{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:04:27Z","timestamp":1784811867430,"version":"3.55.0"},"reference-count":58,"publisher":"Akademiai Kiado Zrt.","issue":"16","license":[{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2024,4,21]]},"abstract":"<jats:p>Az auton\u00f3m neuropathia a cukorbetegs\u00e9g igen gyakori sz\u00f6v\u0151dm\u00e9nye, mely a diabetes\n                    k\u00f3rfejl\u0151d\u00e9se sor\u00e1n m\u00e1r kor\u00e1n kialakul, s\u0151t m\u00e1r a cs\u00f6kkent gl\u00fck\u00f3ztolerancia\n                    st\u00e1dium\u00e1ban is jelen lehet. A betegek \u00e9letmin\u0151s\u00e9g\u00e9re, a cardiovascularis\n                    morbidit\u00e1sra \u00e9s mortalit\u00e1sra gyakorolt prognosztikus jelent\u0151s\u00e9ge, a t\u00f6bbi\n                    sz\u00f6v\u0151dm\u00e9nnyel mutatott \u00f6sszef\u00fcgg\u00e9sei miatt a cardiovascularis auton\u00f3m funkci\u00f3\n                    k\u00e1rosod\u00e1sa a cukorbetegs\u00e9g sz\u00f6v\u0151dm\u00e9nyei k\u00f6z\u00f6tt kiemelt jelent\u0151s\u00e9g\u0171. A\n                    cardiovascularis auton\u00f3m neuropathia klinikai manifeszt\u00e1ci\u00f3i mint a nyugalmi\n                    tachycardia, az orthostaticus hypotonia, a n\u00e9ma myocardialis ischaemia \u00e9s\n                    infarktus vagy \u00e9ppen a QT-t\u00e1vols\u00e1g megny\u00fal\u00e1sa miatt kialakul\u00f3 ritmuszavarok mind\n                    hozz\u00e1j\u00e1rulnak a cardiovascularis auton\u00f3m neuropathia rossz progn\u00f3zis\u00e1hoz. Ezek a\n                    betegek gyakrabban szenvednek el hirtelen sz\u00edvhal\u00e1lt, \u00e9s a perioperat\u00edv\n                    l\u00e9gz\u00e9s-kering\u00e9sle\u00e1ll\u00e1s kock\u00e1zata is nagyobb. A sz\u00f6v\u0151dm\u00e9ny ir\u00e1ny\u00e1ban v\u00e9gzett\n                    sz\u0171r\u0151vizsg\u00e1latok \u00edgy alapvet\u0151 jelent\u0151s\u00e9g\u0171ek. A diagnosztik\u00e1ban a mai napig a\n                    hagyom\u00e1nyos cardiovascularis reflextesztek tekinthet\u0151k arany standardnak, melyek\n                    egyszer\u0171, noninvaz\u00edv, j\u00f3l reproduk\u00e1lhat\u00f3, megfelel\u0151 szenzitivit\u00e1ssal \u00e9s\n                    specificit\u00e1ssal rendelkez\u0151 eszk\u00f6z\u00f6s vizsg\u00e1latok. Az egy\u00e9b vizsg\u00e1lati lehet\u0151s\u00e9gek\n                    k\u00f6z\u00fcl a sz\u00edvfrekvencia-variabilit\u00e1s \u00e9s baroreflex-szenzitivit\u00e1s a progn\u00f3zis\n                    pontosabb meg\u00edt\u00e9l\u00e9s\u00e9re, illetve els\u0151sorban klinikai tanulm\u00e1nyokban v\u00e9gpontokk\u00e9nt\n                    haszn\u00e1latosak. Az \u00f6sszefoglal\u00f3 kit\u00e9r emellett a betegek el\u0151sz\u0171r\u00e9s\u00e9t szolg\u00e1l\u00f3\n                    k\u00e9rd\u0151\u00edves m\u00f3dszerekre \u00e9s a diagnosztika egyszer\u0171s\u00edt\u00e9s\u00e9t c\u00e9lz\u00f3 \u00fajabb\n                    lehet\u0151s\u00e9gekkel kapcsolatos legfrissebb eredm\u00e9nyekre. A cardiovascularis auton\u00f3m\n                    neuropathia kezel\u00e9s\u00e9nek sarokk\u00f6v\u00e9t a megfelel\u0151 glykaemi\u00e1s kontroll \u00e9s a\n                    cardiovascularis kock\u00e1zati t\u00e9nyez\u0151k kontrollja jelenti. Tov\u00e1bbi oki ter\u00e1pi\u00e1s\n                    lehet\u0151s\u00e9g az alfa-liponsav alkalmaz\u00e1sa, melynek az auton\u00f3m funkci\u00f3ra gyakorolt\n                    kedvez\u0151 hat\u00e1sait klinikai vizsg\u00e1lat igazolta. A hagyom\u00e1nyos \u00e9rtelemben vett\n                    glykaemi\u00e1s kontrollon t\u00fal \u00fajabban a glykaemi\u00e1s variabilit\u00e1s \u00e9s egyes\n                    antidiabetikumok idegi funkci\u00f3kra gyakorolt pleiotrop hat\u00e1sai ker\u00fcltek el\u0151t\u00e9rbe.\n                    A tests\u00falycs\u00f6kkent\u00e9s nemcsak a diabetes, de az auton\u00f3m neuropathia tekintet\u00e9ben\n                    is j\u00f3t\u00e9kony hat\u00e1s\u00fa, ugyanakkor az \u00e9letm\u00f3d-ter\u00e1pia tov\u00e1bbi \u00f6sszetev\u0151ivel\n                    kapcsolatban nem egy\u00e9rtelm\u0171ek az adatok. Orv Hetil. 2024; 165(16): 602\u2013612.<\/jats:p>","DOI":"10.1556\/650.2024.33027","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:24:35Z","timestamp":1713659075000},"page":"602-612","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["A diabeteses cardiovascularis auton\u00f3m neuropathia klinikuma, diagnosztik\u00e1ja \u00e9s ter\u00e1pi\u00e1ja"],"prefix":"10.1556","volume":"165","author":[{"given":"P\u00e9ter","family":"Kempler","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika Budapest, Kor\u00e1nyi S\u00e1ndor u. 2\/A, 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"K\u00f6rei","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika Budapest, Kor\u00e1nyi S\u00e1ndor u. 2\/A, 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Spallone V, Ziegler D, Freeman R, et al. Toronto Consensus Panel on\n                    Diabetic Neuropathy. Cardiovascular autonomic neuropathy in diabetes: clinical\n                    impact, assessment, diagnosis, and management. Diabetes Metab Res Rev. 2011; 27:\n                    639\u2013653.","DOI":"10.1002\/dmrr.1239"},{"key":"R2","unstructured":"Sztanek F, Z\u00f6ld E, Harangi M, et al. The classification and\n                    diagnosis of diabetic neuropathy according to recent international guidelines.\n                    [A diabeteses neuropathia oszt\u00e1lyoz\u00e1sa \u00e9s diagnosztik\u00e1ja a leg\u00fajabb nemzetk\u00f6zi\n                    aj\u00e1nl\u00e1sok alapj\u00e1n.] Magyar Belorv Arch. 2018; 71: 193\u2013200.\n                    [Hungarian]"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Putz Zs, Kempler P, Jermendy Gy. Diabetes-specific complications in\n                    prediabetes. 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