510","article-title":"The effectiveness and tolerability of anti-seizure medication in alcohol withdrawal syndrome: a systematic review, meta-analysis and GRADE of the evidence","volume":"117","author":"Lai","year":"2021","unstructured":"39. Lai JY, Kalk N, Roberts E. The effectiveness and tolerability of anti-seizure medication in alcohol withdrawal syndrome: a systematic review, meta-analysis and GRADE of the evidence. Addiction 2021; 117: 5-18.","journal-title":"Addiction"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"40. Amato L, Minozzi S, Vecchi S, et al. Benzodiazepines for alcohol withdrawal. Cochrane Database Syst Rev. 2010; 3: CD005063.","DOI":"10.1002\/14651858.CD005063.pub3"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1213\/01.ANE.0000099719.97261.DA","article-title":"Intrathecal and oral clonidine as prophylaxis for postoperative alcohol withdrawal syndrome: a randomized double-blinded study","volume":"98","author":"Dobrydnjov","year":"2004","unstructured":"41. Dobrydnjov I, Axelsson K, Berggren L, et al. Intrathecal and oral clonidine as prophylaxis for postoperative alcohol withdrawal syndrome: a randomized double-blinded study. Anesth Analg. 2004; 98: 738-744.","journal-title":"Anesth Analg"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1345\/aph.1K678","article-title":"Dexmedetomidine infusion as adjunctive therapy to benzodiazepines for acute alcohol withdrawal","volume":"42","author":"Darrouj","year":"2008","unstructured":"42. Darrouj J, Puri N, Prince E, et al. Dexmedetomidine infusion as adjunctive therapy to benzodiazepines for acute alcohol withdrawal. Ann Pharmacother. 2008; 42: 1703-1705.","journal-title":"Ann Pharmacother"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s11940-007-0024-3","article-title":"The psychiatric management of patients with alcohol dependence","volume":"9","author":"JI","year":"2007","unstructured":"43. Ritvo JI, Park C. The psychiatric management of patients with alcohol dependence. 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