{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:06:53Z","timestamp":1784815613419,"version":"3.55.0"},"reference-count":69,"publisher":"Akademiai Kiado Zrt.","issue":"17","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2024,4,28]]},"abstract":"<jats:p>\u00d6sszefoglal\u00f3 k\u00f6zlem\u00e9ny\u00fcnkben \u00e1ttekintj\u00fck a Raynaud-szindr\u00f3m\u00e1val kapcsolatos azon\n                    leg\u00fajabb eredm\u00e9nyeket, amelyek a 2011-ben k\u00f6z\u00f6lt \u00e1ttekint\u00e9s\u00fcnk \u00f3ta eltelt 13\n                    \u00e9vben megjelentek. Bemutatjuk a k\u00f3rk\u00e9p f\u0151 jellemz\u0151it, diagnosztikai \u00e9s ter\u00e1pi\u00e1s\n                    lehet\u0151s\u00e9geit. Az \u00f6sszefoglal\u00f3ban k\u00fcl\u00f6n hangs\u00falyt fektet\u00fcnk a k\u00f3rk\u00e9ppel\n                    kapcsolatos relev\u00e1ns k\u00e9rd\u00e9sekre \u00e9s tiszt\u00e1zatlan pontokra. R\u00e9szletesen t\u00e1rgyaljuk\n                    a t\u00e9ma tov\u00e1bbi kutat\u00e1si lehet\u0151s\u00e9geit, b\u00edzva abban, hogy inspir\u00e1lni fogja a\n                    Raynaud-szindr\u00f3ma jobb meg\u00e9rt\u00e9s\u00e9t c\u00e9lz\u00f3 vizsg\u00e1latokat. Orv Hetil. 2024; 165(17):\n                    643\u2013651.<\/jats:p>","DOI":"10.1556\/650.2024.33026","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:16:36Z","timestamp":1715570196000},"page":"643-651","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["Raynaud-szindr\u00f3ma, 2024"],"prefix":"10.1556","volume":"165","author":[{"given":"Bal\u00e1zs","family":"F\u00e1bi\u00e1n","sequence":"first","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Magatart\u00e1studom\u00e1nyi Int\u00e9zet Debrecen, M\u00f3ricz Zs. krt. 22., 4032 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Csiki","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Magatart\u00e1studom\u00e1nyi Int\u00e9zet Debrecen, M\u00f3ricz Zs. krt. 22., 4032 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Tak\u00e1ts A, Garai I, Papp G, et al. Raynaud\u2019s syndrome.\n                    [Raynaud-szindr\u00f3ma, 2011.] Orv Hetil. 2012; 153: 403\u2013409.\n                    [Hungarian]","DOI":"10.1556\/OH.2012.29321"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Garner R, Kumari R, Lanyon P, et al. Prevalence, risk factors and\n                    associations of primary Raynaud\u2019s phenomenon: systematic review and\n                    meta-analysis of observational studies. BMJ Open 2015; 5:\n                    e006389.","DOI":"10.1136\/bmjopen-2014-006389"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Pauling JD, Reilly E, Smith T, et al. Evolving symptom\n                    characteristics of Raynaud\u2019s phenomenon in systemic sclerosis and their\n                    association with physician and patient-reported assessments of disease severity.\n                    Arthritis Care Res. 2019; 71: 1119\u20131126.","DOI":"10.1002\/acr.23729"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Gr\u00e9main V, Richard L, Langlois V, et al. Raynaud\u2019s phenomenon of the\n                    tongue. Joint Bone Spine 2017; 84: 231.","DOI":"10.1016\/j.jbspin.2016.02.031"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Barrett ME, Heller MM, Stone HF, et al. Raynaud phenomenon of the\n                    nipple in breastfeeding mothers: an underdiagnosed cause of nipple pain. JAMA\n                    Dermatol. 2013; 149: 300\u2013306.","DOI":"10.1001\/jamadermatol.2013.1560"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Bruni C, Raja J, Denton CP, et al. The clinical relevance of sexual\n                    dysfunction in systemic sclerosis. Autoimmun Rev. 2015; 14:\n                    1111\u20131115.","DOI":"10.1016\/j.autrev.2015.07.016"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Lis-\u015awi\u0119ty A. Recent advances in the workup and management of\n                    Raynaud phenomenon. Pol Arch Intern Med. 2019; 129: 798\u2013808.","DOI":"10.20452\/pamw.15008"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Hughes M, Herrick AL. Raynaud\u2019s phenomenon. Best Pract Res Clin\n                    Rheumatol. 2016; 30: 112\u2013132.","DOI":"10.1016\/j.berh.2016.04.001"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Maverakis E, Patel F, Kronenberg DG, et al. International consensus\n                    criteria for the diagnosis of Raynaud\u2019s phenomenon. J Autoimmun. 2014; 48\u201349:\n                    60\u201365.","DOI":"10.1016\/j.jaut.2014.01.020"},{"key":"R10","unstructured":"Wollersheim H, Thien T. The diagnostic value of clinical signs and\n                    symptoms in patients with Raynaud\u2019s phenomenon. A cross-sectional study. Neth J\n                    Med. 1990; 37: 171\u2013182. Erratum: Neth J Med. 1990; 37(5-6):\n                    247."},{"key":"R11","unstructured":"Maricq HR, Weinrich MC. Diagnosis of Raynaud\u2019s phenomenon assisted\n                    by color charts. J Rheumatol. 1988; 15: 454\u2013459."},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Ingegnoli F, Gualtierotti R, Orenti A, et al. Uniphasic blanching of\n                    the fingers, abnormal capillaroscopy in nonsymptomatic digits, and\n                    autoantibodies. Expanding options to increase the level of suspicion of\n                    connective tissue diseases beyond the classification of Raynaud\u2019s phenomenon. J\n                    Immunol Res. 2015; 2015: 371960.","DOI":"10.1155\/2015\/371960"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Cordeiro RA, de Andrade RM. Raynaud\u2019s phenomenon in the occupational\n                    context. Rev Assoc Med Bras. 2019; 65: 1314\u20131320.","DOI":"10.1590\/1806-9282.65.10.1314"},{"key":"R14","unstructured":"Maricq HR, Carpentier PH, Weinrich MC, et al. Geographic variation\n                    in the prevalence of Raynaud\u2019s phenomenon: a 5 region comparison. J Rheumatol.\n                    1997; 24: 879\u2013889."},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Iwata H, Makimo S, Miyashita K. Prevalence of Raynaud\u2019s phenomenon\n                    in individuals not using vibrating tools. Sangyo Igaku 1987; 29:\n                    500\u2013503.","DOI":"10.1539\/joh1959.29.500"},{"key":"R16","unstructured":"F\u00e1bi\u00e1n B. They psychological aspects of Raynaud\u2019s disease. Doctoral\n                    thesis. [A Raynaud-betegs\u00e9g pszichol\u00f3giai aspektusai. Doktori \u00e9rtekez\u00e9s.]\n                    Debreceni Egyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Doktori Iskola, 2020.\n                    [Hungarian]"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Freedman RR, Mayes MD. Familial aggregation of primary Raynaud\u2019s\n                    disease. Arthritis Rheum. 1996; 39: 1189\u20131191.","DOI":"10.1002\/art.1780390717"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Jones GT, Herrick AL, Woodham SE, et al. Occurrence of Raynaud\u2019s\n                    phenomenon in children ages 12-15 years. Prevalence and association with other\n                    common symptoms. Arthritis Rheum. 2003; 48: 3518\u20133521.","DOI":"10.1002\/art.11340"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Koenig M, Joyal F, Fritzler MJ, et al. Autoantibodies and\n                    microvascular damage are independent predictive factors for the progression of\n                    Raynaud\u2019s phenomenon to systemic sclerosis. A twenty-year prospective study of\n                    586 patients, with validation of proposed criteria for early systemic sclerosis.\n                    Arthritis Rheum. 2008; 58: 3902\u20133912.","DOI":"10.1002\/art.24038"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Hur YM, Chae JH, Chung KW, et al. Feeling of cold hands and feet is\n                    a highly heritable phenotype. Twin Res Hum Genet. 2012; 15:\n                    166\u2013169.","DOI":"10.1375\/twin.15.2.166"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Shemirani AH, Szomj\u00e1k E, Balogh E, et al. Polymorphism of clotting\n                    factors in Hungarian patients with Raynaud\u2019s phenomenon. Blood Coagul\n                    Fibrinolysis 2011; 22: 56\u201359.","DOI":"10.1097\/MBC.0b013e32834234fe"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Smyth AE, Hughes AE, Bruce IN, et al. A case-control study of\n                    candidate vasoactive mediator genes in primary Raynaud\u2019s phenomenon.\n                    Rheumatology 1999; 38: 1094\u20131098.","DOI":"10.1093\/rheumatology\/38.11.1094"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Munir S, Freidin MB, Brain S, et al. Association of Raynaud\u2019s\n                    phenomenon with a polymorphism in the NOS1 gene. PLoS ONE 2018;\n                    13: e0196279.","DOI":"10.1371\/journal.pone.0196279"},{"key":"R24","unstructured":"Plissonneau Duquene P, Pistorius MA, Pottier P, et al. Cold climate\n                    could be an etiologic factor involved in Raynaud\u2019s phenomenon physiopathology.\n                    Epidemiological investigation from 954 consultations in general practic. Int\n                    Angiol. 2015; 34: 467\u2013474."},{"key":"R25","unstructured":"Purdie G, Harrison A, Purdie D. Prevalence of Raynaud\u2019s phenomenon\n                    in the adult New Zealand population. N Z Med J. 2009; 122:\n                    55\u201362."},{"key":"R26","doi-asserted-by":"crossref","unstructured":"Pauling JD, Nagaraja V, Khanna D. Insight into the contrasting\n                    findings of therapeutic trials of digital ischaemic manifestations of systemic\n                    sclerosis. Curr Treat Options Rheumatol. 2019; 5: 85\u2013103.","DOI":"10.1007\/s40674-019-00118-w"},{"key":"R27","unstructured":"Hutchinson J. Raynaud\u2019s phenomena. Med Press Circ. 1901; 128:\n                    403\u2013405."},{"key":"R28","doi-asserted-by":"crossref","unstructured":"Hadler NM. \u201cPrimary Raynaud\u2019s\u201d is not a disease or even a disorder;\n                    it\u2019s a trait. Editorial. J Rheumatol. 1998; 25: 2291\u20132294.","DOI":"10.1016\/S0095-4543(05)70062-2"},{"key":"R29","doi-asserted-by":"crossref","unstructured":"Sandqvist G, Wollmer P, Scheja A, et al. Raynaud\u2019s phenomenon and\n                    its impact on activities in daily life during one year of follow-up in early\n                    systemic sclerosis. Scand J Rheumatol. 2018; 47: 206\u2013209.","DOI":"10.1080\/03009742.2017.1350745"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Pauling JD, Reilly E, Smith T, et al. Factors influencing Raynaud\n                    condition score diary outcomes in systemic sclerosis. J Rheumatol. 2019; 46:\n                    1326\u20131334.","DOI":"10.3899\/jrheum.180818"},{"key":"R31","unstructured":"Freedman RR, Lynn S, Ianni P. Behavioral assessment of Raynaud\u2019s\n                    disease. In: Keefe FJ, Blumenthal JA. (eds.) Assessment strategies in behavioral\n                    medicine. Grune and Stratton, New York, NY, 1982; pp. 99\u2013130."},{"key":"R32","doi-asserted-by":"crossref","unstructured":"Hughes M, Snapir A, Wilkinson J, et al. Prediction and impact of\n                    attacks of Raynaud\u2019s phenomenon, as judged by patient perception. Rheumatology\n                    (United Kingdom) 2015; 54: 1443\u20131447.","DOI":"10.1093\/rheumatology\/kev002"},{"key":"R33","doi-asserted-by":"crossref","unstructured":"Pauling JD, Saketkoo LA, Matucci-Cerinic M, et al. The patient\n                    experience of Raynaud\u2019s phenomenon in systemic sclerosis. Rheumatol (United\n                    Kingdom) 2019; 58: 18\u201326.","DOI":"10.1093\/rheumatology\/key026"},{"key":"R34","doi-asserted-by":"crossref","unstructured":"Cooke JP, Creager MA, Osmundson PJ, et al. Sex differences in\n                    control of cutaneous blood flow. Circulation 1990; 82:\n                    1607\u20131615.","DOI":"10.1161\/01.CIR.82.5.1607"},{"key":"R35","unstructured":"Martinez RM, Saponaro A, Dragagna G, et al. Cutaneous circulation in\n                    Raynaud\u2019s phenomenon during emotional stress. A morphological and functional\n                    study using capillaroscopy and laser-Doppler. Int Angiol. 1992; 11:\n                    316\u2013320."},{"key":"R36","doi-asserted-by":"crossref","unstructured":"F\u00e1bi\u00e1n B, Csiki Z, Bug\u00e1n A. Quality of life of patients with\n                    Raynaud\u2019s disease. [Raynaud-szindr\u00f3m\u00e1s betegek \u00e9letmin\u0151s\u00e9g\u00e9nek jellemz\u0151i.] Orv\n                    Hetil. 2018; 159: 636\u2013641. [Hungarian]","DOI":"10.1556\/650.2018.31034"},{"key":"R37","doi-asserted-by":"crossref","unstructured":"Yucel B, Uzum AK, Ozbey N, et al. Anorexia nervosa and Raynaud\u2019s\n                    phenomenon: a case report. Int J Eat Disord. 2007; 40: 242\u2013252.","DOI":"10.1002\/eat.20418"},{"key":"R38","doi-asserted-by":"crossref","unstructured":"Sachs KV, Harnke B, Mehler PS, et al. Cardiovascular complications\n                    of anorexia nervosa: a systematic review. Int J Eat Disord. 2016; 49:\n                    238\u2013248.","DOI":"10.1002\/eat.22481"},{"key":"R39","doi-asserted-by":"crossref","unstructured":"De Martinis M, Sirufo MM, Ginaldi L. Raynaud\u2019s phenomenon and\n                    nailfold capillaroscopic findings in anorexia nervosa. Curr Med Res Opin. 2018;\n                    34: 547\u2013550.","DOI":"10.1080\/03007995.2017.1417828"},{"key":"R40","doi-asserted-by":"crossref","unstructured":"Abdulle AE, Arends S, van Goor H, et al. Low body weight and\n                    involuntary weight loss are associated with Raynaud\u2019s phenomenon in both men and\n                    women. Scand J Rheumatol. 2021; 50: 153\u2013160.","DOI":"10.1080\/03009742.2020.1780310"},{"key":"R41","doi-asserted-by":"crossref","unstructured":"Bernero E, Sulli A, Ferrari G, et al. Prospective\n                    capillaroscopy-based study on transition from primary to secondary Raynaud\u2019s\n                    phenomenon: preliminary results. Reumatismo 2013; 65: 186\u2013191.","DOI":"10.4081\/reumatismo.2013.186"},{"key":"R42","doi-asserted-by":"crossref","unstructured":"Chojnowski MM, Felis-Giemza A, Olesi\u0144ska M. Capillaroscopy. A role\n                    in modern rheumatology. Reumatologia 2016; 54: 67\u201372.","DOI":"10.5114\/reum.2016.60215"},{"key":"R43","doi-asserted-by":"crossref","unstructured":"Lambova SN, Muller-Ladner U. Editorial. Nailfold capillaroscopy in\n                    rheumatology. Curr Rheumatol Rev. 2018; 14: 2\u20134.","DOI":"10.2174\/1573397114666180215102621"},{"key":"R44","doi-asserted-by":"crossref","unstructured":"Van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification\n                    criteria for systemic sclerosis: an American College of Rheumatology\/European\n                    League against Rheumatism collaborative initiative. Arthritis Rheum. 2013; 65:\n                    2737\u20132747.","DOI":"10.1002\/art.38098"},{"key":"R45","doi-asserted-by":"crossref","unstructured":"Dinsdale G, Roberts C, Moore T, et al. Nailfold capillaroscopy \u2013 how\n                    many fingers should be examined to detect abnormality? Rheumatology (Oxford)\n                    2019; 58: 284\u2013288.","DOI":"10.1093\/rheumatology\/key293"},{"key":"R46","doi-asserted-by":"crossref","unstructured":"Gualtierotti R, Ingegnoli F, Griffini S, et al. Detection of early\n                    endothelial damage in patients with Raynaud\u2019s phenomenon. Microvasc Res. 2017;\n                    113: 22\u201328.","DOI":"10.1016\/j.mvr.2017.04.004"},{"key":"R47","doi-asserted-by":"crossref","unstructured":"Smith V, Vanhaecke A, Herrick AL, et al. Fast track algorithm. How\n                    to differentiate a \u201cscleroderma pattern\u201d from a \u201cnon-scleroderma pattern.\u201d\n                    Autoimmun Rev. 2019; 18: 102394.","DOI":"10.1016\/j.autrev.2019.102394"},{"key":"R48","doi-asserted-by":"crossref","unstructured":"Wilkinson JD, Leggett SA, Marjanovic EJ, et al. A multicenter study\n                    of the validity and reliability of responses to hand cold challenge as measured\n                    by laser speckle contrast imaging and thermography. Outcome measures for\n                    systemic sclerosis-related Raynaud\u2019s phenomenon. Arthritis Rheumatol. 2018; 70:\n                    903\u2013911.","DOI":"10.1002\/art.40457"},{"key":"R49","doi-asserted-by":"crossref","unstructured":"Parker MJ, Oliffe MT, McGill NW. An evaluation of two novel\n                    capillaroscopy techniques in suspected scleroderma-spectrum disorders: a\n                    single-centre cross-sectional study. Mod Rheumatol. 2018; 28:\n                    676\u2013680.","DOI":"10.1080\/14397595.2017.1404179"},{"key":"R50","doi-asserted-by":"crossref","unstructured":"Pauling JD, Domsic RT, Saketkoo LA, et al. Multinational qualitative\n                    research study exploring the patient experience of Raynaud\u2019s phenomenon in\n                    systemic sclerosis. Arthritis Care Res (Hoboken) 2018; 70:\n                    1373\u20131384.","DOI":"10.1002\/acr.23475"},{"key":"R51","doi-asserted-by":"crossref","unstructured":"Pauling JD, Frech TM, Hughes M, et al. Patient-reported outcome\n                    instruments for assessing Raynaud\u2019s phenomenon in systemic sclerosis: a SCTC\n                    vascular working group report. J Scleroderma Relat Disord. 2018; 3:\n                    249\u2013252.","DOI":"10.1177\/2397198318774307"},{"key":"R52","doi-asserted-by":"crossref","unstructured":"Taylor I, Silva I, Barreto S, et al. Raynaud\u2019s phenomenon impact on\n                    quotidian quality of life. Int J Online Biomed Engin. 2020; 16:\n                    88\u2013104.","DOI":"10.3991\/ijoe.v16i09.13993"},{"key":"R53","doi-asserted-by":"crossref","unstructured":"Hajnal RK, Csat\u00e1ri L, F\u00e1bi\u00e1n B, et al. Factors determining the\n                    quality of life in patients with Raynaud\u2019s syndrome. [Az \u00e9letmin\u0151s\u00e9get\n                    meghat\u00e1roz\u00f3 t\u00e9nyez\u0151k Raynaud-szindr\u00f3m\u00e1ban.] Orv Hetil. 2022; 163: 1880\u20131885.\n                    [Hungarian]","DOI":"10.1556\/650.2022.32647"},{"key":"R54","doi-asserted-by":"crossref","unstructured":"Horv\u00e1th L, Boncz I, K\u00edv\u00e9s Z, et al. Hungarian adaptation of the\n                    Peripheral Artery Disease Quality of Life questionnaire. [A perif\u00e9ri\u00e1s\n                    ver\u0151\u00e9rbetegek \u00e9letmin\u0151s\u00e9g\u00e9t vizsg\u00e1l\u00f3 angol nyelv\u0171 k\u00e9rd\u0151\u00edv magyar adapt\u00e1l\u00e1sa.]\n                    Orv Hetil. 2020; 161: 2153\u20132161. [Hungarian]","DOI":"10.1556\/650.2020.31920"},{"key":"R55","doi-asserted-by":"crossref","unstructured":"Pauling JD, Shipley JA, Hart DJ, et al. Use of laser speckle\n                    contrast imaging to assess digital microvascular function in primary Raynaud\n                    phenomenon and systemic sclerosis. A comparison using the Raynaud condition\n                    score diary. J Rheumatol. 2015; 42: 1163\u20131168.","DOI":"10.3899\/jrheum.141437"},{"key":"R56","doi-asserted-by":"crossref","unstructured":"Pauling JD, Yu L, Frech TM, et al. Construct validity and\n                    reliability of the Assessment of Systemic Sclerosis-Associated Raynaud\u2019s\n                    Phenomenon (ASRAP) questionnaire. Rheumatology (Oxford) 2023;\n                    kead371.","DOI":"10.1093\/rheumatology\/kead371"},{"key":"R57","doi-asserted-by":"crossref","unstructured":"Malenfant D, Catton M, Pope JE. The efficacy of complementary and\n                    alternative medicine in the treatment of Raynaud\u2019s phenomenon. A literature\n                    review and meta-analysis. Rheumatology (Oxford) 2009; 48:\n                    791\u2013795.","DOI":"10.1093\/rheumatology\/kep039"},{"key":"R58","doi-asserted-by":"crossref","unstructured":"Daniels J, Pauling JD, Eccleston C. Behaviour change interventions\n                    for the management of Raynaud\u2019s phenomenon. A systematic literature review. BMJ\n                    Open 2018; 8: e024528.","DOI":"10.1136\/bmjopen-2018-024528"},{"key":"R59","doi-asserted-by":"crossref","unstructured":"Khouri C, Lepelley M, Bailly S, et al. Comparative efficacy and\n                    safety of treatments for secondary Raynaud\u2019s phenomenon. A systematic review and\n                    network meta-analysis of randomised trials. Lancet Rheumatol. 2019; 1:\n                    e237\u2013e246.","DOI":"10.1016\/S2665-9913(19)30079-7"},{"key":"R60","doi-asserted-by":"crossref","unstructured":"Coskun Benlidayi I. What are the effects of vasodilators in patients\n                    with primary Raynaud\u2019s phenomenon? A Cochrane review summary with commentary.\n                    Int J Rheum Dis. 2022; 25: 232\u2013235.","DOI":"10.1111\/1756-185X.14243"},{"key":"R61","doi-asserted-by":"crossref","unstructured":"Su KY, Sharma M, Kim HJ, et al. Vasodilators for primary Raynaud\u2019s\n                    phenomenon. Cochrane Database Syst Rev. 2021; 5: CD006687.","DOI":"10.1002\/14651858.CD006687.pub4"},{"key":"R62","doi-asserted-by":"crossref","unstructured":"Cai R, Yi Z, Li T, et al. Botulinum toxin in the treatment of\n                    Raynaud phenomenon in patients with systemic sclerosis: a systemic review. Chin\n                    Med J (Engl) 2022; 135: 1133\u20131134.","DOI":"10.1097\/CM9.0000000000001903"},{"key":"R63","doi-asserted-by":"crossref","unstructured":"Lawson O, Sisti A, Konofaos P. The use of botulinum toxin in Raynaud\n                    phenomenon: a comprehensive literature review. Ann Plast Surg. 2023; 91:\n                    159\u2013186.","DOI":"10.1097\/SAP.0000000000003603"},{"key":"R64","doi-asserted-by":"crossref","unstructured":"Zhou Y, Yu Y, Bi S, et al. Botulinum toxins for the treatment of\n                    Raynaud phenomenon: a systematic review with meta-analysis. J Clin Rheumatol.\n                    2023; 29: e92\u2013e99.","DOI":"10.1097\/RHU.0000000000001965"},{"key":"R65","doi-asserted-by":"crossref","unstructured":"Ennis D, Ahmad Z, Anderson MA, et al. Botulinum toxin in the\n                    management of primary and secondary Raynaud\u2019s phenomenon. Best Pract Res Clin\n                    Rheumatol. 2021; 35: 101684.","DOI":"10.1016\/j.berh.2021.101684"},{"key":"R66","doi-asserted-by":"crossref","unstructured":"Yu JS, Lee D, Hyun D, et al. Herbal medicines for cold\n                    hypersensitivity in the hands and feet: a systematic review and meta-analysis. J\n                    Altern Complement Med. 2018; 24: 1150\u20131158.","DOI":"10.1089\/acm.2018.0009"},{"key":"R67","doi-asserted-by":"crossref","unstructured":"Shepherd AI, Costello JT, Bailey SJ, et al. \u201cBeet\u201d the cold:\n                    beetroot juice supplementation improves peripheral blood flow, endothelial\n                    function, and anti-inflammatory status in individuals with Raynaud\u2019s phenomenon.\n                    J Appl Physiol. 2019; 127: 1478\u20131490.","DOI":"10.1152\/japplphysiol.00292.2019"},{"key":"R68","doi-asserted-by":"crossref","unstructured":"Wakabayashi H, Sugiyama K, Suzuki S, et al. Influence of acute\n                    beetroot juice supplementation on cold-induced vasodilation and fingertip\n                    rewarming. Eur J Appl Physiol. 2023; 123: 495\u2013507.","DOI":"10.1007\/s00421-022-05071-6"},{"key":"R69","doi-asserted-by":"crossref","unstructured":"Kowal-Bielecka O, Fransen J, Avouac J, et al. Update of EULAR\n                    recommendations for the treatment of systemic sclerosis. Ann Rheum Dis. 2017;\n                    76: 1327\u20131339.","DOI":"10.1136\/annrheumdis-2016-209909"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/www.akjournals.com\/view\/journals\/650\/165\/17\/article-p643.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.akjournals.com\/downloadpdf\/journals\/650\/165\/17\/article-p643.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.akjournals.com\/downloadpdf\/journals\/650\/165\/17\/article-p643.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:24:47Z","timestamp":1784813087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akjournals.com\/view\/journals\/650\/165\/17\/article-p643.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,28]]},"references-count":69,"journal-issue":{"issue":"17"},"URL":"https:\/\/doi.org\/10.1556\/650.2024.33026","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,28]]}}}