{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:40:43Z","timestamp":1775144443745,"version":"3.50.1"},"reference-count":54,"publisher":"Akademiai Kiado Zrt.","issue":"34","license":[{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2024,8,25]]},"abstract":"<jats:p>Eur\u00f3pa-szerte a szam\u00e1rk\u00f6h\u00f6g\u00e9s robban\u00e1sszer\u0171 emelked\u00e9s\u00e9t figyelhetj\u00fck meg. Az idei\n                    \u00e9v els\u0151 3 h\u00f3napj\u00e1ban m\u00e1r t\u00f6bb igazolt esetet regisztr\u00e1ltak, mint a tavalyi \u00e9vben\n                    \u00f6sszesen. Magyarorsz\u00e1gon a pertussis epidemiol\u00f3giai helyzete a k\u00f6zelm\u00faltban igen\n                    kedvez\u0151en alakult, 2019 \u00e9s 2023 k\u00f6z\u00f6tt a bejelentett esetsz\u00e1mok medi\u00e1nja 2 f\u0151\n                    volt. A n\u00f6vekv\u0151 incidenci\u00e1t azonban haz\u00e1nkban is \u00e9szlelj\u00fck: 2024. j\u00falius 14-ig\n                    153 jelentett pertussismegbeteged\u00e9sr\u0151l sz\u00e1molhatunk be. A fenyeget\u0151 k\u00f6z\u00f6ss\u00e9gi\n                    terjed\u00e9s megf\u00e9kez\u00e9se megv\u00e1ltozott prevenci\u00f3s hozz\u00e1\u00e1ll\u00e1st \u00e9s fokozott\n                    diagnosztikus aktivit\u00e1st k\u00edv\u00e1n. A kontaktszem\u00e9lyek mihamarabbi azonos\u00edt\u00e1sa \u00e9s\n                    ell\u00e1t\u00e1sa alapvet\u0151 fontoss\u00e1g\u00fa. A betegs\u00e9g az oltatlan, illetve nem teljesk\u00f6r\u0171en\n                    oltott \u00fajsz\u00fcl\u00f6ttekre \u00e9s csecsem\u0151kre a legvesz\u00e9lyesebb. Eset\u00fckben a k\u00f6h\u00f6g\u00e9si\n                    rohamok kapcs\u00e1n jelentkez\u0151 apno\u00e9s epiz\u00f3dok kering\u00e9s- \u00e9s l\u00e9gz\u00e9sle\u00e1ll\u00e1shoz\n                    vezethetnek. Az els\u0151dleges c\u00e9l ennek a popul\u00e1ci\u00f3nak a v\u00e9delme, melynek\n                    leghat\u00e1sosabb m\u00f3dja az \u00e9letkor szerinti k\u00f6telez\u0151 immuniz\u00e1ci\u00f3 k\u00e9sedelem n\u00e9lk\u00fcli\n                    elv\u00e9gz\u00e9se, a f\u00e9szekimmunit\u00e1s biztos\u00edt\u00e1sa \u00e9s a v\u00e1rand\u00f3s n\u0151k akt\u00edv immuniz\u00e1l\u00e1sa. A\n                    v\u00e1rand\u00f3sok pertussisolt\u00e1s\u00e1t \u00e9vtizedek \u00f3ta biztons\u00e1ggal \u00e9s nagy hat\u00e9konys\u00e1ggal\n                    v\u00e9gzik vil\u00e1gszerte. A 16\u201336. gestati\u00f3s h\u00e9t k\u00f6z\u00f6tt b\u00e1rmikor alkalmazhat\u00f3, de a\n                    27\u201331. gestati\u00f3s h\u00e9t k\u00f6z\u00f6tt a legoptim\u00e1lisabb. K\u00f6zlem\u00e9ny\u00fcnkben a korszer\u0171\n                    nemzetk\u00f6zi ir\u00e1nyelvek alapj\u00e1n javaslatokat tesz\u00fcnk a pertussis diagnosztik\u00e1j\u00e1ra,\n                    kezel\u00e9s\u00e9re, a posztexpoz\u00edci\u00f3s kemoprofilaxisra, valamint az akt\u00edv immuniz\u00e1ci\u00f3ra.\n                    A klinikai gyakorlathoz adott javaslataink kiz\u00e1r\u00f3lag a jelenlegi hazai\n                    j\u00e1rv\u00e1ny\u00fcgyi helyzetben \u00e9rv\u00e9nyesek, az aktu\u00e1lis hat\u00f3s\u00e1gi aj\u00e1nl\u00e1s megjelen\u00e9s\u00e9ig.\n                    Orv Hetil. 2024; 165(34): 1307\u20131318.<\/jats:p>","DOI":"10.1556\/650.2024.33127","type":"journal-article","created":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T13:20:50Z","timestamp":1724592050000},"page":"1307-1318","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["Javaslatok \u00e9s megfontol\u00e1sok a magyarorsz\u00e1gi pertussisesetsz\u00e1m-n\u00f6veked\u00e9ssel \u00f6sszef\u00fcgg\u00e9sben"],"prefix":"10.1556","volume":"165","author":[{"given":"Di\u00e1na","family":"Tr\u00f3bert-Sipos","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"P\u00e9k","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Kulcs\u00e1r","sequence":"additional","affiliation":[{"name":"D\u00e9l-pesti Centrumk\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Telephely, V\u00e9d\u0151olt\u00e1si Szakrendel\u00e9s Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc Bal\u00e1zs","family":"Farkas","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Doktori Iskola Budapest Magyarorsz\u00e1g"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Orvosi Mikrobiol\u00f3gia Int\u00e9zet Budapest Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1 Wendelboe AM, Van Rie A, Salmaso S, et al. Duration of immunity against pertussis after natural infection or vaccination. Pediatr Infect Dis J. 2005; 24(5 Suppl): S58-S61.","DOI":"10.1097\/01.inf.0000160914.59160.41"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1080\/21645515.2016.1259780","article-title":"Immune persistence after pertussis vaccination","volume":"13","author":"Chen Z","year":"2017","unstructured":"2 Chen Z, He Q. Immune persistence after pertussis vaccination. Hum Vaccin Immunother. 2017; 13: 744-756.","journal-title":"Hum Vaccin Immunother"},{"key":"ref2","unstructured":"3 Methodological letter of the National Center for Public Health on vaccines in 2023. [A Nemzeti N\u00e9peg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont m\u00f3dszertani levele a 2023. \u00e9vi v\u00e9d\u0151olt\u00e1sokr\u00f3l.] Available from: https:\/\/www.antsz.hu\/data\/cms109510\/VML_NNK_2023_10_10.pdf [accessed: June 14, 2024]. [Hungarian]"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4 Bajor J. Gastrointestinal stromal tumors in neurofibromatosis type 1. [Gastrointestinalis stromatumorok 1-es t\u00edpus\u00fa neurofibromatosisban.] Orv Hetil. 2009; 150: 149-153. [Hungarian]","DOI":"10.1556\/oh.2009.28478"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5 Torzsa P, Raghavendra D, Tafalla M. Seroprevalence of Bordetella pertussis antibodies in adults in Hungary: results of an epidemiological cross-sectional study. [A Bordetellapertussis-antitestek szeroprevalenci\u00e1ja magyarorsz\u00e1gi feln\u0151ttekben.] Orv Hetil. 2018; 159: 503-510. [Hungarian]","DOI":"10.1556\/650.2018.30941"},{"key":"ref5","unstructured":"6 Centers for Disease Control and Prevention. Clinical features of pertussis. Available from: https:\/\/www.cdc.gov\/pertussis\/hcp\/clinical-signs\/ [accessed: June 14, 2024]."},{"key":"ref6","unstructured":"7 State of Iowa. Pertussis. Disease information. 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Diphteria-tetanus-pertussis vaccines. National Institute of Child Health and Human Development, Bethesda (MD), 2006-. [Updated 2024 Jul 15.] Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK500572\/ [accessed: July 20, 2024]."},{"key":"ref10","unstructured":"11 Centers for Disease Control and Prevention, National Notifiable Diseases Surveillance System. Pertussis (whooping cough) (Bordetella pertussis). 2020 case definition. Available from: https:\/\/ndc.services.cdc.gov\/case-definitions\/pertussis-2020\/ [accessed: June 14, 2024]."},{"key":"ref11","unstructured":"12 UK Health Security Agency. Guidance. Pertussis: background information on prevention and management. Available from: https:\/\/www.gov.uk\/guidance\/pertussis-clinical-and-public-health-management [accessed: June 14, 2024]."},{"key":"ref12","unstructured":"13 World Health Organization, Eastern Mediterranean Region. Pertussis. 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BMC Infect Dis. 2005; 5: 40.","journal-title":"BMC Infect Dis"},{"key":"ref15","unstructured":"16 Hungarian Ministry of Public Health. Decree 18\/1998. (VI. 3.) on epidemiological measures necessary to prevent infectious diseases and epidemics. [18\/1998. (VI. 3.) NM rendelet a fert\u0151z\u0151 betegs\u00e9gek \u00e9s a j\u00e1rv\u00e1nyok megel\u0151z\u00e9se \u00e9rdek\u00e9ben sz\u00fcks\u00e9ges j\u00e1rv\u00e1ny\u00fcgyi int\u00e9zked\u00e9sekr\u0151l.] Available from: https:\/\/net.jogtar.hu\/jogszabaly?docid=99800018.nm [accessed: June 14, 2024]. [Hungarian]"},{"key":"ref16","unstructured":"17 Centers for Disease Control and Prevention. Epidemiology and prevention of vaccine-preventable diseases. Chapter 16: pertussis. 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Real-time PCR measurement of persistence of Bordetella pertussis DNA in nasopharyngeal secretions during antibiotic treatment of young children with pertussis. J Clin Microbiol. 2008; 46: 3636-3638.","journal-title":"J Clin Microbiol"},{"key":"ref19","unstructured":"20 New South Wales Health. Recommended investigations for whooping cough. Available from: https:\/\/www.health.nsw.gov.au\/Infectious\/whoopingcough\/Pages\/workers-investigations.aspx [accessed: June 14, 2024]."},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21 Versteegen P, Valente Pinto M, Barkoff AM, et al. Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: a collaborative study in Finland, the Netherlands, and the United Kingdom. EBioMedicine 2021; 65: 103247. Erratum: EBioMedicine 2021; 68: 103420.","DOI":"10.1016\/j.ebiom.2021.103247"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1128\/CVI.13.3.341-348.2006","article-title":"Characterization of serological responses to pertussis","volume":"13","author":"22 Watanabe","year":"2006","unstructured":"22 Watanabe M, Connelly B, Weiss AA. Characterization of serological responses to pertussis. Clin Vaccine Immunol. 2006; 13: 341-348.","journal-title":"Clin Vaccine Immunol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.3390\/antibiotics11111570","article-title":"Macrolide resistance in Bordetella pertussis: current situation and future challenges","volume":"11","author":"23 Ivaska","year":"2022","unstructured":"23 Ivaska L, Barkoff AM, Mertsola J, et al. Macrolide resistance in Bordetella pertussis: current situation and future challenges. Antibiotics (Basel) 2022; 11: 1570.","journal-title":"Antibiotics (Basel)"},{"key":"ref23","unstructured":"24 Centers for Disease Control and Prevention. Whooping cough (pertussis). Treatment of pertussis. Available from: https:\/\/www.cdc.gov\/pertussis\/hcp\/clinical-care\/index.html [accessed: June 14, 2024]."},{"key":"ref24","unstructured":"25 The Royal Children's Hospital Melbourne. Clinical practice guidelines. Whooping cough (pertussis). Available from: https:\/\/www.rch.org.au\/clinicalguide\/guideline_index\/whooping_cough_pertussis\/ [accessed: June 14, 2024]."},{"key":"ref25","unstructured":"26 New South Wales Health. Management of whooping cough (pertussis). Available from: https:\/\/www.health.nsw.gov.au\/Infectious\/whoopingcough\/Pages\/workers-managing-cases.aspx [accessed: June 14, 2024]."},{"key":"ref26","unstructured":"27 New South Wales Health. Pertussis control guideline. 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Ann Intensive Care 2021; 11: 70.","journal-title":"Ann Intensive Care"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1007\/s40121-021-00465-z","article-title":"Pertussis in Individuals with co-morbidities: a systematic review","volume":"10","author":"Macina D","year":"2021","unstructured":"30 Macina D, Evans KE. Pertussis in Individuals with co-morbidities: a systematic review. Infect Dis Ther. 2021; 10: 1141-1170.","journal-title":"Infect Dis Ther"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1080\/14760584.2019.1588727","article-title":"The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review","volume":"18","author":"31 Kandeil","year":"2019","unstructured":"31 Kandeil W, Atanasov P, Avramioti D, et al. The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review. Expert Rev Vaccines 2019; 18: 439-455.","journal-title":"Expert Rev Vaccines"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2324547","DOI":"10.1080\/21645515.2024.2324547","article-title":"Understanding the impact of adult pertussis and current approaches to vaccination: a narrative review and expert panel recommendations","volume":"20","author":"32 Kardos","year":"2024","unstructured":"32 Kardos P, Correia de Sousa J, Heininger U, et al. Understanding the impact of adult pertussis and current approaches to vaccination: a narrative review and expert panel recommendations. Hum Vaccin Immunother. 2024; 20: 2324547.","journal-title":"Hum Vaccin Immunother"},{"key":"ref32","unstructured":"33 Hungarian Ministry of Human Capacities. Decree 1\/2014. (I. 16.) on the procedure of reporting infectious diseases. [1\/2014. (I. 16.) EMMI rendelet a fert\u0151z\u0151 betegs\u00e9gek jelent\u00e9s\u00e9nek rendj\u00e9r\u0151l.] Available from: https:\/\/antsz.hu\/data\/cms63809\/1_2014_I_16_EMMI_2014nov1_jen.pdf [accessed: June 14, 2024]. [Hungarian]"},{"key":"ref33","unstructured":"34 Yukon Communicable Disease Control. Pertussis. Available from: https:\/\/yukon.ca\/sites\/yukon.ca\/files\/ycdc_pertussis.pdf [accessed: June 14, 2024]."},{"key":"ref34","unstructured":"35 Philippine Society for Microbiology and Infectious Diseases. Guidance on the prevention and post-exposure management of pertussis among healthcare workers. 16 April 2024. Available from: https:\/\/www.psmid.org\/wp-content\/uploads\/2024\/05\/PREVENTION-AND-POST-EXPOSURE-MANAGEMENT-OF-PERTUSSIS-AMONG-HEALTHCARE-WORKERS.pdf [accessed: Jun 14, 2024]."},{"key":"ref35","unstructured":"36 UK Health Security Agency. Guidance on the management of cases of pertussis in England during the re-emergence of pertussis in 2024. Update: June 2024. 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J Immunol Res. 2019; 2019: 7134168.","journal-title":"J Immunol Res"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/22221751.2018.1564630","article-title":"Immunization with whole cell but not acellular pertussis vaccines primes CD4 T(RM) cells that sustain protective immunity against nasal colonization with Bordetella pertussis","volume":"8","author":"41 Wilk","year":"2019","unstructured":"41 Wilk MM, Borkner L, Misiak A, et al. Immunization with whole cell but not acellular pertussis vaccines primes CD4 T(RM) cells that sustain protective immunity against nasal colonization with Bordetella pertussis. Emerg Microbes Infect. 2019; 8: 169-185.","journal-title":"Emerg Microbes Infect"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"5787","DOI":"10.1016\/j.vaccine.2014.08.038","article-title":"The effect of timing of maternal tetanus, diphtheria, and acellular pertussis (Tdap) immunization during pregnancy on newborn pertussis antibody levels - a prospective study","volume":"32","author":"42 Abu Raya","year":"2014","unstructured":"42 Abu Raya B, Srugo I, Kessel A, et al. The effect of timing of maternal tetanus, diphtheria, and acellular pertussis (Tdap) immunization during pregnancy on newborn pertussis antibody levels - a prospective study. Vaccine 2014; 32: 5787-5793.","journal-title":"Vaccine"},{"key":"ref42","unstructured":"43 Centers for Disease Control and Prevention. Pregnancy and whooping cough. Vaccinating pregnant patients. 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