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A laborat\u00f3riumi biomarkerek a k\u00e9s\u0151bbi\n                    neurol\u00f3giai kimenetel el\u0151rejelz\u00e9se szempontj\u00e1b\u00f3l is fontosak lehetnek, t\u00e1mpontot\n                    adva az ell\u00e1t\u00f3 klinikusok \u00e9s az agg\u00f3d\u00f3 sz\u00fcl\u0151k sz\u00e1m\u00e1ra. A hypoxi\u00e1s-ischaemi\u00e1s\n                    encephalopathia mellett gyakran el\u0151fordul\u00f3 szervi k\u00e1rosod\u00e1sok elt\u00e9r\u0151 s\u00falyoss\u00e1g\u00fa\n                    \u00e9s v\u00e1ltozatos klinikai k\u00e9pet adnak, melyek megfelel\u0151 ell\u00e1t\u00e1s\u00e1t szint\u00e9n\n                    el\u0151seg\u00edtheti a laborvizsg\u00e1latok elemz\u00e9se. \u00d6sszefoglal\u00f3 k\u00f6zlem\u00e9ny\u00fcnkben a\n                    legfontosabb rutin \u00e9s speci\u00e1lis laborvizsg\u00e1latokat szervrendszerek szerint\n                    csoportos\u00edtva tekintj\u00fck \u00e1t, rem\u00e9lve, hogy ez\u00e1ltal hozz\u00e1j\u00e1rulhatunk az asphyxi\u00e1s\n                    \u00fajsz\u00fcl\u00f6ttek komplex klinikai ell\u00e1t\u00e1s\u00e1nak jav\u00edt\u00e1s\u00e1hoz. Orv Hetil. 2024; 165(47):\n                    1843\u20131853.<\/jats:p>","DOI":"10.1556\/650.2024.33158","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T12:25:10Z","timestamp":1732537510000},"page":"1843-1853","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":4,"title":["A korai laborat\u00f3riumi vizsg\u00e1latok jelent\u0151s\u00e9ge h\u0171t\u00f6tt asphyxi\u00e1s \u00fajsz\u00fcl\u00f6ttek kezel\u00e9s\u00e9ben"],"prefix":"10.1556","volume":"165","author":[{"given":"Kata","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3gia Tansz\u00e9k, MTA Kiv\u00e1l\u00f3 Kutat\u00f3hely Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedek","family":"P\u00e1szthy-Szab\u00f3","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, V\u00e1rosmajori Sz\u00edv- \u00e9s \u00c9rgy\u00f3gy\u00e1szati Klinika Budapest Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Dobi","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3gia Tansz\u00e9k, MTA Kiv\u00e1l\u00f3 Kutat\u00f3hely Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3na","family":"Kerekes","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3gia Tansz\u00e9k, MTA Kiv\u00e1l\u00f3 Kutat\u00f3hely Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Jermendy","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Gyermekgy\u00f3gy\u00e1szati Klinika, Neonatol\u00f3gia Tansz\u00e9k, MTA Kiv\u00e1l\u00f3 Kutat\u00f3hely Budapest, B\u00f3kay J. u. 53\u201354., 1083 Magyarorsz\u00e1g"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Liu L, Johnson HL, Cousens S, et al. 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Identifying early diagnostic\n                    biomarkers associated with neonatal hypoxic-ischemic encephalopathy. Diagnostics\n                    (Basel) 2021; 11: 897.","DOI":"10.3390\/diagnostics11050897"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Muniraman H, Gardner D, Skinner J, et al. Biomarkers of hepatic\n                    injury and function in neonatal hypoxic ischemic encephalopathy and with\n                    therapeutic hypothermia. Eur J Pediatr. 2017; 176: 1295\u20131303. Erratum: Eur J\n                    Pediatr. 2017; 176: 1305\u20131306.","DOI":"10.1007\/s00431-017-2980-2"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Sweetman DU, Strickland T, Isweisi E, et al. 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