{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:18:07Z","timestamp":1778678287189,"version":"3.51.4"},"reference-count":30,"publisher":"Akademiai Kiado Zrt.","issue":"31","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2024,8,4]]},"abstract":"A Stevens\u2013Johnson-szindr\u00f3ma \u00e9s a toxikus epidermalis necrolysis ritka, ugyanakkor\n igen s\u00falyos b\u0151r- \u00e9s ny\u00e1lkah\u00e1rtya-megbeteged\u00e9st okoz\u00f3 hiperszenzitivit\u00e1si\n reakci\u00f3, amelyet els\u0151sorban gy\u00f3gyszer, illetve fert\u0151z\u0151 \u00e1gens v\u00e1lt ki. B\u00e1r ezek a\n k\u00f3rk\u00e9pek potenci\u00e1lisan \u00e9letet vesz\u00e9lyeztet\u0151 \u00e1llapotot id\u00e9znek el\u0151, nem szabad\n megfeledkezni a szem\u00e9szeti k\u00f6vetkezm\u00e9nyekr\u0151l sem, amelyek hossz\u00fa t\u00e1von\n jelent\u0151sen befoly\u00e1solj\u00e1k az egy\u00e9n \u00e9letmin\u0151s\u00e9g\u00e9t. Esetismertet\u00e9s\u00fcnk c\u00e9lja\n felh\u00edvni a figyelmet a fenti k\u00f3rk\u00e9pek szem\u00e9szeti sz\u00f6v\u0151dm\u00e9nyeire \u00e9s a miel\u0151bb\n megkezdett ter\u00e1pia fontoss\u00e1g\u00e1ra. Az akut f\u00e1zisban a betegek 50%-\u00e1ban jelentkezik\n szem\u00e9szeti \u00e9rintetts\u00e9g, ebben az id\u0151szakban a nagy mortalit\u00e1s miatt elveszhet a\n f\u00f3kusz a szem\u00e9szeti intervenci\u00f3r\u00f3l. Az al\u00e1bbiakban egy 17 \u00e9ves beteg eset\u00e9t\n ismertetj\u00fck, akin\u00e9l az epilepszia kezel\u00e9s\u00e9re alkalmazott lamotrigin toxikus\n epidermalis necrolysist induk\u00e1lt. Az \u00e9g\u00e9si intenz\u00edv oszt\u00e1lyon t\u00f6lt\u00f6tt, \u00f6sszesen\n 54 nap els\u0151 4 hete rendk\u00edv\u00fcl kritikus volt. A teljes testfelsz\u00ednre kiterjed\u0151,\n epidermolysishez t\u00e1rsul\u00f3 sziszt\u00e9m\u00e1s sz\u00f6v\u0151dm\u00e9nyeket \u2013 mint hypothermia, akut\n respiratorikus distressz szindr\u00f3ma, szepszis, akut tubularis elhal\u00e1s,\n v\u00e9rszeg\u00e9nys\u00e9g \u00e9s az elektrolit-egyens\u00faly s\u00falyos zavara \u2013 sikeresen kezelt\u00e9k. A\n betegs\u00e9g szem\u00e9szeti t\u00fcneteit kezdett\u0151l fogva j\u00f3l kontroll\u00e1ltuk. K\u00e9t \u00e9v\n eltelt\u00e9vel a szem el\u00fcls\u0151 szegmentum\u00e1ban nem volt jelent\u0151s sz\u00f6v\u0151dm\u00e9ny, a\n l\u00e1t\u00f3\u00e9less\u00e9g teljes maradt. Orv Hetil. 2024; 165(31): 1206\u20131212.<\/jats:p>","DOI":"10.1556\/650.2024.33096","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T01:24:24Z","timestamp":1723685064000},"page":"1206-1212","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["A toxikus epidermalis necrolysis szem\u00e9szeti vonatkoz\u00e1sai"],"prefix":"10.1556","volume":"165","author":[{"given":"Petra","family":"Killik","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika Budapest, M\u00e1ria u. 39., 1085 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Kosty\u00e1l","sequence":"additional","affiliation":[{"name":"Bethesda Gyermekk\u00f3rh\u00e1z, \u00c9g\u00e9ss\u00e9r\u00fclt Gyermekeket Gy\u00f3gy\u00edt\u00f3 Orsz\u00e1gos K\u00f6zpont, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Oszt\u00e1ly Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika Budapest, M\u00e1ria u. 39., 1085 Magyarorsz\u00e1g"},{"name":"Dr. Rolf M. Schwiete Zentrum f\u00fcr Limbusstammzellforschung und kongenitale Aniridie, Universit\u00e4t des Saarlandes Homburg\/Saar N\u00e9metorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Szentm\u00e1ry","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika Budapest, M\u00e1ria u. 39., 1085 Magyarorsz\u00e1g"},{"name":"Dr. Rolf M. Schwiete Zentrum f\u00fcr Limbusstammzellforschung und kongenitale Aniridie, Universit\u00e4t des Saarlandes Homburg\/Saar N\u00e9metorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n Zsolt","family":"Nagy","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika Budapest, M\u00e1ria u. 39., 1085 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto Alexander","family":"Maneschg","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szem\u00e9szeti Klinika Budapest, M\u00e1ria u. 39., 1085 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"R1","unstructured":"Oakley AM, Krishnamurthy K. Stevens-Johnson syndrome. [Updated: 2023\n Apr 10.] In: StatPearls (Internet). StatPearls Publishing, Treasure Island, FL,\n 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459323\/\n [accessed: 2024 May 20]."},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Gregory DG. Treatment of acute Stevens\u2013Johnson syndrome and toxic\n epidermal necrolysis using amniotic membrane: a review of 10 consecutive cases.\n Ophthalmology 2011; 118: 908\u2013914.","DOI":"10.1016\/j.ophtha.2011.01.046"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Lee EY, Knox C, Phillips EJ. Worldwide prevalence of\n antibiotic-associated Stevens-Johnson syndrome and toxic epidermal necrolysis: a\n systematic review and meta-analysis. JAMA Dermatol. 2023; 159:\n 384\u2013392.","DOI":"10.1001\/jamadermatol.2022.6378"},{"key":"R4","unstructured":"Vel\u00e1zquez-C\u00e1rcamo EA, Rodr\u00edguez-Ch\u00e1vez Y, M\u00e9ndez-Flores S, et al.\n Lamotrigine and its relationship with Stevens-Johnson syndrome and toxic\n epidermal necrolysis. [Lamotrigina y su relaci\u00f3n con el s\u00edndrome de\n Stevens-Johnson y la necr\u00f3lisis epid\u00e9rmica t\u00f3xica.] Rev Med Inst Mex Seguro Soc.\n 2020; 58: 202\u2013205. [Spanish]"},{"key":"R5","unstructured":"Pereira-Ospina RD, Bejarano-Quintero AM, Suesc\u00fan-Vargas JM, et al.\n Drug reaction with eosinophilia and systemic symptoms due to carbamazepine.\n Pediatric case. [S\u00edndrome de sensibilidad a f\u00e1rmacos con eosinofilia y s\u00edntomas\n sist\u00e9micos debido a la carbamazepina. Caso pedi\u00e1trico.] Arch Argent Pediatr.\n 2018; 116: e433\u2013e436. [Spanish]"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"T\u00f3th G, Luk\u00e1cs A, Stachon T, et al. Clinical characteristics and\n treatment of ophthalmic sequelae of Stevens\u2013Johnson syndrome and toxic epidermal\n necrolysis at a tertiary eyecare centre in Hungary. Ophthalmol Ther. 2024; 13:\n 1343\u20131356.","DOI":"10.1007\/s40123-024-00924-z"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Harr T, French LE. Stevens-Johnson syndrome and toxic epidermal\n necrolysis. Chem Immunol Allergy 2012; 97: 149\u2013166.","DOI":"10.1159\/000335627"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Chung WH, Hung SI, Hong HS, et al. Medical genetics: a marker for\n Stevens\u2013Johnson syndrome. Nature 2004; 428: 486.","DOI":"10.1038\/428486a"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"T\u00f3th G, Luk\u00e1cs A, Schirra F, et al. Ophthalmic aspects of\n Stevens\u2013Johnson syndrome and toxic epidermal necrolysis: a narrative review.\n Ophthalmol Ther. 2023; 12: 1795\u20131811.","DOI":"10.1007\/s40123-023-00725-w"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Schulze Schwering M, Kayange P, Rothe C. Ocular manifestations in\n patients with Stevens\u2013Johnson syndrome in Malawi. Review of the literature\n illustrated by clinical cases. Graefes Arch Clin Exp Ophthalmol. 2019; 257:\n 2343\u20132348.","DOI":"10.1007\/s00417-019-04421-z"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Frantz R, Huang S, Are A, et al. Stevens\u2013Johnson syndrome and toxic\n epidermal necrolysis: a review of diagnosis and management. Medicina (Kaunas)\n 2021; 57: 895.","DOI":"10.3390\/medicina57090895"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Abulatan IT, Ben-David SG, Morales-Colon LA, et al. A compilation of\n drug etiologies of Stevens-Johnson syndrome and toxic epidermal necrolysis.\n Cureus 2023; 15: e48728.","DOI":"10.7759\/cureus.48728"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Su SC, Mockenhaupt M, Wolkenstein P, et al. Interleukin-15 is\n associated with severity and mortality in Stevens-Johnson syndrome\/toxic\n epidermal necrolysis. 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Management of ocular conditions in the\n burn unit: thermal and chemical burns and Stevens-Johnson syndrome\/toxic\n epidermal necrolysis. J Burn Care Res. 2011; 32: 547\u2013560.","DOI":"10.1097\/BCR.0b013e31822b0f29"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Gueudry J, Roujeau JC, Binaghi M, et al. Risk factors for the\n development of ocular complications of Stevens-Johnson syndrome and toxic\n epidermal necrolysis. Arch Dermato 2009; 145: 157\u2013162.","DOI":"10.1001\/archdermatol.2009.540"},{"key":"R19","unstructured":"Pi\u00e9rard GE, Paquet P, Jennes S, et al. The conundrum of toxic\n epidermal necrolysis. Nova Science Publishers, New York, NY,\n 2015."},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Sotozono C, Ueta M, Koizumi N, et al. Diagnosis and treatment of\n Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular\n complications. 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