{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:55:15Z","timestamp":1762325715076},"reference-count":70,"publisher":"Akademiai Kiado Zrt.","issue":"41","license":[{"start":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T00:00:00Z","timestamp":1697328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,10,15]]},"abstract":"<jats:p>A n\u00f6veked\u00e9si hormon\u2013inzulinszer\u0171 n\u00f6veked\u00e9si faktor-1 (GH\u2013IGF-1-) tengely jelent\u0151s\n                    szerepet t\u00f6lt be a cardiovascularis rendszer fiziol\u00f3gi\u00e1s m\u0171k\u00f6d\u00e9s\u00e9nek\n                    fenntart\u00e1s\u00e1ban. Az elm\u00falt \u00e9vtizedek kutat\u00e1si eredm\u00e9nyei alapj\u00e1n a\n                    GH\u2013IGF-1-tengely r\u00e9szt vesz a perif\u00e9ri\u00e1s ellen\u00e1ll\u00e1s szab\u00e1lyoz\u00e1s\u00e1ban, \u00e9s\n                    hozz\u00e1j\u00e1rul a norm\u00e1lis sz\u00edvizomt\u00f6meg \u00e9s balkamra-funkci\u00f3 megtart\u00e1s\u00e1hoz. A\n                    GH\u2013IGF-1-tengely \u00e9rfalprotekt\u00edv funkci\u00f3i az atherosclerosis ellen\u00e9ben hatnak.\n                    Ellent\u00e9tben a gyermekkori GH-hi\u00e1nnyal, amelyn\u00e9l a betegs\u00e9g egy\u00e9rtelm\u0171 biol\u00f3giai\n                    k\u00f6vetkezm\u00e9nye a gyermek n\u00f6veked\u00e9sbeli visszamarad\u00e1sa, a feln\u0151ttkori\n                    n\u00f6veked\u00e9sihormon-hi\u00e1nynak (adult growth hormone deficiency \u2013 AGHD) nincsenek\n                    specifikus t\u00fcnetei. Az AGHD klinikai megjelen\u00e9s\u00e9t a cardiovascularis\n                    rizik\u00f3t\u00e9nyez\u0151k halmoz\u00f3d\u00e1sa jellemzi, amely miatt a klinikai k\u00e9p legink\u00e1bb a\n                    metabolicus szindr\u00f3m\u00e1hoz hasonl\u00edthat\u00f3. \u00dajabb kutat\u00e1sok AGHD eset\u00e9ben a\n                    tradicion\u00e1lis rizik\u00f3t\u00e9nyez\u0151k mellett kr\u00f3nikus kisfok\u00fa gyullad\u00e1s, prothromboticus\n                    \u00e1llapot \u00e9s oxidat\u00edv stressz jelenl\u00e9t\u00e9re is r\u00e1mutattak, amelyek szint\u00e9n\n                    k\u00f6zrej\u00e1tszhatnak a fokozott kardiometabolikus rizik\u00f3 kialakul\u00e1s\u00e1ban. A tart\u00f3s\n                    GH-szubsztit\u00faci\u00f3 AGHD-betegek eset\u00e9ben a lipidprofil jelent\u0151s javul\u00e1s\u00e1t\n                    eredm\u00e9nyezi, \u00e9s kedvez\u0151 hat\u00e1ssal van a test\u00f6sszet\u00e9telre, a sz\u00edvizomt\u00f6megre, az\n                    endothelfunkci\u00f3ra, valamint az \u00fajonnan felismert, nem tradicion\u00e1lis\n                    rizik\u00f3t\u00e9nyez\u0151kre is. A betegs\u00e9ggel \u00f6sszef\u00fcgg\u0151 fokozott mortalit\u00e1s a mai felfog\u00e1s\n                    szerint multikauz\u00e1lis, \u00e9s nem vezethet\u0151 vissza csup\u00e1n a GH hi\u00e1ny\u00e1ra. A\n                    kedvez\u0151tlen mortalit\u00e1s\u00e9rt az etiol\u00f3gia, az alkalmazott kezel\u00e9s \u00e9s az egy\u00e9b\n                    hypophysishormon-hi\u00e1nyok kezel\u00e9s\u00e9nek neh\u00e9zs\u00e9ge is felel\u0151s lehet. Mindazon\u00e1ltal\n                    hypopituitarismus eset\u00e9ben optim\u00e1lis, a GH-p\u00f3tl\u00e1st is mag\u00e1ban foglal\u00f3\n                    hormonszubsztit\u00faci\u00f3val az \u00e1tlagpopul\u00e1ci\u00f3\u00e9hoz k\u00f6zel\u00edt\u0151 mortalit\u00e1s \u00e9rhet\u0151 el. Orv\n                    Hetil. 2023; 164(41): 1616\u20131627.<\/jats:p>","DOI":"10.1556\/650.2023.32890","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T08:33:22Z","timestamp":1697704402000},"page":"1616-1627","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["A feln\u0151ttkori n\u00f6veked\u00e9sihormon-hi\u00e1ny sz\u00edv- \u00e9s \u00e9rrendszeri sz\u00f6v\u0151dm\u00e9nyei"],"prefix":"10.1556","volume":"164","author":[{"given":"Bal\u00e1zs","family":"Ratku","sequence":"first","affiliation":[{"name":"Debreceni Egyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, S\u00fcrg\u0151ss\u00e9gi \u00e9s Oxiol\u00f3giai Tansz\u00e9k Ny\u00edregyh\u00e1za Magyarorsz\u00e1g"},{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, S\u00fcrg\u0151ss\u00e9gi Orvostani Tansz\u00e9k Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"},{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Eg\u00e9szs\u00e9gtudom\u00e1nyok Doktori Iskola Debrecen Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Sebesty\u00e9n","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, S\u00fcrg\u0151ss\u00e9gi Orvostani Tansz\u00e9k Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"},{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Eg\u00e9szs\u00e9gtudom\u00e1nyok Doktori Iskola Debrecen Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Szelesn\u00e9 \u00c1roksz\u00e1ll\u00e1si","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, S\u00fcrg\u0151ss\u00e9gi \u00e9s Oxiol\u00f3giai Tansz\u00e9k Ny\u00edregyh\u00e1za Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annam\u00e1ria","family":"Erdei","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, Klinikai K\u00f6zpont, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Endokrinol\u00f3giai R\u00e9szleg Debrecen Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Berta","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, Klinikai K\u00f6zpont, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Endokrinol\u00f3giai R\u00e9szleg Debrecen Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, S\u00fcrg\u0151ss\u00e9gi Orvostani Tansz\u00e9k Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Bodor","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, Klinikai K\u00f6zpont, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Endokrinol\u00f3giai R\u00e9szleg Debrecen Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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