{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:34:33Z","timestamp":1770464073630,"version":"3.49.0"},"reference-count":47,"publisher":"Akademiai Kiado Zrt.","issue":"51","license":[{"start":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T00:00:00Z","timestamp":1703376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,12,24]]},"abstract":"<jats:p>A magzat immunol\u00f3giai felismer\u00e9se a sikeres terhess\u00e9g felt\u00e9tele. Ennek alapj\u00e1t a\n                    decidualiz\u00e1ci\u00f3 teremti meg, melynek r\u00e9v\u00e9n l\u00e9trej\u00f6n az embri\u00f3 befogad\u00e1s\u00e1ra\n                    alkalmas sz\u00f6veti k\u00f6rnyezet. A decidualiz\u00e1ci\u00f3 sor\u00e1n kialakul\u00f3 speci\u00e1lis sz\u00f6vet\n                    endokrin \u00e9s immunol\u00f3giai feladatokat ell\u00e1t\u00f3 \u00f6n\u00e1ll\u00f3 szerv, amely szigor\u00faan\n                    szab\u00e1lyozott kapcsolatot tart fenn az embri\u00f3val, vagyis az embri\u00f3 maga is akt\u00edv\n                    r\u00e9sztvev\u0151je a megterm\u00e9keny\u00fcl\u00e9snek. A terhess\u00e9g immunol\u00f3gi\u00e1j\u00e1nak meg\u00e9rt\u00e9se\n                    szempontj\u00e1b\u00f3l rendk\u00edv\u00fcl fontos, hogy a magzat \u00e9s az anya immunrendszere k\u00f6z\u00f6tti\n                    k\u00f6lcs\u00f6nhat\u00e1s dinamikusan v\u00e1ltozik, vagyis a terhess\u00e9g immunol\u00f3giai st\u00e1diumokkal\n                    jellemezhet\u0151. Napjainkban a terhess\u00e9g kronol\u00f3gi\u00e1j\u00e1t az immunol\u00f3giai \u00f3r\u00e1val\n                    reprezent\u00e1lj\u00e1k (\u201eimmune clock\u201d): e szerint az implant\u00e1ci\u00f3 felt\u00e9tele a kor\u00e1bban\n                    elk\u00e9pzelhetetlennek tartott gyullad\u00e1sos mili\u0151, amelyet a magzati n\u00f6veked\u00e9shez\n                    sz\u00fcks\u00e9ges antiinflammatorikus k\u00f6rnyezet v\u00e1lt fel, \u00e9s amelyet a sz\u00fcl\u00e9s\n                    megindul\u00e1s\u00e1hoz n\u00e9lk\u00fcl\u00f6zhetetlen, \u00fajfent gyullad\u00e1sos immunv\u00e1lasz kialakul\u00e1sa\n                    k\u00f6vet. A terhess\u00e9ghez t\u00f6rt\u00e9n\u0151 alkalmazkod\u00e1s nagy rugalmass\u00e1got ig\u00e9nyel az anyai\n                    immunrendszer r\u00e9sz\u00e9r\u0151l annak \u00e9rdek\u00e9ben, hogy egyidej\u0171leg val\u00f3suljon meg az apai\n                    alloantig\u00e9nekkel szembeni tolerancia, a placenta \u00e9s a magzat optim\u00e1lis fejl\u0151d\u00e9se\n                    \u00e9s a fert\u0151z\u00e9sek\/xenobiotikumok elleni v\u00e9delem. Mindez csak speci\u00e1lis \u00e9s szorosan\n                    egy\u00fcttm\u0171k\u00f6d\u0151 immunmili\u0151 kialak\u00edt\u00e1s\u00e1val \u00e9rhet\u0151 el az anyai\u2013magzati felsz\u00ednen,\n                    ahol a term\u00e9szetes \u00e9s az adapt\u00edv immunrendszer sejtes \u00e9s szol\u00fabilis \u00f6sszetev\u0151i\n                    r\u00e1hangol\u00f3dnak a hormon\u00e1lis mili\u0151re, egy\u00fcttm\u0171k\u00f6dnek a mikrobiommal, \u00e9s megfelel\u0151\n                    v\u00e1laszt adnak a trophoblastok immunmodul\u00e1l\u00f3 hat\u00e1saira. A term\u00e9szetes \u00e9s az\n                    adapt\u00edv folyamatok \u00f6sszehangolts\u00e1g\u00e1nak megv\u00e1ltoz\u00e1sa infertilit\u00e1shoz, a\n                    be\u00e1gyaz\u00f3d\u00e1s zavaraihoz \u00e9s terhess\u00e9gi sz\u00f6v\u0151dm\u00e9nyekhez vezethet, ez\u00e9rt\n                    megismer\u00e9s\u00e9nek diagnosztikus \u00e9s ter\u00e1pi\u00e1s k\u00f6vetkezm\u00e9nyei vannak. Orv Hetil. 2023;\n                    164(51): 2006\u20132015.<\/jats:p>","DOI":"10.1556\/650.2023.32935","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T16:55:37Z","timestamp":1704300937000},"page":"2006-2015","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":4,"title":["Terhess\u00e9g az immunsejtek szemsz\u00f6g\u00e9b\u0151l"],"prefix":"10.1556","volume":"164","author":[{"given":"\u00c9va","family":"P\u00e1llinger","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Genetikai, Sejt- \u00e9s Immunbiol\u00f3giai Int\u00e9zet 1089 Budapest, Nagyv\u00e1rad t\u00e9r 4. Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bence","family":"Nagy","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Genetikai, Sejt- \u00e9s Immunbiol\u00f3giai Int\u00e9zet 1089 Budapest, Nagyv\u00e1rad t\u00e9r 4. 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