{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T01:15:53Z","timestamp":1748049353004},"reference-count":21,"publisher":"Akademiai Kiado Zrt.","issue":"47","license":[{"start":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T00:00:00Z","timestamp":1700956800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,11,26]]},"abstract":"<jats:p>A D<jats:sub>3<\/jats:sub>-vitamin-kezel\u00e9s j\u00f3t\u00e9kony hat\u00e1sai ismertek, mell\u00e9khat\u00e1sai\n                    dokument\u00e1ltak. Az esetbemutat\u00e1s kapcs\u00e1n k\u00edv\u00e1njuk ismertetni a t\u00falz\u00f3\n                    D-vitamin-p\u00f3tl\u00e1s vesz\u00e9lyeit, illetve a h\u00e9tk\u00f6znapi orvosi gyakorlatban tapasztalt\n                    hi\u00e1nyoss\u00e1gokra szeretn\u00e9nk ir\u00e1ny\u00edtani a figyelmet. T\u00e1rgyaljuk a\n                    D-vitamin-intoxik\u00e1ci\u00f3 k\u00f3rism\u00e9j\u00e9nek megalkot\u00e1s\u00e1hoz, az elk\u00fcl\u00f6n\u00edt\u0151 k\u00f3rism\u00e9hez\n                    sz\u00fcks\u00e9ges vizsg\u00e1latokat, valamint bemutatjuk a lehets\u00e9ges kezel\u00e9si strat\u00e9gi\u00e1kat.\n                    Az 57 \u00e9ves n\u0151beteget n\u00e9h\u00e1ny napja tart\u00f3 h\u00e1nyinger, h\u00e1ny\u00e1s, hasmen\u00e9s, \u00e1ltal\u00e1nos\n                    gyenges\u00e9g t\u00fcnetei miatt kezelte m\u00e1s int\u00e9zm\u00e9ny 2020 november\u00e9ben. Felv\u00e9telekor a\n                    laborvizsg\u00e1latokban \u00faj kelet\u0171 vesek\u00e1rosod\u00e1s (eGFR 38 ml\/p\/1,73 m<jats:sup>2<\/jats:sup>)\n                    igazol\u00f3dott, a kalcium-anyagcsere ellen\u0151rz\u00e9se nem t\u00f6rt\u00e9nt meg. Nefrol\u00f3giai\n                    konz\u00edliuma akut tubulusk\u00e1rosod\u00e1st felt\u00e9telezett, ez\u00e9rt vesebiopszia elv\u00e9gz\u00e9s\u00e9re\n                    ker\u00fclt sor, immunszerol\u00f3giai vizsg\u00e1latok \u00e9s a sz\u00e9rumfeh\u00e9rje\n                    elektrofor\u00e9zis-vizsg\u00e1lata t\u00f6rt\u00e9nt. A konzervat\u00edv kezel\u00e9s ellen\u00e9re a vesefunkci\u00f3\n                    romlott (eGFR 32 ml\/p\/1,73 m<jats:sup>2<\/jats:sup>). Folyamatban l\u00e9v\u0151 vizsg\u00e1lati\n                    eredm\u00e9nyekkel \u00e9rkezett a beteg klinik\u00e1nkra 2020 december\u00e9ben. Az \u00e9rkez\u00e9sekor\n                    v\u00e9gzett laborvizsg\u00e1latokban s\u00falyos hypercalcaemia igazol\u00f3dott (tCa 3,22 mmol\/l,\n                    iCa 1,74 mmol\/l), vesefunkci\u00f3ja stagn\u00e1lt (eGFR 33 ml\/p\/1,73 m<jats:sup>2<\/jats:sup>).\n                    Intakt parathormonszintje a norm\u00e1ltartom\u00e1ny alatt volt (0,54 pmol\/l),\n                    25-OH-D-vitamin-szintje extr\u00e9m magasnak bizonyult (1106,2 nmol\/l). A beteg ekkor\n                    elismerte, hogy 2020. okt\u00f3berben \u201emegad\u00f3zis\u00fa\u201d parenteralis\n                    D<jats:sub>3<\/jats:sub>-vitamin-k\u00far\u00e1ban r\u00e9szes\u00fclt egy harmadik int\u00e9zm\u00e9nyben; a kezel\u00e9s\n                    pontos d\u00f3zis\u00e1t nem tudta megnevezni, a kezel\u00e9st alkalmaz\u00f3 int\u00e9zm\u00e9ny kil\u00e9t\u00e9t nem\n                    k\u00edv\u00e1nta felfedni. D<jats:sub>3<\/jats:sub>-vitamin-intoxik\u00e1ci\u00f3t v\u00e9lem\u00e9nyezt\u00fcnk. Iv.\n                    parenteralisan krisztalloid, furoszemid, kalcitonin ad\u00e1s\u00e1ban r\u00e9szes\u00fclt, melyek\n                    hat\u00e1s\u00e1ra sz\u00e9rumkalciumszintje normaliz\u00e1l\u00f3dott (2,52 mmol\/l), vesefunkci\u00f3i\n                    javultak (eGFR 54 ml\/p\/1,73 m<jats:sup>2<\/jats:sup>). Sz\u00e9rum-tCa- \u00e9s D-vitamin-szintje\n                    2021. febru\u00e1rra normaliz\u00e1l\u00f3dott, vesefunkci\u00f3i javultak (tCa 2,54 mmol\/l,\n                    25-OH-D-vitamin 125,0 ng\/ml, eGFR 72 ml\/p\/1,73 m<jats:sup>2<\/jats:sup>). A vesebiopszia\n                    akut tubularis necrosis jelenl\u00e9t\u00e9t igazolta. Granulom\u00e1s gyullad\u00e1s, myeloma\n                    multiplex nem igazol\u00f3dott. A D-vitamin-intoxik\u00e1ci\u00f3 t\u00fcnetei nem specifikusak \u00e9s\n                    v\u00e1ltozatosak, differenci\u00e1ldiagnosztikai kih\u00edv\u00e1st jelent egy-egy eset. Orv Hetil.\n                    2023; 164(47): 1871\u20131876.<\/jats:p>","DOI":"10.1556\/650.2023.32914","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T14:07:46Z","timestamp":1701094066000},"page":"1871-1876","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["A vesek\u00e1rosod\u00e1s ritka oka: D3-vitamin-intoxik\u00e1ci\u00f3"],"prefix":"10.1556","volume":"164","author":[{"given":"D\u00e1vid","family":"Hutkai","sequence":"first","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Belgy\u00f3gy\u00e1szati Klinika Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Bodor","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Belgy\u00f3gy\u00e1szati Klinika Debrecen, Nagyerdei krt. 98., 4032 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","unstructured":"1 Thatcher L. 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