{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:47:50Z","timestamp":1785466070012,"version":"3.56.0"},"reference-count":14,"publisher":"Akademiai Kiado Zrt.","issue":"51","license":[{"start":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T00:00:00Z","timestamp":1703376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2023,12,24]]},"abstract":"<jats:p>A gyullad\u00e1sos b\u00e9lbetegs\u00e9ggel (IBD) \u00e9l\u0151 betegekben a colorectalis carcinoma\n                    kialakul\u00e1s\u00e1nak es\u00e9lye az \u00e1tlagpopul\u00e1ci\u00f3ban \u00e9szleltek k\u00e9tszerese. Az invaz\u00edv\n                    daganatokat megel\u0151z\u0151en ezekben a betegekben nagyobb a rizik\u00f3 dysplasia\n                    kialakul\u00e1s\u00e1ra is. Az ut\u00f3bbi \u00e9vekben sz\u00e1mos, IBD-hez t\u00e1rsult, \u00fan.\n                    non-conventionalis dysplasia alt\u00edpust azonos\u00edtottak, melyekr\u0151l a jelenleg is\n                    zajl\u00f3 kutat\u00e1soknak k\u00f6sz\u00f6nhet\u0151en egyre t\u00f6bb inform\u00e1ci\u00f3val rendelkez\u00fcnk. Egy 62\n                    \u00e9ves, 14 \u00e9ve relab\u00e1l\u00f3 colitis ulceros\u00e1val diagnosztiz\u00e1lt \u00e9s kezelt n\u0151beteg\n                    subtotalis colectomi\u00e1s prepar\u00e1tum\u00e1ban colitis ulcerosa mellett a sigmab\u00e9lben\n                    invaz\u00edv adenocarcinom\u00e1t azonos\u00edtottunk mucinosus ter\u00fcletekkel. A daganat\n                    k\u00f6zvetlen k\u00f6rnyezet\u00e9ben kehelysejtszeg\u00e9ny, valamint hypermucinosus IBD-hez\n                    t\u00e1rsult, non-conventionalis dysplasi\u00e1t \u00e9szlelt\u00fcnk, az ut\u00f3bbinak intestinalis \u00e9s\n                    foveolaris alt\u00edpusa is elk\u00fcl\u00f6n\u00edthet\u0151 volt. A felhalmoz\u00f3d\u00f3 ismeretek t\u00fckr\u00e9ben az\n                    IBD-hez t\u00e1rsult, non-conventionalis dysplasi\u00e1k ismerete t\u00f6bb szempontb\u00f3l is\n                    fontos lehet a diagnosztik\u00e1ban \u00e9s a klinikai ell\u00e1t\u00e1sban, ugyanis ezek a laesi\u00f3k\n                    makroszk\u00f3posan laposak vagy l\u00e1thatatlanok lehetnek, megnehez\u00edtve a dysplasia\n                    endoszk\u00f3pos sz\u0171r\u00e9s\u00e9t. Ismeret\u00fck a patol\u00f3gus sz\u00e1m\u00e1ra kiemelten fontos, hiszen a\n                    reakt\u00edv \u00e9s reparat\u00edv folyamatokt\u00f3l val\u00f3 elk\u00fcl\u00f6n\u00edt\u00e9s\u00fck sokszor nagy kih\u00edv\u00e1st\n                    jelent. Tov\u00e1bb\u00e1, a hagyom\u00e1nyos t\u00edpusokn\u00e1l gyakrabban t\u00e1rsultak \u2019high-grade\u2019\n                    dysplasi\u00e1val, valamint colorectalis carcinom\u00e1val. Molekul\u00e1ris h\u00e1tter\u00fcket\n                    tekintve, sokkal gyakrabban \u00e9szlelhet\u0151 benn\u00fck aneuploidia. Mindezen ismeretek a\n                    hagyom\u00e1nyos neoplasi\u00e1khoz k\u00e9pest rosszabb progn\u00f3zis rizik\u00f3t vet\u00edtenek el\u0151, \u00e9s az\n                    esetlegesen nehezen azonos\u00edthat\u00f3 endoszk\u00f3pos k\u00e9p\u00fcket is figyelembe v\u00e9ve\n                    felismer\u00e9s\u00fck ut\u00e1n az IBD-s betegek szorosabb ut\u00e1nk\u00f6vet\u00e9se \u00e9s esetleges\n                    v\u00e9letlenszer\u0171 biopszi\u00e1s mintav\u00e9tel m\u00e9rlegelend\u0151. Orv Hetil. 2023; 164(51):\n                    2039\u20132044.<\/jats:p>","DOI":"10.1556\/650.2023.32946","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T16:55:35Z","timestamp":1704300935000},"page":"2039-2044","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":3,"title":["Hypermucinosus \u00e9s kehelysejtszeg\u00e9ny, gyullad\u00e1sos b\u00e9lbetegs\u00e9ghez t\u00e1rsult, non-conventionalis dysplasia colorectalis adenocarcinoma mellett"],"prefix":"10.1556","volume":"164","author":[{"given":"Szintia","family":"Alm\u00e1si","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet 6725 Szeged, \u00c1llom\u00e1s u. 1. Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"Bar\u00e1th","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet 6725 Szeged, \u00c1llom\u00e1s u. 1. Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panna","family":"Szasz\u00e1k","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet 6725 Szeged, \u00c1llom\u00e1s u. 1. Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"K\u0151v\u00e1ri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mass General Brigham, Harvard Medical School Boston, Massachusetts Amerikai Egyes\u00fclt \u00c1llamok"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Sejben","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet 6725 Szeged, \u00c1llom\u00e1s u. 1. Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.giec.2019.02.008","article-title":"Management of inflammatory bowel disease-associated dysplasia in the modern era","volume":"29","author":"Shah SC","year":"2019","unstructured":"1 Shah SC, Itzkowitz SH. Management of inflammatory bowel disease-associated dysplasia in the modern era. Gastrointest Endosc Clin N Am. 2019; 29: 531-548.","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000104731","article-title":"Dysplasia and cancer in inflammatory bowel disease 10 years after diagnosis: results of a population-based European collaborative follow-up study","volume":"75","author":"2 Katsanos","year":"2007","unstructured":"2 Katsanos KH, Vermeire S, Christodoulou DK, et al. Dysplasia and cancer in inflammatory bowel disease 10 years after diagnosis: results of a population-based European collaborative follow-up study. Digestion 2007; 75: 113-121.","journal-title":"Digestion"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/ecco-jcc\/jjac187","article-title":"ECCO guidelines on inflammatory bowel disease and malignancies","volume":"17","author":"3 Gordon","year":"2023","unstructured":"3 Gordon H, Biancone L, Fiorino G, et al. ECCO guidelines on inflammatory bowel disease and malignancies. J Crohns Colitis 2023; 17: 827-854.","journal-title":"J Crohns Colitis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/s41379-019-0419-1","article-title":"Nonconventional dysplasia in patients with inflammatory bowel disease and colorectal carcinoma: a multicenter clinicopathologic study","volume":"33","author":"4 Choi","year":"2020","unstructured":"4 Choi WT, Yozu M, Miller GC, et al. Nonconventional dysplasia in patients with inflammatory bowel disease and colorectal carcinoma: a multicenter clinicopathologic study. Mod Pathol. 2020; 33: 933-943.","journal-title":"Mod Pathol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/his.14922","article-title":"Non-convetional dysplasia is frequently associated with low-grade tubuloglandular and mucinous adenocarcinomas in inflammatory bowel disease","volume":"83","author":"5 Akarca","year":"2023","unstructured":"5 Akarca FG, Yozu M, Alpert L, et al. Non-convetional dysplasia is frequently associated with low-grade tubuloglandular and mucinous adenocarcinomas in inflammatory bowel disease. Histopathology 2023; 83: 276-285.","journal-title":"Histopathology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4132\/jptm.2021.02.17","article-title":"Non-conventional dysplastic subtypes in inflammatory bowel disease: a review of their diagnostic characteristics and potential clinical implications","volume":"55","author":"6 Choi","year":"2021","unstructured":"6 Choi WT. Non-conventional dysplastic subtypes in inflammatory bowel disease: a review of their diagnostic characteristics and potential clinical implications. J Pathol Transl Med. 2021; 55: 83-93.","journal-title":"J Pathol Transl Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1111\/his.13923","article-title":"DNA flow cytometric and interobserver study of crypt cell atypia in inflammatory bowel disease","volume":"75","author":"7 Wen","year":"2019","unstructured":"7 Wen KW, Umetsu SE, Goldblum JR, et al. DNA flow cytometric and interobserver study of crypt cell atypia in inflammatory bowel disease. Histopathology 2019; 75: 578-588.","journal-title":"Histopathology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1136\/jclinpath-2019-206247","article-title":"Histological and molecular diversity and heterogeneity of precancerous lesions associated with inflammatory bowel diseases","volume":"73","author":"8 Gui","year":"2020","unstructured":"8 Gui X, K\u00f6bel M, Ferraz JG, et al. Histological and molecular diversity and heterogeneity of precancerous lesions associated with inflammatory bowel diseases. J Clin Pathol. 2020; 73: 391-402.","journal-title":"J Clin Pathol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/PAP.0000000000000316","article-title":"A review of their morphologic, clinicopathologic, and molecular characteristics","volume":"29","author":"9 Choi","year":"2022","unstructured":"9 Choi WT, K\u0151v\u00e1ri BP, Lauwers GY. The significance of flat\/invisible dysplasia and nonconventional dysplastic subtypes in inflammatory bowel disease. A review of their morphologic, clinicopathologic, and molecular characteristics. Adv Anat Pathol. 2022; 29: 15-24.","journal-title":"Adv Anat Pathol"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10 Laine L, Kaltenbach T, Barkun A, et al. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastroenterology 2015; 148: 639-651.e28.","DOI":"10.1053\/j.gastro.2015.01.031"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1093\/ecco-jcc\/jjab120","article-title":"Hypermucinous, goblet cell-deficient and crypt cell dysplasias in inflammatory bowel disease are often associated with flat\/invisible endoscopic appearance and advanced neoplasia on follow-up","volume":"16","author":"11 Choi","year":"2022","unstructured":"11 Choi WT, Salomao M, Zhao L, et al. Hypermucinous, goblet cell-deficient and crypt cell dysplasias in inflammatory bowel disease are often associated with flat\/invisible endoscopic appearance and advanced neoplasia on follow-up. J Crohns Colitis 2022; 16: 98-108.","journal-title":"J Crohns Colitis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/his.14298","article-title":"Non-conventional dysplasia in inflammatory bowel disease is more frequently associated with advanced neoplasia and aneuploidy than conventional dysplasia","volume":"78","author":"12 Lee","year":"2021","unstructured":"12 Lee H, Rabinovitch PS, Mattis AN, et al. Non-conventional dysplasia in inflammatory bowel disease is more frequently associated with advanced neoplasia and aneuploidy than conventional dysplasia. Histopathology 2021; 78: 814-830.","journal-title":"Histopathology"},{"key":"ref12","unstructured":"13 K\u0151v\u00e1ri B, Clauditz T, Kamaradova K, et al. Hypermucinous dysplasia in inflammatory bowel disease: a heterogeneous condition with frequent foveolar differentiation. Mod Pathol. 2022; 35(Suppl 2): 481-482."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14 Kamar\u00e1dov\u00e1 K, Vo\u0161mikov\u00e1 H, Rozko\u0161ov\u00e1 K, et al. Non-conventional mucosal lesions (serrated epithelial change, villous hypermucinous change) are frequent in patients with inflammatory bowel disease. Results of molecular and immunohistochemical single institutional study. Virchows Arch. 2020; 476: 231-241.","DOI":"10.1007\/s00428-019-02627-4"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/164\/51\/article-p2039.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/164\/51\/article-p2039.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/164\/51\/article-p2039.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T07:59:34Z","timestamp":1723190374000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/164\/51\/article-p2039.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,24]]},"references-count":14,"journal-issue":{"issue":"51"},"URL":"https:\/\/doi.org\/10.1556\/650.2023.32946","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,24]]}}}