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Az ut\u00f3bbi \u00e9vtizedek kutat\u00e1sai alapj\u00e1n a\n D-vitamin-hi\u00e1ny \u2013 amely a lakoss\u00e1g k\u00f6r\u00fclbel\u00fcl 24\u201340%-\u00e1t \u00e9rinti vil\u00e1gszerte \u2013\n jelent\u0151s szerepet j\u00e1tszik a sz\u00edv-\u00e9r rendszeri, azon bel\u00fcl is a cerebrovascularis\n betegs\u00e9gek kialakul\u00e1s\u00e1ban, amelyek napjainkban a vezet\u0151 hal\u00e1lokok k\u00f6z\u00e9\n tartoznak. Epidemiol\u00f3giai tanulm\u00e1nyok \u00f6sszef\u00fcgg\u00e9st mutatnak a D-vitamin-hi\u00e1ny \u00e9s\n az ischaemi\u00e1s stroke, a vascularis kognit\u00edv zavarok \u00e9s az agyi vascularis\n malformati\u00f3k kialakul\u00e1s\u00e1nak fokozott kock\u00e1zat\u00e1val \u00e9s s\u00falyosabb lefoly\u00e1s\u00e1val. B\u00e1r\n a h\u00e1tt\u00e9rben sz\u00e1mos k\u00f3roki t\u00e9nyez\u0151 szerep\u00e9t felt\u00e9telezik \u2013 mint p\u00e9ld\u00e1ul a\n D-vitamin-hi\u00e1nyra jellemz\u0151 endotheldiszfunkci\u00f3t, a fokozott oxidat\u00edv stresszt \u00e9s\n gyullad\u00e1st, valamint az \u00e9rpermeabilit\u00e1s n\u00f6veked\u00e9s\u00e9t \u2013, a molekul\u00e1ris\n patomechanizmus r\u00e9szletei m\u00e9g nem teljesen felt\u00e1rtak. Emellett a\n D-vitamin-p\u00f3tl\u00e1s szerep\u00e9nek tiszt\u00e1z\u00e1sa a cerebrovascularis betegs\u00e9gek\n megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben m\u00e9g szint\u00e9n tov\u00e1bbi kutat\u00e1sokat ig\u00e9nyel.\n \u00d6sszefoglal\u00f3 k\u00f6zlem\u00e9ny\u00fcnkben vizsg\u00e1ljuk a D-vitamin agyi kering\u00e9sre kifejtett\n hat\u00e1s\u00e1t, illetve \u00f6sszegezz\u00fck a D-vitamin-hi\u00e1nyra jellemz\u0151 molekul\u00e1ris \u00e9s\n funkcion\u00e1lis elv\u00e1ltoz\u00e1sokat, amelyek szerepet j\u00e1tszhatnak a cerebrovascularis\n betegs\u00e9gek kialakul\u00e1s\u00e1ban. Emellett r\u00e9szletesebben t\u00e1rgyaljuk a D-vitamin-hi\u00e1ny\n szerep\u00e9t az ischaemi\u00e1s stroke, a vascularis kognit\u00edv zavarok \u00e9s a cavernosus\n malformati\u00f3k patogenezis\u00e9ben \u00e9s progresszi\u00f3j\u00e1ban. A D-vitamin-hi\u00e1ny komplex\n szerep\u00e9nek meg\u00e9rt\u00e9se e cerebrovascularis k\u00f3rk\u00e9pekben jelent\u0151s\u00e9ggel b\u00edrhat a\n prevenci\u00f3 \u00e9s a ter\u00e1pia szempontj\u00e1b\u00f3l, hiszen a D-vitamin-hi\u00e1ny k\u00f6nnyen\n megsz\u00fcntethet\u0151 cerebrovascularis rizik\u00f3faktor lehet. Orv Hetil. 2024; 165(50):\n 1958\u20131968.<\/jats:p>","DOI":"10.1556\/650.2024.32962","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T10:22:13Z","timestamp":1734344533000},"page":"1958-1968","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":4,"title":["A D-vitamin-hi\u00e1ny mint a cerebrovascularis betegs\u00e9gek kock\u00e1zati t\u00e9nyez\u0151je"],"prefix":"10.1556","volume":"165","author":[{"given":"\u00c9va","family":"P\u00e1l","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Transzl\u00e1ci\u00f3s Medicina Int\u00e9zet Budapest, T\u0171zolt\u00f3 u. 37\u201347., 1094 Magyarorsz\u00e1g"},{"name":"HUN-REN\u2013SE Cerebrovaszkul\u00e1ris \u00e9s Neurokognit\u00edv Betegs\u00e9gek Kutat\u00f3csoport Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Ungv\u00e1ri","sequence":"additional","affiliation":[{"name":"Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Neurosurgery, University of Oklahoma Health Sciences Center Oklahoma City, OK USA"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Doktori Iskola, Elm\u00e9leti \u00e9s Transzl\u00e1ci\u00f3s Orvostudom\u00e1nyok Doktori Tagozat\/N\u00e9peg\u00e9szs\u00e9gtani Int\u00e9zet Budapest Magyarorsz\u00e1g"},{"name":"Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center Oklahoma City, OK USA"},{"name":"The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center Oklahoma City, OK USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szabolcs","family":"V\u00e1rb\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Budapest Magyarorsz\u00e1g"},{"name":"Szegedi Tudom\u00e1nyegyetem, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Szeged Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, Doktori Iskola, Kutat\u00e1smenedzsment Munkacsoport Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel","family":"Bereczki","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Neurol\u00f3giai Klinika Budapest Magyarorsz\u00e1g"},{"name":"HUN-REN\u2013SE Neuroepidemiol\u00f3giai Kutat\u00f3csoport Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Beny\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Transzl\u00e1ci\u00f3s Medicina Int\u00e9zet Budapest, T\u0171zolt\u00f3 u. 37\u201347., 1094 Magyarorsz\u00e1g"},{"name":"HUN-REN\u2013SE Cerebrovaszkul\u00e1ris \u00e9s Neurokognit\u00edv Betegs\u00e9gek Kutat\u00f3csoport Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Norman PE, Powell JT. 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