{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:09:53Z","timestamp":1784902193729,"version":"3.55.0"},"reference-count":21,"publisher":"Akademiai Kiado Zrt.","issue":"29","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"crossref","award":["NKFIA\/OTKA K135798"],"award-info":[{"award-number":["NKFIA\/OTKA K135798"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"crossref","award":["2023-1.2.1-ERA_NET2023-00013"],"award-info":[{"award-number":["2023-1.2.1-ERA_NET2023-00013"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100015498","name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium","doi-asserted-by":"crossref","award":["TKP2021EGA-24"],"award-info":[{"award-number":["TKP2021EGA-24"]}],"id":[{"id":"10.13039\/501100015498","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100015498","name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium","doi-asserted-by":"crossref","award":["TKP2021-NVA-15"],"award-info":[{"award-number":["TKP2021-NVA-15"]}],"id":[{"id":"10.13039\/501100015498","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2024,7,21]]},"abstract":"<jats:p>\n                    Az \u00fajsz\u00fcl\u00f6tt- \u00e9s csecsem\u0151kori hypernatraemia l\u00e1zat okoz\u00f3 hat\u00e1s\u00e1ra 100 \u00e9vvel\n                    ezel\u0151tt Heim P\u00e1l is felh\u00edvta a figyelmet. Az \u00e9vsz\u00e1zados ismeret ellen\u00e9re ritk\u00e1n\n                    gondolunk ennek lehet\u0151s\u00e9g\u00e9re. Egy n\u00e9gynapos, l\u00e1z miatt felvett fi\u00fa \u00fajsz\u00fcl\u00f6tt\n                    esete kapcs\u00e1n mutatjuk be az \u00fajsz\u00fcl\u00f6ttkori hypernatraemia elk\u00fcl\u00f6n\u00edt\u0151 k\u00f3rism\u00e9j\u00e9t.\n                    A hypernatraemia ebben a korban az esetek d\u00f6nt\u0151 r\u00e9sz\u00e9ben el\u00e9gtelen anyatejes\n                    t\u00e1pl\u00e1l\u00e1s, 10%-ot meghalad\u00f3 s\u00falyveszt\u00e9s k\u00f6vetkezm\u00e9nye. A s\u00falyveszt\u00e9s m\u00e9rt\u00e9ke\n                    ar\u00e1nyos a hypernatraemia fok\u00e1val. A l\u00e1z\u00e9rt azonban nem a folyad\u00e9khi\u00e1ny, hanem a\n                    hypernatraemia a felel\u0151s, ahogy azt csecsem\u0151k s\u00f3m\u00e9rgez\u00e9ssel j\u00e1r\u00f3 esetei\n                    mutatj\u00e1k. Mind a dehidr\u00e1ci\u00f3, mind a s\u00f3m\u00e9rgez\u00e9s k\u00f6vetkezt\u00e9ben fell\u00e9p\u0151\n                    hypernatraemia fokozott vizeletozmolalit\u00e1ssal j\u00e1r, a frakcion\u00e1lis\n                    n\u00e1triumkiv\u00e1laszt\u00e1s azonban csak s\u00f3m\u00e9rgez\u00e9sben magas. A felvett \u00fajsz\u00fcl\u00f6tt\n                    vizeletozmolalit\u00e1sa azonban alacsony, 100 mOsm\/kg alatti, fajs\u00falya 1005 g\/l\n                    volt. A hypernatraemia \u00e9s a hipozmol\u00e1ris vizelet egy\u00fcttes fenn\u00e1ll\u00e1sa diabetes\n                    insipidusra utal. Ennek leggyakoribb, X-hez k\u00f6t\u00f6tt, renalis form\u00e1j\u00e1t igazolta a\n                    genetikai vizsg\u00e1lat, az\n                    <jats:italic>AVPR2<\/jats:italic>\n                    \u00f6r\u00f6kl\u00f6tt vari\u00e1ns\u00e1nak\n                    kimutat\u00e1s\u00e1val. A gyermek polyuri\u00e1ja hipotiazid- \u00e9s indometacinkezel\u00e9s hat\u00e1s\u00e1ra\n                    jelent\u0151sen cs\u00f6kkent, a folyad\u00e9kbevitel\n                    <jats:italic>ad libitum<\/jats:italic>\n                    biztos\u00edt\u00e1s\u00e1val nem alakult ki a k\u00f6vetkez\u0151 h\u00f3napokban hypernatraemia. Orv Hetil.\n                    2024; 165(29): 1107\u20131111.\n                  <\/jats:p>","DOI":"10.1556\/650.2024.33086","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T03:37:48Z","timestamp":1721533068000},"page":"1107-1111","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A s\u00f3l\u00e1z"],"prefix":"10.1556","volume":"165","author":[{"given":"K\u00e1lm\u00e1n","family":"Tory","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, B\u00f3kay J. u. 53., 1083 Magyarorsz\u00e1g"},{"name":"MTA-SE Lend\u00fclet Nephrogenetikai Kutat\u00f3csoport Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"L\u00e9gr\u00e1di","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, B\u00f3kay J. u. 53., 1083 Magyarorsz\u00e1g"},{"name":"MTA-SE Lend\u00fclet Nephrogenetikai Kutat\u00f3csoport Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zar\u00e1nd","family":"N\u00e9methi","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, B\u00f3kay J. u. 53., 1083 Magyarorsz\u00e1g"},{"name":"MTA-SE Lend\u00fclet Nephrogenetikai Kutat\u00f3csoport Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Kincs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, B\u00f3kay J. u. 53., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Reusz","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, B\u00f3kay J. u. 53., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tivadar","family":"Tulassay","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, B\u00f3kay J. u. 53., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","unstructured":"Presentation of P\u00e1l Heim on neonatal fever at the Royal Medical\n                    Association on December 22, 1923, in Budapest. [Heim P\u00e1l el\u0151ad\u00e1sa az \u00fajsz\u00fcl\u00f6ttek\n                    els\u0151 \u00e9letnapjaiban fell\u00e9p\u0151 l\u00e1zr\u00f3l, a Budapesti Kir\u00e1lyi Orvosegyes\u00fclet 1923.\n                    december 22-i \u00fcl\u00e9s\u00e9n.] Orv Hetil. 1924; 68: 11\u201312. [Hungarian]"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Lavagno C, Camozzi P, Renzi S, et al. Breastfeeding-associated\n                    hypernatremia: a systematic review of the literature. J Hum Lact. 2016; 32:\n                    67\u201374.","DOI":"10.1177\/0890334415613079"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Oddie SJ, Craven V, Deakin K, et al. Severe neonatal hypernatraemia:\n                    a population based study. Arch Dis Child Fetal Neonatal Ed. 2013; 98:\n                    F384\u2013F387.","DOI":"10.1136\/archdischild-2012-302908"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Pelleboer RA, Bontemps ST, Verkerk PH, et al. 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