{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:26:17Z","timestamp":1774326377908,"version":"3.50.1"},"reference-count":22,"publisher":"Akademiai Kiado Zrt.","issue":"15","license":[{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2024,4,14]]},"abstract":"<jats:p>A gerincf\u00e1jdalom h\u00e1tter\u00e9ben a gyakoribb benignus k\u00f3rk\u00e9pek mellett malignus\n                    elv\u00e1ltoz\u00e1sok \u00e9s s\u00falyos gyullad\u00e1ssal jellemezhet\u0151 k\u00f3rk\u00e9pek is el\u0151fordulhatnak. A\n                    kivizsg\u00e1l\u00e1s sor\u00e1n a r\u00e9szletes laborat\u00f3riumi vizsg\u00e1latok mellett a k\u00e9palkot\u00f3\n                    diagnosztik\u00e1nak kiemelked\u0151 jelent\u0151s\u00e9ge van. A csontf\u00e1jdalom h\u00e1tter\u00e9ben ritk\u00e1n a\n                    kr\u00f3nikus nem bakteri\u00e1lis osteomyelitis is \u00e1llhat. A szerz\u0151k egy 9 \u00e9ves\n                    le\u00e1nygyermek eset\u00e9t mutatj\u00e1k be, aki t\u00f6bb h\u00f3napja fenn\u00e1ll\u00f3, progredi\u00e1l\u00f3 h\u00e1ti\n                    gerincf\u00e1jdalommal jelentkezett szakvizsg\u00e1laton. A laborat\u00f3riumi vizsg\u00e1latok\n                    sor\u00e1n enyh\u00e9n emelkedett gyullad\u00e1sos aktivit\u00e1son k\u00edv\u00fcl k\u00f3rjelz\u0151 elt\u00e9r\u00e9s nem volt.\n                    A m\u00e1gnesesrezonancia-vizsg\u00e1lat (MRI) a thoracalis VIII. csigolyakompresszi\u00f3\n                    mellett a csigolyatestben, az als\u00f3 z\u00e1r\u00f3lemez ment\u00e9n k\u00f6r\u00fcl\u00edrt, hiperintenz\u00edven\n                    halmoz\u00f3 k\u00e9pletet \u00edrt le. A pontos etiol\u00f3gia tiszt\u00e1z\u00e1s\u00e1ra biopszi\u00e1s mintav\u00e9tel\n                    t\u00f6rt\u00e9nt. A sz\u00f6vettani vizsg\u00e1lat a malignit\u00e1st kiz\u00e1rta, kr\u00f3nikus gyullad\u00e1sra\n                    utal\u00f3 elt\u00e9r\u00e9st mutatott. A beteg \u00e1tmenetileg szteroidkezel\u00e9sben r\u00e9szes\u00fclt, de\n                    relapsus jelentkezett, ez\u00e9rt biol\u00f3giai ter\u00e1pia, adalimumab ker\u00fclt bevezet\u00e9sre. A\n                    ter\u00e1pia hat\u00e1sosnak bizonyult, mind a klinikai t\u00fcnetek, mind a k\u00e9palkot\u00f3\n                    vizsg\u00e1latok alapj\u00e1n tart\u00f3s remisszi\u00f3 \u00e9szlelhet\u0151. A jelen esettanulm\u00e1ny a\n                    gerincf\u00e1jdalom h\u00e1tter\u00e9ben \u00e1ll\u00f3 ritka k\u00f3rk\u00e9pre h\u00edvja fel a figyelmet. A k\u00f3rk\u00e9p\n                    diagn\u00f3zis\u00e1ban az MRI kiemelked\u0151 fontoss\u00e1ggal b\u00edr. A betegs\u00e9g kezel\u00e9s\u00e9ben\n                    immunszuppressz\u00edv ter\u00e1pia alkalmaz\u00e1sa sz\u00fcks\u00e9ges. Orv Hetil. 2024; 165(15):\n                    595\u2013600.<\/jats:p>","DOI":"10.1556\/650.2024.33021","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T04:26:36Z","timestamp":1713673596000},"page":"595-600","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["A gyermekkori h\u00e1tf\u00e1jdalom h\u00e1tter\u00e9ben \u00e1ll\u00f3 ritka k\u00f3rk\u00e9p: kr\u00f3nikus nem bakteri\u00e1lis osteomyelitis"],"prefix":"10.1556","volume":"165","author":[{"given":"Janka","family":"Juszt","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7624 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mi","family":"Benedek","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7624 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Mohay","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Orvosi K\u00e9palkot\u00f3 Klinika P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Herbert","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, P\u00e9csi Diagnosztikai K\u00f6zpont P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1d\u00e1m","family":"Gy\u0151ri","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7624 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadett","family":"Mosd\u00f3si","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Gyermekgy\u00f3gy\u00e1szati Klinika P\u00e9cs, J\u00f3zsef A. u. 7., 7624 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1 Danka E, Pint\u00e9r GT, Kereszt\u00fari M, et al. 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The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. Rheumatology 2018; 57: 1203-1211. Erratum: Rheumatology 2018 Aug 1; 57: 1504.","DOI":"10.1093\/rheumatology\/key058"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1002\/art.39013","article-title":"A large national cohort of French patients with chronic recurrent multifocal osteitis","volume":"67","author":"9 Wipff","year":"2015","unstructured":"9 Wipff J, Costantino F, Lemelle I, et al. A large national cohort of French patients with chronic recurrent multifocal osteitis. 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Rheumatol Int. 2016; 36: 769-779.","journal-title":"Rheumatol Int"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13244-022-01288-3","article-title":"Chronic nonbacterial osteomyelitis: the role of whole-body MRI","volume":"13","author":"13 Nico","year":"2022","unstructured":"13 Nico MA, Ara\u00fajo FF, Guimar\u00e3es JB, et al. Chronic nonbacterial osteomyelitis: the role of whole-body MRI. Insights Imaging 2022; 13: 149.","journal-title":"Insights Imaging"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14 LeClair N, Th\u00f6rmer G, Sorge I, et al. Whole-body diffusion-weighted imaging in chronic recurrent multifocal osteomyelitis in children. PLOS ONE 2016; 11: e0147523.","DOI":"10.1371\/journal.pone.0147523"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1007\/s11914-017-0405-9","article-title":"Chronic recurrent multifocal osteomyelitis (CRMO): presentation, pathogenesis, and treatment","volume":"15","author":"15 Hofmann","year":"2017","unstructured":"15 Hofmann SR, Kapplusch F, Girschick HJ, et al. Chronic recurrent multifocal osteomyelitis (CRMO): presentation, pathogenesis, and treatment. Curr Osteoporos Rep. 2017; 15: 542-554.","journal-title":"Curr Osteoporos Rep"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1002\/acr.23462","article-title":"Consensus treatment plans for chronic nonbacterial osteomyelitis refractory to nonsteroidal antiinflammatory drugs and\/or with active spinal lesions","volume":"70","author":"16 Zhao","year":"2018","unstructured":"16 Zhao Y, Wu EY, Oliver MS, et al. Consensus treatment plans for chronic nonbacterial osteomyelitis refractory to nonsteroidal antiinflammatory drugs and\/or with active spinal lesions. Arthritis Care Res. 2018; 70: 1228-1237.","journal-title":"Arthritis Care Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.3899\/jrheum.161255","article-title":"Treatment response and longterm outcomes in children with chronic nonbacterial osteomyelitis","volume":"44","author":"17 Schnabel","year":"2017","unstructured":"17 Schnabel A, Range U, Hahn G, et al. Treatment response and longterm outcomes in children with chronic nonbacterial osteomyelitis. J Rheumatol. 2017; 44: 1058-1065.","journal-title":"J Rheumatol"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18 Beck C, Morbach H, Beer M, et al. Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment. Arthritis Res Ther. 2010; 12: R74.","DOI":"10.1186\/ar2992"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12969-019-0340-7","article-title":"Efficacy of pamidronate in children with chronic non-bacterial osteitis using whole body MRI as a marker of disease activity","volume":"17","author":"19 Bhat","year":"2019","unstructured":"19 Bhat CS, Roderick M, Sen ES, et al. Efficacy of pamidronate in children with chronic non-bacterial osteitis using whole body MRI as a marker of disease activity. Pediatr Rheumatol. 2019; 17: 35.","journal-title":"Pediatr Rheumatol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1093\/rheumatology\/keq122","article-title":"Biologic therapy in refractory chronic non-bacterial osteomyelitis of childhood","volume":"49","author":"20 Eleftheriou","year":"2010","unstructured":"20 Eleftheriou D, Gerschman T, Sebire N, et al. Biologic therapy in refractory chronic non-bacterial osteomyelitis of childhood. Rheumatology 2010; 49: 1505-1512.","journal-title":"Rheumatology"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00296-018-4151-9","article-title":"Comparison of different treatment approaches of pediatric chronic non-bacterial osteomyelitis","volume":"39","author":"21 Kostik","year":"2019","unstructured":"21 Kostik MM, Kopchak OL, Chikova IA, et al. Comparison of different treatment approaches of pediatric chronic non-bacterial osteomyelitis. Rheumatol Int. 2019; 39: 89-96.","journal-title":"Rheumatol Int"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22 Ramanan AV, Hampson LV, Lythgoe H, et al. Defining consensus opinion to develop randomised controlled trials in rare diseases using Bayesian design: an example of a proposed trial of adalimumab versus pamidronate for children with CNO\/CRMO. 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