{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:59:35Z","timestamp":1785437975499,"version":"3.56.0"},"reference-count":28,"publisher":"Akademiai Kiado Zrt.","issue":"30","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2024,7,28]]},"abstract":"<jats:p>\n                    <jats:italic>Bevezet\u00e9s:<\/jats:italic>\n                    A M\u00e9ni\u00e8re-betegs\u00e9g gy\u00f3gy\u00edthatatlan, de menedzselhet\u0151\n                    betegs\u00e9g. Alapja az endolympha ter\u00e9nek \u201ekit\u00e1gul\u00e1sa\u201d, az endolympha hydrops.\n                    Lehet egy- vagy k\u00e9toldali. A t\u00fcnetek megjelen\u00e9se alapj\u00e1n metakr\u00f3n vagy szinkr\u00f3n\n                    megjelen\u00e9sr\u0151l besz\u00e9lhet\u00fcnk. Hasonl\u00f3 t\u00fcnetekkel jelentkezhet az autoimmun\n                    bels\u0151f\u00fcl-betegs\u00e9g.\n                    <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n                    K\u00e9toldali M\u00e9ni\u00e8re-betegs\u00e9ggel\n                    diagnosztiz\u00e1lt betegek (7 beteg: 2 f\u00e9rfi \u00e9s 5 n\u0151) bels\u0151 f\u00fcl\u00e9nek felt\u00e9rk\u00e9pez\u00e9se,\n                    immunol\u00f3giai statusuk felder\u00edt\u00e9se, tov\u00e1bb\u00e1 az egy\u00e9b k\u00f3rk\u00e9pekt\u0151l, f\u0151leg az\n                    autoimmun bels\u0151f\u00fcl-betegs\u00e9gt\u0151l val\u00f3 differenci\u00e1l\u00e1s, tapasztalatok alapj\u00e1n egy\n                    kivizsg\u00e1l\u00e1si protokoll fel\u00e1ll\u00edt\u00e1sa.\n                    <jats:italic>M\u00f3dszer:<\/jats:italic>\n                    K\u00e9toldali\n                    M\u00e9ni\u00e8re-betegekn\u00e9l rohammentes \u00e1llapotban a f\u00fcl-orr-g\u00e9g\u00e9szeti, otoneurol\u00f3giai \u00e9s\n                    immunol\u00f3giai status, valamint az anamn\u00e9zis felv\u00e9tele, tov\u00e1bb\u00e1 az angularis\n                    vestibuloocularis reflex (aVOR) nagy \u00e9s kis frekvenci\u00e1j\u00fa m\u0171k\u00f6d\u00e9s\u00e9nek felm\u00e9r\u00e9se.\n                    Az el\u0151bbit videofejimpulzus-teszt (vHIT), m\u00edg az ut\u00f3bbit kaloriz\u00e1ci\u00f3s teszt\n                    sor\u00e1n vizsg\u00e1ltuk. Tisztahang-k\u00fcsz\u00f6baudiogramot v\u00e9gezt\u00fcnk. M\u00e1gneses rezonanci\u00e1s\n                    k\u00e9palkot\u00f3 seg\u00edts\u00e9g\u00e9vel koponyafelv\u00e9tel k\u00e9sz\u00fclt. Az immunol\u00f3giai laborvizsg\u00e1lat\n                    v\u00e9rsz\u00e9rumb\u00f3l t\u00f6rt\u00e9nt.\n                    <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n                    A betegekn\u00e9l sziszt\u00e9m\u00e1s\n                    autoimmun betegs\u00e9g nem igazol\u00f3dott. Minden esetben k\u00e9toldali, a m\u00e9ly\n                    frekvenci\u00e1kat is \u00e9rint\u0151 pancochlearis sensorineuralis hall\u00e1scs\u00f6kken\u00e9s volt\n                    l\u00e1that\u00f3. vHIT sor\u00e1n k\u00e9t esetben a magas frekvenci\u00e1j\u00fa aVOR \u00e9rintetts\u00e9ge is\n                    igazolhat\u00f3 volt, melyet a betegs\u00e9g el\u0151rehaladotts\u00e1g\u00e1nak v\u00e9lem\u00e9nyezt\u00fcnk. A t\u00f6bbi\n                    esetben \u00e9p m\u0171k\u00f6d\u00e9s\u0171, magas frekvenci\u00e1j\u00fa aVOR-t tal\u00e1ltunk. A kaloriz\u00e1ci\u00f3s teszt\n                    sor\u00e1n minden esetben k\u00e9toldali \u00edvj\u00e1ratparesis volt l\u00e1that\u00f3.\n                    <jats:italic>Megbesz\u00e9l\u00e9s:<\/jats:italic>\n                    A szakirodalomban sz\u00e1mos tanulm\u00e1ny foglalkozik\n                    az \u00e1ltalunk megfigyelt, a vHIT \u00e9s a kaloriz\u00e1ci\u00f3s teszt k\u00f6z\u00f6tti diszkrepanci\u00e1val.\n                    Ez az aVOR receptor\u00e1nak, a crista ampullarisnak az anat\u00f3mi\u00e1j\u00e1b\u00f3l k\u00f6vetkezhet:\n                    m\u00edg a magas frekvenci\u00e1j\u00fa aVOR-t a centr\u00e1lisan elhelyezked\u0151 I-es t\u00edpus\u00fa\n                    sz\u0151rsejtek \u00e9rz\u00e9kelik, addig az alacsony frekvenci\u00e1j\u00fa aVOR-t a perif\u00e9ri\u00e1san\n                    elhelyezked\u0151 II-es t\u00edpus\u00fa sz\u0151rsejtek. Az ut\u00f3bbiak szelekt\u00edv k\u00e1rosod\u00e1s\u00e1t\n                    figyelt\u00e9k meg M\u00e9ni\u00e8re-betegs\u00e9gben \u00e9s autoimmun bels\u0151f\u00fcl-betegs\u00e9gben is.\n                    Ugyanakkor seg\u00edtett a differenci\u00e1l\u00e1sban a betegek rendezett immunol\u00f3giai\n                    statusa, az intrav\u00e9n\u00e1s kortikoszteroidra adott gyenge v\u00e1laszuk, egy esetben\n                    pedig a saccotomi\u00e1t k\u00f6vet\u0151 \u00e1llapotjavul\u00e1s.\n                    <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n                    A\n                    tapasztalatok alapj\u00e1n egy kivizsg\u00e1l\u00e1si protokollt k\u00eds\u00e9relt\u00fcnk meg fel\u00e1ll\u00edtani\n                    olyan betegek eset\u00e9ben, akik k\u00e9toldali f\u00fclt\u00fcnetekkel, rohamokban jelentkez\u0151,\n                    forg\u00f3 jelleg\u0171 sz\u00e9d\u00fcl\u00e9ssel jelentkeznek. Javasoljuk t\u00f6bbek k\u00f6z\u00f6tt a vHIT, a\n                    kaloriz\u00e1ci\u00f3s teszt \u00e9s az immunol\u00f3giai kivizsg\u00e1l\u00e1s elv\u00e9gz\u00e9s\u00e9t is.\n                    Megfontoland\u00f3nak tartjuk egy multicentrikus vizsg\u00e1lat elv\u00e9gz\u00e9s\u00e9t is mindk\u00e9t\n                    k\u00f3rk\u00e9ppel kapcsolatban. Orv Hetil. 2024; 165(30): 1176\u20131183.\n                  <\/jats:p>","DOI":"10.1556\/650.2024.33108","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T03:04:28Z","timestamp":1722308668000},"page":"1176-1183","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["A k\u00e9toldali M\u00e9ni\u00e8re-betegs\u00e9g \u00e9s az autoimmun bels\u0151f\u00fcl-betegs\u00e9g elk\u00fcl\u00f6n\u00edt\u0151 diagnosztik\u00e1ja"],"prefix":"10.1556","volume":"165","author":[{"given":"G\u00e1bor","family":"Varga-Bal\u00e1zs","sequence":"first","affiliation":[{"name":"Gy\u0151r-Moson-Sopron V\u00e1rmegyei Petz Alad\u00e1r Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, F\u00fcl-Orr-G\u00e9g\u00e9szeti \u00e9s Fej-, Nyakseb\u00e9szeti Oszt\u00e1ly Gy\u0151r Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. L\u00e1szl\u00f3","family":"Tam\u00e1s","sequence":"additional","affiliation":[{"name":"Gy\u0151r-Moson-Sopron V\u00e1rmegyei Petz Alad\u00e1r Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, F\u00fcl-Orr-G\u00e9g\u00e9szeti \u00e9s Fej-, Nyakseb\u00e9szeti Oszt\u00e1ly Gy\u0151r Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Nagy","sequence":"additional","affiliation":[{"name":"Gy\u0151r-Moson-Sopron V\u00e1rmegyei Petz Alad\u00e1r Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, Immunol\u00f3giai Szakrendel\u00e9s Gy\u0151r Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Garai","sequence":"additional","affiliation":[{"name":"Gy\u0151r-Moson-Sopron V\u00e1rmegyei Petz Alad\u00e1r Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, F\u00fcl-Orr-G\u00e9g\u00e9szeti \u00e9s Fej-, Nyakseb\u00e9szeti Oszt\u00e1ly Gy\u0151r Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Tompos","sequence":"additional","affiliation":[{"name":"Gy\u0151r-Moson-Sopron V\u00e1rmegyei Petz Alad\u00e1r Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z, F\u00fcl-Orr-G\u00e9g\u00e9szeti \u00e9s Fej-, Nyakseb\u00e9szeti Oszt\u00e1ly Gy\u0151r Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u00e1ta","family":"Bencsik","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, F\u00fcl-Orr-G\u00e9g\u00e9szeti \u00e9s Fej-Nyakseb\u00e9szeti Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Lopez-Escamez JA, Carey J, Chung WH, et al. 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J Laryngol Otol. 2023; 137: 782\u2013788.","DOI":"10.1017\/S0022215122002262"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Rauch SD, Merchant SN, Thedinger BA. Meni\u00e8re\u2019s syndrome and\n                    endolymphatic hydrops: double-blind temporal bone study. Ann Otol Rhinol\n                    Laryngol. 1989; 98: 873\u2013883.","DOI":"10.1177\/000348948909801108"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Merchant SN, Adams JC, Nadol JB. Jr. Pathophysiology of M\u00e9ni\u00e8re\u2019s\n                    syndrome: are symptoms caused by endolymphatic hydrops? Otol Neurotol. 2005; 26:\n                    74\u201381.","DOI":"10.1097\/00129492-200501000-00013"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"K\u00e4mpfe Nordstr\u00f6m CK, Danckwardt-Lilliestr\u00f6m ND, Laurell G, et al.\n                    The human endolymphatic sac and inner ear immunity: macrophage interaction and\n                    molecular expression. 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