{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:22:12Z","timestamp":1723249332400},"reference-count":38,"publisher":"Akademiai Kiado Zrt.","issue":"50","license":[{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,12,17]]},"abstract":"<jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> A terhess\u00e9gi intrahepaticus cholestasis a v\u00e1rand\u00f3ss\u00e1g\n                    alatt el\u0151fordul\u00f3 leggyakoribb m\u00e1jbetegs\u00e9g, amelyre viszket\u00e9s, a m\u00e1jenzimek \u00e9s a\n                    sz\u00e9rum-\u00f6sszepesavszint emelked\u00e9se jellemz\u0151. A betegs\u00e9g jelent\u0151sen emeli az\n                    \u00fajsz\u00fcl\u00f6ttkori morbidit\u00e1st \u00e9s mortalit\u00e1st. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> C\u00e9lunk a\n                    terhess\u00e9gi cholestasis \u00e9lvesz\u00fcl\u00e9sekhez viszony\u00edtott hazai gyakoris\u00e1g\u00e1nak \u00e9s a\n                    terhess\u00e9g alatt kialakul\u00f3 k\u00f3rk\u00e9pekkel mutatott \u00f6sszef\u00fcg\u00e9s\u00e9nek elemz\u00e9se volt.\n                        <jats:italic>M\u00f3dszerek:<\/jats:italic> Szakambulanci\u00e1nkon 2019. janu\u00e1r 1. \u00e9s 2021.\n                    j\u00fanius 30. k\u00f6z\u00f6tt olyan v\u00e1rand\u00f3sokn\u00e1l vizsg\u00e1ltuk az intrahepaticus terhess\u00e9gi\n                    cholestasis el\u0151fordul\u00e1s\u00e1t, akik viszket\u00e9s miatt jelentkeztek vizsg\u00e1latra, \u00e9s a\n                    sz\u00fcl\u00e9s\u00fck oszt\u00e1lyunkon t\u00f6rt\u00e9nt. A betegs\u00e9gek diagn\u00f3zis\u00e1t a nemzetk\u00f6zi defin\u00edci\u00f3k\n                    alapj\u00e1n \u00e1ll\u00edtottuk fel. Az epepang\u00e1s \u00e9s a terhess\u00e9gi k\u00f3rk\u00e9pek kapcsolat\u00e1t\n                    becs\u00fclt r\u00e9szv\u00e9teli val\u00f3sz\u00edn\u0171s\u00e9g szerinti p\u00e1ros\u00edt\u00e1ssal <jats:italic>(propensity score\n                        matching)<\/jats:italic> elemezt\u00fck. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A vizsg\u00e1lt\n                    id\u0151szakban oszt\u00e1lyunkon \u00f6sszesen 5827 v\u00e1rand\u00f3s sz\u00fclt; k\u00f6z\u00fcl\u00fck 105 (1,8%) esetben\n                    \u00e1llap\u00edtottunk meg a terhess\u00e9g alatt kialakult viszket\u00e9st, amelyet 88 (1,5%)\n                    esetben a m\u00e1jenzimek emelked\u00e9se, 17 (0,3%) esetben pedig ezeken k\u00edv\u00fcl a sz\u00e9rum\n                    \u00f6sszepesavszintj\u00e9nek emelked\u00e9se is k\u00eds\u00e9rt. A terhess\u00e9gi viszket\u00e9s \u00e9s a\n                    terhess\u00e9gi epepang\u00e1s nem jelzett kapcsolatot az anyai \u00e9letkorral, a kor\u00e1bbi\n                    terhess\u00e9gek \u00e9s sz\u00fcl\u00e9sek sz\u00e1m\u00e1val, \u00e9s nem mutatott szezonalit\u00e1st. A betegs\u00e9ggel\n                    kezelt v\u00e1rand\u00f3sokban szignifik\u00e1nsan nagyobb volt a gestati\u00f3s diabetes\n                    gyakoris\u00e1ga (16,2%), mint a teljes sz\u00fcl\u00e9szeti popul\u00e1ci\u00f3ban (8,3%), valamint az\n                    illesztett kontrollcsoportban (6,7%) (p&lt;0,05, illetve p&lt;0,05). A\n                    terhess\u00e9gi epepang\u00e1s nem mutatott kapcsolatot a terhess\u00e9gi magas v\u00e9rnyom\u00e1s\n                    k\u00fcl\u00f6nb\u00f6z\u0151 form\u00e1ival, a m\u00e9hen bel\u00fcli n\u00f6veked\u00e9s elmarad\u00e1s\u00e1val \u00e9s a macrosomi\u00e1val\n                    sem. <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> Adataink alapj\u00e1n a terhess\u00e9gi epepang\u00e1s\n                    hazai prevalenci\u00e1ja megegyezik az eur\u00f3pai gyakoris\u00e1ggal, \u00e9s szoros kapcsolatot\n                    mutat a gestati\u00f3s cukorbetegs\u00e9ggel. Orv Hetil. 2023; 164(50): 1985\u20131992.<\/jats:p>","DOI":"10.1556\/650.2023.32933","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:38:00Z","timestamp":1703119080000},"page":"1985-1992","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A terhess\u00e9gi intrahepaticus cholestasis gyakoris\u00e1ga \u00e9s sz\u00f6v\u0151d\u00e9se gestati\u00f3s cukorbetegs\u00e9ggel egy hazai v\u00e1rosi lakoss\u00e1gban"],"prefix":"10.1556","volume":"164","author":[{"given":"Magdolna","family":"Ozsv\u00e1ri-Vid\u00e1kovich","sequence":"first","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly 1115 Budapest, T\u00e9t\u00e9nyi \u00fat 12\u201316. Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos Tibor","family":"Fekete","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Bioinformatikai Tansz\u00e9k Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szilvia","family":"Szakony","sequence":"additional","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, K\u00f6zponti Laborat\u00f3rium Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Theisz","sequence":"additional","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Gasztroenterol\u00f3giai Profil Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Gasparics","sequence":"additional","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Anyagcsere K\u00f6zpont Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"K\u00f6rmendy","sequence":"additional","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, B\u0151rgy\u00f3gy\u00e1szati Szakrendel\u00e9s Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"\u00c1d\u00e1m","sequence":"additional","affiliation":[{"name":"TritonLife R\u00f3bert Mag\u00e1nk\u00f3rh\u00e1z, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Sziller","sequence":"additional","affiliation":[{"name":"D\u00e9l-budai Centrumk\u00f3rh\u00e1z \u2013 Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly 1115 Budapest, T\u00e9t\u00e9nyi \u00fat 12\u201316. 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Intrahepatic cholestasis of pregnancy: a French prospective study. Hepatology 1997; 26: 358-364.","journal-title":"Hepatology"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6 Perez MJ, Macias RI, Marin JJ. Maternal cholestasis induces placental oxidative stress and apoptosis. Protective effect of ursodeoxycholic acid. Placenta 2006; 27: 34-41.","DOI":"10.1016\/j.placenta.2004.10.020"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/S0168-8278(00)80139-7","article-title":"Intrahepatic cholestasis of pregnancy: molecular pathogenesis diagnosis and management","volume":"33","author":"7 Lammert","year":"2000","unstructured":"7 Lammert F, Marschall HU, Glantz A, et al. Intrahepatic cholestasis of pregnancy: molecular pathogenesis diagnosis and management. J Hepatol. 2000; 33: 1012-1021.","journal-title":"J Hepatol"},{"key":"ref7","unstructured":"8 Ovadia C, Seed PT, Sklavounos A, et al. 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BJOG 2002; 109: 282-288.","journal-title":"BJOG"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/1471-0528.12174","article-title":"Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study","volume":"120","author":"32 Wikstro\u0308m Shemer","year":"2013","unstructured":"32 Wikstro\u0308m Shemer E, Marschall HU, Ludvigsson JF, et al. Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study. BJOG 2013; 120: 717-723.","journal-title":"BJOG"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"33 Majewska A, Godek B, Bomba-Opon D, et al. Association between intrahepatic cholestasis in pregnancy and gestational diabetes mellitus. A retrospective analysis. Ginekol Pol. 2019; 90: 458-463.","DOI":"10.5603\/GP.2019.0079"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/S0168-8278(00)80214-7","article-title":"Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals, in Chile","volume":"32","author":"34 Reyes","year":"2000","unstructured":"34 Reyes H, B\u00e1ez ME, Gonz\u00e1lez MC, et al. Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals, in Chile. J Hepatol. 2000; 32: 542-549.","journal-title":"J Hepatol"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"35 Ozsv\u00e1ri-Vid\u00e1kovich M, Somogyi A, Rosta K. Association between intrahepatic cholestasis of pregnancy and gestational diabetes mellitus. 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