{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:03:09Z","timestamp":1785157389483,"version":"3.55.0"},"reference-count":52,"publisher":"Akademiai Kiado Zrt.","issue":"30","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2024,7,28]]},"abstract":"<jats:p>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic>\n                    A kr\u00f3nikus vesebetegs\u00e9g gyakran j\u00e1r egy\u00fctt s\u00falyos\n                    D-vitamin-hi\u00e1nnyal. Kimutat\u00e1sa a sz\u00e9rum 25-hidroxi-D-vitamin-szintj\u00e9nek m\u00e9r\u00e9se\n                    alapj\u00e1n t\u00f6rt\u00e9nik, amelyhez a rutinban f\u0151k\u00e9nt az immunoassay-t alkalmazz\u00e1k. Ennek\n                    h\u00e1tr\u00e1nya, hogy az eredm\u00e9ny f\u00fcgg a minta D-vitamink\u00f6t\u0151 \u00e9s egy\u00e9b feh\u00e9rj\u00e9inek\n                    szintj\u00e9t\u0151l is.\n                    <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n                    Egyes sz\u00e9rumfeh\u00e9rj\u00e9k \u00e9s a\n                    D-vitamin-ell\u00e1totts\u00e1g k\u00f6z\u00f6tti kapcsolat tanulm\u00e1nyoz\u00e1sa\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    -vitamin-naiv, kr\u00f3nikus vesebetegekben.\n                    <jats:italic>M\u00f3dszerek:<\/jats:italic>\n                    103 beteg (30 nem dializ\u00e1lt, 36 peritonealis dializ\u00e1lt \u00e9s 37 hemodializ\u00e1lt)\n                    sz\u00e9rum\u00e1ban m\u00e9rt\u00fck meg az \u00f6sszes 25-hidroxivitamin-D, a kalcium, az \u00f6sszfeh\u00e9rje,\n                    az albumin, a D-vitamink\u00f6t\u0151 feh\u00e9rje \u00e9s az elektroforetikus feh\u00e9rjefrakci\u00f3k\n                    szintj\u00e9t. Az intakt parathormon koncentr\u00e1ci\u00f3t 2. \u00e9s 3. gener\u00e1ci\u00f3s m\u00f3dszerrel is\n                    meghat\u00e1roztuk.\n                    <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    El\u00e9gs\u00e9ges D-vitamin-ell\u00e1totts\u00e1got\n                    egy esetben sem igazoltunk. A nem dializ\u00e1ltak 87%-a, a hemodializ\u00e1ltak 86%-a, a\n                    peritonealisan dializ\u00e1lt betegek mindegyike D-vitamin-hi\u00e1nyos volt. A\n                    dializ\u00e1ltakban a referenciatartom\u00e1nyon k\u00edv\u00fcl es\u0151 alfa-1- (18%), b\u00e9ta- (22%)\n                    globulin \u00e9s az albumin\/globulin h\u00e1nyados (19%) szignifik\u00e1nsan ritk\u00e1bban fordult\n                    el\u0151, mint a dial\u00edzisben nem r\u00e9szes\u00fcl\u0151 esetekben, szemben a D-vitamink\u00f6t\u0151\n                    feh\u00e9rj\u00e9vel (37%). A peritonealisan kezeltekben szignifik\u00e1nsan alacsonyabbnak\n                    bizonyult az \u00f6sszes 25-hidroxivitamin-D, kalcium \u00e9s \u00f6sszfeh\u00e9rje, gamma-globulin,\n                    albumin\/globulin h\u00e1nyados \u00e9rt\u00e9ke \u00e9s szignifik\u00e1nsan magasabbnak az\n                    alfa-1,2-globulin \u00e9s a D-vitamink\u00f6t\u0151 feh\u00e9rje szintje. Csak a peritonealisan\n                    dializ\u00e1lt betegekben igazol\u00f3dott az \u00f6sszes 25-hidroxivitamin-D \u00e9s az intakt\n                    parathormon k\u00f6z\u00f6tt szignifik\u00e1ns negat\u00edv korrel\u00e1ci\u00f3 mindk\u00e9t m\u00f3dszerrel m\u00e9rve, m\u00edg\n                    ez a hemodializ\u00e1lt betegek eset\u00e9ben csak 3. gener\u00e1ci\u00f3s m\u00f3dszerrel igazol\u00f3dott.\n                    <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n                    Kr\u00f3nikus vesebetegekben a gyakori\n                    D-vitamin-hi\u00e1ny s\u00falyosbodik a dial\u00edzis ut\u00e1n, k\u00fcl\u00f6n\u00f6sen a peritonealisan\n                    dializ\u00e1ltakban, ez\u00e9rt nekik nagyobb d\u00f3zis D\n                    <jats:sub>3<\/jats:sub>\n                    -vitamin ad\u00e1sa sz\u00fcks\u00e9ges.\n                    A magas alfa-1-globulin-szint D-vitamin-hi\u00e1nnyal j\u00e1r egy\u00fctt mind a dializ\u00e1lt,\n                    mind a nem dializ\u00e1lt esetekben. A peritonealisan dializ\u00e1ltakban a D-vitamink\u00f6t\u0151\n                    feh\u00e9rje \u00e9s az egy\u00e9b sz\u00e9rumfeh\u00e9rj\u00e9k szintjei gyakrabban elt\u00e9rnek a\n                    referenciatartom\u00e1nyt\u00f3l, mint a hemodializ\u00e1ltakban. A szekunder\n                    hyperparathyreosis kezel\u00e9s\u00e9ben a nat\u00edv D-vitamin ad\u00e1s\u00e1nak is jelent\u0151s\u00e9ge van. Ez\n                    a peritonealis dial\u00edzisben mindk\u00e9t intaktparathormon-m\u00f3dszerrel, de\n                    hemodial\u00edzisben csak a 3. gener\u00e1ci\u00f3s m\u00f3dszerrel igazol\u00f3dott, ez\u00e9rt\n                    hemodial\u00edzisben ennek a m\u00f3dszernek a haszn\u00e1lata javasolt. Orv Hetil. 2024;\n                    165(30): 1154\u20131165.\n                  <\/jats:p>","DOI":"10.1556\/650.2024.33091","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T03:04:04Z","timestamp":1722308644000},"page":"1154-1165","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["A D-vitamin-ell\u00e1totts\u00e1g \u00e9s egyes feh\u00e9rjefrakci\u00f3k k\u00f6z\u00f6tti \u00f6sszef\u00fcgg\u00e9s vizsg\u00e1lata vesebetegekben"],"prefix":"10.1556","volume":"165","author":[{"given":"L\u00e1szl\u00f3","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"Vas V\u00e1rmegyei Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, \u00c1ltal\u00e1nos Belgy\u00f3gy\u00e1szati Oszt\u00e1ly Szombathely Magyarorsz\u00e1g"},{"name":"B. Braun 6. sz\u00e1m\u00fa Dial\u00edzisk\u00f6zpont Szombathely Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter D\u00f3ra","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Vas V\u00e1rmegyei Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, \u00c1ltal\u00e1nos Belgy\u00f3gy\u00e1szati Oszt\u00e1ly Szombathely Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e1ta","family":"P\u00f3t\u00e1rin\u00e9 Kisp\u00e1l","sequence":"additional","affiliation":[{"name":"SYNLAB Kiskunhalasi Laborat\u00f3rium Kiskunhalas Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"L\u0151csei","sequence":"additional","affiliation":[{"name":"Vas V\u00e1rmegyei Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, \u00c1ltal\u00e1nos Belgy\u00f3gy\u00e1szati Oszt\u00e1ly Szombathely Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"K\u00e1lm\u00e1n","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Laborat\u00f3riumi Medicina Int\u00e9zet P\u00e9cs Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzs\u00e9bet","family":"Toldy","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, Diagnosztikai Tansz\u00e9k P\u00e9cs Magyarorsz\u00e1g"},{"name":"SYNLAB Hungary Kft. Diagnosztikai K\u00f6zpont, Klinikai K\u00e9miai \u00e9s Immunol\u00f3giai Laborat\u00f3rium Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Levey AS, Atkins R, Coresh J, et al. Chronic kidney disease as a\n                    global public health problem: approaches and initiatives \u2013 a position statement\n                    from Kidney Disease Improving Global Outcomes. Kidney Int. 2007; 72:\n                    247\u2013259.","DOI":"10.1038\/sj.ki.5002343"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"K\u00f6vesdy CP. Epidemiology of chronic kidney disease: an update 2022.\n                    Kidney Int Suppl. 2022; 12: 7\u201311.","DOI":"10.1016\/j.kisu.2021.11.003"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Nagy J. The chronic kidney disease \u201cepidemy\u201d. 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