{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:10:44Z","timestamp":1784902244213,"version":"3.55.0"},"reference-count":19,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T00:00:00Z","timestamp":1705795200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2024,1,21]]},"abstract":"A papillaris pajzsmirigyr\u00e1k progn\u00f3zis\u00e1t a gyakori nyaki nyirokcsom\u00f3\u00e1tt\u00e9t-k\u00e9pz\u00e9s\n befoly\u00e1solja. Seb\u00e9szi kezel\u00e9s\u00fck min\u0151s\u00e9ge a betegek t\u00fal\u00e9l\u00e9s\u00e9t \u00e9s a recid\u00edva\n el\u0151fordul\u00e1si gyakoris\u00e1g\u00e1t is meghat\u00e1rozza. Az Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet\n Fej-Nyaki Daganatok Multidiszciplin\u00e1ris K\u00f6zpontj\u00e1ban a fej-nyak seb\u00e9sz szerz\u0151k\n \u00e1ltal 2013 \u00e9s 2018 k\u00f6z\u00f6tt oper\u00e1lt, nyaki \u00e1tt\u00e9tet ad\u00f3 papillaris carcinom\u00e1s\n betegek adatait vizsg\u00e1ltuk. 130, nyaki \u00e1tt\u00e9tet ad\u00f3 papillaris\n pajzsmirgy-carcinom\u00e1s beteg eset\u00e9ben az ATA (American Thyroid Association) 2015.\n \u00e9vi ir\u00e1nyelvei alapj\u00e1n teljes pajzsmirigy-elt\u00e1vol\u00edt\u00e1st \u00e9s nyaki\n nyirokcsom\u00f3-dissecti\u00f3t v\u00e9gezt\u00fcnk. Az elt\u00e1vol\u00edtott anyagokat sz\u00f6vettani\n feldolgoz\u00e1sra k\u00fcldt\u00fck, vizsg\u00e1ltuk a nyirokcsom\u00f3\u00e1tt\u00e9t(ek) ar\u00e1ny\u00e1t az \u00e9letkor, a\n nem, a tumor-multifokalit\u00e1s, a k\u00e9toldalis\u00e1g, a tokon k\u00edv\u00fcli terjed\u00e9s, a nyirok-,\n \u00e9rinv\u00e1zi\u00f3 f\u00fcggv\u00e9ny\u00e9ben. Elemezt\u00fck a m\u0171t\u00e9t ut\u00e1n fell\u00e9p\u0151 sz\u00f6v\u0151dm\u00e9nyeket is. 43\n betegn\u00e9l thyreoidectomia, tot\u00e1lis \u00e9s centr\u00e1lis nyaki dissectio (VI. r\u00e9gi\u00f3), 87\n esetben centr\u00e1lis (VI. r\u00e9gi\u00f3) \u00e9s later\u00e1lis (II\u2013V. r\u00e9gi\u00f3) nyaki dissectio\n t\u00f6rt\u00e9nt. \u00c1tmeneti (6 h\u00f3napon bel\u00fcl normaliz\u00e1l\u00f3d\u00f3) hypocalcaemia 30 betegn\u00e9l\n (23%), permanens hypocalcaemia 4 betegn\u00e9l (3%) fordult el\u0151. \u00c1tmeneti nervus\n recurrens b\u00e9nul\u00e1s 12 esetben (9,2%), permanens b\u00e9nul\u00e1s 3 (2,3%) esetben t\u00f6rt\u00e9nt.\n A sz\u00f6vettani \u00e9rt\u00e9kel\u00e9skor \u00e9rbet\u00f6r\u00e9s \u00e9s tokinv\u00e1zi\u00f3 75 betegn\u00e9l (57,7%),\n nyirok\u00e9r-inv\u00e1zi\u00f3 63 betegn\u00e9l (48,5%), Hashimoto-thyreoiditis 51 betegn\u00e9l (39,2%)\n igazol\u00f3dott. Microcarcinoma (1 cm-n\u00e9l kisebb daganat) 43 esetben fordult el\u0151\n (33%). Az elt\u00e1vol\u00edtott nyirokcsom\u00f3k \u00e1tlagosan 48%-a volt \u00e1tt\u00e9tes. Ez csak a\n tumorm\u00e9rettel mutatott szignifik\u00e1ns korrel\u00e1ci\u00f3t, az \u00e9letkorral nem tal\u00e1ltunk\n \u00f6sszef\u00fcgg\u00e9st. Az oldalis\u00e1g, a t\u00f6bbg\u00f3c\u00fas\u00e1g, valamint a tok-, nyirok\u00e9r- \u00e9s\n \u00e9rinv\u00e1zi\u00f3, a Hashimoto-status \u00e9s a beteg neme nem mutatott \u00f6sszef\u00fcgg\u00e9st az\n \u00e1tt\u00e9tes nyirokcsom\u00f3k sz\u00e1m\u00e1val. A t\u00fal\u00e9l\u00e9st befoly\u00e1solta a tok-, \u00e9r- \u00e9s\n nyirok\u00e9r-inv\u00e1zi\u00f3, valamint a tumorm\u00e9ret is. A nyaki \u00e1tt\u00e9tet ad\u00f3, differenci\u00e1lt\n pajzsmirigyr\u00e1kos beteganyagunk kezel\u00e9s\u00e9ben a kivizsg\u00e1l\u00e1si protokollt k\u00f6vet\u0151en a\n teljes pajzsmirigy-elt\u00e1vol\u00edt\u00e1s \u00e9s a megfelel\u0151 r\u00e9gi\u00f3kat tartalmaz\u00f3 nyaki\n dissectio d\u00f6nt\u0151 fontoss\u00e1g\u00fa, a radioj\u00f3d-ter\u00e1pi\u00e1val kieg\u00e9sz\u00edtve az ir\u00e1nyelveknek\n megfelel\u0151 kezel\u00e9si modul. A pajzsmirigydaganat a leggyakoribb endokrin daganatos\n megbeteged\u00e9s, melynek seb\u00e9szi kezel\u00e9se a multidiszciplin\u00e1ris ter\u00e1pia\n legfontosabb eleme. 5 \u00e9v alatt oper\u00e1lt, nyaki \u00e1tt\u00e9tet is ad\u00f3, differenci\u00e1lt\n pajzsmirigyr\u00e1kos beteganyagunkat feldolgozva ismertetj\u00fck eredm\u00e9nyeinket az\n olvas\u00f3val. Orv Hetil. 2024; 165(3): 83\u201388.<\/jats:p>","DOI":"10.1556\/650.2024.32960","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T03:40:07Z","timestamp":1705808407000},"page":"83-88","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":4,"title":["Nyaki \u00e1tt\u00e9tet ad\u00f3 papillaris pajzsmirigyr\u00e1k seb\u00e9szi kezel\u00e9s\u00e9nek eredm\u00e9nyei \u2013 5 \u00e9ves anyagunk feldolgoz\u00e1sa"],"prefix":"10.1556","volume":"165","author":[{"given":"Bernadett","family":"L\u00e9vay","sequence":"first","affiliation":[{"name":"Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Fej-Nyaki Daganatok Multidiszciplin\u00e1ris K\u00f6zpont Budapest, R\u00e1th Gy. u. 7\u20139., 1124 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Daganatpatol\u00f3giai K\u00f6zpont, Seb\u00e9szeti \u00e9s Molekul\u00e1ris Patol\u00f3giai Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"P\u00e9ter","sequence":"additional","affiliation":[{"name":"Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Daganatpatol\u00f3giai K\u00f6zpont, Seb\u00e9szeti \u00e9s Molekul\u00e1ris Patol\u00f3giai Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kiss","sequence":"additional","affiliation":[{"name":"Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Fej-Nyaki Daganatok Multidiszciplin\u00e1ris K\u00f6zpont Budapest, R\u00e1th Gy. u. 7\u20139., 1124 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Sug\u00e1rter\u00e1pi\u00e1s K\u00f6zpont Budapest Magyarorsz\u00e1g"},{"name":"ELTE E\u00f6tv\u00f6s Lor\u00e1nd Tudom\u00e1nyegyetem Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Doh\u00e1n","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. 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